Mus musculus

70 known processes

Aire

autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

(Aliases: MGC123374,MGC123375)

Aire biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein secretion GO:0009306 111 0.863
regulation of cytokine secretion GO:0050707 61 0.691
regulation of cytokine production GO:0001817 266 0.525
t cell differentiation GO:0030217 174 0.478
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.468
t helper 1 type immune response GO:0042088 25 0.455
negative regulation of lymphocyte activation GO:0051250 91 0.453
regulation of cell activation GO:0050865 289 0.429
cytokine production GO:0001816 319 0.424
defense response to bacterium GO:0042742 119 0.421
dna recombination GO:0006310 92 0.410
leukocyte differentiation GO:0002521 342 0.404
cellular response to organonitrogen compound GO:0071417 145 0.402
lymphocyte differentiation GO:0030098 242 0.392
cellular amine metabolic process GO:0044106 44 0.386
b cell activation GO:0042113 161 0.383
regulation of cellular amine metabolic process GO:0033238 20 0.377
regulation of protein localization GO:0032880 231 0.361
production of molecular mediator of immune response GO:0002440 103 0.359
regulation of cell migration GO:0030334 219 0.356
blood vessel morphogenesis GO:0048514 285 0.356
leukocyte proliferation GO:0070661 172 0.356
humoral immune response GO:0006959 57 0.353
regulation of cell division GO:0051302 76 0.349
positive regulation of leukocyte proliferation GO:0070665 73 0.338
t cell activation GO:0042110 289 0.333
regulation of leukocyte proliferation GO:0070663 121 0.332
neuronal action potential GO:0019228 54 0.325
interleukin 1 secretion GO:0050701 16 0.321
negative regulation of interleukin 5 production GO:0032714 4 0.305
regulation of cellular amino acid metabolic process GO:0006521 5 0.304
stem cell differentiation GO:0048863 268 0.304
cell division GO:0051301 120 0.301
regulation of t cell activation GO:0050863 170 0.300
forebrain development GO:0030900 302 0.295
myeloid leukocyte activation GO:0002274 83 0.289
t helper 2 cell cytokine production GO:0035745 4 0.280
germ cell development GO:0007281 185 0.279
action potential GO:0001508 78 0.278
regulation of protein transport GO:0051223 163 0.276
positive regulation of cytokine production GO:0001819 174 0.276
regulation of establishment of protein localization GO:0070201 181 0.276
immunoglobulin mediated immune response GO:0016064 69 0.274
regulation of production of molecular mediator of immune response GO:0002700 65 0.269
positive regulation of nervous system development GO:0051962 221 0.264
positive regulation of cell development GO:0010720 237 0.256
cell type specific apoptotic process GO:0097285 268 0.248
purine ribonucleotide metabolic process GO:0009150 290 0.247
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.246
purine containing compound metabolic process GO:0072521 311 0.244
homeostasis of number of cells GO:0048872 210 0.242
b cell proliferation GO:0042100 53 0.240
regulation of secretion GO:0051046 274 0.225
adaptive immune response GO:0002250 155 0.224
regulation of ion transport GO:0043269 215 0.223
positive regulation of programmed cell death GO:0043068 218 0.223
immunoglobulin production GO:0002377 73 0.223
cell cell recognition GO:0009988 44 0.220
hematopoietic stem cell migration GO:0035701 1 0.218
regulation of lymphocyte activation GO:0051249 240 0.214
positive regulation of lymphocyte proliferation GO:0050671 70 0.213
nucleoside metabolic process GO:0009116 246 0.209
synaptic transmission GO:0007268 329 0.209
lymphocyte proliferation GO:0046651 164 0.209
interleukin 10 secretion GO:0072608 4 0.206
cellular response to cytokine stimulus GO:0071345 189 0.205
extracellular matrix organization GO:0030198 147 0.201
regulation of mapk cascade GO:0043408 248 0.198
positive regulation of lymphocyte activation GO:0051251 140 0.198
mapk cascade GO:0000165 281 0.192
