Mus musculus

0 known processes

Shc2

SHC (Src homology 2 domain containing) transforming protein 2

(Aliases: 6720466E06,ShcB,SCK,Sli)

Shc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to endoplasmic reticulum stress GO:0034976 53 0.356
Worm
amine metabolic process GO:0009308 45 0.245
regulation of cellular amine metabolic process GO:0033238 20 0.201
cellular amine metabolic process GO:0044106 44 0.181
aromatic compound catabolic process GO:0019439 286 0.172
regulation of cellular amino acid metabolic process GO:0006521 5 0.166
single organismal cell cell adhesion GO:0016337 131 0.144
Mouse
cation transport GO:0006812 399 0.122
regulation of cellular ketone metabolic process GO:0010565 66 0.116
glycosyl compound metabolic process GO:1901657 246 0.109
heterocycle catabolic process GO:0046700 280 0.098
ribonucleotide catabolic process GO:0009261 208 0.096
forebrain development GO:0030900 302 0.089
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.089
purine ribonucleotide catabolic process GO:0009154 208 0.088
regulation of secretion GO:0051046 274 0.087
nucleotide catabolic process GO:0009166 217 0.084
purine nucleotide catabolic process GO:0006195 211 0.080
positive regulation of protein phosphorylation GO:0001934 242 0.079
Mouse
sensory perception of mechanical stimulus GO:0050954 107 0.078
ribonucleoside triphosphate metabolic process GO:0009199 220 0.078
cell adhesion GO:0007155 329 0.076
Mouse
purine nucleotide metabolic process GO:0006163 302 0.076
glutamate receptor signaling pathway GO:0007215 35 0.073
purine nucleoside metabolic process GO:0042278 241 0.073
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.071
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.070
nucleoside triphosphate catabolic process GO:0009143 205 0.070
purine ribonucleoside catabolic process GO:0046130 205 0.070
macromolecule catabolic process GO:0009057 281 0.069
purine containing compound metabolic process GO:0072521 311 0.066
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.066
nucleoside triphosphate metabolic process GO:0009141 230 0.066
purine containing compound catabolic process GO:0072523 213 0.065
cellular nitrogen compound catabolic process GO:0044270 280 0.065
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.065
purine nucleoside catabolic process GO:0006152 205 0.063
cellular amino acid metabolic process GO:0006520 103 0.062
regulation of membrane potential GO:0042391 192 0.062
membrane organization GO:0061024 245 0.062
glycosyl compound catabolic process GO:1901658 206 0.060
ribose phosphate metabolic process GO:0019693 291 0.060
organophosphate catabolic process GO:0046434 232 0.058
organonitrogen compound catabolic process GO:1901565 264 0.057
positive regulation of secretion GO:0051047 130 0.056
response to organonitrogen compound GO:0010243 246 0.056
nucleoside phosphate metabolic process GO:0006753 338 0.055
regulation of protein localization GO:0032880 231 0.055
peptidyl amino acid modification GO:0018193 336 0.054
actin cytoskeleton organization GO:0030036 220 0.054
Mouse
nucleotide metabolic process GO:0009117 332 0.053
inorganic cation transmembrane transport GO:0098662 207 0.051
negative regulation of protein metabolic process GO:0051248 282 0.051
locomotory behavior GO:0007626 195 0.050
guanosine containing compound metabolic process GO:1901068 144 0.050
regulation of anatomical structure size GO:0090066 178 0.048
purine ribonucleoside metabolic process GO:0046128 241 0.047
neuromuscular process GO:0050905 99 0.047
regulation of protein serine threonine kinase activity GO:0071900 157 0.046
Mouse
nucleoside metabolic process GO:0009116 246 0.045
small gtpase mediated signal transduction GO:0007264 97 0.045
response to metal ion GO:0010038 47 0.044
Worm
regulation of ion transport GO:0043269 215 0.044
regulation of kinase activity GO:0043549 249 0.044
Mouse Worm
regulation of nucleotide catabolic process GO:0030811 122 0.043
negative regulation of synapse assembly GO:0051964 3 0.042
carbohydrate derivative biosynthetic process GO:1901137 183 0.041
ribonucleotide metabolic process GO:0009259 291 0.041
neuron projection guidance GO:0097485 141 0.041
regulation of establishment of protein localization GO:0070201 181 0.040
calcium ion transport GO:0006816 159 0.040
