Mus musculus

198 known processes

Mlh1

mutL homolog 1 (E. coli)

(Aliases: AI325952,AI317206,AI561766,1110035C23Rik)

Mlh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.696
double strand break repair GO:0006302 48 0.693
dna repair GO:0006281 107 0.684
rna 3 end processing GO:0031123 20 0.440
dna replication GO:0006260 52 0.420
dna metabolic process GO:0006259 303 0.418
cellular hyperosmotic salinity response GO:0071475 0 0.415
double strand break repair via nonhomologous end joining GO:0006303 10 0.312
intra s dna damage checkpoint GO:0031573 4 0.268
mrna 3 end processing GO:0031124 16 0.260
non recombinational repair GO:0000726 10 0.212
negative regulation of dna replication GO:0008156 4 0.200
cellular amino acid metabolic process GO:0006520 103 0.170
organelle fission GO:0048285 170 0.159
regulation of cell cycle GO:0051726 281 0.129
amine metabolic process GO:0009308 45 0.108
apoptotic signaling pathway GO:0097190 306 0.095
base excision repair GO:0006284 9 0.094
dna dependent dna replication GO:0006261 24 0.094
telomere capping GO:0016233 4 0.089
signal transduction involved in dna damage checkpoint GO:0072422 3 0.089
response to ionizing radiation GO:0010212 42 0.088
intrinsic apoptotic signaling pathway GO:0097193 132 0.087
trna wobble base modification GO:0002097 2 0.085
positive regulation of cell death GO:0010942 224 0.083
macromolecule catabolic process GO:0009057 281 0.082
nuclear division GO:0000280 158 0.076
negative regulation of cell cycle GO:0045786 123 0.075
dna integrity checkpoint GO:0031570 28 0.073
positive regulation of apoptotic process GO:0043065 217 0.069
cellular response to ionizing radiation GO:0071479 11 0.068
ncrna 3 end processing GO:0043628 2 0.066
response to radiation GO:0009314 165 0.066
negative regulation of mitotic cell cycle GO:0045930 58 0.064
regulation of chromosome organization GO:0033044 83 0.064
regulation of cellular ketone metabolic process GO:0010565 66 0.062
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.062
hematopoietic progenitor cell differentiation GO:0002244 143 0.062
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.062
cellular ketone metabolic process GO:0042180 84 0.061
cellular nitrogen compound catabolic process GO:0044270 280 0.061
mitotic cell cycle GO:0000278 195 0.057
mitotic cell cycle checkpoint GO:0007093 31 0.056
anatomical structure homeostasis GO:0060249 145 0.056
cellular amine metabolic process GO:0044106 44 0.054
positive regulation of cellular amine metabolic process GO:0033240 5 0.052
dna damage checkpoint GO:0000077 26 0.052
cell cycle checkpoint GO:0000075 47 0.051
positive regulation of programmed cell death GO:0043068 218 0.051
mitotic cell cycle process GO:1903047 159 0.050
regulation of cellular amine metabolic process GO:0033238 20 0.047
response to x ray GO:0010165 11 0.047
regulation of cellular amino acid metabolic process GO:0006521 5 0.047
dna catabolic process endonucleolytic GO:0000737 15 0.046
negative regulation of cell cycle process GO:0010948 69 0.046
regulation of mitotic cell cycle GO:0007346 126 0.045
dna recombination GO:0006310 92 0.044
rna phosphodiester bond hydrolysis GO:0090501 19 0.044
somatic diversification of immune receptors GO:0002200 53 0.044
production of molecular mediator of immune response GO:0002440 103 0.043
regulation of cytokine production GO:0001817 266 0.042
regulation of cell cycle process GO:0010564 160 0.042
organism emergence from protective structure GO:0071684 4 0.041
nuclear dna replication GO:0033260 3 0.041
regulation of mitotic cell cycle phase transition GO:1901990 73 0.039
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.039
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.038
telomere maintenance GO:0000723 19 0.038
rna processing GO:0006396 105 0.038
dna conformation change GO:0071103 37 0.037
cytokine production GO:0001816 319 0.037
chromosome segregation GO:0007059 48 0.037
organonitrogen compound biosynthetic process GO:1901566 192 0.035
regulation of cellular response to stress GO:0080135 159 0.034
response to oxidative stress GO:0006979 123 0.034
cell type specific apoptotic process GO:0097285 268 0.032
lateral inhibition GO:0046331 1 0.032
muscle tissue development GO:0060537 308 0.032
dna catabolic process GO:0006308 19 0.032
leukocyte differentiation GO:0002521 342 0.032
posttranscriptional regulation of gene expression GO:0010608 155 0.031
organic cyclic compound catabolic process GO:1901361 295 0.031
