Mus musculus

0 known processes

Dlat

dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

(Aliases: DLTA,6332404G05Rik,PDC-E2)

Dlat biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
coenzyme metabolic process GO:0006732 52 0.610
Yeast Rat
citrate metabolic process GO:0006101 3 0.482
oxidation reduction process GO:0055114 342 0.445
energy derivation by oxidation of organic compounds GO:0015980 77 0.344
cofactor metabolic process GO:0051186 80 0.338
Yeast Rat
generation of precursor metabolites and energy GO:0006091 103 0.309
nucleobase containing small molecule metabolic process GO:0055086 352 0.202
nadh metabolic process GO:0006734 1 0.201
cellular respiration GO:0045333 38 0.145
tricarboxylic acid metabolic process GO:0072350 5 0.128
nad metabolic process GO:0019674 7 0.124
heterocycle catabolic process GO:0046700 280 0.122
mitochondrial membrane organization GO:0007006 26 0.103
dicarboxylic acid metabolic process GO:0043648 18 0.091
nicotinamide nucleotide metabolic process GO:0046496 12 0.090
nucleoside phosphate metabolic process GO:0006753 338 0.082
ion transmembrane transport GO:0034220 361 0.078
purine ribonucleoside metabolic process GO:0046128 241 0.077
purine ribonucleotide metabolic process GO:0009150 290 0.074
organic cyclic compound catabolic process GO:1901361 295 0.070
pyridine containing compound metabolic process GO:0072524 14 0.066
mitochondrion organization GO:0007005 134 0.063
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.059
intrinsic apoptotic signaling pathway GO:0097193 132 0.056
cellular homeostasis GO:0019725 240 0.054
translation GO:0006412 93 0.052
nucleoside triphosphate metabolic process GO:0009141 230 0.051
transmembrane transport GO:0055085 412 0.050
nucleotide metabolic process GO:0009117 332 0.049
cellular nitrogen compound catabolic process GO:0044270 280 0.049
thioester biosynthetic process GO:0035384 7 0.048
Yeast Rat
purine nucleoside metabolic process GO:0042278 241 0.048
cellular lipid metabolic process GO:0044255 323 0.048
mitochondrial translation GO:0032543 4 0.046
ribonucleoside metabolic process GO:0009119 245 0.044
glycosyl compound metabolic process GO:1901657 246 0.044
regulation of organelle organization GO:0033043 289 0.044
regulation of mitochondrial fission GO:0090140 3 0.043
oxidoreduction coenzyme metabolic process GO:0006733 16 0.042
ribonucleoside triphosphate metabolic process GO:0009199 220 0.042
response to oxidative stress GO:0006979 123 0.041
aromatic compound catabolic process GO:0019439 286 0.041
coenzyme biosynthetic process GO:0009108 23 0.040
Yeast Rat
multicellular organism growth GO:0035264 161 0.040
cellular chemical homeostasis GO:0055082 215 0.039
cofactor transport GO:0051181 4 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
organonitrogen compound catabolic process GO:1901565 264 0.037
ribose phosphate metabolic process GO:0019693 291 0.036
cellular ketone metabolic process GO:0042180 84 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
mitochondrial fusion GO:0008053 9 0.035
membrane organization GO:0061024 245 0.034
cellular ion homeostasis GO:0006873 165 0.034
cation homeostasis GO:0055080 212 0.034
purine containing compound metabolic process GO:0072521 311 0.034
organonitrogen compound biosynthetic process GO:1901566 192 0.033
regulation of membrane potential GO:0042391 192 0.033
atp metabolic process GO:0046034 75 0.033
metal ion homeostasis GO:0055065 189 0.033
cristae formation GO:0042407 3 0.032
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.032
Yeast Rat
nucleoside metabolic process GO:0009116 246 0.031
dna metabolic process GO:0006259 303 0.031
morphogenesis of embryonic epithelium GO:0016331 159 0.029
carbohydrate metabolic process GO:0005975 230 0.029
ribonucleotide metabolic process GO:0009259 291 0.028
cation transport GO:0006812 399 0.028
purine nucleoside monophosphate metabolic process GO:0009126 81 0.028
pyridine containing compound catabolic process GO:0072526 4 0.028
cellular amine metabolic process GO:0044106 44 0.028
