Mus musculus

5 known processes

Dio1

deiodinase, iodothyronine, type I

(Aliases: TXDI1,ITDI1,5DI,MGC107659,D1)

Dio1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hormone metabolic process GO:0042445 86 0.458
Mouse
lipid biosynthetic process GO:0008610 179 0.381
organic hydroxy compound metabolic process GO:1901615 203 0.367
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.347
steroid metabolic process GO:0008202 119 0.289
monosaccharide metabolic process GO:0005996 106 0.284
cellular lipid metabolic process GO:0044255 323 0.259
cellular ketone metabolic process GO:0042180 84 0.231
carbohydrate metabolic process GO:0005975 230 0.208
organic acid biosynthetic process GO:0016053 86 0.185
glycerolipid metabolic process GO:0046486 122 0.174
fatty acid metabolic process GO:0006631 121 0.168
regulation of hormone levels GO:0010817 211 0.162
Mouse
small molecule biosynthetic process GO:0044283 132 0.160
response to inorganic substance GO:0010035 96 0.158
carboxylic acid biosynthetic process GO:0046394 86 0.148
naphthalene metabolic process GO:0018931 1 0.142
response to organic cyclic compound GO:0014070 198 0.136
cholesterol homeostasis GO:0042632 44 0.123
oxidation reduction process GO:0055114 342 0.113
ion transmembrane transport GO:0034220 361 0.113
monocarboxylic acid biosynthetic process GO:0072330 61 0.112
cellular response to hormone stimulus GO:0032870 150 0.108
cellular amino acid metabolic process GO:0006520 103 0.103
Mouse
cellular lipid catabolic process GO:0044242 52 0.103
hexose metabolic process GO:0019318 98 0.102
neutral lipid metabolic process GO:0006638 57 0.087
lipid homeostasis GO:0055088 63 0.087
protein processing GO:0016485 163 0.086
regulation of phospholipase c activity GO:1900274 3 0.085
response to phenylpropanoid GO:0080184 22 0.082
cellular modified amino acid metabolic process GO:0006575 63 0.082
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.081
protein maturation GO:0051604 176 0.076
generation of precursor metabolites and energy GO:0006091 103 0.075
vitamin d3 metabolic process GO:0070640 3 0.074
cation transport GO:0006812 399 0.072
sterol homeostasis GO:0055092 45 0.072
lipid transport GO:0006869 98 0.072
response to organonitrogen compound GO:0010243 246 0.071
cellular amine metabolic process GO:0044106 44 0.071
alcohol metabolic process GO:0006066 116 0.070
regulation of cellular ketone metabolic process GO:0010565 66 0.070
organic anion transport GO:0015711 137 0.070
anion transport GO:0006820 177 0.068
sensory perception GO:0007600 245 0.067
hormone secretion GO:0046879 128 0.067
amine metabolic process GO:0009308 45 0.066
organic acid transport GO:0015849 101 0.066
regulation of glucose metabolic process GO:0010906 60 0.063
phospholipid metabolic process GO:0006644 87 0.062
lipid localization GO:0010876 126 0.062
inorganic ion transmembrane transport GO:0098660 234 0.062
small molecule catabolic process GO:0044282 71 0.059
Mouse
isoprenoid metabolic process GO:0006720 29 0.058
regulation of plasminogen activation GO:0010755 4 0.057
cellular response to cadmium ion GO:0071276 3 0.056
positive regulation of cellular amine metabolic process GO:0033240 5 0.056
cation transmembrane transport GO:0098655 266 0.055
vitamin d biosynthetic process GO:0042368 3 0.055
regulation of lipid metabolic process GO:0019216 118 0.055
response to metal ion GO:0010038 47 0.053
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.051
sensory perception of mechanical stimulus GO:0050954 107 0.049
response to acid chemical GO:0001101 111 0.049
maintenance of location GO:0051235 89 0.048
response to peptide GO:1901652 136 0.046
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.046
oxidative demethylation GO:0070989 1 0.046
response to nutrient levels GO:0031667 109 0.046
carboxylic acid transport GO:0046942 100 0.044
rhythmic process GO:0048511 174 0.044
muscle system process GO:0003012 141 0.043
carboxylic acid catabolic process GO:0046395 51 0.043
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.043
peptide secretion GO:0002790 114 0.043
transmembrane transport GO:0055085 412 0.042
nitrogen compound transport GO:0071705 271 0.042
placenta development GO:0001890 140 0.042
cellular response to lipid GO:0071396 145 0.041
glucose metabolic process GO:0006006 92 0.040
