Mus musculus

327 known processes

Six4

sine oculis-related homeobox 4 homolog (Drosophila)

(Aliases: AI047561,AREC3,TrexBF)

Six4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 1.000
Mouse
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 0.998
regionalization GO:0003002 337 0.995
Mouse
embryonic skeletal system development GO:0048706 120 0.994
embryonic organ morphogenesis GO:0048562 276 0.993
striated muscle tissue development GO:0014706 293 0.990
neural tube closure GO:0001843 90 0.984
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.980
embryonic epithelial tube formation GO:0001838 130 0.972
neural tube formation GO:0001841 108 0.972
skeletal system morphogenesis GO:0048705 203 0.972
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.969
branching involved in ureteric bud morphogenesis GO:0001658 56 0.963
auditory receptor cell fate determination GO:0042668 3 0.960
somitogenesis GO:0001756 69 0.959
branch elongation involved in ureteric bud branching GO:0060681 3 0.950
tube closure GO:0060606 91 0.942
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.942
skeletal system development GO:0001501 356 0.939
tube formation GO:0035148 140 0.931
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.929
sinoatrial node cell differentiation GO:0060921 3 0.923
gastrulation GO:0007369 116 0.915
Mouse Worm
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.915
embryonic skeletal system morphogenesis GO:0048704 91 0.913
somite development GO:0061053 81 0.901
pyramidal neuron migration GO:0021852 1 0.900
regulation of retina development in camera type eye GO:1902866 3 0.894
Mouse
epithelial tube formation GO:0072175 130 0.892
central nervous system neuron differentiation GO:0021953 162 0.891
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.882
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.878
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.875
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.870
preganglionic parasympathetic nervous system development GO:0021783 17 0.870
Mouse
mesoderm formation GO:0001707 62 0.868
Mouse Worm
regulation of heart morphogenesis GO:2000826 22 0.866
Mouse
cochlea morphogenesis GO:0090103 22 0.863
Mouse
respiratory system development GO:0060541 190 0.858
muscle tissue development GO:0060537 308 0.858
neuron fate specification GO:0048665 30 0.855
Mouse
neuron projection guidance GO:0097485 141 0.855
ear morphogenesis GO:0042471 118 0.853
mesoderm development GO:0007498 100 0.849
Mouse Worm Fly
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.847
cell fate commitment GO:0045165 210 0.846
Mouse Worm
formation of primary germ layer GO:0001704 77 0.839
Mouse Worm
trachea cartilage morphogenesis GO:0060535 4 0.836
cartilage development GO:0051216 140 0.827
Mouse
ear development GO:0043583 200 0.819
metanephric capsule specification GO:0072267 1 0.813
branching morphogenesis of an epithelial tube GO:0048754 159 0.800
skeletal muscle cell differentiation GO:0035914 66 0.799
axon guidance GO:0007411 141 0.798
chromatin modification GO:0016568 187 0.795
mammary placode formation GO:0060596 4 0.792
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.792
forebrain neuron fate commitment GO:0021877 13 0.789
positive regulation of stem cell proliferation GO:2000648 59 0.787
Mouse
locus ceruleus development GO:0021703 1 0.785
renal system development GO:0072001 225 0.781
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.781
middle ear morphogenesis GO:0042474 23 0.776
Mouse
embryonic nail plate morphogenesis GO:0035880 3 0.773
cell proliferation in hindbrain GO:0021534 10 0.769
cell fate specification GO:0001708 72 0.766
Mouse Worm
stem cell maintenance GO:0019827 130 0.766
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.762
endodermal cell fate specification GO:0001714 4 0.759
cranial nerve development GO:0021545 41 0.752
autonomic nervous system development GO:0048483 43 0.747
Mouse
negative regulation of cell development GO:0010721 169 0.741
Mouse
skeletal muscle satellite cell differentiation GO:0014816 6 0.739
negative regulation of cell fate specification GO:0009996 4 0.739
regulation of bmp signaling pathway GO:0030510 60 0.739
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.738
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.730
lung development GO:0030324 164 0.728
pallium development GO:0021543 120 0.720
regulation of myoblast differentiation GO:0045661 29 0.714
stem cell differentiation GO:0048863 268 0.714