purine nucleotide metabolic process GO:0006163 302 0.028
regulation of ion transport GO:0043269 215 0.027
response to endoplasmic reticulum stress GO:0034976 53 0.027
macromolecule catabolic process GO:0009057 281 0.027
protein localization to organelle GO:0033365 185 0.026
cellular metal ion homeostasis GO:0006875 151 0.026
organophosphate catabolic process GO:0046434 232 0.026
action potential GO:0001508 78 0.025
inner mitochondrial membrane organization GO:0007007 5 0.025
nucleotide catabolic process GO:0009166 217 0.025
intracellular protein transport GO:0006886 204 0.024
2 oxoglutarate metabolic process GO:0006103 7 0.024
amine metabolic process GO:0009308 45 0.024
cell aging GO:0007569 35 0.024
synapse organization GO:0050808 125 0.024
apoptotic signaling pathway GO:0097190 306 0.023
regulation of cytoplasmic transport GO:1903649 112 0.023
purine nucleoside triphosphate catabolic process GO:0009146 203 0.022
positive regulation of cellular amine metabolic process GO:0033240 5 0.022
positive regulation of organelle organization GO:0010638 128 0.022
multicellular organismal homeostasis GO:0048871 164 0.021
protein maturation GO:0051604 176 0.021
homeostasis of number of cells GO:0048872 210 0.021
cellular response to cytokine stimulus GO:0071345 189 0.021
mitochondrial calcium ion homeostasis GO:0051560 7 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
calcium ion homeostasis GO:0055074 127 0.021
lipid biosynthetic process GO:0008610 179 0.021
muscle cell differentiation GO:0042692 261 0.021
microtubule based process GO:0007017 236 0.020
organic hydroxy compound metabolic process GO:1901615 203 0.020
membrane fusion GO:0061025 38 0.020
anion transport GO:0006820 177 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.020
regulation of cellular amino acid metabolic process GO:0006521 5 0.020
cellular protein complex assembly GO:0043623 116 0.020
establishment of protein localization to organelle GO:0072594 118 0.020
protein processing GO:0016485 163 0.020
epithelial tube morphogenesis GO:0060562 303 0.020
spermatogenesis GO:0007283 284 0.020
leukocyte differentiation GO:0002521 342 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
cell type specific apoptotic process GO:0097285 268 0.020
forebrain development GO:0030900 302 0.020
cation transmembrane transport GO:0098655 266 0.020
regulation of cellular ketone metabolic process GO:0010565 66 0.020
organophosphate biosynthetic process GO:0090407 122 0.019
gtp catabolic process GO:0006184 143 0.019
synaptic transmission GO:0007268 329 0.019
regulation of ion transmembrane transport GO:0034765 119 0.019
response to reactive oxygen species GO:0000302 56 0.019
neuron apoptotic process GO:0051402 142 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
regulation of cell activation GO:0050865 289 0.018
regulation of secretion by cell GO:1903530 249 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
transmission of nerve impulse GO:0019226 76 0.018
regulation of intracellular protein transport GO:0033157 82 0.018
regulation of intracellular transport GO:0032386 159 0.018
sulfur compound biosynthetic process GO:0044272 37 0.018
Yeast Rat
nitrogen compound transport GO:0071705 271 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
nuclear transport GO:0051169 139 0.018
lymphocyte proliferation GO:0046651 164 0.018
nucleoside catabolic process GO:0009164 206 0.017
monocarboxylic acid metabolic process GO:0032787 191 0.017
Yeast Rat
cytoplasmic transport GO:0016482 234 0.017
camera type eye development GO:0043010 266 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
regulation of t cell proliferation GO:0042129 92 0.017
acetyl coa biosynthetic process GO:0006085 5 0.017
Yeast Rat
anatomical structure homeostasis GO:0060249 145 0.017
striated muscle tissue development GO:0014706 293 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
negative regulation of immune system process GO:0002683 209 0.016
regulation of homeostatic process GO:0032844 182 0.016
muscle tissue development GO:0060537 308 0.016