regulation of membrane potential GO:0042391 192 0.192
negative regulation of t cell activation GO:0050868 65 0.190
regulation of vasculature development GO:1901342 88 0.187
axonogenesis GO:0007409 274 0.186
tumor necrosis factor production GO:0032640 50 0.186
cellular metal ion homeostasis GO:0006875 151 0.186
mature dendritic cell differentiation GO:0097029 3 0.184
positive regulation of cell migration GO:0030335 109 0.184
cell activation involved in immune response GO:0002263 126 0.183
positive regulation of protein secretion GO:0050714 52 0.177
positive regulation of cellular amine metabolic process GO:0033240 5 0.176
neuron migration GO:0001764 122 0.175
neuron projection guidance GO:0097485 141 0.172
regulation of erk1 and erk2 cascade GO:0070372 71 0.169
nuclear division GO:0000280 158 0.169
regulation of interleukin 10 secretion GO:2001179 4 0.168
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.162
cellular ketone metabolic process GO:0042180 84 0.161
regulation of cytokine production involved in immune response GO:0002718 26 0.160
memory GO:0007613 58 0.159
carbohydrate derivative biosynthetic process GO:1901137 183 0.156
cellular homeostasis GO:0019725 240 0.156
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.156
purine ribonucleoside catabolic process GO:0046130 205 0.154
regulation of epithelial cell proliferation GO:0050678 141 0.154
positive regulation of t cell differentiation GO:0045582 52 0.152
positive regulation of cell activation GO:0050867 158 0.152
regulation of chemotaxis GO:0050920 53 0.152
organelle fission GO:0048285 170 0.151
regulation of lymphocyte proliferation GO:0050670 117 0.151
meiotic cell cycle GO:0051321 122 0.149
regulation of cellular ketone metabolic process GO:0010565 66 0.149
myeloid leukocyte differentiation GO:0002573 119 0.148
regulation of t cell differentiation GO:0045580 83 0.147
positive regulation of organelle organization GO:0010638 128 0.146
pallium development GO:0021543 120 0.144
purine containing compound catabolic process GO:0072523 213 0.143
positive regulation of cytokine secretion GO:0050715 41 0.141
regulation of monocyte chemotaxis GO:0090025 3 0.141
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.141
regulation of t cell costimulation GO:2000523 2 0.141
response to peptide hormone GO:0043434 127 0.140
learning or memory GO:0007611 148 0.139
t cell differentiation in thymus GO:0033077 77 0.137
regulation of secretion by cell GO:1903530 249 0.137
monocyte extravasation GO:0035696 2 0.136
positive regulation of protein kinase b signaling GO:0051897 32 0.136
bone remodeling GO:0046849 53 0.135
purine ribonucleoside metabolic process GO:0046128 241 0.135
epithelial cell proliferation GO:0050673 174 0.134
cytokine mediated signaling pathway GO:0019221 115 0.132
angiogenesis GO:0001525 201 0.130
positive regulation of angiogenesis GO:0045766 46 0.129
circadian rhythm GO:0007623 114 0.129
response to peptide GO:1901652 136 0.127
leukocyte homeostasis GO:0001776 79 0.126
establishment of protein localization to organelle GO:0072594 118 0.126
heterocycle catabolic process GO:0046700 280 0.126
regulation of lymphocyte differentiation GO:0045619 107 0.125
regulation of cell cycle process GO:0010564 160 0.124
negative regulation of intracellular signal transduction GO:1902532 167 0.124
response to lipopolysaccharide GO:0032496 128 0.124
ribose phosphate metabolic process GO:0019693 291 0.121
protein kinase b signaling GO:0043491 74 0.121
defense response to other organism GO:0098542 197 0.121
regulation of cell motility GO:2000145 236 0.118
negative regulation of cytokine production GO:0001818 84 0.118
myeloid cell differentiation GO:0030099 233 0.118
cytokine secretion GO:0050663 72 0.118
regulation of tumor necrosis factor production GO:0032680 49 0.115
positive regulation of neuron projection development GO:0010976 79 0.114
cellular response to dna damage stimulus GO:0006974 207 0.114