negative regulation of cell cycle phase transition GO:1901988 48 0.031
microtubule cytoskeleton organization GO:0000226 157 0.030
regulation of cell cycle phase transition GO:1901987 77 0.030
heterocycle catabolic process GO:0046700 280 0.030
mrna processing GO:0006397 63 0.029
gland development GO:0048732 330 0.029
peptidyl amino acid modification GO:0018193 336 0.029
somatic cell dna recombination GO:0016444 51 0.029
meiosis i GO:0007127 60 0.029
protein processing GO:0016485 163 0.029
camera type eye development GO:0043010 266 0.029
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.029
regulation of defense response GO:0031347 233 0.028
purine containing compound metabolic process GO:0072521 311 0.028
Yeast
meiotic nuclear division GO:0007126 115 0.028
myeloid cell differentiation GO:0030099 233 0.027
multicellular organismal homeostasis GO:0048871 164 0.027
chromatin modification GO:0016568 187 0.027
regulation of mrna stability GO:0043488 23 0.027
negative regulation of cell proliferation GO:0008285 296 0.027
chromatin organization GO:0006325 206 0.027
protein maturation GO:0051604 176 0.027
positive regulation of cell development GO:0010720 237 0.027
t cell differentiation in thymus GO:0033077 77 0.026
regulation of nuclear cell cycle dna replication GO:0033262 2 0.026
homeostasis of number of cells GO:0048872 210 0.026
signal transduction by p53 class mediator GO:0072331 51 0.026
purine nucleotide metabolic process GO:0006163 302 0.026
Yeast
cellular response to radiation GO:0071478 28 0.026
stem cell differentiation GO:0048863 268 0.026
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
Yeast
negative regulation of dna dependent dna replication GO:2000104 1 0.025
skin development GO:0043588 220 0.025
skeletal muscle organ development GO:0060538 163 0.024
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.024
nucleotide excision repair GO:0006289 13 0.024
neuron death GO:0070997 154 0.024
gene silencing GO:0016458 38 0.023
meiotic cell cycle process GO:1903046 77 0.023
trna wobble uridine modification GO:0002098 2 0.023
interspecies interaction between organisms GO:0044419 83 0.023
positive regulation of nervous system development GO:0051962 221 0.023
positive regulation of protein modification process GO:0031401 299 0.023
blastocyst development GO:0001824 80 0.023
rna dependent dna replication GO:0006278 3 0.022
response to organic cyclic compound GO:0014070 198 0.022
mrna transport GO:0051028 13 0.021
protein acylation GO:0043543 64 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
neuron apoptotic process GO:0051402 142 0.021
cell fate commitment GO:0045165 210 0.021
reciprocal dna recombination GO:0035825 16 0.021
regulation of organelle organization GO:0033043 289 0.021
cellular response to oxidative stress GO:0034599 76 0.021
rna catabolic process GO:0006401 29 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.021
regulation of membrane potential GO:0042391 192 0.021
positive regulation of cytokine production GO:0001819 174 0.021
recombinational repair GO:0000725 21 0.021
cellular response to growth factor stimulus GO:0071363 197 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
cellular response to x ray GO:0071481 2 0.020
histone mrna metabolic process GO:0008334 3 0.020
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.019
trna aminoacylation for protein translation GO:0006418 1 0.019
extrinsic apoptotic signaling pathway GO:0097191 126 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
action potential GO:0001508 78 0.019
mitotic nuclear division GO:0007067 48 0.018
locomotory behavior GO:0007626 195 0.018
muscle cell differentiation GO:0042692 261 0.018
glial cell differentiation GO:0010001 131 0.018
retina development in camera type eye GO:0060041 119 0.018
cation transport GO:0006812 399 0.018
digestive system development GO:0055123 200 0.018
organonitrogen compound catabolic process GO:1901565 264 0.018
Yeast
response to organonitrogen compound GO:0010243 246 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
mitochondrion organization GO:0007005 134 0.017
response to gamma radiation GO:0010332 22 0.017
viral process GO:0016032 41 0.017
oxidation reduction process GO:0055114 342 0.017
epithelial tube morphogenesis GO:0060562 303 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
Yeast
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
b cell activation GO:0042113 161 0.017
cell growth GO:0016049 130 0.017
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.017