sensory perception GO:0007600 245 0.016
male gamete generation GO:0048232 285 0.016
peptidyl amino acid modification GO:0018193 336 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
endocytosis GO:0006897 168 0.016
nucleoside triphosphate catabolic process GO:0009143 205 0.016
ribonucleotide catabolic process GO:0009261 208 0.015
cellular carbohydrate metabolic process GO:0044262 119 0.015
striated muscle cell development GO:0055002 125 0.015
purine containing compound catabolic process GO:0072523 213 0.015
glycosyl compound catabolic process GO:1901658 206 0.015
glycerol ether metabolic process GO:0006662 2 0.015
multicellular organismal signaling GO:0035637 91 0.015
regulation of protein localization GO:0032880 231 0.015
response to inorganic substance GO:0010035 96 0.015
locomotory behavior GO:0007626 195 0.015
mitochondrion degradation GO:0000422 3 0.015
adult behavior GO:0030534 135 0.015
muscle system process GO:0003012 141 0.015
ossification GO:0001503 216 0.015
divalent metal ion transport GO:0070838 172 0.015
positive regulation of cell death GO:0010942 224 0.015
germ cell development GO:0007281 185 0.015
small molecule biosynthetic process GO:0044283 132 0.015
organelle fusion GO:0048284 28 0.015
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
dicarboxylic acid catabolic process GO:0043649 2 0.014
positive regulation of growth GO:0045927 104 0.014
regulation of transmembrane transport GO:0034762 128 0.014
blood vessel morphogenesis GO:0048514 285 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
nucleoside monophosphate metabolic process GO:0009123 85 0.014
multicellular organismal aging GO:0010259 24 0.014
digestive tract morphogenesis GO:0048546 147 0.014
organic anion transport GO:0015711 137 0.014
protein import GO:0017038 101 0.014
spermatid differentiation GO:0048515 115 0.014
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.014
nucleoside phosphate biosynthetic process GO:1901293 79 0.014
protein targeting GO:0006605 143 0.014
positive regulation of protein modification process GO:0031401 299 0.014
spermatid development GO:0007286 108 0.014
dna catabolic process endonucleolytic GO:0000737 15 0.013
digestive tract development GO:0048565 190 0.013
muscle fiber development GO:0048747 76 0.013
negative regulation of cell development GO:0010721 169 0.013
multi multicellular organism process GO:0044706 109 0.013
positive regulation of mitochondrion organization GO:0010822 17 0.013
leukocyte proliferation GO:0070661 172 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
skeletal system development GO:0001501 356 0.013
sulfur compound metabolic process GO:0006790 100 0.013
Yeast Rat
dephosphorylation GO:0016311 129 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
neural tube development GO:0021915 160 0.013
lymphocyte homeostasis GO:0002260 64 0.013
fatty acid metabolic process GO:0006631 121 0.013
ribonucleotide biosynthetic process GO:0009260 59 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
reactive oxygen species metabolic process GO:0072593 84 0.013
response to organic cyclic compound GO:0014070 198 0.013
tissue homeostasis GO:0001894 115 0.013
organelle localization GO:0051640 179 0.013
negative regulation of organelle organization GO:0010639 90 0.013
single organism nuclear import GO:1902593 95 0.013
regulation of secretion GO:0051046 274 0.012
neuron death GO:0070997 154 0.012
divalent inorganic cation transport GO:0072511 178 0.012
cofactor biosynthetic process GO:0051188 41 0.012
Yeast Rat
negative regulation of phosphate metabolic process GO:0045936 184 0.012
immune effector process GO:0002252 321 0.012
aerobic respiration GO:0009060 7 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
digestive system development GO:0055123 200 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
regulation of protein complex assembly GO:0043254 83 0.012
cellularization GO:0007349 1 0.012
defense response to other organism GO:0098542 197 0.012
cognition GO:0050890 149 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
