Mus musculus

281 known processes

Ryr2

ryanodine receptor 2, cardiac

(Aliases: 9330127I20Rik)

Ryr2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 1.000
cell communication involved in cardiac conduction GO:0086065 9 1.000
regulation of membrane depolarization GO:0003254 11 1.000
regulation of striated muscle contraction GO:0006942 25 1.000
cardiac muscle contraction GO:0060048 32 0.999
regulation of muscle contraction GO:0006937 49 0.999
cardiac muscle cell contraction GO:0086003 7 0.999
striated muscle contraction GO:0006941 45 0.999
actin filament based movement GO:0030048 23 0.998
sa node cell action potential GO:0086015 4 0.998
regulation of cardiac muscle contraction GO:0055117 21 0.997
membrane depolarization during sa node cell action potential GO:0086046 2 0.997
regulation of muscle system process GO:0090257 80 0.997
cardiac conduction GO:0061337 17 0.997
ventricular cardiac muscle cell action potential GO:0086005 4 0.996
muscle system process GO:0003012 141 0.994
regulation of ion homeostasis GO:2000021 64 0.993
muscle contraction GO:0006936 101 0.991
blood circulation GO:0008015 195 0.989
heart process GO:0003015 94 0.988
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.988
regulation of cardiac muscle cell contraction GO:0086004 11 0.987
sa node cell to atrial cardiac muscle cell communication GO:0086070 5 0.985
cation transport GO:0006812 399 0.984
cation transmembrane transport GO:0098655 266 0.984
regulation of ion transmembrane transport GO:0034765 119 0.984
inorganic cation transmembrane transport GO:0098662 207 0.984
regulation of heart contraction GO:0008016 77 0.981
heart contraction GO:0060047 93 0.980
regulation of ion transport GO:0043269 215 0.978
cardiac muscle cell action potential GO:0086001 11 0.975
atrial ventricular junction remodeling GO:0003294 2 0.974
regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 5 0.968
regulation of membrane potential GO:0042391 192 0.963
av node cell to bundle of his cell communication GO:0086067 2 0.962
inorganic ion transmembrane transport GO:0098660 234 0.955
ion transmembrane transport GO:0034220 361 0.954
membrane depolarization during action potential GO:0086010 5 0.946
cation homeostasis GO:0055080 212 0.943
regulation of transmembrane transport GO:0034762 128 0.937
neuronal action potential propagation GO:0019227 8 0.929
transmembrane transport GO:0055085 412 0.929
circulatory system process GO:0003013 197 0.882
endoplasmic reticulum to cytosol transport GO:1903513 12 0.879
response to pain GO:0048265 26 0.864
metal ion homeostasis GO:0055065 189 0.864
transmission of nerve impulse GO:0019226 76 0.856
actin mediated cell contraction GO:0070252 15 0.848
regulation of system process GO:0044057 200 0.835
regulation of blood circulation GO:1903522 93 0.828
regulation of renin secretion into blood stream GO:1900133 4 0.818
membrane depolarization during cardiac muscle cell action potential GO:0086012 5 0.801
membrane depolarization GO:0051899 64 0.800
regulation of action potential GO:0098900 4 0.795
regulation of membrane repolarization GO:0060306 7 0.775
regulation of heart rate by cardiac conduction GO:0086091 6 0.772
cell cell signaling involved in cardiac conduction GO:0086019 6 0.761
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 12 0.760
multicellular organismal signaling GO:0035637 91 0.759
regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 2 0.751
cellular response to osmotic stress GO:0071470 7 0.750
action potential GO:0001508 78 0.740
sodium ion transmembrane transport GO:0035725 49 0.736
regulation of heart rate GO:0002027 36 0.725
cellular potassium ion transport GO:0071804 43 0.703
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.700
milk ejection GO:0060156 1 0.685
regulation of ion transmembrane transporter activity GO:0032412 54 0.662
striated muscle tissue development GO:0014706 293 0.644
