Mus musculus

0 known processes

Mthfd2

methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

(Aliases: NMDMC,AW558851)

Mthfd2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
methionine transport GO:0015821 1 0.628
amino acid transmembrane transport GO:0003333 37 0.581
l alpha amino acid transmembrane transport GO:1902475 23 0.392
anion transmembrane transport GO:0098656 71 0.254
neutral amino acid transport GO:0015804 13 0.219
branched chain amino acid transport GO:0015803 2 0.199
organic acid transport GO:0015849 101 0.169
cellular amino acid metabolic process GO:0006520 103 0.157
Human
l amino acid transport GO:0015807 32 0.151
anion transport GO:0006820 177 0.145
nitrogen compound transport GO:0071705 271 0.107
cation transport GO:0006812 399 0.099
ion transmembrane transport GO:0034220 361 0.096
carboxylic acid transport GO:0046942 100 0.085
nucleoside phosphate metabolic process GO:0006753 338 0.084
dna metabolic process GO:0006259 303 0.070
cellular amine metabolic process GO:0044106 44 0.068
organic anion transport GO:0015711 137 0.067
organonitrogen compound biosynthetic process GO:1901566 192 0.064
translation GO:0006412 93 0.055
nucleobase containing small molecule metabolic process GO:0055086 352 0.053
cellular ketone metabolic process GO:0042180 84 0.053
amino acid activation GO:0043038 1 0.051
regulation of cellular amine metabolic process GO:0033238 20 0.050
monocarboxylic acid metabolic process GO:0032787 191 0.049
amino acid transport GO:0006865 61 0.049
amine metabolic process GO:0009308 45 0.048
regulation of cellular amino acid metabolic process GO:0006521 5 0.043
response to organic cyclic compound GO:0014070 198 0.040
ribose phosphate metabolic process GO:0019693 291 0.040
organophosphate biosynthetic process GO:0090407 122 0.040
dna repair GO:0006281 107 0.039
reactive oxygen species metabolic process GO:0072593 84 0.039
sulfur compound transport GO:0072348 9 0.039
transmembrane transport GO:0055085 412 0.038
oxidation reduction process GO:0055114 342 0.038
Human
ossification GO:0001503 216 0.037
regulation of cellular ketone metabolic process GO:0010565 66 0.036
sulfur amino acid transport GO:0000101 2 0.036
cellular response to organonitrogen compound GO:0071417 145 0.035
microtubule based process GO:0007017 236 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
macromolecule catabolic process GO:0009057 281 0.033
alpha amino acid metabolic process GO:1901605 59 0.033
Human
response to organonitrogen compound GO:0010243 246 0.033
nuclear division GO:0000280 158 0.033
nucleotide metabolic process GO:0009117 332 0.032
organelle fission GO:0048285 170 0.031
apoptotic signaling pathway GO:0097190 306 0.031
carboxylic acid biosynthetic process GO:0046394 86 0.031
response to radiation GO:0009314 165 0.031
chromatin organization GO:0006325 206 0.029
male gamete generation GO:0048232 285 0.029
positive regulation of cellular catabolic process GO:0031331 148 0.028
cellular homeostasis GO:0019725 240 0.028
microtubule cytoskeleton organization GO:0000226 157 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
negative regulation of protein metabolic process GO:0051248 282 0.027
carbohydrate metabolic process GO:0005975 230 0.027
rhythmic process GO:0048511 174 0.027
nucleoside triphosphate metabolic process GO:0009141 230 0.027
cellular response to dna damage stimulus GO:0006974 207 0.026
mitotic cell cycle process GO:1903047 159 0.026
spermatogenesis GO:0007283 284 0.026
cellular response to cytokine stimulus GO:0071345 189 0.026
neuron apoptotic process GO:0051402 142 0.025
response to acid chemical GO:0001101 111 0.024
cellular lipid metabolic process GO:0044255 323 0.024
cell type specific apoptotic process GO:0097285 268 0.024
meiotic cell cycle process GO:1903046 77 0.023
regulation of cell cycle GO:0051726 281 0.023
negative regulation of molecular function GO:0044092 258 0.023
striated muscle tissue development GO:0014706 293 0.022
regulation of mitotic cell cycle GO:0007346 126 0.022
small molecule biosynthetic process GO:0044283 132 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.022
sensory organ morphogenesis GO:0090596 242 0.022
carbohydrate homeostasis GO:0033500 128 0.021
regulation of cell division GO:0051302 76 0.021
cellular chemical homeostasis GO:0055082 215 0.021
chromatin modification GO:0016568 187 0.021
regulation of cell cycle process GO:0010564 160 0.021
t cell activation GO:0042110 289 0.021
lipid biosynthetic process GO:0008610 179 0.021
neuron death GO:0070997 154 0.021
forebrain development GO:0030900 302 0.020
positive regulation of cell cycle GO:0045787 92 0.020
protein catabolic process GO:0030163 221 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
mitotic nuclear division GO:0007067 48 0.019
regulation of organelle organization GO:0033043 289 0.019
muscle cell differentiation GO:0042692 261 0.019
cellular protein catabolic process GO:0044257 155 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
muscle tissue development GO:0060537 308 0.019
response to light stimulus GO:0009416 135 0.018
skeletal system development GO:0001501 356 0.018
reactive nitrogen species metabolic process GO:2001057 0 0.018
