Mus musculus

405 known processes

Psen2

presenilin 2

(Aliases: STM2,Alg3,Ad4h,PS2,PS-2,ALG-3,Psnl2)

Psen2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.951
response to symbiont GO:0009608 2 0.943
lateral inhibition GO:0046331 1 0.919
Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.809
neuroblast fate determination GO:0007400 1 0.675
growth involved in heart morphogenesis GO:0003241 4 0.665
hair cycle phase GO:0044851 16 0.659
cell migration involved in endocardial cushion formation GO:0003273 3 0.634
myeloid dendritic cell activation GO:0001773 25 0.621
Mouse
choline transport GO:0015871 3 0.535
Mouse
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.527
regulation of resting membrane potential GO:0060075 3 0.514
Mouse
cardiac right ventricle formation GO:0003219 3 0.433
regulation of pro b cell differentiation GO:2000973 5 0.418
notch receptor processing GO:0007220 4 0.414
Mouse Fly
heart trabecula morphogenesis GO:0061384 26 0.401
cardiac right atrium morphogenesis GO:0003213 3 0.398
biological phase GO:0044848 20 0.365
glial cell fate determination GO:0007403 3 0.360
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.359
regulation of somitogenesis GO:0014807 6 0.357
somite specification GO:0001757 4 0.346
i kappab phosphorylation GO:0007252 6 0.343
atrioventricular node development GO:0003162 3 0.312
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.308
beta amyloid metabolic process GO:0050435 14 0.300
myeloid dendritic cell differentiation GO:0043011 16 0.293
Mouse
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.244
blood vessel endothelial cell differentiation GO:0060837 6 0.243
positive regulation of mesoderm development GO:2000382 2 0.238
peptide metabolic process GO:0006518 46 0.236
positive regulation of keratinocyte differentiation GO:0045618 3 0.236
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.217
positive regulation of osteoclast differentiation GO:0045672 15 0.198
protein glycosylation GO:0006486 55 0.196
Mouse
notch signaling pathway GO:0007219 71 0.194
regulation of extracellular matrix assembly GO:1901201 2 0.192
positive regulation of cell death GO:0010942 224 0.191
leukocyte differentiation GO:0002521 342 0.190
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.187
positive regulation of transcription of notch receptor target GO:0007221 4 0.187
anagen GO:0042640 13 0.186
glomerular mesangial cell differentiation GO:0072008 3 0.186
interleukin 4 secretion GO:0072602 5 0.183
myeloid leukocyte activation GO:0002274 83 0.183
Mouse
glomerular visceral epithelial cell development GO:0072015 6 0.182
regulation of epidermal cell differentiation GO:0045604 21 0.182
venous blood vessel morphogenesis GO:0048845 7 0.181
amine metabolic process GO:0009308 45 0.171
stem cell fate determination GO:0048867 2 0.171
cytokine production GO:0001816 319 0.170
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.169
negative regulation of fat cell differentiation GO:0045599 36 0.165
cytokine secretion GO:0050663 72 0.164
regulation of secretion GO:0051046 274 0.161
negative regulation of immune system process GO:0002683 209 0.159
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.159
compartment pattern specification GO:0007386 4 0.158
positive regulation of astrocyte differentiation GO:0048711 8 0.157
calcium ion dependent exocytosis GO:0017156 35 0.157
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 4 0.155
extracellular structure organization GO:0043062 148 0.154
glomerular mesangial cell development GO:0072144 3 0.151
negative regulation of endothelial cell migration GO:0010596 4 0.149
limb morphogenesis GO:0035108 149 0.148
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.147
extracellular matrix organization GO:0030198 147 0.145
glycoprotein biosynthetic process GO:0009101 89 0.145
Mouse
vascular smooth muscle cell differentiation GO:0035886 11 0.140
regulation of cardioblast differentiation GO:0051890 3 0.140
compound eye development GO:0048749 1 0.138
regulation of astrocyte differentiation GO:0048710 20 0.137
divalent inorganic cation transport GO:0072511 178 0.137
neuroblast fate commitment GO:0014017 1 0.136
cation transport GO:0006812 399 0.136
receptor recycling GO:0001881 11 0.135
anatomical structure maturation GO:0071695 49 0.133
regulation of cellular amino acid metabolic process GO:0006521 5 0.133
protein maturation GO:0051604 176 0.132
mesangial cell development GO:0072143 4 0.130
negative regulation of glial cell proliferation GO:0060253 4 0.130
arterial endothelial cell differentiation GO:0060842 5 0.127
defense response to other organism GO:0098542 197 0.126
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.124
somitogenesis GO:0001756 69 0.123
inorganic cation transmembrane transport GO:0098662 207 0.123
cardiac cell fate specification GO:0060912 2 0.120
defense response to bacterium GO:0042742 119 0.120
placenta blood vessel development GO:0060674 31 0.119
calcium ion homeostasis GO:0055074 127 0.119
positive regulation of programmed cell death GO:0043068 218 0.118
inner ear receptor cell differentiation GO:0060113 61 0.117
mechanoreceptor differentiation GO:0042490 67 0.116
learning or memory GO:0007611 148 0.116