regulation of skeletal muscle fiber development GO:0048742 36 0.712
primary neural tube formation GO:0014020 95 0.712
forebrain neuron differentiation GO:0021879 52 0.712
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.699
diencephalon development GO:0021536 63 0.699
Mouse
epithelial cell morphogenesis GO:0003382 41 0.698
Mouse
regulation of cardioblast proliferation GO:0003264 9 0.696
Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.690
neuroblast migration GO:0097402 1 0.689
Mouse
parasympathetic nervous system development GO:0048486 19 0.687
Mouse
positive regulation of ureteric bud formation GO:0072107 3 0.687
nephron tubule morphogenesis GO:0072078 68 0.685
sensory organ morphogenesis GO:0090596 242 0.684
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.682
Mouse
forebrain generation of neurons GO:0021872 63 0.679
epithelial cell development GO:0002064 159 0.673
Mouse
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.671
retinal bipolar neuron differentiation GO:0060040 5 0.669
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.668
Mouse
stem cell development GO:0048864 219 0.668
Mouse
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.663
Mouse
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.662
aorta morphogenesis GO:0035909 22 0.661
Mouse
olfactory lobe development GO:0021988 32 0.661
specification of organ position GO:0010159 3 0.652
bronchiole development GO:0060435 3 0.647
embryonic viscerocranium morphogenesis GO:0048703 8 0.646
regulation of skeletal muscle cell differentiation GO:2001014 11 0.645
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.643
neural tube development GO:0021915 160 0.642
hindbrain tangential cell migration GO:0021934 2 0.638
spinal cord motor neuron differentiation GO:0021522 35 0.636
endodermal cell fate commitment GO:0001711 12 0.635
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.627
muscle cell development GO:0055001 133 0.627
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.626
epidermis development GO:0008544 187 0.625
muscle fiber development GO:0048747 76 0.624
oculomotor nerve morphogenesis GO:0021622 2 0.619
urogenital system development GO:0001655 261 0.611
morphogenesis of a branching epithelium GO:0061138 193 0.610
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.609
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.608
axonogenesis GO:0007409 274 0.604
skeletal muscle organ development GO:0060538 163 0.602
mesonephric tubule morphogenesis GO:0072171 63 0.602
regulation of mesenchymal cell proliferation GO:0010464 37 0.602
Mouse
telencephalon development GO:0021537 186 0.600
Mouse
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.598
regulation of cardiac chamber formation GO:1901210 1 0.598
myotome development GO:0061055 4 0.597
regulation of stem cell proliferation GO:0072091 78 0.597
Mouse
apoptotic process involved in morphogenesis GO:0060561 25 0.593
cranial ganglion development GO:0061550 5 0.590
skeletal muscle fiber development GO:0048741 58 0.587
muscle tissue morphogenesis GO:0060415 53 0.582
inner ear receptor cell differentiation GO:0060113 61 0.577
lung epithelial cell differentiation GO:0060487 29 0.576
spinal cord development GO:0021510 81 0.575
metanephric nephron tubule formation GO:0072289 4 0.572
cerebellar granule cell precursor proliferation GO:0021930 10 0.571
atrioventricular bundle cell differentiation GO:0003167 1 0.570
lateral line system development GO:0048925 1 0.567
cardiac muscle tissue development GO:0048738 130 0.565
developmental growth involved in morphogenesis GO:0060560 138 0.562
neuron migration GO:0001764 122 0.559
visceral motor neuron differentiation GO:0021524 3 0.559
digestive tract development GO:0048565 190 0.558
Mouse Worm
connective tissue development GO:0061448 179 0.555
Mouse Fly
appendage development GO:0048736 166 0.553
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.553
otic placode formation GO:0043049 1 0.548
regulation of organ morphogenesis GO:2000027 144 0.548
cartilage morphogenesis GO:0060536 11 0.546
regulation of cartilage development GO:0061035 44 0.542
Mouse
regulation of vascular wound healing GO:0061043 2 0.542
pharyngeal system development GO:0060037 17 0.540
lung cell differentiation GO:0060479 30 0.540
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.536
endocardial cushion formation GO:0003272 13 0.536
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.535
establishment of neuroblast polarity GO:0045200 1 0.534
kidney epithelium development GO:0072073 121 0.531
