Mus musculus

35 known processes

Optn

optineurin

(Aliases: HYPL,4930441O07Rik,NRP,FIP2)

Optn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecule catabolic process GO:0009057 281 0.126
protein modification by small protein conjugation GO:0032446 187 0.108
cellular ketone metabolic process GO:0042180 84 0.106
protein modification by small protein conjugation or removal GO:0070647 207 0.106
membrane organization GO:0061024 245 0.102
cellular lipid metabolic process GO:0044255 323 0.098
regulation of cellular amino acid metabolic process GO:0006521 5 0.095
endomembrane system organization GO:0010256 147 0.082
cellular amine metabolic process GO:0044106 44 0.080
protein ubiquitination GO:0016567 171 0.075
cellular amino acid metabolic process GO:0006520 103 0.065
positive regulation of macroautophagy GO:0016239 3 0.065
regulation of cellular amine metabolic process GO:0033238 20 0.063
amine metabolic process GO:0009308 45 0.062
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.062
modification dependent protein catabolic process GO:0019941 133 0.052
oxidation reduction process GO:0055114 342 0.052
positive regulation of cellular amine metabolic process GO:0033240 5 0.050
fatty acid metabolic process GO:0006631 121 0.048
apoptotic signaling pathway GO:0097190 306 0.047
cellular macromolecule catabolic process GO:0044265 206 0.045
regulation of cellular catabolic process GO:0031329 242 0.043
transmembrane transport GO:0055085 412 0.043
cation transport GO:0006812 399 0.043
cellular homeostasis GO:0019725 240 0.043
membrane fusion GO:0061025 38 0.042
positive regulation of protein phosphorylation GO:0001934 242 0.042
modification dependent macromolecule catabolic process GO:0043632 133 0.041
spermatogenesis GO:0007283 284 0.041
positive regulation of protein modification process GO:0031401 299 0.041
mapk cascade GO:0000165 281 0.040
homeostasis of number of cells GO:0048872 210 0.038
peptidyl amino acid modification GO:0018193 336 0.037
organic hydroxy compound metabolic process GO:1901615 203 0.037
nucleotide metabolic process GO:0009117 332 0.036
nucleobase containing small molecule metabolic process GO:0055086 352 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.036
organic cyclic compound catabolic process GO:1901361 295 0.035
i kappab kinase nf kappab signaling GO:0007249 85 0.035
male gamete generation GO:0048232 285 0.034
negative regulation of cellular component organization GO:0051129 194 0.034
response to organic cyclic compound GO:0014070 198 0.034
lipid modification GO:0030258 65 0.033
positive regulation of cellular catabolic process GO:0031331 148 0.033
protein oligomerization GO:0051259 67 0.033
aromatic compound catabolic process GO:0019439 286 0.033
response to extracellular stimulus GO:0009991 127 0.032
cellular response to cytokine stimulus GO:0071345 189 0.032
macroautophagy GO:0016236 21 0.032
cytokine production GO:0001816 319 0.032
regulation of cell migration GO:0030334 219 0.032
monocarboxylic acid metabolic process GO:0032787 191 0.031
small gtpase mediated signal transduction GO:0007264 97 0.031
carbohydrate metabolic process GO:0005975 230 0.031
nucleoside phosphate metabolic process GO:0006753 338 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
cellular response to arsenic containing substance GO:0071243 4 0.030
protein polyubiquitination GO:0000209 33 0.030
purine nucleoside metabolic process GO:0042278 241 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.030
cellular response to extracellular stimulus GO:0031668 81 0.030
regulation of protein serine threonine kinase activity GO:0071900 157 0.030
innate immune response GO:0045087 157 0.030
regulation of organelle organization GO:0033043 289 0.029
negative regulation of intracellular signal transduction GO:1902532 167 0.029
negative regulation of molecular function GO:0044092 258 0.029
lipid biosynthetic process GO:0008610 179 0.029
response to nutrient levels GO:0031667 109 0.029
regulation of cellular response to stress GO:0080135 159 0.029
cellular response to external stimulus GO:0071496 88 0.029
alcohol metabolic process GO:0006066 116 0.029
regulation of kinase activity GO:0043549 249 0.028
protein catabolic process GO:0030163 221 0.028
leukocyte differentiation GO:0002521 342 0.028
ribose phosphate metabolic process GO:0019693 291 0.027
intracellular protein transport GO:0006886 204 0.027
purine ribonucleotide metabolic process GO:0009150 290 0.027
purine containing compound metabolic process GO:0072521 311 0.027
