Mus musculus

14 known processes

Ldha

lactate dehydrogenase A

(Aliases: Ldhm,Ldh1,l7R2)

Ldha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate catabolic process GO:0016052 32 1.000
glycolytic process GO:0006096 20 0.999
pyruvate metabolic process GO:0006090 28 0.997
Mouse
hexose catabolic process GO:0019320 3 0.993
cellular aldehyde metabolic process GO:0006081 12 0.939
generation of precursor metabolites and energy GO:0006091 103 0.913
myosin filament organization GO:0031033 3 0.910
carbohydrate metabolic process GO:0005975 230 0.862
hexose metabolic process GO:0019318 98 0.860
carbohydrate phosphorylation GO:0046835 15 0.824
pentose phosphate shunt GO:0006098 2 0.817
monocarboxylic acid metabolic process GO:0032787 191 0.799
Mouse
monosaccharide metabolic process GO:0005996 106 0.793
nadph regeneration GO:0006740 2 0.745
cellular component assembly involved in morphogenesis GO:0010927 139 0.661
ribose phosphate biosynthetic process GO:0046390 59 0.525
Mouse
purine nucleotide biosynthetic process GO:0006164 65 0.477
Mouse
muscle cell development GO:0055001 133 0.466
cellular protein complex assembly GO:0043623 116 0.465
striated muscle myosin thick filament assembly GO:0071688 1 0.451
carbohydrate derivative biosynthetic process GO:1901137 183 0.432
Mouse
glucose metabolic process GO:0006006 92 0.420
oxidation reduction process GO:0055114 342 0.379
nitrogen compound transport GO:0071705 271 0.322
myosin filament assembly GO:0031034 2 0.319
regulation of translation GO:0006417 71 0.303
nucleoside metabolic process GO:0009116 246 0.283
Mouse
ribonucleoside biosynthetic process GO:0042455 21 0.261
Mouse
atp metabolic process GO:0046034 75 0.259
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.215
purine nucleoside biosynthetic process GO:0042451 19 0.192
Mouse
myotube differentiation GO:0014902 105 0.189
transmembrane transport GO:0055085 412 0.181
negative regulation of cellular protein metabolic process GO:0032269 247 0.180
cellular homeostasis GO:0019725 240 0.180
monosaccharide biosynthetic process GO:0046364 44 0.143
purine nucleoside monophosphate metabolic process GO:0009126 81 0.143
Mouse
response to decreased oxygen levels GO:0036293 59 0.142
Zebrafish
purine nucleoside monophosphate biosynthetic process GO:0009127 9 0.142
Mouse
glucose homeostasis GO:0042593 128 0.140
nucleoside phosphate biosynthetic process GO:1901293 79 0.138
Mouse
hexose biosynthetic process GO:0019319 39 0.133
regulation of hormone levels GO:0010817 211 0.129
gluconeogenesis GO:0006094 39 0.120
sperm motility GO:0030317 47 0.116
Mouse
ribose phosphate metabolic process GO:0019693 291 0.116
Mouse
response to organonitrogen compound GO:0010243 246 0.114
actomyosin structure organization GO:0031032 56 0.109
cellular amino acid metabolic process GO:0006520 103 0.109
purine nucleotide metabolic process GO:0006163 302 0.100
Mouse
regulation of secretion GO:0051046 274 0.099
development of primary sexual characteristics GO:0045137 143 0.092
response to nicotine GO:0035094 6 0.091
cellular amine metabolic process GO:0044106 44 0.083
muscle cell differentiation GO:0042692 261 0.080
purine nucleoside triphosphate metabolic process GO:0009144 226 0.080
Mouse
positive regulation of apoptotic process GO:0043065 217 0.080
somitogenesis GO:0001756 69 0.079
nucleoside biosynthetic process GO:0009163 21 0.078
Mouse
hormone secretion GO:0046879 128 0.078
nadp metabolic process GO:0006739 6 0.073
nucleobase containing small molecule metabolic process GO:0055086 352 0.072
Mouse
purine containing compound metabolic process GO:0072521 311 0.072
Mouse
regulation of coenzyme metabolic process GO:0051196 4 0.071
oxidoreduction coenzyme metabolic process GO:0006733 16 0.070
amine metabolic process GO:0009308 45 0.069
response to molecule of bacterial origin GO:0002237 143 0.067
mitotic cell cycle GO:0000278 195 0.067
positive regulation of cellular amine metabolic process GO:0033240 5 0.065
gonad development GO:0008406 141 0.065
response to organic cyclic compound GO:0014070 198 0.064
insulin secretion GO:0030073 89 0.061
cellular carbohydrate catabolic process GO:0044275 15 0.061