regulation of neuron differentiation GO:0045664 281 0.114
positive regulation of protein transport GO:0051222 93 0.113
aromatic compound catabolic process GO:0019439 286 0.113
cellular response to hormone stimulus GO:0032870 150 0.112
regulation of cell cycle GO:0051726 281 0.111
gland development GO:0048732 330 0.109
positive regulation of oligodendrocyte differentiation GO:0048714 9 0.109
inflammatory response GO:0006954 244 0.108
lymphocyte activation involved in immune response GO:0002285 93 0.108
leukocyte migration GO:0050900 124 0.107
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.105
negative regulation of phosphorus metabolic process GO:0010563 184 0.105
b cell differentiation GO:0030183 78 0.105
striated muscle tissue development GO:0014706 293 0.104
regulation of adaptive immune response GO:0002819 90 0.104
cellular response to lipid GO:0071396 145 0.104
t cell proliferation GO:0042098 120 0.102
regulation of leukocyte differentiation GO:1902105 159 0.102
extrinsic apoptotic signaling pathway GO:0097191 126 0.102
ribonucleoside metabolic process GO:0009119 245 0.101
positive regulation of cell motility GO:2000147 116 0.101
nucleobase containing small molecule metabolic process GO:0055086 352 0.100
nuclear import GO:0051170 95 0.100
positive regulation of mapk cascade GO:0043410 170 0.099
negative regulation of t cell proliferation GO:0042130 38 0.099
regulation of protein secretion GO:0050708 82 0.098
wnt signaling pathway GO:0016055 188 0.098
cellular amino acid metabolic process GO:0006520 103 0.097
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.096
sensory perception of sound GO:0007605 97 0.096
regulation of b cell activation GO:0050864 81 0.095
positive regulation of regulatory t cell differentiation GO:0045591 4 0.095
purine nucleoside catabolic process GO:0006152 205 0.095
endocytosis GO:0006897 168 0.094
negative regulation of cell proliferation GO:0008285 296 0.093
nucleoside catabolic process GO:0009164 206 0.093
chromatin organization GO:0006325 206 0.092
protein localization to nucleus GO:0034504 121 0.092
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.091
protein catabolic process GO:0030163 221 0.091
locomotory behavior GO:0007626 195 0.091
leukocyte apoptotic process GO:0071887 71 0.090
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.089
forebrain cell migration GO:0021885 58 0.089
dna metabolic process GO:0006259 303 0.089
nucleoside phosphate metabolic process GO:0006753 338 0.088
positive regulation of cell projection organization GO:0031346 95 0.088
hair follicle development GO:0001942 85 0.086
negative regulation of apoptotic signaling pathway GO:2001234 104 0.085
negative regulation of protein metabolic process GO:0051248 282 0.084
carbohydrate derivative catabolic process GO:1901136 231 0.083
response to light stimulus GO:0009416 135 0.083
negative regulation of macrophage apoptotic process GO:2000110 3 0.083
macromolecule catabolic process GO:0009057 281 0.083
chemotaxis GO:0006935 247 0.083
positive regulation of cytokine biosynthetic process GO:0042108 40 0.083
regulation of dendritic cell chemotaxis GO:2000508 1 0.082
glial cell differentiation GO:0010001 131 0.082
regulation of alpha beta t cell activation GO:0046634 53 0.082
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.082
epidermis development GO:0008544 187 0.081
ribonucleoside triphosphate metabolic process GO:0009199 220 0.081
defense response to gram positive bacterium GO:0050830 50 0.081
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.080
positive regulation of nucleoside metabolic process GO:0045979 91 0.080
cytokine biosynthetic process GO:0042089 68 0.080
somatic diversification of immunoglobulins GO:0016445 43 0.080
nuclear transport GO:0051169 139 0.080
leukocyte chemotaxis GO:0030595 69 0.079
response to organonitrogen compound GO:0010243 246 0.078
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.078