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.527
regulation of cardiac chamber morphogenesis GO:1901219 2 0.524
cerebral cortex neuron differentiation GO:0021895 19 0.523
smoothened signaling pathway GO:0007224 105 0.522
protein methylation GO:0006479 81 0.516
chondrocyte differentiation GO:0002062 72 0.516
Mouse
astrocyte fate commitment GO:0060018 4 0.515
mesenchyme development GO:0060485 152 0.514
regulation of tongue muscle cell differentiation GO:2001035 2 0.511
kidney mesenchyme development GO:0072074 14 0.507
embryonic heart tube formation GO:0003144 1 0.506
negative regulation of neuron projection development GO:0010977 50 0.505
closure of optic fissure GO:0061386 2 0.504
cardioblast proliferation GO:0003263 8 0.503
Mouse
neural crest cell differentiation GO:0014033 54 0.500
axis elongation involved in somitogenesis GO:0090245 4 0.500
cell differentiation in spinal cord GO:0021515 53 0.492
pericardium development GO:0060039 16 0.490
positive regulation of transcription by glucose GO:0046016 3 0.485
gland development GO:0048732 330 0.483
embryonic camera type eye development GO:0031076 36 0.482
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.482
his purkinje system cell differentiation GO:0060932 2 0.480
trophectodermal cell differentiation GO:0001829 21 0.474
regulation of neural retina development GO:0061074 3 0.472
Mouse
otic vesicle development GO:0071599 14 0.470
Mouse
hindbrain morphogenesis GO:0021575 46 0.469
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.469
mesenchymal cell development GO:0014031 93 0.468
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.468
morphogenesis of a branching structure GO:0001763 203 0.467
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.466
segmentation GO:0035282 93 0.464
heart formation GO:0060914 16 0.461
Mouse
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.450
semicircular canal formation GO:0060876 1 0.448
cell differentiation in hindbrain GO:0021533 24 0.446
respiratory gaseous exchange GO:0007585 43 0.445
negative regulation of nervous system development GO:0051961 156 0.441
Mouse
metencephalon development GO:0022037 89 0.439
rhombomere 3 morphogenesis GO:0021658 2 0.436
nephron development GO:0072006 109 0.435
protein alkylation GO:0008213 81 0.429
camera type eye development GO:0043010 266 0.428
Mouse
pattern specification involved in metanephros development GO:0072268 4 0.428
otic vesicle morphogenesis GO:0071600 10 0.427
limb development GO:0060173 166 0.427
determination of left right symmetry GO:0007368 80 0.426
cranial nerve morphogenesis GO:0021602 26 0.425
Mouse
myoblast differentiation GO:0045445 52 0.424
cell proliferation in midbrain GO:0033278 2 0.423
carbon catabolite repression of transcription GO:0045013 1 0.421
rhombomere 2 development GO:0021568 2 0.418
forebrain regionalization GO:0021871 25 0.416
Mouse
appendage morphogenesis GO:0035107 149 0.416
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.415
pituitary gland development GO:0021983 38 0.412
Mouse
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.409
digestive system development GO:0055123 200 0.406
Mouse Worm
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.406
neural tube patterning GO:0021532 43 0.405
mesenchymal stem cell proliferation GO:0097168 1 0.405
Mouse
determination of heart left right asymmetry GO:0061371 48 0.404
neural crest cell fate commitment GO:0014034 1 0.403
epithelial cell proliferation GO:0050673 174 0.401
salivary gland morphogenesis GO:0007435 33 0.400
embryonic appendage morphogenesis GO:0035113 126 0.395
epithelial tube morphogenesis GO:0060562 303 0.395
cardiac chamber morphogenesis GO:0003206 93 0.393
telencephalon cell migration GO:0022029 55 0.392
bmp signaling pathway GO:0030509 93 0.391
olfactory bulb development GO:0021772 30 0.389
corticotropin hormone secreting cell differentiation GO:0060128 3 0.388
inner ear morphogenesis GO:0042472 101 0.387
ectodermal placode development GO:0071696 16 0.387
mesodermal cell differentiation GO:0048333 22 0.386
Mouse Worm
regulation of auditory receptor cell differentiation GO:0045607 4 0.383
face morphogenesis GO:0060325 29 0.381
endocardial cushion morphogenesis GO:0003203 18 0.380
odontogenesis GO:0042476 78 0.380
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.378
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.377
peripheral nervous system neuron axonogenesis GO:0048936 3 0.374
optic vesicle morphogenesis GO:0003404 2 0.372
Mouse