fructose 6 phosphate metabolic process GO:0006002 1 0.061
mitochondrion organization GO:0007005 134 0.060
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.059
leukocyte proliferation GO:0070661 172 0.058
alpha amino acid metabolic process GO:1901605 59 0.058
purine ribonucleoside metabolic process GO:0046128 241 0.058
Mouse
myofibril assembly GO:0030239 34 0.056
regulation of cofactor metabolic process GO:0051193 5 0.055
cellular amide metabolic process GO:0043603 58 0.054
translation GO:0006412 93 0.053
mesoderm formation GO:0001707 62 0.052
nucleotide metabolic process GO:0009117 332 0.051
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.051
cell redox homeostasis GO:0045454 6 0.051
maintenance of location GO:0051235 89 0.050
cellular response to organonitrogen compound GO:0071417 145 0.050
regulation of glycolytic process GO:0006110 10 0.049
positive regulation of peptide secretion GO:0002793 33 0.048
cation transport GO:0006812 399 0.048
organophosphate biosynthetic process GO:0090407 122 0.047
Mouse
cofactor metabolic process GO:0051186 80 0.045
purine nucleoside triphosphate biosynthetic process GO:0009145 7 0.045
Mouse
regulation of cell cycle GO:0051726 281 0.044
inorganic cation transmembrane transport GO:0098662 207 0.043
response to lipopolysaccharide GO:0032496 128 0.043
cytoplasmic transport GO:0016482 234 0.043
response to oxidative stress GO:0006979 123 0.042
regulation of peptide transport GO:0090087 91 0.042
organic hydroxy compound biosynthetic process GO:1901617 77 0.042
Mouse
positive regulation of hormone secretion GO:0046887 38 0.042
regulation of cellular amino acid metabolic process GO:0006521 5 0.040
cristae formation GO:0042407 3 0.040
regulation of cellular ketone metabolic process GO:0010565 66 0.040
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.040
Mouse
cytokine production GO:0001816 319 0.040
formation of primary germ layer GO:0001704 77 0.039
organic hydroxy compound metabolic process GO:1901615 203 0.039
Mouse
regulation of membrane potential GO:0042391 192 0.039
regulation of phosphatidylcholine biosynthetic process GO:2001245 2 0.038
multicellular organismal aging GO:0010259 24 0.038
ion transmembrane transport GO:0034220 361 0.038
skin development GO:0043588 220 0.037
apoptotic signaling pathway GO:0097190 306 0.036
genitalia development GO:0048806 37 0.036
regulation of cell activation GO:0050865 289 0.036
regulation of cellular amine metabolic process GO:0033238 20 0.035
carbohydrate homeostasis GO:0033500 128 0.034
negative regulation of cell cycle phase transition GO:1901988 48 0.034
placenta development GO:0001890 140 0.032
regulation of cellular catabolic process GO:0031329 242 0.032
pyridine nucleotide biosynthetic process GO:0019363 4 0.032
protein targeting GO:0006605 143 0.031
homeostasis of number of cells GO:0048872 210 0.031
alcohol metabolic process GO:0006066 116 0.031
glycosyl compound biosynthetic process GO:1901659 21 0.031
Mouse
negative regulation of peptide secretion GO:0002792 16 0.030
cation transmembrane transport GO:0098655 266 0.028
positive regulation of hydrolase activity GO:0051345 148 0.028
pyridine containing compound metabolic process GO:0072524 14 0.028
metal ion homeostasis GO:0055065 189 0.028
peptidyl amino acid modification GO:0018193 336 0.028
purine ribonucleotide catabolic process GO:0009154 208 0.028
nucleoside triphosphate metabolic process GO:0009141 230 0.028
Mouse
cellular lipid metabolic process GO:0044255 323 0.028
purine ribonucleotide biosynthetic process GO:0009152 59 0.027
Mouse
energy derivation by oxidation of organic compounds GO:0015980 77 0.027
lipid localization GO:0010876 126 0.027
t cell activation GO:0042110 289 0.027
organonitrogen compound biosynthetic process GO:1901566 192 0.026
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.026
spermatogenesis GO:0007283 284 0.026
regulation of glucose metabolic process GO:0010906 60 0.026
purine nucleoside metabolic process GO:0042278 241 0.026
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.026
apoptotic mitochondrial changes GO:0008637 48 0.026