neuronal action potential GO:0019228 54 0.636
membrane repolarization GO:0086009 7 0.634
regulation of homeostatic process GO:0032844 182 0.629
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9 0.627
divalent metal ion transport GO:0070838 172 0.627
regulation of actin filament based movement GO:1903115 12 0.623
divalent inorganic cation transport GO:0072511 178 0.623
cell communication by electrical coupling involved in cardiac conduction GO:0086064 2 0.615
potassium ion transport GO:0006813 52 0.612
potassium ion transmembrane transport GO:0071805 43 0.563
cardiac ventricle development GO:0003231 83 0.556
regulation of actin filament based process GO:0032970 99 0.513
adult locomotory behavior GO:0008344 91 0.501
foramen ovale closure GO:0035922 1 0.499
sodium ion homeostasis GO:0055078 7 0.494
adult behavior GO:0030534 135 0.485
sequestering of metal ion GO:0051238 19 0.484
reflex GO:0060004 22 0.469
locomotory behavior GO:0007626 195 0.469
calcium ion transmembrane transport GO:0070588 85 0.464
apoptotic signaling pathway GO:0097190 306 0.457
response to osmotic stress GO:0006970 21 0.434
regulation of sensory perception of pain GO:0051930 8 0.414
cellular ion homeostasis GO:0006873 165 0.406
regulation of potassium ion transmembrane transporter activity GO:1901016 7 0.404
cellular divalent inorganic cation homeostasis GO:0072503 127 0.401
regulation of voltage gated calcium channel activity GO:1901385 4 0.400
regulation of feeding behavior GO:0060259 3 0.399
regulation of metal ion transport GO:0010959 106 0.392
regulation of intracellular transport GO:0032386 159 0.383
muscle tissue development GO:0060537 308 0.381
multicellular organismal response to stress GO:0033555 62 0.365
calcium ion transport GO:0006816 159 0.363
sodium ion transport GO:0006814 73 0.360
sensory perception of sound GO:0007605 97 0.350
cell communication by chemical coupling GO:0010643 2 0.349
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.346
sensory perception of mechanical stimulus GO:0050954 107 0.344
monovalent inorganic cation homeostasis GO:0055067 33 0.338
regulation of calcium ion transport GO:0051924 69 0.333
cellular homeostasis GO:0019725 240 0.332
regulation of membrane depolarization during action potential GO:0098902 1 0.330
cellular calcium ion homeostasis GO:0006874 119 0.325
regulation of cellular ketone metabolic process GO:0010565 66 0.305
negative regulation of ion transport GO:0043271 28 0.303
synaptic transmission GO:0007268 329 0.298
positive regulation of heart rate GO:0010460 10 0.293
cardiac chamber development GO:0003205 108 0.283
muscle adaptation GO:0043500 39 0.274
neuromuscular process GO:0050905 99 0.267
cellular response to abiotic stimulus GO:0071214 56 0.266
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 10 0.264
myelination GO:0042552 74 0.262
cell type specific apoptotic process GO:0097285 268 0.256
heart morphogenesis GO:0003007 178 0.255
regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 1 0.254
response to muscle inactivity involved in regulation of muscle adaptation GO:0014877 4 0.246
intrinsic apoptotic signaling pathway GO:0097193 132 0.245
cytosolic calcium ion homeostasis GO:0051480 70 0.245
regulation of calcium ion transmembrane transport GO:1903169 20 0.244
regulation of cation channel activity GO:2001257 22 0.240
negative regulation of potassium ion transport GO:0043267 7 0.235
cardiac conduction system development GO:0003161 12 0.232
organic anion transport GO:0015711 137 0.231
cardiac chamber morphogenesis GO:0003206 93 0.230
release of sequestered calcium ion into cytosol GO:0051209 42 0.226
response to organic cyclic compound GO:0014070 198 0.226
septum primum development GO:0003284 4 0.226
striated muscle cell development GO:0055002 125 0.221
Mouse
cellular metal ion homeostasis GO:0006875 151 0.216
