Mus musculus

488 known processes

P2rx7

purinergic receptor P2X, ligand-gated ion channel, 7

(Aliases: P2X7R,P2X(7),AI467586)

P2rx7 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response to gram positive bacterium GO:0050830 50 0.893
positive regulation of cytokine production GO:0001819 174 0.864
immune effector process GO:0002252 321 0.854
regulation of cytokine production GO:0001817 266 0.772
small gtpase mediated signal transduction GO:0007264 97 0.743
positive regulation of cell activation GO:0050867 158 0.697
inflammatory response GO:0006954 244 0.673
cytokine mediated signaling pathway GO:0019221 115 0.645
leukocyte mediated immunity GO:0002443 174 0.643
positive regulation of monocyte chemotaxis GO:0090026 2 0.624
leukocyte activation involved in immune response GO:0002366 126 0.615
helper t cell chemotaxis GO:0035704 1 0.607
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.602
regulation of eosinophil degranulation GO:0043309 1 0.599
immune response activating signal transduction GO:0002757 116 0.564
cytokine production GO:0001816 319 0.550
positive regulation of defense response GO:0031349 124 0.538
regulation of monocyte extravasation GO:2000437 2 0.507
regulation of cell activation GO:0050865 289 0.500
positive regulation of monocyte extravasation GO:2000439 1 0.499
positive regulation of innate immune response GO:0045089 80 0.489
t cell differentiation GO:0030217 174 0.469
regulation of establishment of protein localization GO:0070201 181 0.455
defense response to other organism GO:0098542 197 0.453
eosinophil activation GO:0043307 1 0.436
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.434
alpha beta t cell activation GO:0046631 91 0.431
t cell extravasation GO:0072683 4 0.431
positive regulation of adaptive immune response GO:0002821 61 0.416
extrinsic apoptotic signaling pathway GO:0097191 126 0.405
multicellular organismal homeostasis GO:0048871 164 0.404
innate immune response GO:0045087 157 0.402
regulation of adaptive immune response GO:0002819 90 0.399
defense response to bacterium GO:0042742 119 0.398
ras protein signal transduction GO:0007265 77 0.391
negative regulation of defense response GO:0031348 77 0.390
leukocyte differentiation GO:0002521 342 0.378
activation of immune response GO:0002253 138 0.377
axon guidance GO:0007411 141 0.371
regulation of defense response GO:0031347 233 0.369
positive regulation of t cell extravasation GO:2000409 2 0.369
positive regulation of lymphocyte activation GO:0051251 140 0.369
cytokine biosynthetic process GO:0042089 68 0.368
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.366
activation of innate immune response GO:0002218 56 0.365
t helper 17 cell chemotaxis GO:0035705 1 0.361
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.355
exocytosis GO:0006887 121 0.355
positive regulation of mapk cascade GO:0043410 170 0.353
g protein coupled receptor signaling pathway GO:0007186 243 0.353
calcium mediated signaling GO:0019722 46 0.349
leukocyte chemotaxis GO:0030595 69 0.336
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.331
response to molecule of bacterial origin GO:0002237 143 0.329
eosinophil mediated immunity GO:0002447 1 0.328
negative regulation of growth GO:0045926 99 0.324
dna metabolic process GO:0006259 303 0.322
production of molecular mediator of immune response GO:0002440 103 0.319
regulation of kinase activity GO:0043549 249 0.313
cation transport GO:0006812 399 0.313
regulation of innate immune response GO:0045088 91 0.310
cell activation involved in immune response GO:0002263 126 0.308
regulation of lymphocyte activation GO:0051249 240 0.306
regulation of lymphocyte proliferation GO:0050670 117 0.306
response to organonitrogen compound GO:0010243 246 0.304
second messenger mediated signaling GO:0019932 73 0.300
regulation of leukocyte proliferation GO:0070663 121 0.298
positive regulation of t cell costimulation GO:2000525 2 0.298
myeloid leukocyte activation GO:0002274 83 0.296