peptidyl proline hydroxylation GO:0019511 3 0.026
regulation of carbohydrate metabolic process GO:0006109 75 0.025
nucleoside phosphate metabolic process GO:0006753 338 0.025
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.025
Mouse
lymphocyte proliferation GO:0046651 164 0.025
protein catabolic process GO:0030163 221 0.025
positive regulation of cell death GO:0010942 224 0.025
pigmentation GO:0043473 71 0.024
ribonucleotide metabolic process GO:0009259 291 0.024
Mouse
muscle system process GO:0003012 141 0.024
striated muscle cell development GO:0055002 125 0.024
muscle cell cellular homeostasis GO:0046716 12 0.023
mitotic cell cycle checkpoint GO:0007093 31 0.023
regulation of mitotic cell cycle GO:0007346 126 0.023
cell type specific apoptotic process GO:0097285 268 0.023
anatomical structure homeostasis GO:0060249 145 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
regulation of lymphocyte activation GO:0051249 240 0.022
response to heat GO:0009408 27 0.022
neuron death GO:0070997 154 0.022
locomotory behavior GO:0007626 195 0.022
pyridine nucleotide metabolic process GO:0019362 12 0.021
amide transport GO:0042886 138 0.021
cation homeostasis GO:0055080 212 0.021
regulation of secretion by cell GO:1903530 249 0.021
cellular ketone metabolic process GO:0042180 84 0.021
regulation of cytokine production GO:0001817 266 0.021
regulation of hydrolase activity GO:0051336 246 0.021
regulation of cell cycle phase transition GO:1901987 77 0.021
cellular modified amino acid metabolic process GO:0006575 63 0.021
regulation of transferase activity GO:0051338 263 0.021
cellular response to cytokine stimulus GO:0071345 189 0.021
regulation of nucleoside metabolic process GO:0009118 130 0.020
t cell proliferation GO:0042098 120 0.020
organic acid transport GO:0015849 101 0.020
cellular ion homeostasis GO:0006873 165 0.020
somite development GO:0061053 81 0.020
nucleotide biosynthetic process GO:0009165 78 0.020
Mouse
axonogenesis GO:0007409 274 0.020
syncytium formation GO:0006949 43 0.020
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity GO:0031585 2 0.020
organic hydroxy compound transport GO:0015850 93 0.019
neural tube formation GO:0001841 108 0.019
regulation of t cell activation GO:0050863 170 0.019
regulation of protein localization GO:0032880 231 0.019
regulation of metal ion transport GO:0010959 106 0.019
positive regulation of insulin secretion GO:0032024 26 0.019
response to estrogen GO:0043627 24 0.019
glycerolipid metabolic process GO:0046486 122 0.019
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.019
intrinsic apoptotic signaling pathway GO:0097193 132 0.019
segmentation GO:0035282 93 0.019
g protein coupled receptor signaling pathway GO:0007186 243 0.019
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.019
spermatid differentiation GO:0048515 115 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
regulation of leukocyte proliferation GO:0070663 121 0.018
cellular response to dna damage stimulus GO:0006974 207 0.018
potassium ion transport GO:0006813 52 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
purine ribonucleoside monophosphate biosynthetic process GO:0009168 9 0.018
Mouse
male gamete generation GO:0048232 285 0.018
epithelial cell development GO:0002064 159 0.018
ribonucleoside monophosphate biosynthetic process GO:0009156 9 0.018
Mouse
regulation of protein kinase activity GO:0045859 232 0.018
negative regulation of cell cycle GO:0045786 123 0.018
positive regulation of protein modification process GO:0031401 299 0.017
extracellular matrix organization GO:0030198 147 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
inorganic ion transmembrane transport GO:0098660 234 0.017
developmental maturation GO:0021700 193 0.017
oxygen homeostasis GO:0032364 2 0.017
purine ribonucleoside triphosphate biosynthetic process GO:0009206 6 0.017
Mouse
negative regulation of cell proliferation GO:0008285 296 0.017
circadian regulation of gene expression GO:0032922 48 0.017
transition metal ion homeostasis GO:0055076 54 0.017
b cell activation GO:0042113 161 0.017
