Mus musculus

50 known processes

Gpx2

glutathione peroxidase 2

(Aliases: GPx-GI,GSHPx-GI,GSHPx-2)

Gpx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.109
cell junction maintenance GO:0034331 4 0.102
protein localization to membrane GO:0072657 108 0.063
apoptotic signaling pathway GO:0097190 306 0.060
Mouse
protein maturation GO:0051604 176 0.055
regulation of response to wounding GO:1903034 189 0.051
organelle localization GO:0051640 179 0.050
protein processing GO:0016485 163 0.047
negative regulation of cellular component organization GO:0051129 194 0.047
epithelial cell development GO:0002064 159 0.046
Mouse
regulation of proteolysis GO:0030162 164 0.045
regulation of cell motility GO:2000145 236 0.044
transmembrane transport GO:0055085 412 0.043
positive regulation of cell death GO:0010942 224 0.043
fertilization GO:0009566 127 0.042
cell type specific apoptotic process GO:0097285 268 0.041
Mouse
regulation of organelle organization GO:0033043 289 0.041
positive regulation of apoptotic process GO:0043065 217 0.041
striated muscle tissue development GO:0014706 293 0.040
Mouse
oocyte construction GO:0007308 2 0.040
regulation of cellular amino acid metabolic process GO:0006521 5 0.040
endomembrane system organization GO:0010256 147 0.039
muscle tissue development GO:0060537 308 0.039
Mouse
multicellular organismal water homeostasis GO:0050891 23 0.038
positive regulation of programmed cell death GO:0043068 218 0.038
membrane organization GO:0061024 245 0.037
establishment of organelle localization GO:0051656 122 0.037
ras protein signal transduction GO:0007265 77 0.037
cellular amine metabolic process GO:0044106 44 0.036
regulation of cell cycle process GO:0010564 160 0.036
regulation of cell migration GO:0030334 219 0.035
regulation of transferase activity GO:0051338 263 0.035
regulation of apoptotic signaling pathway GO:2001233 197 0.034
Mouse
regulation of protein processing GO:0070613 96 0.034
cytokine production GO:0001816 319 0.034
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.033
cellular response to dna damage stimulus GO:0006974 207 0.033
small gtpase mediated signal transduction GO:0007264 97 0.032
regulation of endopeptidase activity GO:0052548 89 0.032
response to organic cyclic compound GO:0014070 198 0.031
regulation of cytokine production GO:0001817 266 0.031
reactive oxygen species metabolic process GO:0072593 84 0.030
Mouse
amine metabolic process GO:0009308 45 0.030
regulation of peptidase activity GO:0052547 96 0.030
cellular amino acid metabolic process GO:0006520 103 0.030
negative regulation of molecular function GO:0044092 258 0.029
regulation of cellular ketone metabolic process GO:0010565 66 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.028
regulation of neuron differentiation GO:0045664 281 0.028
cellular component assembly involved in morphogenesis GO:0010927 139 0.028
adherens junction maintenance GO:0034334 1 0.028
keratinocyte differentiation GO:0030216 48 0.028
dephosphorylation GO:0016311 129 0.028
cellular lipid metabolic process GO:0044255 323 0.028
Mouse
negative regulation of proteolysis GO:0045861 74 0.028
regulation of mapk cascade GO:0043408 248 0.027
lipid homeostasis GO:0055088 63 0.027
anatomical structure homeostasis GO:0060249 145 0.027
negative regulation of cellular protein metabolic process GO:0032269 247 0.027
immune response activating signal transduction GO:0002757 116 0.026
positive regulation of mapk cascade GO:0043410 170 0.026
cellularization GO:0007349 1 0.026
cellular macromolecule catabolic process GO:0044265 206 0.025
negative regulation of organelle organization GO:0010639 90 0.025
regulation of body fluid levels GO:0050878 162 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.024
negative regulation of cell proliferation GO:0008285 296 0.024
regulation of cell cycle GO:0051726 281 0.024
negative regulation of cellular amine metabolic process GO:0033239 1 0.024
sensory perception of sound GO:0007605 97 0.024
Mouse
interspecies interaction between organisms GO:0044419 83 0.024
nucleobase containing small molecule metabolic process GO:0055086 352 0.024
response to lipopolysaccharide GO:0032496 128 0.023
negative regulation of synapse assembly GO:0051964 3 0.023
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.023
microtubule based process GO:0007017 236 0.023