actin cytoskeleton organization GO:0030036 220 0.213
cognition GO:0050890 149 0.208
sensory perception GO:0007600 245 0.206
cytosolic calcium ion transport GO:0060401 48 0.205
regulation of secretion GO:0051046 274 0.204
second messenger mediated signaling GO:0019932 73 0.203
neuron migration GO:0001764 122 0.203
calcium ion transport into cytosol GO:0060402 48 0.201
regulation of transporter activity GO:0032409 57 0.199
regulation of cell activation GO:0050865 289 0.197
forebrain development GO:0030900 302 0.188
sensory perception of pain GO:0019233 47 0.184
regulation of sensory perception GO:0051931 8 0.180
adult walking behavior GO:0007628 41 0.177
muscle cell development GO:0055001 133 0.176
Mouse
positive regulation of muscle tissue development GO:1901863 32 0.173
axon ensheathment GO:0008366 76 0.173
neuron apoptotic process GO:0051402 142 0.172
calcium ion homeostasis GO:0055074 127 0.169
positive regulation of heart contraction GO:0045823 14 0.159
positive regulation of striated muscle tissue development GO:0045844 31 0.158
regulation of potassium ion transport GO:0043266 16 0.154
cellular chemical homeostasis GO:0055082 215 0.150
maintenance of location GO:0051235 89 0.146
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.146
hormone secretion GO:0046879 128 0.142
regulation of organ growth GO:0046620 61 0.138
sensory perception of light stimulus GO:0050953 54 0.135
negative regulation of homeostatic process GO:0032845 71 0.132
associative learning GO:0008306 61 0.132
neurotransmitter transport GO:0006836 76 0.130
heart growth GO:0060419 45 0.130
regulation of neuron projection development GO:0010975 169 0.128
calcium mediated signaling GO:0019722 46 0.128
hindbrain development GO:0030902 128 0.127
regulation of anatomical structure size GO:0090066 178 0.124
positive regulation of ion transport GO:0043270 65 0.123
vascular process in circulatory system GO:0003018 62 0.123
spongiotrophoblast layer development GO:0060712 15 0.121
positive regulation of blood circulation GO:1903524 22 0.119
response to inactivity GO:0014854 4 0.119
peptide transport GO:0015833 133 0.119
neuron neuron synaptic transmission GO:0007270 69 0.116
neuromuscular process controlling posture GO:0050884 14 0.114
dna metabolic process GO:0006259 303 0.114
response to light stimulus GO:0009416 135 0.114
negative regulation of cardiac muscle cell proliferation GO:0060044 5 0.112
ventricular cardiac myofibril assembly GO:0055005 3 0.111
regulation of ryanodine sensitive calcium release channel activity GO:0060314 10 0.110
positive regulation of protein phosphorylation GO:0001934 242 0.109
endomembrane system organization GO:0010256 147 0.109
t cell activation GO:0042110 289 0.109
nitrogen compound transport GO:0071705 271 0.108
telencephalon development GO:0021537 186 0.108
cellular amine metabolic process GO:0044106 44 0.108
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.107
axonogenesis GO:0007409 274 0.107
peptide hormone secretion GO:0030072 109 0.105
regulation of cardiac muscle tissue development GO:0055024 31 0.105
negative regulation of molecular function GO:0044092 258 0.105
response to muscle inactivity GO:0014870 4 0.104
regulation of neuron differentiation GO:0045664 281 0.103
cellular amino acid metabolic process GO:0006520 103 0.102
fear response GO:0042596 33 0.101
sarcomere organization GO:0045214 24 0.100
smooth muscle contraction GO:0006939 44 0.100
sinoatrial node cell differentiation GO:0060921 3 0.099
cardiac muscle tissue development GO:0048738 130 0.099
organelle assembly GO:0070925 177 0.097
regulation of cellular amine metabolic process GO:0033238 20 0.096
regulation of protein localization GO:0032880 231 0.096
metencephalon development GO:0022037 89 0.094
bundle of his development GO:0003166 4 0.093
blood vessel morphogenesis GO:0048514 285 0.093