actin cytoskeleton organization GO:0030036 220 0.017
anion transport GO:0006820 177 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
ras protein signal transduction GO:0007265 77 0.017
epidermis development GO:0008544 187 0.017
response to inorganic substance GO:0010035 96 0.017
reactive oxygen species metabolic process GO:0072593 84 0.016
respiratory system development GO:0060541 190 0.016
ribonucleotide biosynthetic process GO:0009260 59 0.016
Mouse
phospholipid metabolic process GO:0006644 87 0.016
learning or memory GO:0007611 148 0.016
ribonucleoside triphosphate biosynthetic process GO:0009201 6 0.016
Mouse
rhythmic process GO:0048511 174 0.016
regulation of phospholipid biosynthetic process GO:0071071 3 0.016
regulation of mapk cascade GO:0043408 248 0.016
dna metabolic process GO:0006259 303 0.016
cellular response to lipid GO:0071396 145 0.016
regulation of protein serine threonine kinase activity GO:0071900 157 0.016
organic anion transport GO:0015711 137 0.016
protein polymerization GO:0051258 57 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
immune response regulating signaling pathway GO:0002764 125 0.016
response to acid chemical GO:0001101 111 0.016
protein ubiquitination GO:0016567 171 0.016
nicotinamide nucleotide metabolic process GO:0046496 12 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
Mouse
myeloid cell homeostasis GO:0002262 114 0.016
regulation of organelle organization GO:0033043 289 0.016
epithelial cell proliferation GO:0050673 174 0.016
negative regulation of neuron death GO:1901215 98 0.015
cellular divalent inorganic cation homeostasis GO:0072503 127 0.015
regulation of endopeptidase activity GO:0052548 89 0.015
regulation of defense response GO:0031347 233 0.015
regulation of cysteine type endopeptidase activity GO:2000116 65 0.015
pyridine containing compound catabolic process GO:0072526 4 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
Mouse
regulation of ion transport GO:0043269 215 0.015
negative regulation of cell cycle process GO:0010948 69 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.015
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.015
leukocyte differentiation GO:0002521 342 0.015
lateral inhibition GO:0046331 1 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
4 hydroxyproline metabolic process GO:0019471 5 0.015
striated muscle contraction GO:0006941 45 0.015
aromatic compound catabolic process GO:0019439 286 0.014
fat cell differentiation GO:0045444 160 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.014
protein oligomerization GO:0051259 67 0.014
peptide hormone secretion GO:0030072 109 0.014
second messenger mediated signaling GO:0019932 73 0.014
regulation of fat cell differentiation GO:0045598 81 0.014
regionalization GO:0003002 337 0.014
organelle assembly GO:0070925 177 0.014
lymphocyte differentiation GO:0030098 242 0.014
regulation of proteolysis GO:0030162 164 0.013
response to steroid hormone GO:0048545 56 0.013
sensory perception GO:0007600 245 0.013
heterocycle catabolic process GO:0046700 280 0.013
activation of immune response GO:0002253 138 0.013
positive regulation of nucleoside metabolic process GO:0045979 91 0.013
protein processing GO:0016485 163 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
phosphatidylethanolamine metabolic process GO:0046337 2 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
neuron neuron synaptic transmission GO:0007270 69 0.013
regulation of transmembrane transport GO:0034762 128 0.013
g2 dna damage checkpoint GO:0031572 8 0.013
regulation of peptide secretion GO:0002791 77 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
gas homeostasis GO:0033483 3 0.013
cellular response to acid chemical GO:0071229 68 0.013
regulation of kinase activity GO:0043549 249 0.013
immune response activating signal transduction GO:0002757 116 0.013
monocarboxylic acid biosynthetic process GO:0072330 61 0.013
Mouse
sulfur compound metabolic process GO:0006790 100 0.013
forebrain development GO:0030900 302 0.013
negative regulation of translation GO:0017148 22 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.013
