Mus musculus

22 known processes

Npc2

Niemann Pick type C2

(Aliases: HE1,2700012J19Rik,AU045843,AA408070)

Npc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sphingolipid catabolic process GO:0030149 7 0.240
cation homeostasis GO:0055080 212 0.191
membrane lipid catabolic process GO:0046466 8 0.148
sphingoid metabolic process GO:0046519 5 0.146
vacuole organization GO:0007033 38 0.139
sphingolipid metabolic process GO:0006665 45 0.130
maintenance of location GO:0051235 89 0.124
glycolipid metabolic process GO:0006664 25 0.123
membrane lipid metabolic process GO:0006643 53 0.117
ceramide catabolic process GO:0046514 7 0.117
anatomical structure homeostasis GO:0060249 145 0.113
ion transmembrane transport GO:0034220 361 0.113
glycosphingolipid catabolic process GO:0046479 5 0.109
carbohydrate derivative catabolic process GO:1901136 231 0.109
cellular homeostasis GO:0019725 240 0.105
regulation of secretion GO:0051046 274 0.100
regulation of membrane potential GO:0042391 192 0.094
t cell activation GO:0042110 289 0.093
metal ion homeostasis GO:0055065 189 0.092
regulation of peptidase activity GO:0052547 96 0.092
carbohydrate catabolic process GO:0016052 32 0.091
oxidation reduction process GO:0055114 342 0.081
lipid localization GO:0010876 126 0.077
cellular chemical homeostasis GO:0055082 215 0.076
glucose homeostasis GO:0042593 128 0.075
cellular divalent inorganic cation homeostasis GO:0072503 127 0.075
carbohydrate metabolic process GO:0005975 230 0.073
wound healing GO:0042060 157 0.068
glycolipid catabolic process GO:0019377 5 0.067
carbohydrate homeostasis GO:0033500 128 0.065
protein maturation GO:0051604 176 0.062
calcium ion homeostasis GO:0055074 127 0.061
apoptotic signaling pathway GO:0097190 306 0.060
monosaccharide metabolic process GO:0005996 106 0.059
sequestering of metal ion GO:0051238 19 0.058
immune effector process GO:0002252 321 0.058
vesicle organization GO:0016050 60 0.055
rho protein signal transduction GO:0007266 32 0.053
cellular metal ion homeostasis GO:0006875 151 0.052
regulation of vesicle mediated transport GO:0060627 139 0.050
germ cell development GO:0007281 185 0.047
regulation of angiotensin levels in blood GO:0002002 4 0.047
transmembrane transport GO:0055085 412 0.044
ceramide metabolic process GO:0006672 31 0.043
muscle tissue development GO:0060537 308 0.042
positive regulation of cell death GO:0010942 224 0.042
positive regulation of programmed cell death GO:0043068 218 0.041
cation transport GO:0006812 399 0.041
liposaccharide metabolic process GO:1903509 27 0.041
regulation of apoptotic signaling pathway GO:2001233 197 0.040
myotube cell development GO:0014904 60 0.040
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.039
lytic vacuole organization GO:0080171 21 0.039
cell killing GO:0001906 67 0.038
neuromuscular process GO:0050905 99 0.037
lipid transport GO:0006869 98 0.036
multicellular organismal homeostasis GO:0048871 164 0.036
endocytosis GO:0006897 168 0.036
divalent inorganic cation homeostasis GO:0072507 138 0.035
regulation of cell shape GO:0008360 39 0.035
establishment of protein localization to membrane GO:0090150 54 0.035
natural killer cell degranulation GO:0043320 3 0.035
multi multicellular organism process GO:0044706 109 0.035
release of sequestered calcium ion into cytosol GO:0051209 42 0.034
cellular ketone metabolic process GO:0042180 84 0.034
neuromuscular process controlling balance GO:0050885 59 0.033
response to extracellular stimulus GO:0009991 127 0.033
antigen processing and presentation GO:0019882 47 0.033
adult locomotory behavior GO:0008344 91 0.033
oligosaccharide metabolic process GO:0009311 11 0.032
endomembrane system organization GO:0010256 147 0.032
regulation of hydrolase activity GO:0051336 246 0.031
actin filament branching GO:0090135 1 0.031
locomotory behavior GO:0007626 195 0.030
hexose metabolic process GO:0019318 98 0.030