positive regulation of cell development GO:0010720 237 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
response to inorganic substance GO:0010035 96 0.018
myeloid cell differentiation GO:0030099 233 0.018
regulation of secretion by cell GO:1903530 249 0.018
maintenance of location GO:0051235 89 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
gland development GO:0048732 330 0.018
monosaccharide metabolic process GO:0005996 106 0.017
cation transmembrane transport GO:0098655 266 0.017
myeloid leukocyte differentiation GO:0002573 119 0.017
germ cell development GO:0007281 185 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
circadian rhythm GO:0007623 114 0.017
digestive system development GO:0055123 200 0.017
positive regulation of programmed cell death GO:0043068 218 0.017
hormone secretion GO:0046879 128 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
dna recombination GO:0006310 92 0.017
regulation of cell activation GO:0050865 289 0.016
lymphocyte proliferation GO:0046651 164 0.016
ribonucleoside triphosphate catabolic process GO:0009203 199 0.016
regulation of homeostatic process GO:0032844 182 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
hexose metabolic process GO:0019318 98 0.016
regulation of hormone levels GO:0010817 211 0.016
divalent metal ion transport GO:0070838 172 0.016
positive regulation of protein modification process GO:0031401 299 0.016
cellular macromolecule catabolic process GO:0044265 206 0.016
mapk cascade GO:0000165 281 0.016
protein processing GO:0016485 163 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
sensory perception GO:0007600 245 0.016
amide transport GO:0042886 138 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
regulation of membrane potential GO:0042391 192 0.015
regulation of nucleotide metabolic process GO:0006140 169 0.015
leukocyte differentiation GO:0002521 342 0.015
positive regulation of chromosome segregation GO:0051984 4 0.015
organic acid biosynthetic process GO:0016053 86 0.015
urogenital system development GO:0001655 261 0.015
neuromuscular process GO:0050905 99 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
cytokine production GO:0001816 319 0.015
defense response to other organism GO:0098542 197 0.015
meiotic cell cycle GO:0051321 122 0.015
positive regulation of cell death GO:0010942 224 0.015
t cell proliferation GO:0042098 120 0.015
b cell activation GO:0042113 161 0.015
purine ribonucleoside metabolic process GO:0046128 241 0.015
protein methylation GO:0006479 81 0.015
macromolecule methylation GO:0043414 120 0.015
homeostasis of number of cells GO:0048872 210 0.014
purine containing compound metabolic process GO:0072521 311 0.014
fatty acid metabolic process GO:0006631 121 0.014
positive regulation of organelle organization GO:0010638 128 0.014
mitotic cell cycle GO:0000278 195 0.014
organophosphate catabolic process GO:0046434 232 0.014
aromatic compound catabolic process GO:0019439 286 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
membrane organization GO:0061024 245 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
sequestering of metal ion GO:0051238 19 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
regulation of cellular component size GO:0032535 121 0.014
sequestering of calcium ion GO:0051208 18 0.014
trna aminoacylation GO:0043039 1 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
regulation of neuron differentiation GO:0045664 281 0.014
inflammatory response GO:0006954 244 0.014
dna endoreduplication GO:0042023 4 0.014
glucose homeostasis GO:0042593 128 0.014
ras protein signal transduction GO:0007265 77 0.014
connective tissue development GO:0061448 179 0.014
organic cyclic compound catabolic process GO:1901361 295 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
protein ubiquitination GO:0016567 171 0.014
glucose metabolic process GO:0006006 92 0.014
regulation of protein catabolic process GO:0042176 108 0.013
regulation of purine nucleotide metabolic process GO:1900542 169 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
multicellular organism growth GO:0035264 161 0.013
response to extracellular stimulus GO:0009991 127 0.013
peptide transport GO:0015833 133 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
leukocyte proliferation GO:0070661 172 0.013
protein alkylation GO:0008213 81 0.013
circadian regulation of gene expression GO:0032922 48 0.013
cell maturation GO:0048469 127 0.013
carbohydrate biosynthetic process GO:0016051 74 0.013
cell adhesion GO:0007155 329 0.013
ribonucleoside metabolic process GO:0009119 245 0.013
ribonucleotide metabolic process GO:0009259 291 0.013
coenzyme metabolic process GO:0006732 52 0.013
Human
cellular response to acid chemical GO:0071229 68 0.013
regulation of protein kinase activity GO:0045859 232 0.013
compound eye development GO:0048749 1 0.013
histone modification GO:0016570 159 0.013
methylation GO:0032259 134 0.013
skeletal muscle organ development GO:0060538 163 0.012
regulation of cytokine production GO:0001817 266 0.012
cytoplasmic transport GO:0016482 234 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
