Mus musculus

0 known processes

L2hgdh

L-2-hydroxyglutarate dehydrogenase

(Aliases: MGC28775,BC016226)

L2hgdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.079
mitochondrion organization GO:0007005 134 0.057
transmembrane transport GO:0055085 412 0.057
organic cyclic compound catabolic process GO:1901361 295 0.056
cellular nitrogen compound catabolic process GO:0044270 280 0.055
heterocycle catabolic process GO:0046700 280 0.054
nucleobase containing small molecule metabolic process GO:0055086 352 0.050
aromatic compound catabolic process GO:0019439 286 0.047
cellular ketone metabolic process GO:0042180 84 0.039
cellular amine metabolic process GO:0044106 44 0.039
glycosyl compound metabolic process GO:1901657 246 0.037
intracellular protein transport GO:0006886 204 0.037
amine metabolic process GO:0009308 45 0.036
purine ribonucleotide metabolic process GO:0009150 290 0.035
macromolecule catabolic process GO:0009057 281 0.034
protein localization to organelle GO:0033365 185 0.032
translation GO:0006412 93 0.030
posttranscriptional regulation of gene expression GO:0010608 155 0.029
regulation of cellular amino acid metabolic process GO:0006521 5 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.028
regulation of cellular ketone metabolic process GO:0010565 66 0.028
nucleoside metabolic process GO:0009116 246 0.028
male gamete generation GO:0048232 285 0.027
regulation of organelle organization GO:0033043 289 0.027
ion transmembrane transport GO:0034220 361 0.027
purine nucleoside metabolic process GO:0042278 241 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.027
cation transport GO:0006812 399 0.027
organonitrogen compound biosynthetic process GO:1901566 192 0.026
cellular macromolecule catabolic process GO:0044265 206 0.026
response to oxidative stress GO:0006979 123 0.026
nucleoside phosphate metabolic process GO:0006753 338 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
purine ribonucleoside metabolic process GO:0046128 241 0.025
regulation of cellular catabolic process GO:0031329 242 0.025
membrane organization GO:0061024 245 0.025
oxidation reduction process GO:0055114 342 0.024
cytoplasmic transport GO:0016482 234 0.024
apoptotic signaling pathway GO:0097190 306 0.024
organonitrogen compound catabolic process GO:1901565 264 0.024
regulation of cell activation GO:0050865 289 0.024
cellular amino acid catabolic process GO:0009063 25 0.024
purine containing compound metabolic process GO:0072521 311 0.024
ribonucleotide metabolic process GO:0009259 291 0.023
cellular homeostasis GO:0019725 240 0.023
small gtpase mediated signal transduction GO:0007264 97 0.023
nucleotide metabolic process GO:0009117 332 0.022
ribonucleoside metabolic process GO:0009119 245 0.022
mitochondrial translation GO:0032543 4 0.021
alpha amino acid metabolic process GO:1901605 59 0.021
response to organonitrogen compound GO:0010243 246 0.021
ribonucleotide catabolic process GO:0009261 208 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
dna metabolic process GO:0006259 303 0.021
establishment of protein localization to organelle GO:0072594 118 0.021
cell type specific apoptotic process GO:0097285 268 0.020
spermatogenesis GO:0007283 284 0.019
cation transmembrane transport GO:0098655 266 0.019
protein catabolic process GO:0030163 221 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
organophosphate catabolic process GO:0046434 232 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
endomembrane system organization GO:0010256 147 0.018
rho protein signal transduction GO:0007266 32 0.018
purine nucleoside catabolic process GO:0006152 205 0.018
cofactor metabolic process GO:0051186 80 0.018
ras protein signal transduction GO:0007265 77 0.018
action potential GO:0001508 78 0.018
cellular protein complex assembly GO:0043623 116 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
multicellular organismal homeostasis GO:0048871 164 0.018
protein maturation GO:0051604 176 0.018
nitrogen compound transport GO:0071705 271 0.018
peptidyl amino acid modification GO:0018193 336 0.017
regulation of mitochondrion organization GO:0010821 27 0.017
anion transport GO:0006820 177 0.017
protein targeting GO:0006605 143 0.017
generation of precursor metabolites and energy GO:0006091 103 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
protein processing GO:0016485 163 0.017
leukocyte differentiation GO:0002521 342 0.017
regulation of membrane potential GO:0042391 192 0.017
neuronal action potential GO:0019228 54 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
multicellular organismal signaling GO:0035637 91 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
regulation of protein localization GO:0032880 231 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
immune effector process GO:0002252 321 0.016
transmission of nerve impulse GO:0019226 76 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
cellular chemical homeostasis GO:0055082 215 0.016
coenzyme metabolic process GO:0006732 52 0.016
homeostasis of number of cells GO:0048872 210 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
purine containing compound catabolic process GO:0072523 213 0.015
regulation of cellular response to stress GO:0080135 159 0.015
purine nucleoside triphosphate catabolic process GO:0009146 203 0.015
regulation of cytokine production GO:0001817 266 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.015
regulation of defense response GO:0031347 233 0.015
locomotory behavior GO:0007626 195 0.015