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.017
reactive oxygen species metabolic process GO:0072593 84 0.017
rna polyadenylation GO:0043631 6 0.017
developmental programmed cell death GO:0010623 41 0.017
lymphocyte differentiation GO:0030098 242 0.017
sensory organ morphogenesis GO:0090596 242 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
Yeast
regulation of apoptotic signaling pathway GO:2001233 197 0.016
regulation of neuron death GO:1901214 134 0.016
regulation of neuron apoptotic process GO:0043523 122 0.016
cellular response to abiotic stimulus GO:0071214 56 0.016
lipoprotein metabolic process GO:0042157 43 0.016
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.016
cajal body organization GO:0030576 1 0.016
regulation of dna replication GO:0006275 17 0.016
mitotic recombination GO:0006312 3 0.016
cell activation involved in immune response GO:0002263 126 0.016
methylation GO:0032259 134 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
Yeast
regulation of cell activation GO:0050865 289 0.016
chemotaxis GO:0006935 247 0.016
metal ion homeostasis GO:0055065 189 0.016
cellular response to gamma radiation GO:0071480 4 0.016
meiotic cell cycle GO:0051321 122 0.016
digestive tract development GO:0048565 190 0.015
atp catabolic process GO:0006200 55 0.015
Yeast
calcium ion transport GO:0006816 159 0.015
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.015
striated muscle tissue development GO:0014706 293 0.015
regulation of histone modification GO:0031056 56 0.015
wound healing GO:0042060 157 0.015
regulation of chromatin organization GO:1902275 57 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
epidermis development GO:0008544 187 0.015
dna endoreduplication GO:0042023 4 0.015
skeletal system development GO:0001501 356 0.015
rhythmic process GO:0048511 174 0.015
regulation of hydrolase activity GO:0051336 246 0.015
cellular response to organonitrogen compound GO:0071417 145 0.015
response to drug GO:0042493 75 0.015
epithelial cell proliferation GO:0050673 174 0.015
divalent inorganic cation transport GO:0072511 178 0.015
t cell activation GO:0042110 289 0.015
mrna metabolic process GO:0016071 84 0.015
regulation of multi organism process GO:0043900 111 0.015
trna metabolic process GO:0006399 11 0.015
histone modification GO:0016570 159 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.014
response to oxygen levels GO:0070482 62 0.014
adaptive immune response GO:0002250 155 0.014
response to lipopolysaccharide GO:0032496 128 0.014
response to uv GO:0009411 44 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
hematopoietic stem cell differentiation GO:0060218 8 0.014
protein autophosphorylation GO:0046777 61 0.014
maintenance of location GO:0051235 89 0.014
nucleoside phosphate catabolic process GO:1901292 222 0.014
Yeast
peptidyl lysine acetylation GO:0018394 45 0.014
nitrogen compound transport GO:0071705 271 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
telomere maintenance via telomerase GO:0007004 1 0.014
immunoglobulin mediated immune response GO:0016064 69 0.014
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.014
aromatic compound catabolic process GO:0019439 286 0.014
striated muscle cell development GO:0055002 125 0.014
digestive tract morphogenesis GO:0048546 147 0.014
t cell differentiation GO:0030217 174 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
engulfment of apoptotic cell GO:0043652 3 0.014
embryonic organ morphogenesis GO:0048562 276 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.013
cellular response to peptide GO:1901653 92 0.013
immune effector process GO:0002252 321 0.013
divalent metal ion transport GO:0070838 172 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
Yeast
skeletal muscle cell differentiation GO:0035914 66 0.013
regulation of body fluid levels GO:0050878 162 0.013
reciprocal meiotic recombination GO:0007131 16 0.013
germ cell development GO:0007281 185 0.013
ribonucleotide metabolic process GO:0009259 291 0.013
Yeast
hyperosmotic salinity response GO:0042538 1 0.013
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.013
regulation of protein localization GO:0032880 231 0.013
internal protein amino acid acetylation GO:0006475 42 0.013
positive regulation of protein autophosphorylation GO:0031954 4 0.013
regulation of transferase activity GO:0051338 263 0.013
protein palmitoylation GO:0018345 14 0.013
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.013
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.013