embryonic digit morphogenesis GO:0042733 56 0.372
tendon formation GO:0035992 4 0.372
regulation of organ formation GO:0003156 34 0.369
Mouse
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.369
subpallium neuron fate commitment GO:0060163 2 0.369
forebrain development GO:0030900 302 0.369
Mouse
regulation of heart looping GO:1901207 1 0.367
neural crest cell migration GO:0001755 32 0.366
semicircular canal morphogenesis GO:0048752 7 0.365
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.361
telencephalon regionalization GO:0021978 14 0.359
Mouse
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.358
positive regulation of nervous system development GO:0051962 221 0.356
regulation of myotube differentiation GO:0010830 62 0.354
nephron tubule development GO:0072080 84 0.353
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.352
cell cell signaling involved in mammary gland development GO:0060764 2 0.351
submandibular salivary gland formation GO:0060661 1 0.349
ureteric bud development GO:0001657 94 0.348
hindbrain development GO:0030902 128 0.348
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.346
mesonephros development GO:0001823 97 0.344
mesoderm morphogenesis GO:0048332 64 0.341
Mouse Worm
cerebral cortex cell migration GO:0021795 44 0.341
heart morphogenesis GO:0003007 178 0.341
Mouse
regulation of neuron projection development GO:0010975 169 0.340
rhythmic process GO:0048511 174 0.339
Mouse
nephric duct formation GO:0072179 4 0.339
positive regulation of smoothened signaling pathway GO:0045880 23 0.337
organ induction GO:0001759 21 0.337
Mouse
noradrenergic neuron differentiation GO:0003357 6 0.336
chromatin organization GO:0006325 206 0.335
histone methylation GO:0016571 71 0.334
respiratory system process GO:0003016 25 0.329
bone development GO:0060348 120 0.329
histone modification GO:0016570 159 0.328
respiratory tube development GO:0030323 167 0.324
regulation of embryonic development GO:0045995 71 0.323
noradrenergic neuron development GO:0003358 3 0.319
negative regulation of heart looping GO:1901208 1 0.319
pons development GO:0021548 13 0.318
metanephros morphogenesis GO:0003338 24 0.316
Mouse
somite rostral caudal axis specification GO:0032525 13 0.316
vagus nerve morphogenesis GO:0021644 2 0.315
regulation of epithelial to mesenchymal transition GO:0010717 22 0.314
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.314
cardiac septum morphogenesis GO:0060411 46 0.313
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.312
mesodermal cell fate specification GO:0007501 11 0.310
Mouse Worm
vascular wound healing GO:0061042 3 0.307
negative regulation of epithelial cell proliferation GO:0050680 64 0.307
aorta development GO:0035904 23 0.306
Mouse
cartilage condensation GO:0001502 18 0.306
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.306
cardiac right ventricle formation GO:0003219 3 0.305
positive regulation of neuron differentiation GO:0045666 141 0.305
medulla oblongata development GO:0021550 3 0.304
cardiac left ventricle formation GO:0003218 1 0.302
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.297
neuron projection extension GO:1990138 64 0.297
nephron epithelium morphogenesis GO:0072088 68 0.296
cranial nerve formation GO:0021603 4 0.295
cell proliferation in forebrain GO:0021846 30 0.295
Mouse
embryonic genitalia morphogenesis GO:0030538 4 0.294
sympathetic nervous system development GO:0048485 22 0.293
digestive tract morphogenesis GO:0048546 147 0.293
Mouse Worm
mesenchymal cell differentiation GO:0048762 107 0.292
Mouse
rhombomere 5 development GO:0021571 4 0.291
cell fate determination GO:0001709 32 0.290
trigeminal ganglion development GO:0061551 5 0.290
carbon catabolite activation of transcription GO:0045991 4 0.288
compound eye development GO:0048749 1 0.288
mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis GO:0072309 3 0.287
cranial suture morphogenesis GO:0060363 8 0.286
rhombomere 3 development GO:0021569 4 0.285
sensory perception of sound GO:0007605 97 0.285
Mouse
palate development GO:0060021 76 0.284
specification of organ identity GO:0010092 30 0.283
Mouse
pancreatic pp cell fate commitment GO:0003329 2 0.282
development of primary sexual characteristics GO:0045137 143 0.281
ureteric bud elongation GO:0060677 6 0.281
morphogenesis of embryonic epithelium GO:0016331 159 0.280
mesonephric tubule development GO:0072164 94 0.280
mesenchymal to epithelial transition GO:0060231 12 0.280
Mouse
covalent chromatin modification GO:0016569 163 0.280
