Mus musculus

84 known processes

Nphp3

nephronophthisis 3 (adolescent)

(Aliases: pcy,MGC141550,C230078J01,3632410F03Rik,AI550417,D330020E01Rik)

Nphp3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small gtpase mediated signal transduction GO:0007264 97 0.375
sperm egg recognition GO:0035036 37 0.173
cell cell recognition GO:0009988 44 0.158
cellular lipid metabolic process GO:0044255 323 0.127
single fertilization GO:0007338 82 0.115
positive regulation of lipid kinase activity GO:0090218 11 0.111
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.095
protein processing GO:0016485 163 0.091
brain renin angiotensin system GO:0002035 5 0.089
negative regulation of cellular component organization GO:0051129 194 0.088
purine nucleotide metabolic process GO:0006163 302 0.086
wnt signaling pathway GO:0016055 188 0.070
Human
protein catabolic process GO:0030163 221 0.066
binding of sperm to zona pellucida GO:0007339 34 0.066
regulation of transferase activity GO:0051338 263 0.066
protein maturation GO:0051604 176 0.065
positive regulation of lipid metabolic process GO:0045834 40 0.065
regulation of kinase activity GO:0043549 249 0.063
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 18 0.062
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.057
blood circulation GO:0008015 195 0.055
ras protein signal transduction GO:0007265 77 0.054
regulation of lipid kinase activity GO:0043550 14 0.052
fertilization GO:0009566 127 0.052
protein modification by small protein conjugation or removal GO:0070647 207 0.052
cell recognition GO:0008037 83 0.051
macromolecule catabolic process GO:0009057 281 0.049
regulation of systemic arterial blood pressure GO:0003073 61 0.047
aromatic compound catabolic process GO:0019439 286 0.047
membrane organization GO:0061024 245 0.047
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.046
ribonucleotide metabolic process GO:0009259 291 0.046
cellular amino acid metabolic process GO:0006520 103 0.046
heterocycle catabolic process GO:0046700 280 0.042
organonitrogen compound catabolic process GO:1901565 264 0.041
protein ubiquitination GO:0016567 171 0.040
nucleoside triphosphate metabolic process GO:0009141 230 0.040
cellular protein catabolic process GO:0044257 155 0.039
cellular amine metabolic process GO:0044106 44 0.038
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.038
positive regulation of kinase activity GO:0033674 155 0.037
protein modification by small protein conjugation GO:0032446 187 0.037
positive regulation of hydrolase activity GO:0051345 148 0.037
regulation of cellular ketone metabolic process GO:0010565 66 0.037
nucleotide metabolic process GO:0009117 332 0.036
nucleoside metabolic process GO:0009116 246 0.036
ribonucleoside triphosphate metabolic process GO:0009199 220 0.035
cellular macromolecule catabolic process GO:0044265 206 0.035
cilium morphogenesis GO:0060271 102 0.034
zymogen activation GO:0031638 41 0.034
protein targeting GO:0006605 143 0.034
kidney development GO:0001822 213 0.034
regulation of blood pressure GO:0008217 93 0.033
cation transmembrane transport GO:0098655 266 0.033
amine metabolic process GO:0009308 45 0.033
regulation of body fluid levels GO:0050878 162 0.033
apoptotic signaling pathway GO:0097190 306 0.032
phospholipid metabolic process GO:0006644 87 0.032
purine ribonucleotide catabolic process GO:0009154 208 0.032
urogenital system development GO:0001655 261 0.032
embryonic organ morphogenesis GO:0048562 276 0.032
Human
nucleoside phosphate catabolic process GO:1901292 222 0.032
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.031
organophosphate catabolic process GO:0046434 232 0.031
purine nucleotide catabolic process GO:0006195 211 0.031
purine ribonucleoside catabolic process GO:0046130 205 0.031
protein localization to organelle GO:0033365 185 0.030
oxidation reduction process GO:0055114 342 0.030
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
organelle localization GO:0051640 179 0.029
organic cyclic compound catabolic process GO:1901361 295 0.029
intracellular protein transport GO:0006886 204 0.029
regulation of cellular catabolic process GO:0031329 242 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
negative regulation of defense response GO:0031348 77 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.027
regulation of cellular amine metabolic process GO:0033238 20 0.027
regulation of lipid metabolic process GO:0019216 118 0.026
purine ribonucleotide metabolic process GO:0009150 290 0.026
regulation of intracellular transport GO:0032386 159 0.026
cellular homeostasis GO:0019725 240 0.026
purine nucleoside metabolic process GO:0042278 241 0.026
regulation of neuron differentiation GO:0045664 281 0.025
protein localization to nucleus GO:0034504 121 0.025
nucleoside catabolic process GO:0009164 206 0.025
cytoplasmic transport GO:0016482 234 0.025
regulation of neurotransmitter levels GO:0001505 87 0.025
locomotory behavior GO:0007626 195 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.025
ion transmembrane transport GO:0034220 361 0.024
nucleobase containing small molecule metabolic process GO:0055086 352 0.024
regulation of blood volume by renin angiotensin GO:0002016 7 0.024
glucose homeostasis GO:0042593 128 0.023
cell adhesion GO:0007155 329 0.023
ribonucleoside triphosphate catabolic process GO:0009203 199 0.023