ion transmembrane transport GO:0034220 361 0.027
lipid catabolic process GO:0016042 69 0.027
regulation of cytokine production GO:0001817 266 0.027
regulation of membrane potential GO:0042391 192 0.027
cellular response to nutrient levels GO:0031669 64 0.027
organonitrogen compound biosynthetic process GO:1901566 192 0.026
ribonucleotide catabolic process GO:0009261 208 0.026
autophagy GO:0006914 45 0.026
skeletal system development GO:0001501 356 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
posttranscriptional regulation of gene expression GO:0010608 155 0.026
myeloid cell differentiation GO:0030099 233 0.025
organophosphate catabolic process GO:0046434 232 0.025
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.025
regulation of transferase activity GO:0051338 263 0.025
nucleoside phosphate catabolic process GO:1901292 222 0.025
locomotory behavior GO:0007626 195 0.025
ubiquitin dependent protein catabolic process GO:0006511 129 0.025
cellular response to starvation GO:0009267 57 0.025
ribonucleotide metabolic process GO:0009259 291 0.025
immune effector process GO:0002252 321 0.024
cellular protein catabolic process GO:0044257 155 0.024
metal ion homeostasis GO:0055065 189 0.024
purine containing compound catabolic process GO:0072523 213 0.024
regulation of mapk cascade GO:0043408 248 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
mitochondrion degradation GO:0000422 3 0.024
glycosyl compound metabolic process GO:1901657 246 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
positive regulation of cell development GO:0010720 237 0.023
cellular chemical homeostasis GO:0055082 215 0.023
regulation of defense response GO:0031347 233 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
purine ribonucleotide catabolic process GO:0009154 208 0.023
multicellular organismal signaling GO:0035637 91 0.023
camera type eye development GO:0043010 266 0.022
male anatomical structure morphogenesis GO:0090598 4 0.022
ras protein signal transduction GO:0007265 77 0.022
cation transmembrane transport GO:0098655 266 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
heterocycle catabolic process GO:0046700 280 0.022
sensory perception GO:0007600 245 0.022
nitrogen compound transport GO:0071705 271 0.022
small molecule biosynthetic process GO:0044283 132 0.022
glycerolipid metabolic process GO:0046486 122 0.022
negative regulation of cellular amine metabolic process GO:0033239 1 0.022
male genitalia morphogenesis GO:0048808 4 0.022
cellular lipid catabolic process GO:0044242 52 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.021
cellular response to lipid GO:0071396 145 0.021
organonitrogen compound catabolic process GO:1901565 264 0.021
nucleoside catabolic process GO:0009164 206 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
response to peptide GO:1901652 136 0.021
negative regulation of protein metabolic process GO:0051248 282 0.020
nucleoside metabolic process GO:0009116 246 0.020
regulation of hormone levels GO:0010817 211 0.020
development of primary sexual characteristics GO:0045137 143 0.020
divalent metal ion transport GO:0070838 172 0.020
cellular ion homeostasis GO:0006873 165 0.020
cell adhesion GO:0007155 329 0.020
response to inorganic substance GO:0010035 96 0.020
regulation of body fluid levels GO:0050878 162 0.020
maintenance of location GO:0051235 89 0.020
microtubule based process GO:0007017 236 0.020
gland development GO:0048732 330 0.020
small molecule catabolic process GO:0044282 71 0.020
actin cytoskeleton organization GO:0030036 220 0.020
action potential GO:0001508 78 0.020
adult behavior GO:0030534 135 0.020
ossification GO:0001503 216 0.020
negative regulation of phosphate metabolic process GO:0045936 184 0.020
protein maturation GO:0051604 176 0.020
neuronal action potential GO:0019228 54 0.019
skin development GO:0043588 220 0.019
ribonucleoside metabolic process GO:0009119 245 0.019
transmission of nerve impulse GO:0019226 76 0.019
monocarboxylic acid catabolic process GO:0072329 27 0.019
organic anion transport GO:0015711 137 0.019
reactive nitrogen species metabolic process GO:2001057 0 0.019
regulation of anatomical structure size GO:0090066 178 0.019
cell maturation GO:0048469 127 0.019
cell type specific apoptotic process GO:0097285 268 0.019
positive regulation of organelle organization GO:0010638 128 0.019
microtubule cytoskeleton organization GO:0000226 157 0.019
negative regulation of protein modification process GO:0031400 163 0.019
cytoplasmic transport GO:0016482 234 0.019