blood vessel morphogenesis GO:0048514 285 0.294
regulation of protein transport GO:0051223 163 0.288
immune response regulating signaling pathway GO:0002764 125 0.287
g protein coupled receptor internalization GO:0002031 3 0.284
carbohydrate derivative biosynthetic process GO:1901137 183 0.284
erk1 and erk2 cascade GO:0070371 77 0.283
negative regulation of phosphorus metabolic process GO:0010563 184 0.270
negative regulation of immune system process GO:0002683 209 0.269
ossification GO:0001503 216 0.265
positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8 0.261
positive regulation of chemotaxis GO:0050921 38 0.257
axonogenesis GO:0007409 274 0.256
regulation of leukocyte differentiation GO:1902105 159 0.253
glial cell differentiation GO:0010001 131 0.251
positive regulation of protein modification process GO:0031401 299 0.250
positive regulation of neutrophil chemotaxis GO:0090023 12 0.250
organic anion transport GO:0015711 137 0.247
granulocyte chemotaxis GO:0071621 39 0.243
regulation of leukocyte mediated immunity GO:0002703 104 0.242
positive regulation of leukocyte differentiation GO:1902107 86 0.241
response to lipopolysaccharide GO:0032496 128 0.240
positive regulation of immunological synapse formation GO:2000522 1 0.239
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.236
cell killing GO:0001906 67 0.233
leukocyte migration GO:0050900 124 0.230
regulation of mapk cascade GO:0043408 248 0.229
negative regulation of eosinophil degranulation GO:0043310 1 0.227
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.225
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.224
monocyte extravasation GO:0035696 2 0.221
myeloid leukocyte mediated immunity GO:0002444 42 0.221
alpha beta t cell differentiation GO:0046632 69 0.215
negative regulation of intracellular signal transduction GO:1902532 167 0.214
cellular response to prostaglandin d stimulus GO:0071799 1 0.213
lymphocyte mediated immunity GO:0002449 139 0.213
regulation of alpha beta t cell activation GO:0046634 53 0.211
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.211
microglia differentiation GO:0014004 2 0.210
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.210
apoptotic signaling pathway GO:0097190 306 0.209
positive regulation of growth GO:0045927 104 0.208
positive regulation of immune effector process GO:0002699 107 0.207
regulation of ossification GO:0030278 112 0.206
lymphocyte proliferation GO:0046651 164 0.205
regulation of anatomical structure size GO:0090066 178 0.202
Mouse
positive regulation of programmed cell death GO:0043068 218 0.200
positive regulation of alpha beta t cell activation GO:0046635 39 0.200
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.198
cell chemotaxis GO:0060326 81 0.197
microglial cell activation involved in immune response GO:0002282 1 0.196
regulation of phospholipase c activity GO:1900274 3 0.195
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.195
signal transduction in absence of ligand GO:0038034 55 0.195
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.195
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.194
regulation of hematopoietic stem cell migration GO:2000471 1 0.191
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.191
organonitrogen compound biosynthetic process GO:1901566 192 0.190
positive regulation of cell migration GO:0030335 109 0.186
regulation of interferon gamma production GO:0032649 57 0.185
t cell activation GO:0042110 289 0.183
membrane lipid biosynthetic process GO:0046467 32 0.183
myeloid leukocyte differentiation GO:0002573 119 0.181
dendritic cell differentiation GO:0097028 26 0.180
positive regulation of t cell activation GO:0050870 101 0.178
blood circulation GO:0008015 195 0.177
Mouse
wound healing GO:0042060 157 0.176
Mouse
cell division GO:0051301 120 0.176
regulated secretory pathway GO:0045055 32 0.173
eosinophil activation involved in immune response GO:0002278 1 0.170
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.169