negative regulation of cell proliferation GO:0008285 296 0.093
regulation of neurological system process GO:0031644 22 0.091
regulation of calcium ion transport into cytosol GO:0010522 31 0.090
acetylcholine secretion neurotransmission GO:0014055 2 0.090
regulation of cardiac muscle tissue growth GO:0055021 26 0.089
cardiac muscle cell differentiation GO:0055007 69 0.089
cardiac ventricle morphogenesis GO:0003208 50 0.089
cardiac muscle cell action potential involved in contraction GO:0086002 6 0.089
cellular protein complex assembly GO:0043623 116 0.088
regulation of potassium ion transmembrane transport GO:1901379 11 0.087
muscle cell differentiation GO:0042692 261 0.087
Mouse
cardiac myofibril assembly GO:0055003 12 0.087
behavioral fear response GO:0001662 28 0.087
peptide secretion GO:0002790 114 0.087
learning GO:0007612 98 0.086
nucleoside phosphate metabolic process GO:0006753 338 0.085
Human
regulation of cell shape GO:0008360 39 0.084
cell fate commitment GO:0045165 210 0.084
regulation of hormone levels GO:0010817 211 0.082
feeding behavior GO:0007631 62 0.081
memory GO:0007613 58 0.081
endoplasmic reticulum organization GO:0007029 10 0.081
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 7 0.081
amine metabolic process GO:0009308 45 0.080
cerebellum development GO:0021549 77 0.080
response to organonitrogen compound GO:0010243 246 0.080
muscle cell fate specification GO:0042694 1 0.078
olfactory learning GO:0008355 2 0.078
determination of left right symmetry GO:0007368 80 0.078
camera type eye development GO:0043010 266 0.078
detection of light stimulus GO:0009583 25 0.076
ensheathment of neurons GO:0007272 76 0.075
stem cell development GO:0048864 219 0.075
embryonic heart tube morphogenesis GO:0003143 51 0.074
embryonic organ morphogenesis GO:0048562 276 0.074
organ growth GO:0035265 117 0.073
regulation of establishment of protein localization GO:0070201 181 0.073
regulation of mapk cascade GO:0043408 248 0.073
regulation of heart growth GO:0060420 31 0.073
amide transport GO:0042886 138 0.071
positive regulation of osteoblast differentiation GO:0045669 34 0.071
cardiocyte differentiation GO:0035051 87 0.069
cardiac septum development GO:0003279 59 0.069
neurotransmitter secretion GO:0007269 62 0.069
skeletal system development GO:0001501 356 0.069
Mouse
heart trabecula formation GO:0060347 14 0.069
regulation of peptide hormone secretion GO:0090276 75 0.068
positive regulation of sodium ion transport GO:0010765 13 0.067
purine containing compound catabolic process GO:0072523 213 0.066
Human
ventricular septum development GO:0003281 42 0.066
regulation of peptide transport GO:0090087 91 0.066
axon guidance GO:0007411 141 0.066
negative regulation of calcium ion transmembrane transporter activity GO:1901020 1 0.065
positive regulation of calcium ion transmembrane transporter activity GO:1901021 8 0.065
vasodilation GO:0042311 28 0.065
nucleobase containing small molecule metabolic process GO:0055086 352 0.065
Human
macromolecule catabolic process GO:0009057 281 0.064
regulation of sodium ion transport GO:0002028 29 0.064
negative regulation of protein metabolic process GO:0051248 282 0.064
regulation of cardiac muscle cell proliferation GO:0060043 23 0.063
regulation of protein complex assembly GO:0043254 83 0.063
renal system process GO:0003014 48 0.063
regulation of cell projection organization GO:0031344 206 0.062
cellular component assembly involved in morphogenesis GO:0010927 139 0.062
cellular ketone metabolic process GO:0042180 84 0.062
myosin filament assembly GO:0031034 2 0.061
negative regulation of cardiac muscle tissue development GO:0055026 8 0.061
insulin secretion GO:0030073 89 0.061
regulation of hormone secretion GO:0046883 88 0.061
response to radiation GO:0009314 165 0.060
regulation of blood vessel size GO:0050880 56 0.060
regulation of peptide secretion GO:0002791 77 0.060