nicotinamide nucleotide biosynthetic process GO:0019359 4 0.013
sensory organ morphogenesis GO:0090596 242 0.013
monocarboxylic acid transport GO:0015718 44 0.012
substantia nigra development GO:0021762 2 0.012
Human
regulation of apoptotic signaling pathway GO:2001233 197 0.012
positive regulation of growth GO:0045927 104 0.012
positive regulation of proteolysis GO:0045862 85 0.012
regulation of cellular response to stress GO:0080135 159 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
innate immune response GO:0045087 157 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
proteasomal protein catabolic process GO:0010498 98 0.012
carboxylic acid transport GO:0046942 100 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
morphogenesis of a branching epithelium GO:0061138 193 0.012
nuclear transport GO:0051169 139 0.012
myeloid cell differentiation GO:0030099 233 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
glutamine family amino acid biosynthetic process GO:0009084 2 0.012
protein maturation GO:0051604 176 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
compound eye development GO:0048749 1 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
mapk cascade GO:0000165 281 0.011
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.011
regulation of receptor activity GO:0010469 41 0.011
respiratory tube development GO:0030323 167 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
regulation of leukocyte apoptotic process GO:2000106 56 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
dephosphorylation GO:0016311 129 0.011
localization within membrane GO:0051668 4 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
neuronal action potential GO:0019228 54 0.011
circadian rhythm GO:0007623 114 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.011
cellular nitrogen compound catabolic process GO:0044270 280 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.011
positive regulation of cell activation GO:0050867 158 0.011
small molecule catabolic process GO:0044282 71 0.011
determination of adult lifespan GO:0008340 11 0.011
activation of cysteine type endopeptidase activity GO:0097202 27 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
peptide transport GO:0015833 133 0.011
mesoderm development GO:0007498 100 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
divalent metal ion transport GO:0070838 172 0.011
purine containing compound catabolic process GO:0072523 213 0.011
skeletal system development GO:0001501 356 0.011
intracellular protein transport GO:0006886 204 0.011
glycerophospholipid metabolic process GO:0006650 71 0.011
regulation of interleukin 8 production GO:0032677 3 0.010
inflammatory response GO:0006954 244 0.010
positive regulation of transmembrane transport GO:0034764 29 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
connective tissue development GO:0061448 179 0.010
response to nutrient levels GO:0031667 109 0.010
renal system development GO:0072001 225 0.010
cell adhesion GO:0007155 329 0.010
gland development GO:0048732 330 0.010
iron ion homeostasis GO:0055072 36 0.010
defecation GO:0030421 1 0.010
cellular response to molecule of bacterial origin GO:0071219 83 0.010
divalent inorganic cation transport GO:0072511 178 0.010
regulation of lymphocyte differentiation GO:0045619 107 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
chromatin organization GO:0006325 206 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010

Ldha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.637
carbohydrate metabolism disease DOID:0050013 0 0.382
glucose metabolism disease DOID:4194 0 0.382
acquired metabolic disease DOID:0060158 0 0.382
disease of anatomical entity DOID:7 0 0.082
nervous system disease DOID:863 0 0.082
immune system disease DOID:2914 0 0.062
anemia DOID:2355 0 0.047
hematopoietic system disease DOID:74 0 0.047
central nervous system disease DOID:331 0 0.017
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
neurodegenerative disease DOID:1289 0 0.011
organ system cancer DOID:0050686 0 0.011
neuropathy DOID:870 0 0.011