myeloid cell differentiation GO:0030099 233 0.169
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.167
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.166
positive regulation of nervous system development GO:0051962 221 0.162
cellular response to cytokine stimulus GO:0071345 189 0.162
regulation of t cell costimulation GO:2000523 2 0.157
forebrain development GO:0030900 302 0.157
t helper 1 type immune response GO:0042088 25 0.153
regulation of t cell extravasation GO:2000407 3 0.153
regulation of immunological synapse formation GO:2000520 2 0.152
regulation of protein secretion GO:0050708 82 0.151
negative regulation of cellular component organization GO:0051129 194 0.150
transmembrane transport GO:0055085 412 0.146
regulation of response to wounding GO:1903034 189 0.146
myeloid cell activation involved in immune response GO:0002275 34 0.145
regulation of blood vessel size GO:0050880 56 0.144
Mouse
regulation of cell motility GO:2000145 236 0.144
adult behavior GO:0030534 135 0.143
negative regulation of ras protein signal transduction GO:0046580 18 0.143
negative regulation of phosphate metabolic process GO:0045936 184 0.142
positive regulation of cytokine biosynthetic process GO:0042108 40 0.142
negative regulation of cell proliferation GO:0008285 296 0.139
action potential GO:0001508 78 0.137
Rat
memory GO:0007613 58 0.137
vasoconstriction GO:0042310 27 0.137
Mouse
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.136
cellular amino acid metabolic process GO:0006520 103 0.134
positive regulation of lymphocyte differentiation GO:0045621 61 0.134
interleukin 12 secretion GO:0072610 3 0.133
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.133
lymphocyte differentiation GO:0030098 242 0.131
regulation of exocytosis GO:0017157 61 0.130
interferon gamma production GO:0032609 67 0.129
eosinophil degranulation GO:0043308 1 0.128
fat cell differentiation GO:0045444 160 0.128
lymphocyte activation involved in immune response GO:0002285 93 0.127
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.127
sequestering of metal ion GO:0051238 19 0.127
regulation of secretion GO:0051046 274 0.127
toll like receptor signaling pathway GO:0002224 38 0.126
regulation of tube size GO:0035150 57 0.125
Mouse
membrane organization GO:0061024 245 0.125
homeostasis of number of cells GO:0048872 210 0.124
positive regulation of leukocyte mediated immunity GO:0002705 70 0.124
purine containing compound metabolic process GO:0072521 311 0.123
chemotaxis GO:0006935 247 0.122
regulation of secretion by cell GO:1903530 249 0.122
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.122
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.121
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.121
carboxylic acid transport GO:0046942 100 0.118
negative regulation of cell activation GO:0050866 111 0.118
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.118
positive regulation of phospholipase c activity GO:0010863 2 0.118
ribonucleoside metabolic process GO:0009119 245 0.117
immune complex clearance by monocytes and macrophages GO:0002436 2 0.117
mapk cascade GO:0000165 281 0.116
response to acid chemical GO:0001101 111 0.114
phosphatidylinositol mediated signaling GO:0048015 41 0.113
positive regulation of behavior GO:0048520 40 0.113
platelet activation GO:0030168 40 0.113
Mouse
glycosyl compound metabolic process GO:1901657 246 0.112
cellular response to growth factor stimulus GO:0071363 197 0.112
angiogenesis GO:0001525 201 0.112
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.112
leukocyte proliferation GO:0070661 172 0.111
circulatory system process GO:0003013 197 0.111
Mouse
telencephalon cell migration GO:0022029 55 0.109
response to growth factor GO:0070848 198 0.109
b cell activation involved in immune response GO:0002312 50 0.108
antigen receptor mediated signaling pathway GO:0050851 64 0.108
rhythmic process GO:0048511 174 0.107
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.107