anion transport GO:0006820 177 0.019
carboxylic acid transport GO:0046942 100 0.019
epithelial cell proliferation GO:0050673 174 0.018
cofactor metabolic process GO:0051186 80 0.018
cellular response to oxidative stress GO:0034599 76 0.018
muscle tissue development GO:0060537 308 0.018
chromatin organization GO:0006325 206 0.018
divalent inorganic cation transport GO:0072511 178 0.018
response to starvation GO:0042594 65 0.018
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.018
intrinsic apoptotic signaling pathway GO:0097193 132 0.018
fat cell differentiation GO:0045444 160 0.018
placenta development GO:0001890 140 0.018
multicellular organismal homeostasis GO:0048871 164 0.018
t cell activation GO:0042110 289 0.018
protein import GO:0017038 101 0.017
spermatid development GO:0007286 108 0.017
myeloid leukocyte differentiation GO:0002573 119 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
synaptic transmission GO:0007268 329 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
response to acid chemical GO:0001101 111 0.017
inorganic cation transmembrane transport GO:0098662 207 0.017
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.017
immune response activating signal transduction GO:0002757 116 0.017
carboxylic acid biosynthetic process GO:0046394 86 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
reactive oxygen species metabolic process GO:0072593 84 0.016
cellular response to molecule of bacterial origin GO:0071219 83 0.016
chromatin modification GO:0016568 187 0.016
regulation of protein kinase activity GO:0045859 232 0.016
defense response to other organism GO:0098542 197 0.016
lateral inhibition GO:0046331 1 0.016
regulation of proteolysis GO:0030162 164 0.016
central nervous system neuron differentiation GO:0021953 162 0.016
nucleoside triphosphate catabolic process GO:0009143 205 0.016
calcium ion transport GO:0006816 159 0.016
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
lipid oxidation GO:0034440 29 0.016
response to lipopolysaccharide GO:0032496 128 0.016
establishment of protein localization to organelle GO:0072594 118 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
organic acid biosynthetic process GO:0016053 86 0.016
activation of immune response GO:0002253 138 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
cellular carbohydrate metabolic process GO:0044262 119 0.016
positive regulation of nervous system development GO:0051962 221 0.015
organic acid transport GO:0015849 101 0.015
sulfur compound metabolic process GO:0006790 100 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
circulatory system process GO:0003013 197 0.015
nucleotide catabolic process GO:0009166 217 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.015
regulation of endopeptidase activity GO:0052548 89 0.015
purine nucleoside catabolic process GO:0006152 205 0.015
regulation of hydrolase activity GO:0051336 246 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
regulation of metal ion transport GO:0010959 106 0.015
regulation of secretion GO:0051046 274 0.015
compound eye development GO:0048749 1 0.015
cation homeostasis GO:0055080 212 0.015
regulation of ion transmembrane transport GO:0034765 119 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
regulation of cell activation GO:0050865 289 0.015
leukocyte proliferation GO:0070661 172 0.015
positive regulation of cell death GO:0010942 224 0.015
protein processing GO:0016485 163 0.015
gonad development GO:0008406 141 0.015
organelle fission GO:0048285 170 0.015
male sex differentiation GO:0046661 109 0.015
lymphocyte differentiation GO:0030098 242 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
muscle cell differentiation GO:0042692 261 0.015
regulation of ion transport GO:0043269 215 0.015
forebrain development GO:0030900 302 0.015
cellular response to inorganic substance GO:0071241 37 0.014
plasma membrane organization GO:0007009 90 0.014
protein targeting GO:0006605 143 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
regulation of protein localization GO:0032880 231 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
regulation of cell cycle GO:0051726 281 0.014
cytokine mediated signaling pathway GO:0019221 115 0.014
positive regulation of hydrolase activity GO:0051345 148 0.014
fatty acid beta oxidation GO:0006635 16 0.014
regulation of secretion by cell GO:1903530 249 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
regulation of cell motility GO:2000145 236 0.014
response to peptide hormone GO:0043434 127 0.014