calcium ion transport GO:0006816 159 0.030
heterocycle catabolic process GO:0046700 280 0.030
tissue homeostasis GO:0001894 115 0.030
ras protein signal transduction GO:0007265 77 0.030
morphogenesis of a branching epithelium GO:0061138 193 0.030
arp2 3 complex mediated actin nucleation GO:0034314 3 0.030
fertilization GO:0009566 127 0.030
angiogenesis GO:0001525 201 0.029
positive regulation of apoptotic process GO:0043065 217 0.029
positive regulation of secretion GO:0051047 130 0.029
sequestering of calcium ion GO:0051208 18 0.029
blood vessel morphogenesis GO:0048514 285 0.029
organelle fusion GO:0048284 28 0.029
multi organism reproductive behavior GO:0044705 29 0.029
cellular response to external stimulus GO:0071496 88 0.028
reactive oxygen species metabolic process GO:0072593 84 0.028
generation of precursor metabolites and energy GO:0006091 103 0.028
carbohydrate biosynthetic process GO:0016051 74 0.028
cellular protein complex assembly GO:0043623 116 0.028
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.028
intrinsic apoptotic signaling pathway GO:0097193 132 0.028
cellular response to hormone stimulus GO:0032870 150 0.027
divalent inorganic cation transport GO:0072511 178 0.027
regulation of cellular amino acid metabolic process GO:0006521 5 0.027
protein processing GO:0016485 163 0.027
leukocyte mediated cytotoxicity GO:0001909 62 0.027
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.027
water soluble vitamin biosynthetic process GO:0042364 3 0.027
response to inorganic substance GO:0010035 96 0.026
organonitrogen compound catabolic process GO:1901565 264 0.026
male courtship behavior GO:0008049 2 0.026
lysosome organization GO:0007040 21 0.026
multicellular organismal signaling GO:0035637 91 0.025
purine nucleoside triphosphate metabolic process GO:0009144 226 0.025
regulation of neuron apoptotic process GO:0043523 122 0.025
adaptive immune response GO:0002250 155 0.025
cellular ion homeostasis GO:0006873 165 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
nucleoside metabolic process GO:0009116 246 0.025
lymphocyte proliferation GO:0046651 164 0.024
divalent metal ion transport GO:0070838 172 0.024
adult behavior GO:0030534 135 0.024
cellular lipid catabolic process GO:0044242 52 0.024
exocytosis GO:0006887 121 0.024
macromolecule catabolic process GO:0009057 281 0.023
striated muscle tissue development GO:0014706 293 0.023
lipid biosynthetic process GO:0008610 179 0.022
cell growth GO:0016049 130 0.022
leukocyte homeostasis GO:0001776 79 0.022
phagosome maturation GO:0090382 4 0.022
developmental maturation GO:0021700 193 0.022
astrocyte cell migration GO:0043615 3 0.022
homeostasis of number of cells GO:0048872 210 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
regulation of cytoplasmic transport GO:1903649 112 0.022
positive regulation of lymphocyte activation GO:0051251 140 0.022
membrane depolarization GO:0051899 64 0.021
response to nutrient levels GO:0031667 109 0.021
neuronal action potential GO:0019228 54 0.021
posttranscriptional regulation of gene expression GO:0010608 155 0.021
organelle assembly GO:0070925 177 0.021
hexose catabolic process GO:0019320 3 0.021
skeletal muscle fiber development GO:0048741 58 0.020
regulation of angiotensin metabolic process GO:0060177 4 0.020
striated muscle cell development GO:0055002 125 0.020
regulation of proteolysis GO:0030162 164 0.020
negative regulation of cellular protein metabolic process GO:0032269 247 0.020
membrane protein proteolysis GO:0033619 10 0.020
cellular calcium ion homeostasis GO:0006874 119 0.020
guanosine containing compound metabolic process GO:1901068 144 0.020
male gamete generation GO:0048232 285 0.020
regulation of cell projection organization GO:0031344 206 0.020
oligosaccharide catabolic process GO:0009313 2 0.020
ribonucleotide metabolic process GO:0009259 291 0.020
male gonad development GO:0008584 88 0.020