cytoplasmic transport GO:0016482 234 0.060
negative regulation of transporter activity GO:0032410 7 0.059
cardiac cell development GO:0055006 41 0.059
detection of external stimulus GO:0009581 61 0.059
divalent inorganic cation homeostasis GO:0072507 138 0.058
response to monosaccharide GO:0034284 67 0.057
vagus nerve development GO:0021564 3 0.057
carboxylic acid transport GO:0046942 100 0.056
his purkinje system cell differentiation GO:0060932 2 0.056
regulation of organelle organization GO:0033043 289 0.055
visual perception GO:0007601 52 0.055
ear morphogenesis GO:0042471 118 0.055
positive regulation of cellular amine metabolic process GO:0033240 5 0.055
regulation of behavioral fear response GO:2000822 2 0.055
regulation of transferase activity GO:0051338 263 0.054
anion transport GO:0006820 177 0.054
negative regulation of ion transmembrane transport GO:0034766 10 0.054
inflammatory response GO:0006954 244 0.053
negative regulation of cation channel activity GO:2001258 1 0.053
organelle localization GO:0051640 179 0.053
cerebral cortex development GO:0021987 86 0.053
ribose phosphate metabolic process GO:0019693 291 0.053
Human
epithelial cell proliferation GO:0050673 174 0.052
conditioned taste aversion GO:0001661 4 0.052
amino acid transport GO:0006865 61 0.051
cell communication by electrical coupling GO:0010644 4 0.050
purine ribonucleoside metabolic process GO:0046128 241 0.050
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.049
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.049
negative regulation of neuron projection development GO:0010977 50 0.049
determination of heart left right asymmetry GO:0061371 48 0.048
reproductive behavior GO:0019098 32 0.048
regulation of cardiac muscle cell action potential GO:0098901 1 0.048
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.048
urogenital system development GO:0001655 261 0.047
potassium ion homeostasis GO:0055075 4 0.046
skeletal myofibril assembly GO:0014866 4 0.046
regulation of blood pressure GO:0008217 93 0.046
striated muscle cell proliferation GO:0014855 39 0.045
regulation of epithelial cell proliferation GO:0050678 141 0.045
negative regulation of protein phosphorylation GO:0001933 126 0.045
cellular response to monosaccharide stimulus GO:0071326 47 0.045
odontogenesis of dentin containing tooth GO:0042475 66 0.045
monosaccharide metabolic process GO:0005996 106 0.044
positive regulation of cation channel activity GO:2001259 8 0.044
establishment of glial blood brain barrier GO:0060857 2 0.044
organic hydroxy compound metabolic process GO:1901615 203 0.044
learning or memory GO:0007611 148 0.043
oligodendrocyte differentiation GO:0048709 53 0.043
myofibril assembly GO:0030239 34 0.043
sensory organ morphogenesis GO:0090596 242 0.043
regulation of protein transport GO:0051223 163 0.043
cardiac atrium development GO:0003230 24 0.043
mapk cascade GO:0000165 281 0.043
protein polymerization GO:0051258 57 0.043
carbohydrate metabolic process GO:0005975 230 0.042
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.042
cardiac muscle cell proliferation GO:0060038 31 0.041
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 5 0.041
negative regulation of cellular protein metabolic process GO:0032269 247 0.041
cell cell signaling involved in lung development GO:0060495 1 0.040
negative regulation of phosphorylation GO:0042326 166 0.040
regulation of neurotransmitter secretion GO:0046928 29 0.040
mitotic cell cycle process GO:1903047 159 0.039
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 0.039
limb development GO:0060173 166 0.039
actomyosin structure organization GO:0031032 56 0.039
regulation of tongue muscle cell differentiation GO:2001035 2 0.039
positive regulation of calcium ion transport GO:0051928 27 0.039
negative regulation of growth GO:0045926 99 0.038