transmission of nerve impulse GO:0019226 76 0.040
epithelial cell development GO:0002064 159 0.039
monocarboxylic acid catabolic process GO:0072329 27 0.039
icosanoid metabolic process GO:0006690 33 0.038
bile acid metabolic process GO:0008206 17 0.038
acylglycerol metabolic process GO:0006639 55 0.037
regulation of secretion GO:0051046 274 0.037
cellular amide metabolic process GO:0043603 58 0.036
naphthalene containing compound metabolic process GO:0090420 1 0.036
triglyceride metabolic process GO:0006641 51 0.036
organic hydroxy compound biosynthetic process GO:1901617 77 0.035
positive regulation of programmed cell death GO:0043068 218 0.035
muscle contraction GO:0006936 101 0.035
sensory perception of sound GO:0007605 97 0.034
establishment of blood nerve barrier GO:0008065 3 0.033
secondary alcohol metabolic process GO:1902652 3 0.033
energy derivation by oxidation of organic compounds GO:0015980 77 0.033
amide transport GO:0042886 138 0.033
long chain fatty acid metabolic process GO:0001676 26 0.033
wound healing GO:0042060 157 0.033
positive regulation of lipid metabolic process GO:0045834 40 0.033
renal system development GO:0072001 225 0.032
multicellular organismal signaling GO:0035637 91 0.032
response to lipopolysaccharide GO:0032496 128 0.032
lipid catabolic process GO:0016042 69 0.032
glucuronate metabolic process GO:0019585 2 0.032
response to temperature stimulus GO:0009266 55 0.032
regulation of carbohydrate metabolic process GO:0006109 75 0.031
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.031
carbohydrate biosynthetic process GO:0016051 74 0.031
regulation of body fluid levels GO:0050878 162 0.031
peptide metabolic process GO:0006518 46 0.030
positive regulation of cell death GO:0010942 224 0.030
response to extracellular stimulus GO:0009991 127 0.030
synaptic transmission GO:0007268 329 0.029
fatty acid oxidation GO:0019395 28 0.029
cellular response to inorganic substance GO:0071241 37 0.029
urogenital system development GO:0001655 261 0.029
response to starvation GO:0042594 65 0.029
monosaccharide biosynthetic process GO:0046364 44 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.029
peptide transport GO:0015833 133 0.028
organic acid catabolic process GO:0016054 51 0.028
Mouse
inflammatory response GO:0006954 244 0.028
gluconeogenesis GO:0006094 39 0.028
response to steroid hormone GO:0048545 56 0.028
cell adhesion GO:0007155 329 0.028
peptidyl amino acid modification GO:0018193 336 0.028
regulation of steroid biosynthetic process GO:0050810 26 0.028
cellular homeostasis GO:0019725 240 0.028
extracellular matrix organization GO:0030198 147 0.027
terpenoid metabolic process GO:0006721 25 0.027
regulation of hormone secretion GO:0046883 88 0.027
renal tubular secretion GO:0097254 2 0.027
metal ion homeostasis GO:0055065 189 0.027
negative regulation of molecular function GO:0044092 258 0.027
blood circulation GO:0008015 195 0.027
response to oxidative stress GO:0006979 123 0.027
lipid modification GO:0030258 65 0.027
monocarboxylic acid transport GO:0015718 44 0.026
negative regulation of protein metabolic process GO:0051248 282 0.026
cellular response to steroid hormone stimulus GO:0071383 33 0.026
fatty acid derivative metabolic process GO:1901568 33 0.026
neuronal action potential GO:0019228 54 0.026
regulation of fatty acid metabolic process GO:0019217 28 0.026
action potential GO:0001508 78 0.026
telencephalon development GO:0021537 186 0.026
heme metabolic process GO:0042168 16 0.026
carbohydrate homeostasis GO:0033500 128 0.026
glycerophospholipid metabolic process GO:0006650 71 0.026
morphogenesis of a branching epithelium GO:0061138 193 0.025
cell substrate adhesion GO:0031589 130 0.025
response to stilbenoid GO:0035634 22 0.025
inorganic cation transmembrane transport GO:0098662 207 0.025
development of primary female sexual characteristics GO:0046545 73 0.024
regulation of kinase activity GO:0043549 249 0.024
skeletal system development GO:0001501 356 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
androgen biosynthetic process GO:0006702 4 0.024
circulatory system process GO:0003013 197 0.024
pigment metabolic process GO:0042440 32 0.024
hexose biosynthetic process GO:0019319 39 0.024
detection of stimulus GO:0051606 84 0.024
short chain fatty acid catabolic process GO:0019626 2 0.023