small molecule biosynthetic process GO:0044283 132 0.020
regulation of protein kinase activity GO:0045859 232 0.020
organic hydroxy compound transport GO:0015850 93 0.020
lysosomal transport GO:0007041 10 0.019
fat cell differentiation GO:0045444 160 0.019
small gtpase mediated signal transduction GO:0007264 97 0.019
cytoplasmic transport GO:0016482 234 0.019
actin cytoskeleton organization GO:0030036 220 0.019
sensory system development GO:0048880 3 0.019
plasma membrane organization GO:0007009 90 0.019
cytosolic calcium ion transport GO:0060401 48 0.019
t cell mediated immunity GO:0002456 50 0.019
ceramide biosynthetic process GO:0046513 20 0.019
lipid storage GO:0019915 36 0.019
regulation of cellular ketone metabolic process GO:0010565 66 0.018
positive regulation of cell activation GO:0050867 158 0.018
negative regulation of neuron death GO:1901215 98 0.018
positive regulation of t cell activation GO:0050870 101 0.018
muscle cell development GO:0055001 133 0.018
positive regulation of cell projection organization GO:0031346 95 0.018
regulation of hormone levels GO:0010817 211 0.018
sensory perception GO:0007600 245 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
reactive oxygen species biosynthetic process GO:1903409 8 0.018
phagolysosome assembly GO:0001845 3 0.018
leukocyte mediated immunity GO:0002443 174 0.018
regulation of cell activation GO:0050865 289 0.018
action potential GO:0001508 78 0.018
lung development GO:0030324 164 0.018
nuclear transport GO:0051169 139 0.018
nucleoside triphosphate metabolic process GO:0009141 230 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.017
positive regulation of cell motility GO:2000147 116 0.017
cytosolic calcium ion homeostasis GO:0051480 70 0.017
epithelial cell proliferation GO:0050673 174 0.017
mapk cascade GO:0000165 281 0.017
protein oligomerization GO:0051259 67 0.017
antigen processing and presentation of exogenous antigen GO:0019884 26 0.017
nucleotide metabolic process GO:0009117 332 0.017
central nervous system morphogenesis GO:0021551 2 0.017
cellular carbohydrate metabolic process GO:0044262 119 0.017
regulation of calcium ion transport GO:0051924 69 0.017
cellular response to nutrient levels GO:0031669 64 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
sensory perception of sound GO:0007605 97 0.017
coagulation GO:0050817 78 0.017
vesicle fusion GO:0006906 16 0.016
extrinsic apoptotic signaling pathway GO:0097191 126 0.016
skeletal muscle organ development GO:0060538 163 0.016
amine metabolic process GO:0009308 45 0.016
nucleobase containing small molecule metabolic process GO:0055086 352 0.016
regulation of endopeptidase activity GO:0052548 89 0.016
positive regulation of cellular component biogenesis GO:0044089 94 0.016
cellular amine metabolic process GO:0044106 44 0.016
response to monosaccharide GO:0034284 67 0.016
regulation of protein processing GO:0070613 96 0.016
neuron death GO:0070997 154 0.016
organism emergence from protective structure GO:0071684 4 0.016
organic acid transport GO:0015849 101 0.016
membrane organization GO:0061024 245 0.016
ossification GO:0001503 216 0.016
blastocyst development GO:0001824 80 0.016
energy derivation by oxidation of organic compounds GO:0015980 77 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
multicellular organismal catabolic process GO:0044243 7 0.016
regulation of intracellular transport GO:0032386 159 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
regulation of ion transport GO:0043269 215 0.016
multicellular organismal metabolic process GO:0044236 28 0.016
lipid catabolic process GO:0016042 69 0.016
purine ribonucleoside metabolic process GO:0046128 241 0.016
respiratory system development GO:0060541 190 0.015
aminoglycan metabolic process GO:0006022 34 0.015
regulation of homeostatic process GO:0032844 182 0.015
positive regulation of apoptotic signaling pathway GO:2001235 95 0.015