negative regulation of nervous system development GO:0051961 156 0.038
epidermis development GO:0008544 187 0.038
angiogenesis GO:0001525 201 0.038
nucleoside catabolic process GO:0009164 206 0.038
Human
cardiac muscle tissue growth GO:0055017 37 0.038
g protein coupled receptor signaling pathway GO:0007186 243 0.038
negative regulation of transmembrane transport GO:0034763 15 0.038
muscle tissue morphogenesis GO:0060415 53 0.038
gene silencing GO:0016458 38 0.038
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.038
canonical wnt signaling pathway GO:0060070 130 0.038
embryonic limb morphogenesis GO:0030326 126 0.038
response to alkaloid GO:0043279 34 0.038
lymphocyte proliferation GO:0046651 164 0.038
positive regulation of mapk cascade GO:0043410 170 0.038
sinoatrial node cell development GO:0060931 3 0.037
cardiac muscle cell development GO:0055013 39 0.037
myosin filament organization GO:0031033 3 0.037
mitotic cell cycle GO:0000278 195 0.037
forebrain neuron differentiation GO:0021879 52 0.037
clara cell differentiation GO:0060486 4 0.037
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.037
atrial septum development GO:0003283 12 0.036
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.036
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.036
detection of stimulus GO:0051606 84 0.036
Human
response to denervation involved in regulation of muscle adaptation GO:0014894 4 0.035
tricuspid valve development GO:0003175 3 0.035
respiratory system development GO:0060541 190 0.035
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.035
myotube differentiation GO:0014902 105 0.035
Mouse
central nervous system neuron differentiation GO:0021953 162 0.035
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.035
ribonucleoside catabolic process GO:0042454 206 0.035
Human
exocytosis GO:0006887 121 0.035
positive regulation of epithelial cell proliferation GO:0050679 68 0.034
regulation of resting membrane potential GO:0060075 3 0.034
regulation of wnt signaling pathway GO:0030111 123 0.034
regulation of high voltage gated calcium channel activity GO:1901841 2 0.034
establishment or maintenance of cell polarity GO:0007163 86 0.034
visual learning GO:0008542 44 0.034
microtubule based process GO:0007017 236 0.034
ribonucleotide catabolic process GO:0009261 208 0.034
Human
behavioral response to pain GO:0048266 15 0.033
oocyte construction GO:0007308 2 0.033
acetate ester transport GO:1901374 2 0.033
microtubule cytoskeleton organization GO:0000226 157 0.033
stem cell differentiation GO:0048863 268 0.033
protein catabolic process GO:0030163 221 0.033
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.033
gliogenesis GO:0042063 141 0.033
cellular response to growth factor stimulus GO:0071363 197 0.033
positive regulation of potassium ion transport GO:0043268 3 0.033
multi multicellular organism process GO:0044706 109 0.033
regulation of systemic arterial blood pressure GO:0003073 61 0.032
cell adhesion GO:0007155 329 0.032
positive regulation of cellular catabolic process GO:0031331 148 0.032
Human
detection of visible light GO:0009584 14 0.032
mesodermal cell migration GO:0008078 4 0.032
skeletal system morphogenesis GO:0048705 203 0.032
negative regulation of phosphorus metabolic process GO:0010563 184 0.032
response to lipopolysaccharide GO:0032496 128 0.032
regulation of cell cycle GO:0051726 281 0.032
positive regulation of ossification GO:0045778 47 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
cell junction organization GO:0034330 77 0.031
regulation of secretion by cell GO:1903530 249 0.031
cellular response to carbohydrate stimulus GO:0071322 50 0.031
protein localization to membrane GO:0072657 108 0.031
regulation of cardiac chamber formation GO:1901210 1 0.031
cell cell junction organization GO:0045216 72 0.031
acid secretion GO:0046717 33 0.031
neuron death GO:0070997 154 0.030
