Mus musculus

10 known processes

Cul2

cullin 2

(Aliases: 1300003D18Rik,AI327301,KIAA4106,mKIAA4106,4932411N15Rik)

Cul2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.387
protein modification by small protein conjugation or removal GO:0070647 207 0.247
protein catabolic process GO:0030163 221 0.207
dna metabolic process GO:0006259 303 0.194
macromolecule catabolic process GO:0009057 281 0.180
microtubule based process GO:0007017 236 0.157
modification dependent protein catabolic process GO:0019941 133 0.156
cellular protein catabolic process GO:0044257 155 0.151
proteasomal protein catabolic process GO:0010498 98 0.146
translation GO:0006412 93 0.142
ubiquitin dependent protein catabolic process GO:0006511 129 0.128
protein modification by small protein removal GO:0070646 21 0.097
cellular macromolecule catabolic process GO:0044265 206 0.095
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.086
dna repair GO:0006281 107 0.076
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.064
modification dependent macromolecule catabolic process GO:0043632 133 0.061
synaptic transmission GO:0007268 329 0.060
Fly
cytoplasmic transport GO:0016482 234 0.055
ribose phosphate metabolic process GO:0019693 291 0.049
protein localization to organelle GO:0033365 185 0.049
cellular amino acid metabolic process GO:0006520 103 0.049
mitotic cell cycle process GO:1903047 159 0.047
regulation of organelle organization GO:0033043 289 0.047
protein targeting GO:0006605 143 0.045
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.045
regulation of cellular catabolic process GO:0031329 242 0.041
protein polyubiquitination GO:0000209 33 0.038
protein modification by small protein conjugation GO:0032446 187 0.038
nucleoside metabolic process GO:0009116 246 0.038
synapse organization GO:0050808 125 0.037
Fly
ribonucleoside triphosphate catabolic process GO:0009203 199 0.037
purine nucleoside catabolic process GO:0006152 205 0.036
regulation of protein localization GO:0032880 231 0.034
posttranscriptional regulation of gene expression GO:0010608 155 0.033
trna metabolic process GO:0006399 11 0.033
purine ribonucleotide metabolic process GO:0009150 290 0.033
nucleoside monophosphate catabolic process GO:0009125 59 0.032
cellular response to dna damage stimulus GO:0006974 207 0.031
trna processing GO:0008033 11 0.031
male gamete generation GO:0048232 285 0.030
mitochondrial transport GO:0006839 36 0.030
transmembrane transport GO:0055085 412 0.030
negative regulation of wnt signaling pathway GO:0030178 73 0.029
negative regulation of cell proliferation GO:0008285 296 0.029
compound eye development GO:0048749 1 0.029
heterocycle catabolic process GO:0046700 280 0.029
response to oxidative stress GO:0006979 123 0.028
endocytosis GO:0006897 168 0.028
organelle fission GO:0048285 170 0.028
regulation of protein catabolic process GO:0042176 108 0.028
organophosphate catabolic process GO:0046434 232 0.027
membrane organization GO:0061024 245 0.027
regulation of ion transport GO:0043269 215 0.027
establishment of protein localization to organelle GO:0072594 118 0.026
regulation of cell cycle GO:0051726 281 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
locomotory behavior GO:0007626 195 0.026
chromatin organization GO:0006325 206 0.025
negative regulation of cell development GO:0010721 169 0.025
regulation of membrane potential GO:0042391 192 0.025
nucleoside phosphate catabolic process GO:1901292 222 0.025
protein ubiquitination GO:0016567 171 0.025
lateral inhibition GO:0046331 1 0.025
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.025
microtubule cytoskeleton organization GO:0000226 157 0.024
mesenchyme development GO:0060485 152 0.024
cellular nitrogen compound catabolic process GO:0044270 280 0.024
organelle assembly GO:0070925 177 0.024
intracellular protein transport GO:0006886 204 0.024
regulation of proteolysis GO:0030162 164 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
purine containing compound catabolic process GO:0072523 213 0.023
maintenance of location GO:0051235 89 0.022
regulation of mitochondrial fission GO:0090140 3 0.022
purine ribonucleoside catabolic process GO:0046130 205 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.022
aromatic compound catabolic process GO:0019439 286 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
positive regulation of cellular catabolic process GO:0031331 148 0.022
mitotic cell cycle GO:0000278 195 0.022
positive regulation of dna templated transcription elongation GO:0032786 2 0.021
neuron apoptotic process GO:0051402 142 0.021
protein polymerization GO:0051258 57 0.021
positive regulation of proteolysis GO:0045862 85 0.021
spermatogenesis GO:0007283 284 0.020
response to light stimulus GO:0009416 135 0.020
regulation of secretion GO:0051046 274 0.020
ion transmembrane transport GO:0034220 361 0.020
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.020
muscle cell differentiation GO:0042692 261 0.020
lipid localization GO:0010876 126 0.020
regulation of establishment of protein localization GO:0070201 181 0.019
multi multicellular organism process GO:0044706 109 0.019
organonitrogen compound catabolic process GO:1901565 264 0.019
cellular response to organonitrogen compound GO:0071417 145 0.019
nuclear transport GO:0051169 139 0.019
protein deubiquitination GO:0016579 19 0.019
inflammatory response GO:0006954 244 0.019
cell division GO:0051301 120 0.018
nitrogen compound transport GO:0071705 271 0.018
protein import GO:0017038 101 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
neuron death GO:0070997 154 0.018
regulation of translation GO:0006417 71 0.018
mitochondrial translation GO:0032543 4 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