regulation of inflammatory response GO:0050727 147 0.107
positive regulation of protein phosphorylation GO:0001934 242 0.106
regulation of blood circulation GO:1903522 93 0.106
Mouse
renal system development GO:0072001 225 0.105
cytoplasmic transport GO:0016482 234 0.104
divalent inorganic cation transport GO:0072511 178 0.104
regulation of cytokine secretion GO:0050707 61 0.104
positive regulation of neutrophil migration GO:1902624 12 0.102
neuron projection guidance GO:0097485 141 0.102
sphingolipid metabolic process GO:0006665 45 0.101
negative regulation of protein metabolic process GO:0051248 282 0.101
calcium ion transport into cytosol GO:0060402 48 0.101
positive regulation of acute inflammatory response GO:0002675 16 0.100
regulation of cell migration GO:0030334 219 0.100
mature dendritic cell differentiation GO:0097029 3 0.100
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.100
immune complex clearance GO:0002434 2 0.099
regulation of dendritic cell chemotaxis GO:2000508 1 0.099
cell adhesion GO:0007155 329 0.099
anion transport GO:0006820 177 0.099
calcium ion transport GO:0006816 159 0.099
cd4 positive alpha beta t cell activation GO:0035710 45 0.098
antigen processing and presentation GO:0019882 47 0.098
t cell proliferation GO:0042098 120 0.098
regulation of osteoblast proliferation GO:0033688 15 0.097
negative regulation of cytokine production GO:0001818 84 0.096
regulation of myeloid cell differentiation GO:0045637 96 0.096
morphogenesis of a branching epithelium GO:0061138 193 0.095
multicellular organismal signaling GO:0035637 91 0.095
Rat
regulation of protein kinase b signaling GO:0051896 56 0.094
wnt signaling pathway GO:0016055 188 0.093
epithelial tube morphogenesis GO:0060562 303 0.093
vascular process in circulatory system GO:0003018 62 0.092
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.091
positive regulation of kinase activity GO:0033674 155 0.091
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.091
organophosphate biosynthetic process GO:0090407 122 0.091
nucleobase containing small molecule metabolic process GO:0055086 352 0.090
positive regulation of t cell proliferation GO:0042102 52 0.090
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.089
regulation of homeostatic process GO:0032844 182 0.089
cation homeostasis GO:0055080 212 0.089
myeloid leukocyte migration GO:0097529 57 0.088
ribose phosphate metabolic process GO:0019693 291 0.088
forebrain cell migration GO:0021885 58 0.087
positive regulation of cell motility GO:2000147 116 0.087
tumor necrosis factor production GO:0032640 50 0.087
regulation of cytokine biosynthetic process GO:0042035 59 0.087
regulation of chemotaxis GO:0050920 53 0.086
regulation of intracellular transport GO:0032386 159 0.086
regulation of membrane potential GO:0042391 192 0.085
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.085
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.082
positive regulation of inflammatory response GO:0050729 47 0.082
reactive oxygen species biosynthetic process GO:1903409 8 0.082
tumor necrosis factor biosynthetic process GO:0042533 10 0.082
tissue remodeling GO:0048771 102 0.082
regulation of transferase activity GO:0051338 263 0.081
granulocyte migration GO:0097530 43 0.080
regulation of leukocyte degranulation GO:0043300 20 0.080
ear development GO:0043583 200 0.080
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.079
regulation of neuron projection development GO:0010975 169 0.079
purine nucleotide metabolic process GO:0006163 302 0.078
glycosyl compound catabolic process GO:1901658 206 0.078
metal ion homeostasis GO:0055065 189 0.078
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.077
somatic diversification of immune receptors GO:0002200 53 0.076
regulation of ion transport GO:0043269 215 0.075
inorganic cation transmembrane transport GO:0098662 207 0.075
t cell activation involved in immune response GO:0002286 43 0.074
extracellular structure organization GO:0043062 148 0.074