regulation of cellular component biogenesis GO:0044087 181 0.040
cation transmembrane transport GO:0098655 266 0.040
gtp catabolic process GO:0006184 143 0.040
carbohydrate derivative catabolic process GO:1901136 231 0.038
positive regulation of gtpase activity GO:0043547 85 0.038
angiogenesis GO:0001525 201 0.037
Mouse
response to inorganic substance GO:0010035 96 0.037
Worm
wnt signaling pathway GO:0016055 188 0.037
divalent inorganic cation transport GO:0072511 178 0.036
cellular ketone metabolic process GO:0042180 84 0.036
positive regulation of cellular amine metabolic process GO:0033240 5 0.036
purine nucleoside triphosphate catabolic process GO:0009146 203 0.035
rhythmic process GO:0048511 174 0.035
regulation of glutamate receptor signaling pathway GO:1900449 16 0.035
transmembrane transport GO:0055085 412 0.035
protein localization to membrane GO:0072657 108 0.034
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.034
Mouse
negative regulation of cellular component organization GO:0051129 194 0.034
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.033
regulation of peptide secretion GO:0002791 77 0.033
skeletal system development GO:0001501 356 0.033
organic hydroxy compound metabolic process GO:1901615 203 0.033
Fly
nucleoside catabolic process GO:0009164 206 0.032
associative learning GO:0008306 61 0.032
regulation of purine nucleotide catabolic process GO:0033121 122 0.032
ion transmembrane transport GO:0034220 361 0.032
organonitrogen compound biosynthetic process GO:1901566 192 0.032
regulation of wnt signaling pathway GO:0030111 123 0.031
learning GO:0007612 98 0.031
positive regulation of rho gtpase activity GO:0032321 41 0.031
gtp metabolic process GO:0046039 144 0.031
positive regulation of gtp catabolic process GO:0033126 85 0.030
positive regulation of protein modification process GO:0031401 299 0.030
Mouse
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.030
single organism cell adhesion GO:0098602 156 0.030
Mouse
compound eye development GO:0048749 1 0.030
protein catabolic process GO:0030163 221 0.029
regulation of protein transport GO:0051223 163 0.029
positive regulation of ras gtpase activity GO:0032320 65 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.028
actin cytoskeleton reorganization GO:0031532 21 0.028
Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.028
sulfur compound metabolic process GO:0006790 100 0.028
regulation of cell projection organization GO:0031344 206 0.028
regulation of homeostatic process GO:0032844 182 0.028
protein import into nucleus GO:0006606 95 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.028
regulation of hydrolase activity GO:0051336 246 0.027
innate immune response GO:0045087 157 0.027
Fly
cell type specific apoptotic process GO:0097285 268 0.027
glucose homeostasis GO:0042593 128 0.027
protein maturation GO:0051604 176 0.027
regulation of secretion by cell GO:1903530 249 0.027
regulation of transferase activity GO:0051338 263 0.027
Mouse Worm
axon guidance GO:0007411 141 0.026
synaptic transmission GO:0007268 329 0.026
Mouse
spermatogenesis GO:0007283 284 0.026
response to peptide GO:1901652 136 0.026
cellular macromolecule catabolic process GO:0044265 206 0.025
peptide transport GO:0015833 133 0.025
chromatin organization GO:0006325 206 0.025
myeloid cell differentiation GO:0030099 233 0.025
multicellular organism growth GO:0035264 161 0.025
regulation of cell activation GO:0050865 289 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
synaptic vesicle transport GO:0048489 57 0.025
adult behavior GO:0030534 135 0.025
positive regulation of nervous system development GO:0051962 221 0.024
learning or memory GO:0007611 148 0.024
Mouse
establishment or maintenance of cell polarity GO:0007163 86 0.024
amide transport GO:0042886 138 0.024
tor signaling GO:0031929 21 0.024
Fly
regulation of nucleoside metabolic process GO:0009118 130 0.024
protein targeting GO:0006605 143 0.024
establishment of synaptic vesicle localization GO:0097480 57 0.024
immune effector process GO:0002252 321 0.024
Fly
ras protein signal transduction GO:0007265 77 0.023
cellular chemical homeostasis GO:0055082 215 0.023
regulation of cytokine production GO:0001817 266 0.023
response to extracellular stimulus GO:0009991 127 0.023