cell cell signaling involved in cell fate commitment GO:0045168 35 0.279
Mouse
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.278
cardiac muscle cell myoblast differentiation GO:0060379 8 0.278
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.278
primitive streak formation GO:0090009 10 0.277
negative regulation of wnt signaling pathway GO:0030178 73 0.275
Mouse
positive regulation of wnt signaling pathway GO:0030177 45 0.274
skeletal muscle fiber differentiation GO:0098528 5 0.273
regulation of chondrocyte differentiation GO:0032330 33 0.273
Mouse
midbrain hindbrain boundary development GO:0030917 9 0.272
pulmonary valve formation GO:0003193 1 0.269
establishment or maintenance of neuroblast polarity GO:0045196 1 0.269
regulation of cell cycle GO:0051726 281 0.269
Mouse
pancreas development GO:0031016 57 0.268
forelimb morphogenesis GO:0035136 40 0.268
cardiac septum development GO:0003279 59 0.267
midbrain hindbrain boundary maturation GO:0021732 1 0.266
rhombomere morphogenesis GO:0021593 2 0.265
mesangial cell differentiation GO:0072007 4 0.265
developmental maturation GO:0021700 193 0.263
Mouse
trochlear nerve development GO:0021558 3 0.262
bronchiole morphogenesis GO:0060436 1 0.261
ventricular septum morphogenesis GO:0060412 27 0.260
myotube differentiation GO:0014902 105 0.259
extraocular skeletal muscle development GO:0002074 2 0.259
ureteric bud morphogenesis GO:0060675 62 0.257
renal tubule morphogenesis GO:0061333 72 0.257
chemotaxis GO:0006935 247 0.255
mechanoreceptor differentiation GO:0042490 67 0.255
myotube cell development GO:0014904 60 0.253
regulation of branch elongation involved in ureteric bud branching GO:0072095 3 0.253
ganglion development GO:0061548 13 0.251
renal tubule development GO:0061326 87 0.251
positive regulation of cell development GO:0010720 237 0.251
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.251
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.251
prostate gland morphogenesis GO:0060512 32 0.250
blood vessel morphogenesis GO:0048514 285 0.249
Mouse
regulation of organelle organization GO:0033043 289 0.248
muscle cell differentiation GO:0042692 261 0.248
mitral valve morphogenesis GO:0003183 4 0.248
dopaminergic neuron differentiation GO:0071542 14 0.248
dorsal spinal cord development GO:0021516 20 0.247
gliogenesis GO:0042063 141 0.246
sensory system development GO:0048880 3 0.245
meiotic cell cycle GO:0051321 122 0.245
lung epithelium development GO:0060428 37 0.241
development of primary male sexual characteristics GO:0046546 88 0.240
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.239
Mouse
ectodermal placode formation GO:0060788 16 0.239
glial cell differentiation GO:0010001 131 0.239
metanephric capsule formation GO:0072266 1 0.238
negative regulation of transcription by glucose GO:0045014 1 0.238
positive regulation of glial cell proliferation GO:0060252 4 0.238
gonad development GO:0008406 141 0.237
outflow tract morphogenesis GO:0003151 53 0.237
Mouse
cardiac right atrium morphogenesis GO:0003213 3 0.236
organelle assembly GO:0070925 177 0.236
epithelial cell maturation GO:0002070 15 0.235
Mouse
canonical wnt signaling pathway GO:0060070 130 0.234
nephron morphogenesis GO:0072028 69 0.233
negative regulation of branching involved in ureteric bud morphogenesis GO:0090191 4 0.233
Mouse
brain segmentation GO:0035284 3 0.232
globus pallidus development GO:0021759 2 0.232
sensory perception of mechanical stimulus GO:0050954 107 0.232
Mouse
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.231
semicircular canal fusion GO:0060879 1 0.230
methylation GO:0032259 134 0.229
morphogenesis of an epithelial sheet GO:0002011 27 0.229
tooth mineralization GO:0034505 9 0.228
regulation of cell motility GO:2000145 236 0.228
trachea formation GO:0060440 3 0.227
regulation of neuron differentiation GO:0045664 281 0.226
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.226
mesenchymal cell differentiation involved in kidney development GO:0072161 6 0.225
Mouse
positive regulation of neuroblast proliferation GO:0002052 19 0.224
blastocyst formation GO:0001825 33 0.223
sinoatrial node cell development GO:0060931 3 0.223
glomerular mesangial cell differentiation GO:0072008 3 0.223
bundle of his development GO:0003166 4 0.222
regulation of ureteric bud formation GO:0072106 3 0.222
negative regulation of cardiac chamber formation GO:1901211 1 0.220
neural crest formation GO:0014029 2 0.219
facial nerve morphogenesis GO:0021610 11 0.218
Mouse
lens morphogenesis in camera type eye GO:0002089 24 0.218