endocytosis GO:0006897 168 0.014
male gonad development GO:0008584 88 0.014
protein localization to nucleus GO:0034504 121 0.014
positive regulation of kinase activity GO:0033674 155 0.014
regulation of binding GO:0051098 111 0.014
response to epidermal growth factor GO:0070849 4 0.014
organelle localization GO:0051640 179 0.014
developmental maturation GO:0021700 193 0.014
anatomical structure homeostasis GO:0060249 145 0.014
regulation of autophagy GO:0010506 30 0.014
regulation of protein transport GO:0051223 163 0.014
lymphocyte proliferation GO:0046651 164 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
rho protein signal transduction GO:0007266 32 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
divalent inorganic cation homeostasis GO:0072507 138 0.013
regulation of cytoskeleton organization GO:0051493 122 0.013
germ cell development GO:0007281 185 0.013
stress activated mapk cascade GO:0051403 80 0.013
muscle system process GO:0003012 141 0.013
response to organonitrogen compound GO:0010243 246 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
axonogenesis GO:0007409 274 0.013
lipid localization GO:0010876 126 0.013
regulation of neuron differentiation GO:0045664 281 0.013
regulation of system process GO:0044057 200 0.013
cell growth GO:0016049 130 0.013
dephosphorylation GO:0016311 129 0.013
regulation of vesicle mediated transport GO:0060627 139 0.013
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
cellular protein complex assembly GO:0043623 116 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
cytokine biosynthetic process GO:0042089 68 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
single organism nuclear import GO:1902593 95 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.013
cellular response to cadmium ion GO:0071276 3 0.013
blood circulation GO:0008015 195 0.013
actin filament organization GO:0007015 113 0.013
cellular response to acid chemical GO:0071229 68 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
monosaccharide metabolic process GO:0005996 106 0.013
regulation of response to wounding GO:1903034 189 0.013
striated muscle tissue development GO:0014706 293 0.013
nuclear division GO:0000280 158 0.013
purine nucleotide catabolic process GO:0006195 211 0.013
response to insulin GO:0032868 100 0.013
metencephalon development GO:0022037 89 0.013
sequestering of metal ion GO:0051238 19 0.013
blood vessel morphogenesis GO:0048514 285 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
regulation of homeostatic process GO:0032844 182 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
positive regulation of monocyte chemotaxis GO:0090026 2 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.013
negative regulation of organelle organization GO:0010639 90 0.012
negative regulation of cell development GO:0010721 169 0.012
fertilization GO:0009566 127 0.012
histone modification GO:0016570 159 0.012
cell junction maintenance GO:0034331 4 0.012
positive regulation of cytokine production GO:0001819 174 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.012
embryonic organ morphogenesis GO:0048562 276 0.012
nuclear transport GO:0051169 139 0.012
wound healing GO:0042060 157 0.012
regulation of transmembrane transport GO:0034762 128 0.012
protein localization to organelle GO:0033365 185 0.012
translation GO:0006412 93 0.012
sensory organ morphogenesis GO:0090596 242 0.012
meiosis i GO:0007127 60 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
interleukin 8 production GO:0032637 4 0.012
inflammatory response GO:0006954 244 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
acetate metabolic process GO:0006083 1 0.012
glycerolipid biosynthetic process GO:0045017 50 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
regulation of t cell activation GO:0050863 170 0.012
myeloid cell homeostasis GO:0002262 114 0.012
muscle contraction GO:0006936 101 0.012
regulation of cellular component size GO:0032535 121 0.012
cellularization GO:0007349 1 0.012
neuron death GO:0070997 154 0.012
positive regulation of transferase activity GO:0051347 167 0.012
rna interference GO:0016246 2 0.012
response to endoplasmic reticulum stress GO:0034976 53 0.012
positive regulation of defense response GO:0031349 124 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
epithelial cell development GO:0002064 159 0.012
peptidyl serine modification GO:0018209 83 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
phospholipid metabolic process GO:0006644 87 0.012