axonogenesis GO:0007409 274 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
carbohydrate homeostasis GO:0033500 128 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
purine containing compound catabolic process GO:0072523 213 0.022
purine nucleoside triphosphate catabolic process GO:0009146 203 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.021
extrinsic apoptotic signaling pathway GO:0097191 126 0.021
cellular ketone metabolic process GO:0042180 84 0.021
endothelial cell migration GO:0043542 44 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
regulation of cell projection organization GO:0031344 206 0.021
nucleocytoplasmic transport GO:0006913 139 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
inorganic cation transmembrane transport GO:0098662 207 0.020
negative regulation of protein modification process GO:0031400 163 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.020
glycosyl compound metabolic process GO:1901657 246 0.020
negative regulation of inflammatory response GO:0050728 61 0.020
carbohydrate derivative biosynthetic process GO:1901137 183 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
glycoprotein biosynthetic process GO:0009101 89 0.020
ribonucleotide catabolic process GO:0009261 208 0.020
epithelial cell development GO:0002064 159 0.020
cytokine mediated signaling pathway GO:0019221 115 0.020
regulation of organelle organization GO:0033043 289 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.019
regulation of inflammatory response GO:0050727 147 0.019
regulation of hydrolase activity GO:0051336 246 0.019
purine ribonucleoside metabolic process GO:0046128 241 0.019
fat cell differentiation GO:0045444 160 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
regulation of hippo signaling GO:0035330 1 0.019
endocrine process GO:0050886 39 0.019
epithelial cell migration GO:0010631 63 0.019
maintenance of location GO:0051235 89 0.019
atp metabolic process GO:0046034 75 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
nucleoside triphosphate catabolic process GO:0009143 205 0.018
inflammatory response GO:0006954 244 0.018
rac protein signal transduction GO:0016601 13 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
organic anion transport GO:0015711 137 0.018
canonical wnt signaling pathway GO:0060070 130 0.018
Human
glycoprotein metabolic process GO:0009100 116 0.018
neuronal action potential GO:0019228 54 0.018
muscle contraction GO:0006936 101 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
amide transport GO:0042886 138 0.017
positive regulation of cell development GO:0010720 237 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.017
protein import into nucleus GO:0006606 95 0.017
positive regulation of proteolysis GO:0045862 85 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
anatomical structure homeostasis GO:0060249 145 0.016
Human
transmembrane transport GO:0055085 412 0.016
nucleotide catabolic process GO:0009166 217 0.016
single organism cell adhesion GO:0098602 156 0.016
regulation of cell cycle GO:0051726 281 0.016
protein localization to membrane GO:0072657 108 0.016
forebrain development GO:0030900 302 0.016
establishment of organelle localization GO:0051656 122 0.016
inorganic ion transmembrane transport GO:0098660 234 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.016
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.015
regulation of system process GO:0044057 200 0.015
modification dependent macromolecule catabolic process GO:0043632 133 0.015
lung development GO:0030324 164 0.015
Human
carbohydrate metabolic process GO:0005975 230 0.015
carboxylic acid catabolic process GO:0046395 51 0.015
circulatory system process GO:0003013 197 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
positive regulation of nervous system development GO:0051962 221 0.015
protein import GO:0017038 101 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
transmission of nerve impulse GO:0019226 76 0.015
renal system development GO:0072001 225 0.015
respiratory system development GO:0060541 190 0.015
Human
myeloid leukocyte differentiation GO:0002573 119 0.015
regulation of cellular component size GO:0032535 121 0.014
rho protein signal transduction GO:0007266 32 0.014
rna interference GO:0016246 2 0.014
response to extracellular stimulus GO:0009991 127 0.014
peptidyl amino acid modification GO:0018193 336 0.014
purine nucleoside monophosphate catabolic process GO:0009128 58 0.014
establishment of protein localization to organelle GO:0072594 118 0.014
establishment of protein localization to membrane GO:0090150 54 0.014
cation transport GO:0006812 399 0.014
endocytosis GO:0006897 168 0.014
nitrogen compound transport GO:0071705 271 0.014
regulation of cell size GO:0008361 72 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
male gamete generation GO:0048232 285 0.014
cellular component assembly involved in morphogenesis GO:0010927 139 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
organelle disassembly GO:1903008 2 0.014
regulation of anatomical structure size GO:0090066 178 0.014
regulation of neuron projection development GO:0010975 169 0.014
establishment of blood nerve barrier GO:0008065 3 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
glycosyl compound catabolic process GO:1901658 206 0.014
negative regulation of response to wounding GO:1903035 77 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