compound eye development GO:0048749 1 0.023
regulation of protein maturation GO:1903317 96 0.023
regulation of membrane potential GO:0042391 192 0.023
spermatogenesis GO:0007283 284 0.023
regulation of defense response GO:0031347 233 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
establishment of protein localization to membrane GO:0090150 54 0.022
plasma membrane organization GO:0007009 90 0.022
nucleoside phosphate metabolic process GO:0006753 338 0.022
meiotic cell cycle GO:0051321 122 0.022
mesendoderm migration GO:0090133 1 0.022
protein localization to plasma membrane GO:0072659 57 0.021
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.021
modification dependent protein catabolic process GO:0019941 133 0.021
multicellular organismal signaling GO:0035637 91 0.021
regulation of protein kinase activity GO:0045859 232 0.021
aromatic compound catabolic process GO:0019439 286 0.020
wound healing GO:0042060 157 0.020
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.020
organophosphate catabolic process GO:0046434 232 0.020
response to organonitrogen compound GO:0010243 246 0.020
purine containing compound metabolic process GO:0072521 311 0.020
positive regulation of vesicle fusion GO:0031340 2 0.020
angiogenesis GO:0001525 201 0.020
Mouse
macromolecule catabolic process GO:0009057 281 0.020
muscle cell differentiation GO:0042692 261 0.019
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.019
detection of external stimulus GO:0009581 61 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.019
negative regulation of bone trabecula formation GO:1900155 1 0.019
organic hydroxy compound transport GO:0015850 93 0.019
regulation of kinase activity GO:0043549 249 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
sensory perception GO:0007600 245 0.019
Mouse
positive regulation of cell activation GO:0050867 158 0.019
response to inorganic substance GO:0010035 96 0.019
Mouse
heart process GO:0003015 94 0.019
Mouse
organic hydroxy compound metabolic process GO:1901615 203 0.019
nk t cell proliferation GO:0001866 2 0.018
cytoplasmic transport GO:0016482 234 0.018
protein ubiquitination GO:0016567 171 0.018
cell growth GO:0016049 130 0.018
steroid metabolic process GO:0008202 119 0.018
microtubule cytoskeleton organization GO:0000226 157 0.018
response to radiation GO:0009314 165 0.018
Mouse
negative regulation of protein maturation GO:1903318 79 0.018
cellular response to epidermal growth factor stimulus GO:0071364 4 0.018
glucose homeostasis GO:0042593 128 0.018
regulation of transmembrane transport GO:0034762 128 0.018
regulation of establishment of protein localization GO:0070201 181 0.018
regulation of protein serine threonine kinase activity GO:0071900 157 0.018
formation of organ boundary GO:0010160 1 0.018
lymphocyte proliferation GO:0046651 164 0.018
intrinsic apoptotic signaling pathway GO:0097193 132 0.017
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.017
regulation of ion transmembrane transport GO:0034765 119 0.017
alcohol metabolic process GO:0006066 116 0.017
protein oligomerization GO:0051259 67 0.017
oocyte axis specification GO:0007309 2 0.017
lipoprotein metabolic process GO:0042157 43 0.017
cellular response to oxidative stress GO:0034599 76 0.017
Yeast Mouse
regulation of cell projection organization GO:0031344 206 0.017
regulation of hydrolase activity GO:0051336 246 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
regulation of cellular response to stress GO:0080135 159 0.017
Mouse
transmission of nerve impulse GO:0019226 76 0.017
detection of stimulus GO:0051606 84 0.017
regulation of nuclear division GO:0051783 56 0.017
neuron apoptotic process GO:0051402 142 0.017
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.017
urogenital system development GO:0001655 261 0.016
mapk cascade GO:0000165 281 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
cellular protein catabolic process GO:0044257 155 0.016
vasodilation GO:0042311 28 0.016
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
cation transport GO:0006812 399 0.016
tissue homeostasis GO:0001894 115 0.016
establishment of vesicle localization GO:0051650 81 0.016
cation transmembrane transport GO:0098655 266 0.016
positive regulation of protein modification process GO:0031401 299 0.016
negative regulation of peptidase activity GO:0010466 46 0.016