b cell activation GO:0042113 161 0.015
nucleoside triphosphate catabolic process GO:0009143 205 0.015
sensory perception GO:0007600 245 0.015
inorganic ion transmembrane transport GO:0098660 234 0.015
protein import GO:0017038 101 0.015
cation homeostasis GO:0055080 212 0.015
t cell activation GO:0042110 289 0.014
regulation of translation GO:0006417 71 0.014
negative regulation of molecular function GO:0044092 258 0.014
response to organic cyclic compound GO:0014070 198 0.014
metal ion homeostasis GO:0055065 189 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
germ cell development GO:0007281 185 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
negative regulation of immune system process GO:0002683 209 0.014
nucleoside phosphate catabolic process GO:1901292 222 0.014
regulation of t cell activation GO:0050863 170 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
glycosyl compound catabolic process GO:1901658 206 0.014
regulation of hydrolase activity GO:0051336 246 0.014
cellular lipid metabolic process GO:0044255 323 0.014
spermatid differentiation GO:0048515 115 0.014
multicellular organism growth GO:0035264 161 0.013
muscle tissue development GO:0060537 308 0.013
regulation of homeostatic process GO:0032844 182 0.013
negative regulation of cellular component organization GO:0051129 194 0.013
skeletal system development GO:0001501 356 0.013
sulfur compound metabolic process GO:0006790 100 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
nucleoside catabolic process GO:0009164 206 0.013
tissue homeostasis GO:0001894 115 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
renal system development GO:0072001 225 0.013
positive regulation of cell death GO:0010942 224 0.013
nucleotide catabolic process GO:0009166 217 0.013
regulation of ion transport GO:0043269 215 0.013
cytokine production GO:0001816 319 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
ribonucleoside catabolic process GO:0042454 206 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
lymphocyte differentiation GO:0030098 242 0.013
camera type eye development GO:0043010 266 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
carboxylic acid biosynthetic process GO:0046394 86 0.012
myeloid cell differentiation GO:0030099 233 0.012
regulation of transmembrane transport GO:0034762 128 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
gland development GO:0048732 330 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
regulation of anatomical structure size GO:0090066 178 0.012
small molecule catabolic process GO:0044282 71 0.012
response to endoplasmic reticulum stress GO:0034976 53 0.012
defecation GO:0030421 1 0.012
sulfur compound biosynthetic process GO:0044272 37 0.012
organic acid biosynthetic process GO:0016053 86 0.012
regulation of kinase activity GO:0043549 249 0.012
striated muscle tissue development GO:0014706 293 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
urogenital system development GO:0001655 261 0.012
small molecule biosynthetic process GO:0044283 132 0.012
spermatid development GO:0007286 108 0.012
lymphocyte proliferation GO:0046651 164 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
divalent inorganic cation transport GO:0072511 178 0.012
response to extracellular stimulus GO:0009991 127 0.011
innate immune response GO:0045087 157 0.011
neuron apoptotic process GO:0051402 142 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
coenzyme biosynthetic process GO:0009108 23 0.011
organic acid transport GO:0015849 101 0.011
divalent metal ion transport GO:0070838 172 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
male anatomical structure morphogenesis GO:0090598 4 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
adult behavior GO:0030534 135 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
positive regulation of protein modification process GO:0031401 299 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
regulation of hormone levels GO:0010817 211 0.011
anatomical structure homeostasis GO:0060249 145 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
leukocyte mediated immunity GO:0002443 174 0.011
cell maturation GO:0048469 127 0.011
carboxylic acid catabolic process GO:0046395 51 0.011
regulation of apoptotic signaling pathway GO:2001233 197 0.011
lipid biosynthetic process GO:0008610 179 0.011
response to nutrient levels GO:0031667 109 0.010
response to inorganic substance GO:0010035 96 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
cell adhesion GO:0007155 329 0.010
cellular ion homeostasis GO:0006873 165 0.010
reactive oxygen species metabolic process GO:0072593 84 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
positive regulation of cell development GO:0010720 237 0.010
cellular modified amino acid metabolic process GO:0006575 63 0.010
carbohydrate homeostasis GO:0033500 128 0.010
regulation of purine nucleotide metabolic process GO:1900542 169 0.010

L2hgdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
amino acid metabolic disorder DOID:9252 0 0.052
inherited metabolic disorder DOID:655 0 0.052
disease of metabolism DOID:0014667 0 0.052
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.031
immune system disease DOID:2914 0 0.018
central nervous system disease DOID:331 0 0.014
neurodegenerative disease DOID:1289 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
musculoskeletal system disease DOID:17 0 0.013
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
hematopoietic system disease DOID:74 0 0.012