response to testosterone GO:0033574 3 0.013
regulation of defense response to bacterium GO:1900424 3 0.012
inflammatory response GO:0006954 244 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.012
tissue homeostasis GO:0001894 115 0.012
cellular lipid metabolic process GO:0044255 323 0.012
regulation of cysteine type endopeptidase activity GO:2000116 65 0.012
pallium development GO:0021543 120 0.012
cellular response to acid chemical GO:0071229 68 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
ncrna processing GO:0034470 26 0.012
multicellular organismal signaling GO:0035637 91 0.012
gliogenesis GO:0042063 141 0.012
cardiac muscle cell contraction GO:0086003 7 0.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.012
regulation of kinase activity GO:0043549 249 0.012
deoxyribose phosphate metabolic process GO:0019692 9 0.012
regulation of chromatin modification GO:1903308 57 0.012
dna templated transcription termination GO:0006353 4 0.012
forebrain development GO:0030900 302 0.012
ectopic germ cell programmed cell death GO:0035234 9 0.012
maintenance of protein localization in organelle GO:0072595 2 0.012
negative regulation of growth GO:0045926 99 0.012
antimicrobial peptide biosynthetic process GO:0002777 2 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
transmembrane transport GO:0055085 412 0.012
cation homeostasis GO:0055080 212 0.011
3 utr mediated mrna stabilization GO:0070935 2 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
Yeast
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
lymphocyte proliferation GO:0046651 164 0.011
positive regulation of endopeptidase activity GO:0010950 43 0.011
pancreas development GO:0031016 57 0.011
macromolecule methylation GO:0043414 120 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
Yeast
regulation of ion transport GO:0043269 215 0.011
regulation of proteolysis GO:0030162 164 0.011
organophosphate catabolic process GO:0046434 232 0.011
Yeast
cellular ion homeostasis GO:0006873 165 0.011
multicellular organism growth GO:0035264 161 0.011
limb development GO:0060173 166 0.011
nucleotide metabolic process GO:0009117 332 0.011
Yeast
innate immune response GO:0045087 157 0.011
negative regulation of immune system process GO:0002683 209 0.011
antibacterial peptide biosynthetic process GO:0002780 2 0.011
respiratory system development GO:0060541 190 0.011
lipid biosynthetic process GO:0008610 179 0.011
nucleoside metabolic process GO:0009116 246 0.011
Yeast
regulation of cell migration GO:0030334 219 0.011
stem cell development GO:0048864 219 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
Yeast
appendage morphogenesis GO:0035107 149 0.011
neuron migration GO:0001764 122 0.011
regulation of secretion by cell GO:1903530 249 0.010
mitotic g1 dna damage checkpoint GO:0031571 4 0.010
organelle assembly GO:0070925 177 0.010
rna interference GO:0016246 2 0.010
regulation of t cell activation GO:0050863 170 0.010
cellular chemical homeostasis GO:0055082 215 0.010
leukocyte mediated immunity GO:0002443 174 0.010
response to acid chemical GO:0001101 111 0.010
protein modification by small protein conjugation GO:0032446 187 0.010
leukocyte proliferation GO:0070661 172 0.010
leukocyte activation involved in immune response GO:0002366 126 0.010
apoptotic dna fragmentation GO:0006309 7 0.010
body fluid secretion GO:0007589 53 0.010
regulation of chromatin silencing GO:0031935 2 0.010
lymphocyte homeostasis GO:0002260 64 0.010
urogenital system development GO:0001655 261 0.010
lymphocyte apoptotic process GO:0070227 54 0.010
positive regulation of apoptotic signaling pathway GO:2001235 95 0.010
regulation of leukocyte proliferation GO:0070663 121 0.010
hatching GO:0035188 4 0.010
cytoplasmic transport GO:0016482 234 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.010
cartilage development GO:0051216 140 0.010
carbohydrate derivative catabolic process GO:1901136 231 0.010
Yeast
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
Yeast
viral life cycle GO:0019058 36 0.010
translation GO:0006412 93 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
Yeast

Mlh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.087
disease of cellular proliferation DOID:14566 0 0.087
organ system cancer DOID:0050686 0 0.071
thoracic cancer DOID:5093 0 0.033
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018
breast cancer DOID:1612 0 0.016
immune system cancer DOID:0060083 0 0.012
hematologic cancer DOID:2531 0 0.012