regulation of systemic arterial blood pressure GO:0003073 61 0.074
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.073
response to hypoxia GO:0001666 58 0.073
Mouse
inflammatory response to antigenic stimulus GO:0002437 30 0.073
leukocyte degranulation GO:0043299 27 0.073
positive regulation of fat cell differentiation GO:0045600 32 0.072
cellular homeostasis GO:0019725 240 0.072
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.072
cellular lipid metabolic process GO:0044255 323 0.072
microglial cell activation GO:0001774 3 0.071
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.071
positive regulation of endothelial cell proliferation GO:0001938 17 0.071
positive regulation of transferase activity GO:0051347 167 0.071
multicellular organismal response to stress GO:0033555 62 0.070
Mouse
t cell differentiation involved in immune response GO:0002292 30 0.070
hypersensitivity GO:0002524 10 0.069
kidney development GO:0001822 213 0.069
blastocyst development GO:0001824 80 0.069
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.068
reactive oxygen species metabolic process GO:0072593 84 0.068
purine ribonucleoside metabolic process GO:0046128 241 0.068
nucleoside triphosphate catabolic process GO:0009143 205 0.068
ribonucleotide biosynthetic process GO:0009260 59 0.068
regulation of t helper 1 type immune response GO:0002825 17 0.067
cellular response to acid chemical GO:0071229 68 0.067
pattern recognition receptor signaling pathway GO:0002221 47 0.067
regulation of monocyte chemotaxis GO:0090025 3 0.067
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.067
alpha beta t cell activation involved in immune response GO:0002287 31 0.066
sensory perception GO:0007600 245 0.066
carbohydrate derivative catabolic process GO:1901136 231 0.066
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.066
interspecies interaction between organisms GO:0044419 83 0.066
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.066
regulation of protein kinase activity GO:0045859 232 0.066
camp biosynthetic process GO:0006171 31 0.066
multicellular organism growth GO:0035264 161 0.066
cytokine metabolic process GO:0042107 71 0.066
ameboidal type cell migration GO:0001667 128 0.065
cation transmembrane transport GO:0098655 266 0.065
regulation of neutrophil differentiation GO:0045658 2 0.065
osteoclast differentiation GO:0030316 62 0.065
regulation of hypersensitivity GO:0002883 10 0.065
nucleoside catabolic process GO:0009164 206 0.064
negative regulation of response to wounding GO:1903035 77 0.064
positive regulation of t helper 1 type immune response GO:0002827 12 0.064
regulation of muscle contraction GO:0006937 49 0.064
Mouse
cell fate commitment GO:0045165 210 0.063
positive regulation of protein transport GO:0051222 93 0.063
white fat cell proliferation GO:0070343 2 0.063
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.063
muscle tissue development GO:0060537 308 0.063
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.063
mast cell activation involved in immune response GO:0002279 20 0.062
lipid biosynthetic process GO:0008610 179 0.062
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.062
dna recombination GO:0006310 92 0.061
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.061
positive regulation of protein kinase activity GO:0045860 144 0.060
neuron projection extension GO:1990138 64 0.059
protein kinase b signaling GO:0043491 74 0.059
learning or memory GO:0007611 148 0.059
gland development GO:0048732 330 0.059
positive regulation of interferon gamma production GO:0032729 39 0.059
neuronal action potential GO:0019228 54 0.059
Rat
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.059
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.058
smooth muscle contraction GO:0006939 44 0.058
Mouse
regulation of tissue remodeling GO:0034103 38 0.058
phagocytosis GO:0006909 66 0.058
positive regulation of phospholipase activity GO:0010518 3 0.058
morphogenesis of a branching structure GO:0001763 203 0.057