protein localization to organelle GO:0033365 185 0.030
Human Worm
cardiac muscle tissue morphogenesis GO:0055008 44 0.030
regulation of apoptotic signaling pathway GO:2001233 197 0.030
chemotaxis GO:0006935 247 0.030
regulation of neurotransmitter levels GO:0001505 87 0.030
telencephalon cell migration GO:0022029 55 0.030
negative regulation of calcium ion transmembrane transport GO:1903170 1 0.030
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.030
response to temperature stimulus GO:0009266 55 0.029
response to purine containing compound GO:0014074 28 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
Human
membrane organization GO:0061024 245 0.029
oocyte axis specification GO:0007309 2 0.029
negative regulation of neuron apoptotic process GO:0043524 92 0.029
regulation of cytoskeleton organization GO:0051493 122 0.029
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.029
positive regulation of behavior GO:0048520 40 0.028
positive regulation of protein modification process GO:0031401 299 0.028
acetylcholine transport GO:0015870 2 0.028
regionalization GO:0003002 337 0.028
leukocyte migration GO:0050900 124 0.028
hematopoietic progenitor cell differentiation GO:0002244 143 0.028
negative regulation of phosphate metabolic process GO:0045936 184 0.028
negative regulation of apoptotic signaling pathway GO:2001234 104 0.028
ventral spinal cord development GO:0021517 48 0.028
synaptic transmission gabaergic GO:0051932 19 0.028
negative regulation of cardiac muscle tissue growth GO:0055022 7 0.028
embryonic skeletal system development GO:0048706 120 0.027
cellular lipid metabolic process GO:0044255 323 0.027
anatomical structure homeostasis GO:0060249 145 0.027
establishment of neuroblast polarity GO:0045200 1 0.027
response to drug GO:0042493 75 0.027
Rat Fly
appendage development GO:0048736 166 0.027
sequestering of calcium ion GO:0051208 18 0.027
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.027
negative regulation of cellular component organization GO:0051129 194 0.026
dephosphorylation GO:0016311 129 0.026
heterocycle catabolic process GO:0046700 280 0.026
Human
phospholipid metabolic process GO:0006644 87 0.026
embryonic digit morphogenesis GO:0042733 56 0.026
cyclic nucleotide metabolic process GO:0009187 59 0.026
response to peptide GO:1901652 136 0.026
glycerolipid metabolic process GO:0046486 122 0.026
eating behavior GO:0042755 15 0.026
epithelial tube morphogenesis GO:0060562 303 0.026
regulation of protein kinase activity GO:0045859 232 0.026
positive regulation of cell death GO:0010942 224 0.025
Worm
peptidyl amino acid modification GO:0018193 336 0.025
purine ribonucleotide metabolic process GO:0009150 290 0.025
Human
nucleotide catabolic process GO:0009166 217 0.025
Human
positive regulation of cell development GO:0010720 237 0.025
synaptic transmission glutamatergic GO:0035249 36 0.025
sensory perception of chemical stimulus GO:0007606 51 0.025
positive regulation of transporter activity GO:0032411 17 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
Human
mesenchyme development GO:0060485 152 0.025
labyrinthine layer development GO:0060711 49 0.025
limbic system development GO:0021761 72 0.025
multi organism behavior GO:0051705 62 0.025
ventricular septum morphogenesis GO:0060412 27 0.025

Ryr2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cardiovascular system disease DOID:1287 0 0.900
Human
disease of anatomical entity DOID:7 0 0.900
Human
muscular disease DOID:0080000 0 0.343
Human
musculoskeletal system disease DOID:17 0 0.343
Human
myopathy DOID:423 0 0.343
Human
muscle tissue disease DOID:66 0 0.343
Human
heart disease DOID:114 0 0.213
Human
intrinsic cardiomyopathy DOID:0060036 0 0.097
Human
cardiomyopathy DOID:0050700 0 0.097
Human
nervous system disease DOID:863 0 0.053
central nervous system disease DOID:331 0 0.047