regulation of protein localization GO:0032880 231 0.016
modification dependent macromolecule catabolic process GO:0043632 133 0.016
skeletal muscle tissue regeneration GO:0043403 20 0.015
Mouse
regulation of cell activation GO:0050865 289 0.015
immune response regulating signaling pathway GO:0002764 125 0.015
purine containing compound catabolic process GO:0072523 213 0.015
stem cell development GO:0048864 219 0.015
leukocyte proliferation GO:0070661 172 0.015
rap protein signal transduction GO:0032486 3 0.015
coagulation GO:0050817 78 0.015
negative regulation of cell activation GO:0050866 111 0.015
proteasomal protein catabolic process GO:0010498 98 0.015
germ cell development GO:0007281 185 0.015
action potential GO:0001508 78 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.015
skeletal muscle organ development GO:0060538 163 0.015
Mouse
negative regulation of defense response GO:0031348 77 0.015
multicellular organismal homeostasis GO:0048871 164 0.015
glycosyl compound catabolic process GO:1901658 206 0.015
negative regulation of protein processing GO:0010955 79 0.015
blastocyst development GO:0001824 80 0.015
exocytosis GO:0006887 121 0.014
retrograde transport endosome to golgi GO:0042147 2 0.014
protein catabolic process GO:0030163 221 0.014
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.014
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.014
negative regulation of endopeptidase activity GO:0010951 44 0.014
negative regulation of protein modification process GO:0031400 163 0.014
positive regulation of kinase activity GO:0033674 155 0.014
peptidyl amino acid modification GO:0018193 336 0.014
natural killer cell proliferation GO:0001787 3 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
skin development GO:0043588 220 0.014
heterocycle catabolic process GO:0046700 280 0.014
regulation of synaptic plasticity GO:0048167 87 0.014
inclusion body assembly GO:0070841 3 0.014
chromatin organization GO:0006325 206 0.014
rho protein signal transduction GO:0007266 32 0.014
single organismal cell cell adhesion GO:0016337 131 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
epinephrine secretion GO:0048242 1 0.014
blood vessel morphogenesis GO:0048514 285 0.013
Mouse
purine nucleoside metabolic process GO:0042278 241 0.013
regulation of intracellular transport GO:0032386 159 0.013
positive regulation of cytokine production GO:0001819 174 0.013
epithelial cell migration GO:0010631 63 0.013
Mouse
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
satellite cell activation involved in skeletal muscle regeneration GO:0014901 3 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
glycoprotein metabolic process GO:0009100 116 0.013
regulation of cell cycle phase transition GO:1901987 77 0.013
av node cell to bundle of his cell communication GO:0086067 2 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.013
regulation of secretion GO:0051046 274 0.013
cholesterol metabolic process GO:0008203 56 0.013
protein oxidation GO:0018158 2 0.013
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.013
single fertilization GO:0007338 82 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
male gamete generation GO:0048232 285 0.013
regulation of protein transport GO:0051223 163 0.013
regulation of cell division GO:0051302 76 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.013
regulation of satellite cell activation involved in skeletal muscle regeneration GO:0014717 3 0.013
chromosome segregation GO:0007059 48 0.013
innate immune response in mucosa GO:0002227 3 0.013
negative regulation of hydrolase activity GO:0051346 71 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
regulation of ion transport GO:0043269 215 0.012
neuronal action potential GO:0019228 54 0.012
membrane depolarization GO:0051899 64 0.012
intracellular mrna localization GO:0008298 4 0.012
organelle fission GO:0048285 170 0.012
cellular ketone metabolic process GO:0042180 84 0.012
calcium ion dependent exocytosis GO:0017156 35 0.012
immune effector process GO:0002252 321 0.012
regulation of keratinocyte differentiation GO:0045616 11 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.012
cellular response to lipid GO:0071396 145 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
regulation of mitotic cell cycle phase transition GO:1901990 73 0.012