cell maturation GO:0048469 127 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.023
regulation of steroid metabolic process GO:0019218 39 0.023
gland development GO:0048732 330 0.023
lipid oxidation GO:0034440 29 0.023
response to molecule of bacterial origin GO:0002237 143 0.023
purine containing compound metabolic process GO:0072521 311 0.023
response to drug GO:0042493 75 0.022
ensheathment of neurons GO:0007272 76 0.022
positive regulation of plasminogen activation GO:0010756 2 0.022
glycoprotein metabolic process GO:0009100 116 0.022
fat soluble vitamin biosynthetic process GO:0042362 4 0.022
regulation of protein processing GO:0070613 96 0.022
regulation of blood vessel size GO:0050880 56 0.022
carbohydrate transport GO:0008643 62 0.022
regulation of lipid biosynthetic process GO:0046890 54 0.022
regulation of system process GO:0044057 200 0.022
cellular response to insulin stimulus GO:0032869 78 0.022
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.021
regulation of cholesterol metabolic process GO:0090181 14 0.021
developmental maturation GO:0021700 193 0.021
glucose transport GO:0015758 56 0.021
regulation of transferase activity GO:0051338 263 0.021
sulfur compound metabolic process GO:0006790 100 0.020
sodium ion transmembrane transport GO:0035725 49 0.020
extracellular structure organization GO:0043062 148 0.020
g protein coupled receptor signaling pathway GO:0007186 243 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
engulfment of apoptotic cell GO:0043652 3 0.020
uronic acid metabolic process GO:0006063 2 0.020
diterpenoid metabolic process GO:0016101 24 0.020
zymogen activation GO:0031638 41 0.020
organic cyclic compound catabolic process GO:1901361 295 0.020
Mouse
regulation of membrane potential GO:0042391 192 0.019
porphyrin containing compound metabolic process GO:0006778 22 0.019
regulation of translation GO:0006417 71 0.019
cellular response to testosterone stimulus GO:0071394 1 0.019
protein activation cascade GO:0072376 19 0.019
camera type eye development GO:0043010 266 0.019
regulation of cell cycle GO:0051726 281 0.019
response to estrogen GO:0043627 24 0.019
arachidonic acid metabolic process GO:0019369 14 0.019
regulation of blood pressure GO:0008217 93 0.019
steroid biosynthetic process GO:0006694 47 0.019
cellular alcohol biosynthetic process GO:0044108 3 0.019
ear development GO:0043583 200 0.019
glycoprotein biosynthetic process GO:0009101 89 0.018
endocrine system development GO:0035270 98 0.018
sulfate assimilation GO:0000103 3 0.018
regulation of anatomical structure size GO:0090066 178 0.018
fatty acid catabolic process GO:0009062 25 0.018
cellular alcohol metabolic process GO:0044107 3 0.018
fatty acid biosynthetic process GO:0006633 41 0.018
protein glycosylation GO:0006486 55 0.018
response to xenobiotic stimulus GO:0009410 13 0.018
regulation of protein maturation GO:1903317 96 0.018
cellular response to extracellular stimulus GO:0031668 81 0.018
regulation of peptide secretion GO:0002791 77 0.018
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 3 0.017
nucleoside phosphate biosynthetic process GO:1901293 79 0.017
cellular response to peptide hormone stimulus GO:0071375 92 0.017
cellular response to organic cyclic compound GO:0071407 87 0.017
respiratory tube development GO:0030323 167 0.017
phenol containing compound metabolic process GO:0018958 60 0.017
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.017
establishment of protein localization to organelle GO:0072594 118 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
regulation of hydrolase activity GO:0051336 246 0.017
positive regulation of phospholipase activity GO:0010518 3 0.017
positive regulation of fatty acid oxidation GO:0046321 4 0.017
negative regulation of protein maturation GO:1903318 79 0.017
positive regulation of apoptotic process GO:0043065 217 0.017
amino acid transmembrane transport GO:0003333 37 0.016
regulation of carbohydrate biosynthetic process GO:0043255 40 0.016
cofactor metabolic process GO:0051186 80 0.016
ribonucleoside triphosphate metabolic process GO:0009199 220 0.016
hormone mediated signaling pathway GO:0009755 23 0.016
cholesterol metabolic process GO:0008203 56 0.016
response to peptide hormone GO:0043434 127 0.016
aromatic compound catabolic process GO:0019439 286 0.016