keratinocyte differentiation GO:0030216 48 0.078
cellular calcium ion homeostasis GO:0006874 119 0.077
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.077
amine metabolic process GO:0009308 45 0.077
transmission of nerve impulse GO:0019226 76 0.077
compound eye development GO:0048749 1 0.077
interleukin 13 secretion GO:0072611 2 0.076
negative regulation of protein catabolic process GO:0042177 36 0.076
negative regulation of cell cycle process GO:0010948 69 0.076
b cell mediated immunity GO:0019724 71 0.076
glycosyl compound metabolic process GO:1901657 246 0.076
myeloid cell homeostasis GO:0002262 114 0.075
response to molecule of bacterial origin GO:0002237 143 0.075
gastrulation GO:0007369 116 0.075
neuron death GO:0070997 154 0.075
cellular response to peptide GO:1901653 92 0.074
negative regulation of secretion GO:0051048 61 0.074
response to alcohol GO:0097305 48 0.074
ameboidal type cell migration GO:0001667 128 0.074
cognition GO:0050890 149 0.073
alpha beta t cell differentiation GO:0046632 69 0.073
lymphocyte homeostasis GO:0002260 64 0.073
rhythmic process GO:0048511 174 0.073
single organism nuclear import GO:1902593 95 0.073
ribonucleotide catabolic process GO:0009261 208 0.073
protein localization to organelle GO:0033365 185 0.071
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.070
cellular ion homeostasis GO:0006873 165 0.070
regulation of intracellular transport GO:0032386 159 0.070
positive regulation of behavior GO:0048520 40 0.070
negative regulation of immune system process GO:0002683 209 0.069
regulation of cellular catabolic process GO:0031329 242 0.069
antimicrobial peptide production GO:0002775 2 0.069
eosinophil degranulation GO:0043308 1 0.068
cellular response to alcohol GO:0097306 23 0.068
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.068
regulation of antimicrobial humoral response GO:0002759 3 0.068
regionalization GO:0003002 337 0.068
stem cell proliferation GO:0072089 117 0.066
nucleoside triphosphate catabolic process GO:0009143 205 0.066
regulation of multi organism process GO:0043900 111 0.066
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.066
organophosphate catabolic process GO:0046434 232 0.066
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.065
mucopolysaccharide metabolic process GO:1903510 25 0.065
positive regulation of epithelial cell proliferation GO:0050679 68 0.065
tissue homeostasis GO:0001894 115 0.065
calcium ion transport GO:0006816 159 0.064
nucleocytoplasmic transport GO:0006913 139 0.064
leukocyte activation involved in immune response GO:0002366 126 0.064
axon ensheathment GO:0008366 76 0.064
regulation of morphogenesis of a branching structure GO:0060688 53 0.063
positive regulation of t cell proliferation GO:0042102 52 0.063
regulation of type 2 immune response GO:0002828 18 0.063
interleukin 1 beta secretion GO:0050702 16 0.063
immune effector process GO:0002252 321 0.063
regulation of t cell proliferation GO:0042129 92 0.062
molting cycle GO:0042303 90 0.062
purine nucleoside metabolic process GO:0042278 241 0.062
positive regulation of monocyte chemotaxis GO:0090026 2 0.061
protein import GO:0017038 101 0.061
positive regulation of t cell extravasation GO:2000409 2 0.061
meiotic nuclear division GO:0007126 115 0.061
purine nucleoside triphosphate catabolic process GO:0009146 203 0.061
regulation of interleukin 5 secretion GO:2000662 2 0.060
ribonucleoside triphosphate catabolic process GO:0009203 199 0.060
multicellular organismal signaling GO:0035637 91 0.059
cellular chemical homeostasis GO:0055082 215 0.059
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.058
endodermal cell fate specification GO:0001714 4 0.058
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.058
lymphocyte mediated immunity GO:0002449 139 0.058
g protein coupled receptor signaling pathway GO:0007186 243 0.057
regulation of map kinase activity GO:0043405 120 0.057