multi organism behavior GO:0051705 62 0.015
myelination GO:0042552 74 0.015
negative regulation of vesicle fusion GO:0031339 1 0.015
lamellipodium morphogenesis GO:0072673 5 0.015
lymphocyte mediated immunity GO:0002449 139 0.015
glycosyl compound catabolic process GO:1901658 206 0.015
reactive nitrogen species metabolic process GO:2001057 0 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
dephosphorylation GO:0016311 129 0.015
innate immune response GO:0045087 157 0.015
glycosylceramide metabolic process GO:0006677 4 0.015
protein localization to cell leading edge GO:1902463 1 0.015
microtubule based process GO:0007017 236 0.014
urogenital system development GO:0001655 261 0.014
anion transport GO:0006820 177 0.014
glycosphingolipid metabolic process GO:0006687 18 0.014
blood circulation GO:0008015 195 0.014
neuromuscular process controlling posture GO:0050884 14 0.014
organic anion transport GO:0015711 137 0.014
superoxide metabolic process GO:0006801 27 0.014
skeletal system development GO:0001501 356 0.014
male sex differentiation GO:0046661 109 0.014
epithelium migration GO:0090132 63 0.014
reproductive behavior GO:0019098 32 0.014
regulation of cellular response to stress GO:0080135 159 0.014
bone development GO:0060348 120 0.014
negative regulation of response to oxidative stress GO:1902883 10 0.014
regulation of cell motility GO:2000145 236 0.014
learning or memory GO:0007611 148 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
t cell proliferation GO:0042098 120 0.013
ribonucleoside metabolic process GO:0009119 245 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
neuron apoptotic process GO:0051402 142 0.013
protein localization to plasma membrane GO:0072659 57 0.013
positive regulation of peptidase activity GO:0010952 49 0.013
cellular response to extracellular stimulus GO:0031668 81 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
protein localization to membrane GO:0072657 108 0.013
regulation of leukocyte mediated immunity GO:0002703 104 0.013
l ascorbic acid metabolic process GO:0019852 4 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
regulation of metal ion transport GO:0010959 106 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.013
extracellular structure organization GO:0043062 148 0.013
inflammatory response GO:0006954 244 0.013
regulation of transferase activity GO:0051338 263 0.013
regulation of t cell activation GO:0050863 170 0.013
aromatic compound catabolic process GO:0019439 286 0.013
oogenesis GO:0048477 56 0.013
organophosphate catabolic process GO:0046434 232 0.013
regulation of body fluid levels GO:0050878 162 0.013
phospholipid metabolic process GO:0006644 87 0.013
response to organic cyclic compound GO:0014070 198 0.012
response to acid chemical GO:0001101 111 0.012
negative regulation of molecular function GO:0044092 258 0.012
galactose metabolic process GO:0006012 4 0.012
negative regulation of proteolysis GO:0045861 74 0.012
organelle fission GO:0048285 170 0.012
gtp metabolic process GO:0046039 144 0.012
meiotic cell cycle GO:0051321 122 0.012
single fertilization GO:0007338 82 0.012
glycosaminoglycan metabolic process GO:0030203 34 0.012
positive regulation of mitochondrial calcium ion concentration GO:0051561 3 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
cellular response to oxidative stress GO:0034599 76 0.012
regulation of lamellipodium morphogenesis GO:2000392 1 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
cilium morphogenesis GO:0060271 102 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
development of primary sexual characteristics GO:0045137 143 0.012
cellular response to glucose stimulus GO:0071333 45 0.012
negative regulation of wnt signaling pathway GO:0030178 73 0.012
ketone catabolic process GO:0042182 3 0.012
t cell differentiation GO:0030217 174 0.012
sensory organ morphogenesis GO:0090596 242 0.012