apoptotic signaling pathway GO:0097190 306 0.023
mucopolysaccharide metabolic process GO:1903510 25 0.023
homeostasis of number of cells GO:0048872 210 0.022
negative regulation of cellular amine metabolic process GO:0033239 1 0.022
positive regulation of protein autophosphorylation GO:0031954 4 0.022
regulation of cell migration GO:0030334 219 0.022
canonical wnt signaling pathway GO:0060070 130 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
Mouse Fly
regulation of transporter activity GO:0032409 57 0.022
cellular response to cytokine stimulus GO:0071345 189 0.022
cellular lipid metabolic process GO:0044255 323 0.022
detection of stimulus GO:0051606 84 0.022
peptide secretion GO:0002790 114 0.022
regulation of cytoskeleton organization GO:0051493 122 0.021
intrinsic apoptotic signaling pathway GO:0097193 132 0.021
oocyte anterior posterior axis specification GO:0007314 2 0.021
regulation of map kinase activity GO:0043405 120 0.021
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.021
positive regulation of cellular catabolic process GO:0031331 148 0.021
phenol containing compound metabolic process GO:0018958 60 0.021
Fly
guanosine containing compound catabolic process GO:1901069 144 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.020
regulation of gtp catabolic process GO:0033124 113 0.020
positive regulation of neuron projection development GO:0010976 79 0.020
developmental maturation GO:0021700 193 0.020
regulation of long term synaptic depression GO:1900452 3 0.020
regulation of system process GO:0044057 200 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
hemostasis GO:0007599 78 0.020
regulation of synaptic plasticity GO:0048167 87 0.020
cytokine mediated signaling pathway GO:0019221 115 0.020
extrinsic apoptotic signaling pathway GO:0097191 126 0.019
microtubule cytoskeleton organization GO:0000226 157 0.019
regulation of cell motility GO:2000145 236 0.019
cation homeostasis GO:0055080 212 0.019
negative regulation of molecular function GO:0044092 258 0.019
cellular divalent inorganic cation homeostasis GO:0072503 127 0.019
protein processing GO:0016485 163 0.019
covalent chromatin modification GO:0016569 163 0.019
synaptic vesicle recycling GO:0036465 19 0.019
aminoglycan metabolic process GO:0006022 34 0.019
germ cell development GO:0007281 185 0.019
memory GO:0007613 58 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
paraxial mesodermal cell differentiation GO:0048342 2 0.018
protein localization to nucleus GO:0034504 121 0.018
cellular protein complex assembly GO:0043623 116 0.018
male gamete generation GO:0048232 285 0.018
positive regulation of kinase activity GO:0033674 155 0.018
Mouse Worm
establishment of protein localization to organelle GO:0072594 118 0.018
pigment metabolic process GO:0042440 32 0.018
Fly
regulation of cell cycle GO:0051726 281 0.017
negative regulation of kinase activity GO:0033673 81 0.017
chromatin modification GO:0016568 187 0.017
response to molecule of bacterial origin GO:0002237 143 0.017
leukocyte differentiation GO:0002521 342 0.017
rho protein signal transduction GO:0007266 32 0.017
carbohydrate homeostasis GO:0033500 128 0.017
regulation of cellular component size GO:0032535 121 0.017
glucose metabolic process GO:0006006 92 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
positive regulation of organelle organization GO:0010638 128 0.017
nuclear transport GO:0051169 139 0.017
regulation of leukocyte differentiation GO:1902105 159 0.017
regulation of peptide transport GO:0090087 91 0.016
endomembrane system organization GO:0010256 147 0.016
glycosaminoglycan metabolic process GO:0030203 34 0.016
muscle contraction GO:0006936 101 0.016
negative regulation of protein phosphorylation GO:0001933 126 0.016
positive regulation of hydrolase activity GO:0051345 148 0.016
skeletal muscle organ development GO:0060538 163 0.016
axonogenesis GO:0007409 274 0.016
neurotransmitter secretion GO:0007269 62 0.016
neuron migration GO:0001764 122 0.016
dendrite development GO:0016358 115 0.016
central nervous system neuron development GO:0021954 67 0.016
lymphocyte apoptotic process GO:0070227 54 0.016
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.016
negative regulation of transferase activity GO:0051348 85 0.016