positive regulation of protein modification process GO:0031401 299 0.057
hormone secretion GO:0046879 128 0.057
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.056
positive regulation of response to wounding GO:1903036 66 0.056
alpha beta t cell activation GO:0046631 91 0.056
cellular response to organic cyclic compound GO:0071407 87 0.056
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.056
negative regulation of leukocyte proliferation GO:0070664 46 0.055
eosinophil activation GO:0043307 1 0.055
nucleoside phosphate biosynthetic process GO:1901293 79 0.054
peptidyl tyrosine phosphorylation GO:0018108 143 0.054
cellular nitrogen compound catabolic process GO:0044270 280 0.054
anatomical structure homeostasis GO:0060249 145 0.054
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.053
mitotic nuclear division GO:0007067 48 0.053
regulation of protein kinase activity GO:0045859 232 0.053
respiratory system development GO:0060541 190 0.053
nucleotide catabolic process GO:0009166 217 0.053
regulation of interleukin 1 beta secretion GO:0050706 15 0.052
cytoplasmic transport GO:0016482 234 0.052
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.052
nucleoside triphosphate metabolic process GO:0009141 230 0.052
energy derivation by oxidation of organic compounds GO:0015980 77 0.052
nucleoside phosphate catabolic process GO:1901292 222 0.052
developmental maturation GO:0021700 193 0.051
spermatogenesis GO:0007283 284 0.050
polysaccharide metabolic process GO:0005976 39 0.050
cell recognition GO:0008037 83 0.050
regulation of interleukin 1 secretion GO:0050704 15 0.050
positive regulation of nucleotide catabolic process GO:0030813 88 0.050
microglial cell activation involved in immune response GO:0002282 1 0.050
positive regulation of alpha beta t cell activation GO:0046635 39 0.050
telencephalon development GO:0021537 186 0.050
cerebral cortex development GO:0021987 86 0.050
exocytosis GO:0006887 121 0.050
meiotic cell cycle process GO:1903046 77 0.050
t helper 1 cell differentiation GO:0045063 13 0.050
axon guidance GO:0007411 141 0.050
antimicrobial peptide biosynthetic process GO:0002777 2 0.049
cellular divalent inorganic cation homeostasis GO:0072503 127 0.049
divalent inorganic cation transport GO:0072511 178 0.049
sensory perception GO:0007600 245 0.048
regulation of mitotic cell cycle phase transition GO:1901990 73 0.048
erk1 and erk2 cascade GO:0070371 77 0.048
negative regulation of eosinophil degranulation GO:0043310 1 0.048
cerebral cortex cell migration GO:0021795 44 0.048
macrophage activation GO:0042116 27 0.048
purine nucleoside triphosphate metabolic process GO:0009144 226 0.048
antibacterial peptide production GO:0002778 2 0.048
regulation of mitosis GO:0007088 29 0.048
t cell costimulation GO:0031295 14 0.048
regulation of angiogenesis GO:0045765 81 0.048
mitotic cell cycle process GO:1903047 159 0.047
regulation of interleukin 13 secretion GO:2000665 2 0.047
membrane organization GO:0061024 245 0.047
intracellular protein transport GO:0006886 204 0.047
cellular response to peptide hormone stimulus GO:0071375 92 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
positive regulation of neuron differentiation GO:0045666 141 0.045
regulation of transferase activity GO:0051338 263 0.045
regulation of organelle organization GO:0033043 289 0.045
positive regulation of nucleotide metabolic process GO:0045981 114 0.045
glycoprotein metabolic process GO:0009100 116 0.045
regulation of nucleoside metabolic process GO:0009118 130 0.045
negative regulation of cell activation GO:0050866 111 0.044
myelination GO:0042552 74 0.044
corticotropin releasing hormone secretion GO:0043396 2 0.044
regulation of cytokine biosynthetic process GO:0042035 59 0.044
negative regulation of adaptive immune response GO:0002820 25 0.043
ribonucleoside catabolic process GO:0042454 206 0.043
cellular response to dexamethasone stimulus GO:0071549 8 0.043