neuronal action potential GO:0019228 54 0.012
telencephalon development GO:0021537 186 0.012
response to extracellular stimulus GO:0009991 127 0.012
positive regulation of cell development GO:0010720 237 0.012
leukocyte homeostasis GO:0001776 79 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
regulation of hydrolase activity GO:0051336 246 0.012
regulation of cell cycle GO:0051726 281 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
axonogenesis GO:0007409 274 0.012
pyruvate transport GO:0006848 2 0.012
connective tissue development GO:0061448 179 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
regulation of cellular response to stress GO:0080135 159 0.012
response to nutrient levels GO:0031667 109 0.012
mitotic cell cycle GO:0000278 195 0.012
muscle cell development GO:0055001 133 0.012
sequestering of calcium ion GO:0051208 18 0.012
epithelial cell proliferation GO:0050673 174 0.012
regulation of lymphocyte proliferation GO:0050670 117 0.012
acyl coa metabolic process GO:0006637 19 0.012
Yeast Rat
protein catabolic process GO:0030163 221 0.012
g protein coupled receptor signaling pathway GO:0007186 243 0.012
protein import into nucleus GO:0006606 95 0.011
regulation of mitochondrion organization GO:0010821 27 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
purine ribonucleotide biosynthetic process GO:0009152 59 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
t cell activation GO:0042110 289 0.011
response to organonitrogen compound GO:0010243 246 0.011
myeloid cell differentiation GO:0030099 233 0.011
maintenance of location GO:0051235 89 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
primary neural tube formation GO:0014020 95 0.011
regulation of protein transport GO:0051223 163 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
cellular amide metabolic process GO:0043603 58 0.011
circulatory system process GO:0003013 197 0.011
ras protein signal transduction GO:0007265 77 0.011
cellular macromolecule catabolic process GO:0044265 206 0.011
regulation of ion transmembrane transporter activity GO:0032412 54 0.011
learning GO:0007612 98 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
lymphocyte differentiation GO:0030098 242 0.011
oocyte axis specification GO:0007309 2 0.011
regulation of protein targeting GO:1903533 61 0.011
glycerolipid metabolic process GO:0046486 122 0.011
negative regulation of protein modification process GO:0031400 163 0.011
myelination GO:0042552 74 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
regulation of multi organism process GO:0043900 111 0.011
heart morphogenesis GO:0003007 178 0.011
glucose homeostasis GO:0042593 128 0.010
response to radiation GO:0009314 165 0.010
neuron neuron synaptic transmission GO:0007270 69 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
apoptotic mitochondrial changes GO:0008637 48 0.010
neural tube formation GO:0001841 108 0.010
dna catabolic process GO:0006308 19 0.010
ensheathment of neurons GO:0007272 76 0.010
phospholipid metabolic process GO:0006644 87 0.010
regulation of anatomical structure size GO:0090066 178 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
carboxylic acid biosynthetic process GO:0046394 86 0.010
regulation of cytokine production GO:0001817 266 0.010
cellular response to oxidative stress GO:0034599 76 0.010
sperm individualization GO:0007291 1 0.010
muscle contraction GO:0006936 101 0.010
regulation of metal ion transport GO:0010959 106 0.010
tube formation GO:0035148 140 0.010

Dlat disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.094
nervous system disease DOID:863 0 0.094
central nervous system disease DOID:331 0 0.026
neurodegenerative disease DOID:1289 0 0.026
sensory system disease DOID:0050155 0 0.024
eye and adnexa disease DOID:1492 0 0.024
eye disease DOID:5614 0 0.024
immune system disease DOID:2914 0 0.015
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.014
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
retinal disease DOID:5679 0 0.011
hematopoietic system disease DOID:74 0 0.010