regulation of t cell activation GO:0050863 170 0.016
protein localization to plasma membrane GO:0072659 57 0.016
protein ubiquitination GO:0016567 171 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
dna metabolic process GO:0006259 303 0.016
actin polymerization or depolymerization GO:0008154 54 0.015
secondary metabolic process GO:0019748 18 0.015
Fly
positive regulation of cell development GO:0010720 237 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
regulation of neuron differentiation GO:0045664 281 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
regulation of body fluid levels GO:0050878 162 0.015
neuron neuron synaptic transmission GO:0007270 69 0.015
Mouse
regulation of glucose metabolic process GO:0010906 60 0.015
nitrogen compound transport GO:0071705 271 0.015
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
chemotaxis GO:0006935 247 0.015
regulation of carbohydrate metabolic process GO:0006109 75 0.015
negative regulation of protein modification process GO:0031400 163 0.015
neuroblast division in subventricular zone GO:0021849 2 0.014
negative regulation of cell adhesion GO:0007162 45 0.014
regulation of gamma aminobutyric acid secretion GO:0014052 2 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
peptidyl tyrosine phosphorylation GO:0018108 143 0.014
receptor localization to synapse GO:0097120 4 0.014
genetic imprinting GO:0071514 27 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.014
regulation of protein targeting GO:1903533 61 0.014
gland development GO:0048732 330 0.014
mitotic cell cycle GO:0000278 195 0.014
kidney development GO:0001822 213 0.014
connective tissue development GO:0061448 179 0.014
positive regulation of response to wounding GO:1903036 66 0.014
potassium ion transport GO:0006813 52 0.014
maternal determination of anterior posterior axis embryo GO:0008358 2 0.014
segmentation GO:0035282 93 0.014
establishment of protein localization to membrane GO:0090150 54 0.014
negative regulation of hydrolase activity GO:0051346 71 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
peptidyl serine phosphorylation GO:0018105 74 0.014
epidermal growth factor receptor signaling pathway GO:0007173 28 0.014
Mouse Fly
blood vessel morphogenesis GO:0048514 285 0.014
Mouse
histone modification GO:0016570 159 0.014
tissue remodeling GO:0048771 102 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.014
sensory perception of touch GO:0050975 2 0.013
cytosolic calcium ion homeostasis GO:0051480 70 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
sensory organ morphogenesis GO:0090596 242 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.013
renal system development GO:0072001 225 0.013
single organism nuclear import GO:1902593 95 0.013
positive regulation of secretion by cell GO:1903532 114 0.013
organelle localization GO:0051640 179 0.013
positive regulation of transferase activity GO:0051347 167 0.013
Mouse Worm
regulation of binding GO:0051098 111 0.013
nucleoside phosphate biosynthetic process GO:1901293 79 0.013
regulation of protein catabolic process GO:0042176 108 0.013
regulation of neuron projection development GO:0010975 169 0.013
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.013
adherens junction organization GO:0034332 28 0.013
metal ion homeostasis GO:0055065 189 0.013
proteasomal protein catabolic process GO:0010498 98 0.013
cytokine production GO:0001816 319 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
oocyte axis specification GO:0007309 2 0.013
translation GO:0006412 93 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
multi multicellular organism process GO:0044706 109 0.013
regulation of protein autophosphorylation GO:0031952 8 0.013
somitogenesis GO:0001756 69 0.012
modification dependent protein catabolic process GO:0019941 133 0.012
action potential GO:0001508 78 0.012
regulation of cell adhesion GO:0030155 154 0.012
positive regulation of cell adhesion GO:0045785 80 0.012
actin filament organization GO:0007015 113 0.012
cellular homeostasis GO:0019725 240 0.012
ribonucleotide biosynthetic process GO:0009260 59 0.012
hexose metabolic process GO:0019318 98 0.012
regulation of organelle organization GO:0033043 289 0.012
central nervous system neuron differentiation GO:0021953 162 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