trna wobble base modification GO:0002097 2 0.017
ncrna processing GO:0034470 26 0.017
stem cell development GO:0048864 219 0.017
germ cell development GO:0007281 185 0.017
Fly
cellular homeostasis GO:0019725 240 0.017
nuclear division GO:0000280 158 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
cation transport GO:0006812 399 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
regulation of cellular component biogenesis GO:0044087 181 0.016
Fly
cellular response to hormone stimulus GO:0032870 150 0.016
organelle localization GO:0051640 179 0.016
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.016
regulation of cell migration GO:0030334 219 0.016
purine containing compound metabolic process GO:0072521 311 0.016
wnt signaling pathway GO:0016055 188 0.016
regulation of transmembrane transport GO:0034762 128 0.016
nucleoside catabolic process GO:0009164 206 0.016
cellular protein complex assembly GO:0043623 116 0.016
regulation of vesicle mediated transport GO:0060627 139 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
organelle disassembly GO:1903008 2 0.016
chromatin modification GO:0016568 187 0.016
purine nucleoside metabolic process GO:0042278 241 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
rna processing GO:0006396 105 0.015
double strand break repair GO:0006302 48 0.015
endomembrane system organization GO:0010256 147 0.015
stem cell differentiation GO:0048863 268 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
regulation of kinase activity GO:0043549 249 0.014
digestion GO:0007586 40 0.014
regulation of neuron death GO:1901214 134 0.014
mapk cascade GO:0000165 281 0.014
canonical wnt signaling pathway GO:0060070 130 0.014
mirna catabolic process GO:0010587 2 0.014
striated muscle myosin thick filament assembly GO:0071688 1 0.014
regulation of cellular protein catabolic process GO:1903362 61 0.014
regulation of cell motility GO:2000145 236 0.014
glycosyl compound catabolic process GO:1901658 206 0.014
cellular response to peptide GO:1901653 92 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
multi organism behavior GO:0051705 62 0.014
neural tube formation GO:0001841 108 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.014
Fly
single fertilization GO:0007338 82 0.014
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
negative regulation of cell cycle GO:0045786 123 0.013
protein oligomerization GO:0051259 67 0.013
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
snrna metabolic process GO:0016073 1 0.013
multicellular organismal protein metabolic process GO:0044268 2 0.013
lymphocyte proliferation GO:0046651 164 0.013
regulation of peptidase activity GO:0052547 96 0.013
regulation of defense response GO:0031347 233 0.013
dna recombination GO:0006310 92 0.013
purine nucleotide catabolic process GO:0006195 211 0.013
positive regulation of organelle organization GO:0010638 128 0.013
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.013
muscle cell development GO:0055001 133 0.013
response to organonitrogen compound GO:0010243 246 0.013
protein complex disassembly GO:0043241 40 0.012
learning or memory GO:0007611 148 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of cellular amino acid metabolic process GO:0006521 5 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
response to peptide GO:1901652 136 0.012
amine metabolic process GO:0009308 45 0.012
regulation of hydrolase activity GO:0051336 246 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
covalent chromatin modification GO:0016569 163 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
purine nucleoside monophosphate catabolic process GO:0009128 58 0.012
dephosphorylation GO:0016311 129 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
regulation of proteasomal protein catabolic process GO:0061136 46 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
negative regulation of protein modification process GO:0031400 163 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
nucleotide catabolic process GO:0009166 217 0.012
cation transmembrane transport GO:0098655 266 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
regulation of secretion by cell GO:1903530 249 0.012
trna wobble uridine modification GO:0002098 2 0.012
spermatid differentiation GO:0048515 115 0.012
inorganic cation transmembrane transport GO:0098662 207 0.012
meiotic cell cycle process GO:1903046 77 0.012
regulation of multi organism process GO:0043900 111 0.012
positive regulation of cellular protein catabolic process GO:1903364 34 0.012
regulation of chromosome organization GO:0033044 83 0.012
skeletal muscle organ development GO:0060538 163 0.011
peripheral nervous system development GO:0007422 53 0.011
response to organic cyclic compound GO:0014070 198 0.011
spermatid development GO:0007286 108 0.011
regulation of protein complex assembly GO:0043254 83 0.011
regulation of cellular amine metabolic process GO:0033238 20 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
divalent metal ion transport GO:0070838 172 0.011
histone modification GO:0016570 159 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
positive regulation of cell death GO:0010942 224 0.011
atp metabolic process GO:0046034 75 0.011
ribonucleoside metabolic process GO:0009119 245 0.011
mitotic cytokinesis GO:0000281 4 0.010
regulation of stem cell differentiation GO:2000736 50 0.010
myosin filament assembly GO:0031034 2 0.010
protein import into nucleus GO:0006606 95 0.010
cellular amine metabolic process GO:0044106 44 0.010
negative regulation of phosphorylation GO:0042326 166 0.010
positive regulation of protein catabolic process GO:0045732 60 0.010
glycosyl compound metabolic process GO:1901657 246 0.010

Cul2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.014