positive regulation of secretion GO:0051047 130 0.042
regulation of alpha beta t cell differentiation GO:0046637 35 0.042
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.042
regulation of muscle tissue development GO:1901861 97 0.042
lymphocyte costimulation GO:0031294 15 0.042
positive regulation of hydrolase activity GO:0051345 148 0.042
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.042
cytokine production involved in immune response GO:0002367 34 0.042
regulation of axon extension GO:0030516 43 0.042
digestive system development GO:0055123 200 0.042
negative regulation of cell cycle GO:0045786 123 0.041
lung development GO:0030324 164 0.041
purine nucleotide metabolic process GO:0006163 302 0.041
mrna transcription from rna polymerase ii promoter GO:0042789 4 0.041
spleen development GO:0048536 39 0.041
plasma membrane organization GO:0007009 90 0.041
regulation of b cell proliferation GO:0030888 39 0.040
organonitrogen compound catabolic process GO:1901565 264 0.040
regulation of leukocyte apoptotic process GO:2000106 56 0.040
positive regulation of jnk cascade GO:0046330 46 0.040
regulation of nucleotide catabolic process GO:0030811 122 0.040
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.040
calcium ion homeostasis GO:0055074 127 0.040
ras protein signal transduction GO:0007265 77 0.040
stem cell development GO:0048864 219 0.040
positive regulation of t cell costimulation GO:2000525 2 0.040
mesenchymal cell differentiation GO:0048762 107 0.039
positive regulation of antimicrobial peptide production GO:0002225 1 0.039
gtp metabolic process GO:0046039 144 0.039
interleukin 6 production GO:0032635 58 0.039
regulation of t helper 2 cell cytokine production GO:2000551 3 0.039
multicellular organismal homeostasis GO:0048871 164 0.039
regulation of antimicrobial peptide production GO:0002784 1 0.039
epithelial cell development GO:0002064 159 0.038
paraxial mesodermal cell fate commitment GO:0048343 2 0.038
mesenchyme development GO:0060485 152 0.038
nucleotide metabolic process GO:0009117 332 0.038
negative regulation of cell development GO:0010721 169 0.038
visual behavior GO:0007632 45 0.038
regulation of acute inflammatory response GO:0002673 27 0.038
small gtpase mediated signal transduction GO:0007264 97 0.037
regulation of monocyte extravasation GO:2000437 2 0.037
positive regulation of chemotaxis GO:0050921 38 0.037
negative regulation of type 2 immune response GO:0002829 8 0.037
regulation of organ morphogenesis GO:2000027 144 0.037
camera type eye development GO:0043010 266 0.037
regulation of mitotic cell cycle GO:0007346 126 0.037
regulation of intracellular protein transport GO:0033157 82 0.037
positive regulation of apoptotic process GO:0043065 217 0.036
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.036
negative regulation of cellular component organization GO:0051129 194 0.035
positive regulation of glial cell differentiation GO:0045687 21 0.035
developmental induction GO:0031128 34 0.035
glucose homeostasis GO:0042593 128 0.035
regulation of glial cell differentiation GO:0045685 41 0.035
immune complex clearance GO:0002434 2 0.035
negative regulation of interleukin 13 secretion GO:2000666 1 0.035
cytosolic calcium ion homeostasis GO:0051480 70 0.035
t cell activation involved in immune response GO:0002286 43 0.035
gastrin induced gastric acid secretion GO:0001698 1 0.034
regulation of t helper 1 cell differentiation GO:0045625 7 0.034
central nervous system neuron differentiation GO:0021953 162 0.034
antigen processing and presentation GO:0019882 47 0.034
mitotic cell cycle GO:0000278 195 0.034
positive regulation of interferon gamma production GO:0032729 39 0.034
positive regulation of endopeptidase activity GO:0010950 43 0.034
cellular response to steroid hormone stimulus GO:0071383 33 0.034
syncytium formation GO:0006949 43 0.034
regulation of immunological synapse formation GO:2000520 2 0.033