cellular response to lipid GO:0071396 145 0.012
regulation of response to wounding GO:1903034 189 0.012
regulation of transferase activity GO:0051338 263 0.012
nucleotide catabolic process GO:0009166 217 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
nucleoside catabolic process GO:0009164 206 0.012
regulation of chromosome organization GO:0033044 83 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
peptidyl amino acid modification GO:0018193 336 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
regulation of proteolysis GO:0030162 164 0.012
regulation of cell adhesion GO:0030155 154 0.012
cellular biogenic amine metabolic process GO:0006576 28 0.012
mitochondrion organization GO:0007005 134 0.012
camera type eye development GO:0043010 266 0.012
amino acid import into cell GO:1902837 4 0.012
regulation of cell projection organization GO:0031344 206 0.012
attachment of spindle microtubules to kinetochore GO:0008608 4 0.012
chromosome organization involved in meiosis GO:0070192 39 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
respiratory tube development GO:0030323 167 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
calcium ion transport GO:0006816 159 0.012
positive regulation of protein phosphorylation GO:0001934 242 0.012
regulation of proteasomal protein catabolic process GO:0061136 46 0.012
single organism cell adhesion GO:0098602 156 0.012
regulation of secretion GO:0051046 274 0.012
negative regulation of cell development GO:0010721 169 0.012
response to nutrient levels GO:0031667 109 0.012
sulfur compound metabolic process GO:0006790 100 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
nucleocytoplasmic transport GO:0006913 139 0.011
cell activation involved in immune response GO:0002263 126 0.011
actin cytoskeleton organization GO:0030036 220 0.011
cellular response to abiotic stimulus GO:0071214 56 0.011
response to amino acid GO:0043200 37 0.011
metal ion homeostasis GO:0055065 189 0.011
regulation of mapk cascade GO:0043408 248 0.011
peptide hormone secretion GO:0030072 109 0.011
regulation of hydrolase activity GO:0051336 246 0.011
positive regulation of leukocyte differentiation GO:1902107 86 0.011
male sex differentiation GO:0046661 109 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
nucleoside metabolic process GO:0009116 246 0.011
response to peptide GO:1901652 136 0.011
anatomical structure homeostasis GO:0060249 145 0.011
cellular amino acid biosynthetic process GO:0008652 22 0.011
regulation of cell migration GO:0030334 219 0.011
regulation of anatomical structure size GO:0090066 178 0.011
myosin filament assembly GO:0031034 2 0.011
protein maturation GO:0051604 176 0.011
response to oxidative stress GO:0006979 123 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
alcohol metabolic process GO:0006066 116 0.011
lung development GO:0030324 164 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
lymphocyte differentiation GO:0030098 242 0.011
negative regulation of protein modification process GO:0031400 163 0.011
leukocyte mediated immunity GO:0002443 174 0.011
regulation of kinase activity GO:0043549 249 0.011
regulation of nucleotide catabolic process GO:0030811 122 0.011
regulation of cell size GO:0008361 72 0.011
organonitrogen compound catabolic process GO:1901565 264 0.011
purine containing compound catabolic process GO:0072523 213 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
renal system development GO:0072001 225 0.011
protein modification by small protein conjugation or removal GO:0070647 207 0.011
covalent chromatin modification GO:0016569 163 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
organism emergence from protective structure GO:0071684 4 0.010
innate immune response GO:0045087 157 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
kidney development GO:0001822 213 0.010
posttranscriptional regulation of gene expression GO:0010608 155 0.010
cofactor metabolic process GO:0051186 80 0.010
Human
positive regulation of cell activation GO:0050867 158 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
modification dependent macromolecule catabolic process GO:0043632 133 0.010
leukocyte apoptotic process GO:0071887 71 0.010
response to peptide hormone GO:0043434 127 0.010
response to insulin GO:0032868 100 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
ribose phosphate biosynthetic process GO:0046390 59 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
regulation of cell motility GO:2000145 236 0.010
ribonucleoside catabolic process GO:0042454 206 0.010

Mthfd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.172
nervous system disease DOID:863 0 0.172
neuropathy DOID:870 0 0.172
neuromuscular disease DOID:440 0 0.085
disease of cellular proliferation DOID:14566 0 0.042
cancer DOID:162 0 0.025
charcot marie tooth disease type 2 DOID:0050539 0 0.023
charcot marie tooth disease DOID:10595 0 0.023
central nervous system disease DOID:331 0 0.022
neurodegenerative disease DOID:1289 0 0.021
organ system cancer DOID:0050686 0 0.019
disease of metabolism DOID:0014667 0 0.015
immune system disease DOID:2914 0 0.012
inherited metabolic disorder DOID:655 0 0.010