fatty acid transport GO:0015908 28 0.012
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.012
regulation of blood pressure GO:0008217 93 0.012
nucleoside catabolic process GO:0009164 206 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
nuclear division GO:0000280 158 0.012
response to drug GO:0042493 75 0.012
axon ensheathment GO:0008366 76 0.012
lymphocyte homeostasis GO:0002260 64 0.011
transmission of nerve impulse GO:0019226 76 0.011
cation transmembrane transport GO:0098655 266 0.011
chemotaxis GO:0006935 247 0.011
lamellipodium organization GO:0097581 29 0.011
regulation of cell migration GO:0030334 219 0.011
negative regulation of protein processing GO:0010955 79 0.011
negative regulation of protein maturation GO:1903318 79 0.011
circulatory system process GO:0003013 197 0.011
cellular glucose homeostasis GO:0001678 52 0.011
regulation of calcium ion transport into cytosol GO:0010522 31 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
sensory perception of mechanical stimulus GO:0050954 107 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
purine nucleotide metabolic process GO:0006163 302 0.011
negative regulation of response to wounding GO:1903035 77 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
mitochondrion organization GO:0007005 134 0.011
regulation of protein complex assembly GO:0043254 83 0.011
positive regulation of necrotic cell death GO:0010940 1 0.011
leukocyte differentiation GO:0002521 342 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
regulation of heart contraction GO:0008016 77 0.011
regulation of neuron projection development GO:0010975 169 0.011
protein catabolic process GO:0030163 221 0.011
antigen processing and presentation of peptide antigen GO:0048002 29 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
extracellular matrix organization GO:0030198 147 0.011
organic cyclic compound catabolic process GO:1901361 295 0.011
cofactor transport GO:0051181 4 0.011
spermatogenesis GO:0007283 284 0.011
positive regulation of lamellipodium organization GO:1902745 3 0.011
regulation of ossification GO:0030278 112 0.011
nucleotide catabolic process GO:0009166 217 0.011
lung morphogenesis GO:0060425 50 0.011
cellular amino acid metabolic process GO:0006520 103 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
female gamete generation GO:0007292 74 0.011
lymphocyte differentiation GO:0030098 242 0.011
cell type specific apoptotic process GO:0097285 268 0.010
regulation of leukocyte apoptotic process GO:2000106 56 0.010
regulation of actin nucleation GO:0051125 4 0.010
purine ribonucleotide catabolic process GO:0009154 208 0.010
regulation of protein catabolic process GO:0042176 108 0.010
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.010
myotube differentiation GO:0014902 105 0.010
positive regulation of protein modification process GO:0031401 299 0.010
connective tissue development GO:0061448 179 0.010

Npc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.878
Human
lipid storage disease DOID:9455 0 0.878
Human
lysosomal storage disease DOID:3211 0 0.878
Human
inherited metabolic disorder DOID:655 0 0.878
Human
central nervous system disease DOID:331 0 0.321
brain disease DOID:936 0 0.321
disease of anatomical entity DOID:7 0 0.321
Human
nervous system disease DOID:863 0 0.321
sphingolipidosis DOID:1927 0 0.300
Human
cerebral degeneration DOID:1443 0 0.120
epilepsy syndrome DOID:1826 0 0.093
electroclinical syndrome DOID:0050701 0 0.093
variable age at onset electroclinical syndrome DOID:0050706 0 0.040
progressive myoclonus epilepsy DOID:891 0 0.040
immune system disease DOID:2914 0 0.031
Human
neuronal ceroid lipofuscinosis DOID:14503 0 0.018
lymphatic system disease DOID:75 0 0.014
Human
neurodegenerative disease DOID:1289 0 0.013
primary immunodeficiency disease DOID:612 0 0.012
acquired metabolic disease DOID:0060158 0 0.011