hair cycle GO:0042633 90 0.033
skeletal system development GO:0001501 356 0.033
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.033
t helper 17 cell chemotaxis GO:0035705 1 0.033
glycosyl compound catabolic process GO:1901658 206 0.033
regulation of ras protein signal transduction GO:0046578 114 0.033
regulation of response to wounding GO:1903034 189 0.033
leukocyte degranulation GO:0043299 27 0.033
regulation of icosanoid secretion GO:0032303 8 0.033
purine nucleotide catabolic process GO:0006195 211 0.033
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.033
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.033
regulation of interleukin 10 production GO:0032653 21 0.033
organic cyclic compound catabolic process GO:1901361 295 0.033
myeloid leukocyte migration GO:0097529 57 0.033
regulation of nucleotide metabolic process GO:0006140 169 0.032
negative regulation of organelle organization GO:0010639 90 0.032
generation of precursor metabolites and energy GO:0006091 103 0.032
positive regulation of t cell activation GO:0050870 101 0.032
respiratory tube development GO:0030323 167 0.032
skin development GO:0043588 220 0.032
cell adhesion GO:0007155 329 0.032
telencephalon cell migration GO:0022029 55 0.032
negative regulation of secretion by cell GO:1903531 54 0.032
regulation of leukocyte mediated immunity GO:0002703 104 0.032
regulation of t cell extravasation GO:2000407 3 0.032
sensory perception of mechanical stimulus GO:0050954 107 0.032
apoptotic signaling pathway GO:0097190 306 0.032
protein import into nucleus GO:0006606 95 0.031
lung cell differentiation GO:0060479 30 0.031
positive regulation of monocyte extravasation GO:2000439 1 0.031
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.031
extracellular structure organization GO:0043062 148 0.031
regulation of nuclear division GO:0051783 56 0.031
guanosine containing compound catabolic process GO:1901069 144 0.031
regulation of dendritic cell antigen processing and presentation GO:0002604 7 0.031
male gamete generation GO:0048232 285 0.031
stem cell maintenance GO:0019827 130 0.031
regulation of eosinophil degranulation GO:0043309 1 0.031
regulation of protein catabolic process GO:0042176 108 0.031
nucleotide biosynthetic process GO:0009165 78 0.031
positive regulation of immunological synapse formation GO:2000522 1 0.030
regulation of interleukin 1 beta production GO:0032651 25 0.030
ensheathment of neurons GO:0007272 76 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.030
activation of adenylate cyclase activity GO:0007190 4 0.030
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.030
renal vesicle induction GO:0072034 3 0.029
eosinophil mediated immunity GO:0002447 1 0.029
ribonucleotide biosynthetic process GO:0009260 59 0.029
divalent inorganic cation homeostasis GO:0072507 138 0.029
leukocyte mediated immunity GO:0002443 174 0.029
cellular response to ketone GO:1901655 12 0.029
regulation of purine nucleotide metabolic process GO:1900542 169 0.029
negative regulation of vasculature development GO:1901343 26 0.029
negative regulation of epithelial cell proliferation GO:0050680 64 0.029
inflammatory cell apoptotic process GO:0006925 11 0.029
neuroblast differentiation GO:0014016 2 0.029
lymphocyte apoptotic process GO:0070227 54 0.028
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.028
regulation of asymmetric cell division GO:0009786 4 0.028
blastocyst development GO:0001824 80 0.028
response to inorganic substance GO:0010035 96 0.028
regulation of defense response GO:0031347 233 0.028
conditioned taste aversion GO:0001661 4 0.028

Aire disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.071
disease of anatomical entity DOID:7 0 0.071
musculoskeletal system disease DOID:17 0 0.071
connective tissue disease DOID:65 0 0.071
immune system disease DOID:2914 0 0.069
hypersensitivity reaction disease DOID:0060056 0 0.069