Mouse
progesterone metabolic process GO:0042448 4 0.016
calcitriol biosynthetic process from calciol GO:0036378 3 0.016
inter male aggressive behavior GO:0002121 3 0.016
mesonephric epithelium development GO:0072163 94 0.016
development of primary sexual characteristics GO:0045137 143 0.016
retinoid metabolic process GO:0001523 24 0.016
purine nucleotide metabolic process GO:0006163 302 0.015
regulation of neuron differentiation GO:0045664 281 0.015
sensory organ morphogenesis GO:0090596 242 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
intracellular receptor signaling pathway GO:0030522 74 0.015
proteoglycan biosynthetic process GO:0030166 20 0.015
nucleobase containing small molecule metabolic process GO:0055086 352 0.015
cell growth GO:0016049 130 0.015
kidney development GO:0001822 213 0.015
multicellular organism growth GO:0035264 161 0.015
Mouse
cellular response to molecule of bacterial origin GO:0071219 83 0.015
negative regulation of growth GO:0045926 99 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
cellular response to starvation GO:0009267 57 0.015
protein oligomerization GO:0051259 67 0.015
regulation of response to wounding GO:1903034 189 0.015
negative regulation of protein processing GO:0010955 79 0.015
morphogenesis of a branching structure GO:0001763 203 0.015
negative regulation of lipid metabolic process GO:0045833 30 0.015
neurohypophysis development GO:0021985 2 0.015
single organism cell adhesion GO:0098602 156 0.014
endocrine process GO:0050886 39 0.014
regulation of tube size GO:0035150 57 0.014
glycogen metabolic process GO:0005977 32 0.014
mechanoreceptor differentiation GO:0042490 67 0.014
vasoconstriction GO:0042310 27 0.014
negative regulation of gluconeogenesis GO:0045721 9 0.014
negative regulation of proteolysis GO:0045861 74 0.014
regulation of erk1 and erk2 cascade GO:0070372 71 0.014
female sex differentiation GO:0046660 84 0.014
cellular response to peptide GO:1901653 92 0.014
immune effector process GO:0002252 321 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
myeloid leukocyte differentiation GO:0002573 119 0.014
unsaturated fatty acid metabolic process GO:0033559 31 0.014
male sex differentiation GO:0046661 109 0.014
mapk cascade GO:0000165 281 0.014
regulation of cellular amino acid metabolic process GO:0006521 5 0.014
endocytosis GO:0006897 168 0.014
protein autophosphorylation GO:0046777 61 0.014
forebrain development GO:0030900 302 0.014
prostate gland stromal morphogenesis GO:0060741 2 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
cellular chemical homeostasis GO:0055082 215 0.014
organic hydroxy compound transport GO:0015850 93 0.014
purine ribonucleotide metabolic process GO:0009150 290 0.014
response to testosterone GO:0033574 3 0.014
nephron development GO:0072006 109 0.014
regulation of vesicle mediated transport GO:0060627 139 0.013
female gonad development GO:0008585 71 0.013
regulation of vitamin metabolic process GO:0030656 3 0.013
fertilization GO:0009566 127 0.013
fatty acid transport GO:0015908 28 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.013
positive regulation of protein kinase activity GO:0045860 144 0.013
appendage development GO:0048736 166 0.013
very long chain fatty acid metabolic process GO:0000038 8 0.013
ectodermal cell differentiation GO:0010668 3 0.013
response to oxygen levels GO:0070482 62 0.013
carnitine transport GO:0015879 3 0.013
translation GO:0006412 93 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.013
response to monosaccharide GO:0034284 67 0.013
cellular response to nutrient levels GO:0031669 64 0.013
cation homeostasis GO:0055080 212 0.013
purine containing compound biosynthetic process GO:0072522 70 0.013
macromolecule glycosylation GO:0043413 55 0.013
regulation of antimicrobial humoral response GO:0002759 3 0.013
regulation of fatty acid oxidation GO:0046320 10 0.013
negative regulation of immune system process GO:0002683 209 0.012
organonitrogen compound catabolic process GO:1901565 264 0.012
Mouse
regulation of secretion by cell GO:1903530 249 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
carbon catabolite activation of transcription GO:0045991 4 0.012
positive regulation of transferase activity GO:0051347 167 0.012
response to corticosterone GO:0051412 1 0.012