glycoprotein metabolic process GO:0009100 116 0.057
positive regulation of intracellular transport GO:0032388 70 0.057
neutrophil differentiation GO:0030223 3 0.057
regulation of vasoconstriction GO:0019229 14 0.057
Mouse
endothelial cell proliferation GO:0001935 27 0.057
positive regulation of cell death GO:0010942 224 0.057
amino acid transport GO:0006865 61 0.057
acute inflammatory response GO:0002526 41 0.057
urinary bladder smooth muscle contraction GO:0014832 5 0.056
Mouse
lysosome localization GO:0032418 20 0.056
cyclic purine nucleotide metabolic process GO:0052652 43 0.056
stem cell development GO:0048864 219 0.056
coagulation GO:0050817 78 0.056
Mouse
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.056
regulation of cell size GO:0008361 72 0.055
cellular response to molecule of bacterial origin GO:0071219 83 0.055
nucleoside phosphate metabolic process GO:0006753 338 0.054
regulation of neuron differentiation GO:0045664 281 0.054
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.054
positive regulation of cell development GO:0010720 237 0.054
regulation of vesicle mediated transport GO:0060627 139 0.054
negative regulation of multi organism process GO:0043901 68 0.054
regulation of canonical wnt signaling pathway GO:0060828 82 0.054
regulation of protein serine threonine kinase activity GO:0071900 157 0.053
ion transmembrane transport GO:0034220 361 0.053
regulation of interleukin 2 production GO:0032663 28 0.053
glycerophospholipid metabolic process GO:0006650 71 0.053
positive regulation of hydrolase activity GO:0051345 148 0.053
Mouse
response to prostaglandin d GO:0071798 1 0.052
cellular carbohydrate metabolic process GO:0044262 119 0.052
positive regulation of response to wounding GO:1903036 66 0.052
negative regulation of inflammatory response GO:0050728 61 0.052
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.052
nucleotide metabolic process GO:0009117 332 0.051
epidermis development GO:0008544 187 0.051
sphingosine 1 phosphate signaling pathway GO:0003376 3 0.051
muscle system process GO:0003012 141 0.051
Mouse
immunoglobulin mediated immune response GO:0016064 69 0.051
cellular metal ion homeostasis GO:0006875 151 0.051
cognition GO:0050890 149 0.050
vascular endothelial growth factor production GO:0010573 13 0.050
regulation of cell adhesion GO:0030155 154 0.050
negative regulation of lymphocyte proliferation GO:0050672 45 0.050
germ cell development GO:0007281 185 0.050
regulation of b cell activation GO:0050864 81 0.050
calcium ion homeostasis GO:0055074 127 0.049
negative regulation of regulated secretory pathway GO:1903306 7 0.049
release of sequestered calcium ion into cytosol GO:0051209 42 0.049
response to oxygen levels GO:0070482 62 0.049
Mouse
innate immune response activating signal transduction GO:0002758 50 0.049
positive regulation of t cell differentiation GO:0045582 52 0.049
canonical wnt signaling pathway GO:0060070 130 0.049
telencephalon development GO:0021537 186 0.049
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.048
positive regulation of protein secretion GO:0050714 52 0.048
acid secretion GO:0046717 33 0.048
cellular ketone metabolic process GO:0042180 84 0.048
regulation of acute inflammatory response GO:0002673 27 0.048
positive regulation of heart rate by epinephrine norepinephrine GO:0001996 4 0.048
leukocyte apoptotic process GO:0071887 71 0.048
neutrophil chemotaxis GO:0030593 36 0.048
adaptive immune response GO:0002250 155 0.048
regulation of system process GO:0044057 200 0.048
Mouse
neutrophil migration GO:1990266 37 0.047
regulation of lymphocyte differentiation GO:0045619 107 0.047
ribonucleotide metabolic process GO:0009259 291 0.047
regulation of t cell differentiation GO:0045580 83 0.046
type 2 immune response GO:0042092 23 0.046
regulation of cellular response to growth factor stimulus GO:0090287 82 0.046
monocarboxylic acid metabolic process GO:0032787 191 0.046
oocyte differentiation GO:0009994 35 0.046