Mouse
endocrine system development GO:0035270 98 0.216
Mouse
retina development in camera type eye GO:0060041 119 0.216
Mouse
circadian rhythm GO:0007623 114 0.215
Mouse
cell migration in hindbrain GO:0021535 16 0.215
mesonephric epithelium development GO:0072163 94 0.215
blastocyst development GO:0001824 80 0.214
renal vesicle induction GO:0072034 3 0.214
limb morphogenesis GO:0035108 149 0.213
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.212
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.212
male gonad development GO:0008584 88 0.212
hair cell differentiation GO:0035315 40 0.212
ectoderm formation GO:0001705 3 0.210
cerebral cortex radially oriented cell migration GO:0021799 31 0.209
glomerular mesangial cell development GO:0072144 3 0.209
heart valve morphogenesis GO:0003179 21 0.208
sinoatrial node development GO:0003163 4 0.203
male sex determination GO:0030238 14 0.202
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.202
mesenchymal cell proliferation GO:0010463 44 0.202
Mouse
negative regulation of gastrulation GO:2000542 3 0.201
dorsal ventral neural tube patterning GO:0021904 28 0.199
hair follicle development GO:0001942 85 0.198
nerve development GO:0021675 67 0.198
molting cycle GO:0042303 90 0.197
lung proximal distal axis specification GO:0061115 1 0.197
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.196
embryonic forelimb morphogenesis GO:0035115 32 0.196
positive regulation of epithelial cell proliferation GO:0050679 68 0.196
notch signaling pathway GO:0007219 71 0.196
positive regulation of epithelial cell migration GO:0010634 19 0.195
oculomotor nerve development GO:0021557 4 0.195
negative regulation of skeletal muscle cell differentiation GO:2001015 1 0.195
regulation of neural precursor cell proliferation GO:2000177 70 0.194
Mouse
limbic system development GO:0021761 72 0.193
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.193
regulation of cell fate commitment GO:0010453 19 0.191
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.191
regulation of histone modification GO:0031056 56 0.190
regulation of canonical wnt signaling pathway GO:0060828 82 0.190
negative regulation of glial cell proliferation GO:0060253 4 0.190
circulatory system process GO:0003013 197 0.190
regulation of establishment of planar polarity involved in neural tube closure GO:0090178 15 0.190
outer ear morphogenesis GO:0042473 5 0.190
body morphogenesis GO:0010171 45 0.190
regulation of neuroblast proliferation GO:1902692 27 0.189
Mouse
locomotory behavior GO:0007626 195 0.189
dendrite development GO:0016358 115 0.189
microtubule based process GO:0007017 236 0.186
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.186
positive regulation of bmp signaling pathway GO:0030513 23 0.186
cell proliferation involved in heart morphogenesis GO:0061323 15 0.186
Mouse
inner cell mass cellular morphogenesis GO:0001828 1 0.185
regulation of histone methylation GO:0031060 30 0.184
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.183
Mouse
regulation of transcription from rna polymerase ii promoter involved in forebrain neuron fate commitment GO:0021882 3 0.183
cellular protein complex assembly GO:0043623 116 0.182
negative regulation of chondrocyte differentiation GO:0032331 13 0.182
tricuspid valve development GO:0003175 3 0.180
ectodermal placode morphogenesis GO:0071697 16 0.180
mammary gland morphogenesis GO:0060443 54 0.180
central nervous system neuron development GO:0021954 67 0.178
negative regulation of organelle organization GO:0010639 90 0.178
wnt signaling pathway GO:0016055 188 0.177
Mouse
synapse organization GO:0050808 125 0.177
morphogenesis of a polarized epithelium GO:0001738 37 0.174
development of primary female sexual characteristics GO:0046545 73 0.174
heart field specification GO:0003128 6 0.174
endocardial cushion development GO:0003197 26 0.173
kidney morphogenesis GO:0060993 83 0.173
ascending aorta morphogenesis GO:0035910 3 0.172
epithelial to mesenchymal transition GO:0001837 47 0.171
muscle cell fate specification GO:0042694 1 0.169
regulation of skeletal muscle cell proliferation GO:0014857 7 0.169
Mouse
mitral valve development GO:0003174 4 0.168
circadian behavior GO:0048512 13 0.168
Mouse
erythrocyte differentiation GO:0030218 88 0.167
cardiac chamber development GO:0003205 108 0.166
central nervous system neuron axonogenesis GO:0021955 28 0.166

Six4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.175
nervous system disease DOID:863 0 0.175