regulation of triglyceride metabolic process GO:0090207 17 0.012
regulation of homeostatic process GO:0032844 182 0.012
male gamete generation GO:0048232 285 0.012
glycosylation GO:0070085 62 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
benzene containing compound metabolic process GO:0042537 5 0.012
positive regulation of fatty acid biosynthetic process GO:0045723 3 0.012
regulation of peptide hormone secretion GO:0090276 75 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
sterol metabolic process GO:0016125 58 0.012
fat cell differentiation GO:0045444 160 0.012
limb development GO:0060173 166 0.012
cell fate commitment GO:0045165 210 0.012
regulation of protein transport GO:0051223 163 0.012
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.012
organophosphate catabolic process GO:0046434 232 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
ribose phosphate metabolic process GO:0019693 291 0.012
monosaccharide transport GO:0015749 58 0.012
regulation of intracellular transport GO:0032386 159 0.011
testosterone biosynthetic process GO:0061370 2 0.011
peptide hormone secretion GO:0030072 109 0.011
regulation of mapk cascade GO:0043408 248 0.011
purine ribonucleoside catabolic process GO:0046130 205 0.011
ectodermal cell fate commitment GO:0001712 1 0.011
cellular response to gonadotropin stimulus GO:0071371 4 0.011
mesonephros development GO:0001823 97 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
gonad development GO:0008406 141 0.011
membrane organization GO:0061024 245 0.011
regulation of defense response GO:0031347 233 0.011
organ growth GO:0035265 117 0.011
sensory system development GO:0048880 3 0.011
kidney epithelium development GO:0072073 121 0.011
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.011
epithelial cell proliferation GO:0050673 174 0.011
regulation of protein kinase activity GO:0045859 232 0.011
female gamete generation GO:0007292 74 0.011
response to insulin GO:0032868 100 0.011
leukocyte differentiation GO:0002521 342 0.011
vesicle organization GO:0016050 60 0.011
sulfur compound biosynthetic process GO:0044272 37 0.011
axonogenesis GO:0007409 274 0.011
cellular response to oxidative stress GO:0034599 76 0.011
nuclear division GO:0000280 158 0.011
negative regulation of cellular component organization GO:0051129 194 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
organelle fission GO:0048285 170 0.011
anion transmembrane transport GO:0098656 71 0.011
macromolecule catabolic process GO:0009057 281 0.011
secondary metabolic process GO:0019748 18 0.011
polyol metabolic process GO:0019751 26 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
sensory perception of smell GO:0007608 26 0.011
regulation of peptide transport GO:0090087 91 0.011
axon ensheathment GO:0008366 76 0.011
response to osmotic stress GO:0006970 21 0.011
amino acid betaine transport GO:0015838 3 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
chemotaxis GO:0006935 247 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
molting cycle GO:0042303 90 0.011
positive regulation of phospholipase c activity GO:0010863 2 0.011
regulation of cellular response to stress GO:0080135 159 0.011
regulation of gluconeogenesis GO:0006111 30 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
myeloid cell differentiation GO:0030099 233 0.010
cellular response to biotic stimulus GO:0071216 92 0.010
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.010
mrna metabolic process GO:0016071 84 0.010
nucleotide metabolic process GO:0009117 332 0.010
cell recognition GO:0008037 83 0.010
purine nucleoside metabolic process GO:0042278 241 0.010
muscle cell differentiation GO:0042692 261 0.010
lateral line system development GO:0048925 1 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
cytoplasmic transport GO:0016482 234 0.010
cellular response to antibiotic GO:0071236 4 0.010
cell type specific apoptotic process GO:0097285 268 0.010
nucleotide biosynthetic process GO:0009165 78 0.010

Dio1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
lipid metabolism disorder DOID:3146 0 0.024
inherited metabolic disorder DOID:655 0 0.024
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
steroid inherited metabolic disorder DOID:1701 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012