spermatid development GO:0007286 108 0.012
cellular response to peptide GO:1901653 92 0.012
organelle fission GO:0048285 170 0.012
positive regulation of membrane potential GO:0045838 15 0.012
response to peptide hormone GO:0043434 127 0.012
cellular protein catabolic process GO:0044257 155 0.012
smoothened signaling pathway GO:0007224 105 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
cellular response to lipid GO:0071396 145 0.012
response to light stimulus GO:0009416 135 0.012
cognition GO:0050890 149 0.012
Mouse
monosaccharide metabolic process GO:0005996 106 0.012
negative regulation of protein catabolic process GO:0042177 36 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
lateral inhibition GO:0046331 1 0.011
response to lipopolysaccharide GO:0032496 128 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
endocrine system development GO:0035270 98 0.011
neuron apoptotic process GO:0051402 142 0.011
positive regulation of hormone secretion GO:0046887 38 0.011
cyclic purine nucleotide metabolic process GO:0052652 43 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
post embryonic retina morphogenesis in camera type eye GO:0060060 3 0.011
positive regulation of map kinase activity GO:0043406 84 0.011
Mouse
negative regulation of protein processing GO:0010955 79 0.011
platelet activation GO:0030168 40 0.011
leukocyte proliferation GO:0070661 172 0.011
regulation of hormone secretion GO:0046883 88 0.011
peptide hormone secretion GO:0030072 109 0.011
negative regulation of growth GO:0045926 99 0.011
proteoglycan metabolic process GO:0006029 38 0.011
protein kinase a signaling GO:0010737 7 0.011
mapk cascade GO:0000165 281 0.011
Mouse
second messenger mediated signaling GO:0019932 73 0.011
skeletal system morphogenesis GO:0048705 203 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
somatotropin secreting cell differentiation GO:0060126 4 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
bronchiole morphogenesis GO:0060436 1 0.011
nucleotide biosynthetic process GO:0009165 78 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
endocytosis GO:0006897 168 0.011
glucose transport GO:0015758 56 0.011
cytoplasmic transport GO:0016482 234 0.011
nuclear import GO:0051170 95 0.011
positive regulation of cyclic nucleotide metabolic process GO:0030801 24 0.011
ureteric bud morphogenesis GO:0060675 62 0.011
g protein coupled acetylcholine receptor signaling pathway GO:0007213 4 0.011
cell cell junction organization GO:0045216 72 0.011
insulin secretion GO:0030073 89 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.011
glycoprotein metabolic process GO:0009100 116 0.011
regulation of extent of cell growth GO:0061387 52 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
interleukin 8 production GO:0032637 4 0.010
asymmetric neuroblast division GO:0055059 1 0.010
fat cell differentiation GO:0045444 160 0.010
regulation of proteolysis GO:0030162 164 0.010
cellular response to biotic stimulus GO:0071216 92 0.010
regulation of endopeptidase activity GO:0052548 89 0.010
lymphocyte homeostasis GO:0002260 64 0.010
negative regulation of mapk cascade GO:0043409 65 0.010
synaptic vesicle localization GO:0097479 59 0.010
response to monosaccharide GO:0034284 67 0.010
retina morphogenesis in camera type eye GO:0060042 45 0.010
small molecule biosynthetic process GO:0044283 132 0.010
negative regulation of cell projection organization GO:0031345 56 0.010
mitotic cytokinesis GO:0000281 4 0.010
divalent metal ion transport GO:0070838 172 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
regulation of neural retina development GO:0061074 3 0.010
actomyosin structure organization GO:0031032 56 0.010
maintenance of location GO:0051235 89 0.010
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.010
organic hydroxy compound biosynthetic process GO:1901617 77 0.010
notch signaling pathway GO:0007219 71 0.010
regulation of chromosome organization GO:0033044 83 0.010

Shc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
disease of cellular proliferation DOID:14566 0 0.014
epilepsy syndrome DOID:1826 0 0.013
central nervous system disease DOID:331 0 0.013
brain disease DOID:936 0 0.013
electroclinical syndrome DOID:0050701 0 0.013