interspecies interaction between organisms GO:0044419 83 0.012
fatty acid catabolic process GO:0009062 25 0.012
regulation of innate immune response GO:0045088 91 0.011
response to oxygen levels GO:0070482 62 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
monocarboxylic acid biosynthetic process GO:0072330 61 0.011
calcium ion homeostasis GO:0055074 127 0.011
regulation of multi organism process GO:0043900 111 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
single organism cell adhesion GO:0098602 156 0.011
guanosine containing compound catabolic process GO:1901069 144 0.011
lipid transport GO:0006869 98 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
glucose metabolic process GO:0006006 92 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
coenzyme metabolic process GO:0006732 52 0.011
regulation of fat cell differentiation GO:0045598 81 0.011
carboxylic acid catabolic process GO:0046395 51 0.011
sequestering of calcium ion GO:0051208 18 0.011
meiotic cell cycle GO:0051321 122 0.011
negative regulation of immune system process GO:0002683 209 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
amide transport GO:0042886 138 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
positive regulation of fatty acid oxidation GO:0046321 4 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
regulation of protein catabolic process GO:0042176 108 0.011
cerebellar cortex development GO:0021695 48 0.011
negative regulation of cell activation GO:0050866 111 0.011
cellular amide metabolic process GO:0043603 58 0.011
nuclear import GO:0051170 95 0.011
protein localization to membrane GO:0072657 108 0.011
peptidyl serine phosphorylation GO:0018105 74 0.011
cytokine metabolic process GO:0042107 71 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
peptide transport GO:0015833 133 0.011
digestive system development GO:0055123 200 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
digestive tract development GO:0048565 190 0.011
cell substrate adhesion GO:0031589 130 0.011
response to radiation GO:0009314 165 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
immune response regulating signaling pathway GO:0002764 125 0.011
myelination GO:0042552 74 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
mitochondrion organization GO:0007005 134 0.011
spermatid differentiation GO:0048515 115 0.011
hexose metabolic process GO:0019318 98 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
ensheathment of neurons GO:0007272 76 0.011
cellular alcohol biosynthetic process GO:0044108 3 0.011
neuron apoptotic process GO:0051402 142 0.011
positive regulation of growth GO:0045927 104 0.011
positive regulation of proteolysis GO:0045862 85 0.011
membrane tubulation GO:0097320 4 0.011
glial cell differentiation GO:0010001 131 0.010
asymmetric stem cell division GO:0098722 3 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
regulation of mitochondrial fission GO:0090140 3 0.010
regulation of mitotic cell cycle GO:0007346 126 0.010
dna metabolic process GO:0006259 303 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
fat soluble vitamin biosynthetic process GO:0042362 4 0.010
regulation of cell adhesion GO:0030155 154 0.010
regulation of translation GO:0006417 71 0.010
response to amino acid GO:0043200 37 0.010
positive regulation of nucleotide metabolic process GO:0045981 114 0.010
male meiosis GO:0007140 37 0.010
leukocyte migration GO:0050900 124 0.010
protein import into nucleus GO:0006606 95 0.010
regulation of cell projection organization GO:0031344 206 0.010
epidermis development GO:0008544 187 0.010
neutral lipid metabolic process GO:0006638 57 0.010
oocyte axis specification GO:0007309 2 0.010
regulation of map kinase activity GO:0043405 120 0.010
mitotic cell cycle process GO:1903047 159 0.010
exocytosis GO:0006887 121 0.010

Optn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.134
musculoskeletal system disease DOID:17 0 0.134
connective tissue disease DOID:65 0 0.134
bone disease DOID:0080001 0 0.076
bone remodeling disease DOID:0080005 0 0.061
disease of metabolism DOID:0014667 0 0.030
nervous system disease DOID:863 0 0.019
central nervous system disease DOID:331 0 0.017
inherited metabolic disorder DOID:655 0 0.016
sensory system disease DOID:0050155 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
cardiovascular system disease DOID:1287 0 0.013
immune system disease DOID:2914 0 0.012
neuromuscular disease DOID:440 0 0.011
neuropathy DOID:870 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.010