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.046
regulation of erk1 and erk2 cascade GO:0070372 71 0.046
hematopoietic stem cell migration GO:0035701 1 0.045
positive regulation of glial cell differentiation GO:0045687 21 0.045
peptidyl amino acid modification GO:0018193 336 0.045
serotonin receptor signaling pathway GO:0007210 8 0.045
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.045
oxidation reduction process GO:0055114 342 0.045
t cell receptor signaling pathway GO:0050852 46 0.045
cytokine secretion GO:0050663 72 0.045
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.045
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.045
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.045
mast cell degranulation GO:0043303 19 0.045
peptidyl tyrosine modification GO:0018212 145 0.045
heterocycle catabolic process GO:0046700 280 0.045
cell growth GO:0016049 130 0.044
mast cell mediated immunity GO:0002448 20 0.044
positive regulation of homeostatic process GO:0032846 64 0.044
cardiac muscle tissue growth involved in heart morphogenesis GO:0003245 1 0.044
regulation of calcium mediated signaling GO:0050848 19 0.044
regulation of cellular component biogenesis GO:0044087 181 0.044
regulation of mast cell degranulation GO:0043304 16 0.044
regulation of dna recombination GO:0000018 34 0.044
response to transforming growth factor beta GO:0071559 88 0.043
rho protein signal transduction GO:0007266 32 0.043
regulation of toll like receptor signaling pathway GO:0034121 20 0.043
cyclic nucleotide biosynthetic process GO:0009190 44 0.043
skeletal system morphogenesis GO:0048705 203 0.043
activation of adenylate cyclase activity GO:0007190 4 0.043
tissue homeostasis GO:0001894 115 0.043
growth of symbiont in host GO:0044117 23 0.042
cellular response to lipopolysaccharide GO:0071222 77 0.042
regulation of alpha beta t cell differentiation GO:0046637 35 0.042
odontogenesis of dentin containing tooth GO:0042475 66 0.042
plasma membrane organization GO:0007009 90 0.042
dicarboxylic acid transport GO:0006835 29 0.042
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.042
positive regulation of calcium mediated signaling GO:0050850 15 0.042
branching involved in salivary gland morphogenesis GO:0060445 26 0.042
aromatic compound catabolic process GO:0019439 286 0.041
sodium ion transport GO:0006814 73 0.041
Rat
tolerance induction GO:0002507 14 0.041
regulation of osteoclast differentiation GO:0045670 36 0.041
mammary gland morphogenesis GO:0060443 54 0.041
positive regulation of camp metabolic process GO:0030816 19 0.041
interleukin 6 production GO:0032635 58 0.041
chemokine mediated signaling pathway GO:0070098 17 0.040
sequestering of calcium ion GO:0051208 18 0.040
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.040
positive regulation of apoptotic signaling pathway GO:2001235 95 0.040
extracellular matrix organization GO:0030198 147 0.040
positive regulation of stem cell proliferation GO:2000648 59 0.040
gastrin induced gastric acid secretion GO:0001698 1 0.040
negative regulation of innate immune response GO:0045824 17 0.039
generation of precursor metabolites and energy GO:0006091 103 0.039
regulation of regulated secretory pathway GO:1903305 20 0.039
organic cyclic compound catabolic process GO:1901361 295 0.039
anatomical structure homeostasis GO:0060249 145 0.039
humoral immune response GO:0006959 57 0.039
regulation of osteoblast differentiation GO:0045667 67 0.039
regulation of t cell activation GO:0050863 170 0.039
exocrine system development GO:0035272 45 0.039
negative regulation of exocytosis GO:0045920 12 0.038
regulation of rho protein signal transduction GO:0035023 71 0.038
vesicle localization GO:0051648 86 0.038
branching morphogenesis of an epithelial tube GO:0048754 159 0.038
regulation of cell cycle GO:0051726 281 0.038

P2rx7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.060
disease of cellular proliferation DOID:14566 0 0.060
organ system cancer DOID:0050686 0 0.060