regulation of epithelial cell proliferation GO:0050678 141 0.014
ribonucleoside monophosphate metabolic process GO:0009161 80 0.014
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.014
Human
regulation of response to wounding GO:1903034 189 0.013
endomembrane system organization GO:0010256 147 0.013
negative regulation of wnt signaling pathway GO:0030178 73 0.013
Human
regulation of secretion GO:0051046 274 0.013
kidney morphogenesis GO:0060993 83 0.013
cellular ion homeostasis GO:0006873 165 0.013
anion transport GO:0006820 177 0.013
regulation of hormone levels GO:0010817 211 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
homeostasis of number of cells GO:0048872 210 0.013
positive regulation of transferase activity GO:0051347 167 0.013
nucleotide biosynthetic process GO:0009165 78 0.013
macromolecular complex disassembly GO:0032984 43 0.013
spermatid differentiation GO:0048515 115 0.013
organic acid transport GO:0015849 101 0.013
response to peptide GO:1901652 136 0.013
regulation of wnt signaling pathway GO:0030111 123 0.012
Human
multicellular organism growth GO:0035264 161 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
positive regulation of cell growth GO:0030307 33 0.012
regulation of feeding behavior GO:0060259 3 0.012
myosin filament assembly GO:0031034 2 0.012
regulation of purine nucleotide catabolic process GO:0033121 122 0.012
ribose phosphate biosynthetic process GO:0046390 59 0.012
photoreceptor cell outer segment organization GO:0035845 5 0.012
positive regulation of nucleoside metabolic process GO:0045979 91 0.012
cilium assembly GO:0042384 81 0.012
heart morphogenesis GO:0003007 178 0.012
Human
microtubule based process GO:0007017 236 0.012
retina development in camera type eye GO:0060041 119 0.012
somatic stem cell maintenance GO:0035019 47 0.012
sequestering of metal ion GO:0051238 19 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of proteolysis GO:0030162 164 0.012
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.012
regulation of fat cell differentiation GO:0045598 81 0.012
rna processing GO:0006396 105 0.012
striated muscle tissue development GO:0014706 293 0.012
respiratory tube development GO:0030323 167 0.012
Human
epithelial tube morphogenesis GO:0060562 303 0.012
Human
regulation of defense response GO:0031347 233 0.012
ameboidal type cell migration GO:0001667 128 0.012
cellular protein complex assembly GO:0043623 116 0.012
rhythmic process GO:0048511 174 0.012
germ cell development GO:0007281 185 0.011
regulation of extent of cell growth GO:0061387 52 0.011
organelle assembly GO:0070925 177 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
regulation of protein targeting GO:1903533 61 0.011
response to acid chemical GO:0001101 111 0.011
small molecule biosynthetic process GO:0044283 132 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
extracellular structure organization GO:0043062 148 0.011
circadian regulation of gene expression GO:0032922 48 0.011
cell growth GO:0016049 130 0.011
negative regulation of organelle organization GO:0010639 90 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
regulation of protein kinase activity GO:0045859 232 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.011
mapk cascade GO:0000165 281 0.011
ossification GO:0001503 216 0.011
nucleoside monophosphate catabolic process GO:0009125 59 0.011
ribonucleoside monophosphate catabolic process GO:0009158 57 0.011
intracellular mrna localization GO:0008298 4 0.011
leukocyte homeostasis GO:0001776 79 0.011
mrna metabolic process GO:0016071 84 0.011
striated muscle myosin thick filament assembly GO:0071688 1 0.011
developmental cell growth GO:0048588 84 0.011
cell division GO:0051301 120 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
negative regulation of intracellular transport GO:0032387 38 0.011
single organism nuclear import GO:1902593 95 0.011
sequestering of calcium ion GO:0051208 18 0.011
regulation of establishment of protein localization GO:0070201 181 0.010
generation of precursor metabolites and energy GO:0006091 103 0.010
action potential GO:0001508 78 0.010
response to organonitrogen compound GO:0010243 246 0.010
cation homeostasis GO:0055080 212 0.010
calcium ion transport GO:0006816 159 0.010
muscle cell differentiation GO:0042692 261 0.010
defecation GO:0030421 1 0.010
proteoglycan biosynthetic process GO:0030166 20 0.010
nuclear transport GO:0051169 139 0.010
mitochondrion distribution GO:0048311 4 0.010
sensory perception GO:0007600 245 0.010
response to organic cyclic compound GO:0014070 198 0.010
regulation of metal ion transport GO:0010959 106 0.010
protein depolymerization GO:0051261 34 0.010
cardiocyte differentiation GO:0035051 87 0.010
hormone secretion GO:0046879 128 0.010
regulation of protein catabolic process GO:0042176 108 0.010
neurotransmitter transport GO:0006836 76 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
regulation of keratinocyte proliferation GO:0010837 15 0.010
morphogenesis of embryonic epithelium GO:0016331 159 0.010

Nphp3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nephronophthisis DOID:12712 0 0.048
Human
disease of metabolism DOID:0014667 0 0.027
inherited metabolic disorder DOID:655 0 0.021
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
immune system disease DOID:2914 0 0.011