negative regulation of cell size GO:0045792 3 0.012
fatty acid metabolic process GO:0006631 121 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
regulation of protein catabolic process GO:0042176 108 0.012
muscle cell development GO:0055001 133 0.012
Mouse
purine ribonucleotide catabolic process GO:0009154 208 0.012
positive regulation of organelle organization GO:0010638 128 0.012
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.012
regulation of endocytosis GO:0030100 69 0.012
sterol homeostasis GO:0055092 45 0.012
sterol metabolic process GO:0016125 58 0.012
negative regulation of dendritic spine development GO:0061000 3 0.012
ossification GO:0001503 216 0.012
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.012
nucleoside metabolic process GO:0009116 246 0.011
response to oxidative stress GO:0006979 123 0.011
Yeast Mouse
negative regulation of multi organism process GO:0043901 68 0.011
regulation of exit from mitosis GO:0007096 1 0.011
extracellular structure organization GO:0043062 148 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
establishment or maintenance of cell polarity GO:0007163 86 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
camera type eye development GO:0043010 266 0.011
epidermis development GO:0008544 187 0.011
foramen ovale closure GO:0035922 1 0.011
regulation of multi organism process GO:0043900 111 0.011
ion transmembrane transport GO:0034220 361 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
negative regulation of response to wounding GO:1903035 77 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
negative regulation of keratinocyte differentiation GO:0045617 4 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
sensory perception of mechanical stimulus GO:0050954 107 0.011
Mouse
humoral immune response GO:0006959 57 0.011
myoblast proliferation GO:0051450 11 0.011
Mouse
regulation of ovulation GO:0060278 3 0.011
cellular response to cadmium ion GO:0071276 3 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
directional locomotion GO:0033058 3 0.011
lung development GO:0030324 164 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
rab protein signal transduction GO:0032482 1 0.011
cellular response to amino acid stimulus GO:0071230 29 0.011
regulation of keratinocyte proliferation GO:0010837 15 0.011
regulation of organ morphogenesis GO:2000027 144 0.011
retina homeostasis GO:0001895 23 0.011
tissue migration GO:0090130 68 0.011
Mouse
peptide metabolic process GO:0006518 46 0.011
innate immune response GO:0045087 157 0.011
response to estrogen GO:0043627 24 0.011
positive regulation of defense response GO:0031349 124 0.011
ribonucleoside metabolic process GO:0009119 245 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.011
fucosylation GO:0036065 9 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.010
macromolecule methylation GO:0043414 120 0.010
retina development in camera type eye GO:0060041 119 0.010
positive regulation of intracellular transport GO:0032388 70 0.010
negative regulation of cell development GO:0010721 169 0.010
cell division GO:0051301 120 0.010
protein homooligomerization GO:0051260 43 0.010
nuclear division GO:0000280 158 0.010
dna metabolic process GO:0006259 303 0.010
sensory organ morphogenesis GO:0090596 242 0.010
mitotic cell cycle GO:0000278 195 0.010
organ or tissue specific immune response GO:0002251 13 0.010
regulation of renin secretion into blood stream GO:1900133 4 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
protein secretion GO:0009306 111 0.010
negative regulation of cytoskeleton organization GO:0051494 36 0.010
ribonucleoside triphosphate metabolic process GO:0009199 220 0.010
molting cycle GO:0042303 90 0.010
cell cell junction organization GO:0045216 72 0.010
wnt signaling pathway GO:0016055 188 0.010
ribonucleoside triphosphate catabolic process GO:0009203 199 0.010

Gpx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
sensory system disease DOID:0050155 0 0.027
nervous system disease DOID:863 0 0.027
eye disease DOID:5614 0 0.021
eye and adnexa disease DOID:1492 0 0.021
inherited metabolic disorder DOID:655 0 0.016
disease of metabolism DOID:0014667 0 0.016
retinal disease DOID:5679 0 0.012
retinal degeneration DOID:8466 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011