negative regulation of myotube differentiation GO:0010832 9 0.115
transition metal ion transport GO:0000041 38 0.114
Fly
positive regulation of leukocyte differentiation GO:1902107 86 0.114
ossification GO:0001503 216 0.114
regulation of myeloid leukocyte differentiation GO:0002761 58 0.113
keratinocyte differentiation GO:0030216 48 0.113
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.112
protein secretion GO:0009306 111 0.111
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.111
regulation of cellular ketone metabolic process GO:0010565 66 0.111
inflammatory response GO:0006954 244 0.110
mesangial cell differentiation GO:0072007 4 0.108
carbohydrate derivative biosynthetic process GO:1901137 183 0.108
Mouse
i kappab kinase nf kappab signaling GO:0007249 85 0.108
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.108
kidney development GO:0001822 213 0.107
response to organonitrogen compound GO:0010243 246 0.107
regulation of receptor recycling GO:0001919 8 0.107
positive regulation of apoptotic process GO:0043065 217 0.106
mesenchyme development GO:0060485 152 0.105
cellular amide metabolic process GO:0043603 58 0.105
calcium ion transport GO:0006816 159 0.104
vascular smooth muscle cell development GO:0097084 7 0.104
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.101
regulation of mitotic cell cycle phase transition GO:1901990 73 0.101
hematopoietic progenitor cell differentiation GO:0002244 143 0.101
pharynx development GO:0060465 1 0.100
photoreceptor cell differentiation GO:0046530 52 0.099
negative regulation of glial cell differentiation GO:0045686 21 0.098
transmembrane transport GO:0055085 412 0.097
sensory organ boundary specification GO:0008052 1 0.095
beta amyloid formation GO:0034205 9 0.095
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.094
developmental maturation GO:0021700 193 0.094
mitotic cell cycle GO:0000278 195 0.094
formation of organ boundary GO:0010160 1 0.092
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.092
inorganic ion transmembrane transport GO:0098660 234 0.092
protein processing GO:0016485 163 0.090
positive regulation of apoptotic signaling pathway GO:2001235 95 0.090
negative regulation of exocytosis GO:0045920 12 0.089
negative regulation of osteoblast differentiation GO:0045668 30 0.087
regulation of keratinocyte differentiation GO:0045616 11 0.087
myeloid leukocyte differentiation GO:0002573 119 0.086
regulation of leukocyte differentiation GO:1902105 159 0.086
embryonic limb morphogenesis GO:0030326 126 0.086
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.085
response to peptide GO:1901652 136 0.084
immune effector process GO:0002252 321 0.084
glomerulus morphogenesis GO:0072102 10 0.084
negative regulation of endothelial cell differentiation GO:0045602 2 0.083
immune response activating signal transduction GO:0002757 116 0.083
neurotransmitter secretion GO:0007269 62 0.083
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.083
t cell activation GO:0042110 289 0.082
cell cell signaling involved in cell fate commitment GO:0045168 35 0.082
Fly
limb development GO:0060173 166 0.081
appendage development GO:0048736 166 0.081
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.080
glycoprotein metabolic process GO:0009100 116 0.080
Mouse
ion transmembrane transport GO:0034220 361 0.079
myeloid cell differentiation GO:0030099 233 0.078
muscle tissue development GO:0060537 308 0.078
myotube differentiation GO:0014902 105 0.077
circulatory system process GO:0003013 197 0.077
regulation of cardiac cell fate specification GO:2000043 1 0.076
swimming behavior GO:0036269 1 0.076
glomerulus development GO:0032835 40 0.076
regulation of osteoclast differentiation GO:0045670 36 0.076
long term memory GO:0007616 15 0.075
divalent inorganic cation homeostasis GO:0072507 138 0.074
embryonic digit morphogenesis GO:0042733 56 0.074
membrane protein proteolysis GO:0033619 10 0.073
Human
photoreceptor cell morphogenesis GO:0008594 3 0.073
aortic valve morphogenesis GO:0003180 4 0.073
negative regulation of cell development GO:0010721 169 0.073
Mouse
memory GO:0007613 58 0.073
positive regulation of cell cycle phase transition GO:1901989 17 0.073
glycosylation GO:0070085 62 0.073
Mouse
positive regulation of homeostatic process GO:0032846 64 0.073
endothelial tube morphogenesis GO:0061154 2 0.073
forebrain development GO:0030900 302 0.072
glomerular epithelial cell development GO:0072310 6 0.071
cell fate determination involved in pattern specification GO:0060582 1 0.071
exocytosis GO:0006887 121 0.071
Mouse
regulation of secretion by cell GO:1903530 249 0.070
epidermis development GO:0008544 187 0.070
negative regulation of molecular function GO:0044092 258 0.070
embryonic organ morphogenesis GO:0048562 276 0.070
Mouse
prostate glandular acinus development GO:0060525 12 0.070
positive regulation of notch signaling pathway GO:0045747 18 0.069
cardiac vascular smooth muscle cell development GO:0060948 3 0.068
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.068
cellular amino acid metabolic process GO:0006520 103 0.068
regulation of mitotic cell cycle GO:0007346 126 0.067
regulation of membrane potential GO:0042391 192 0.067
Mouse
striated muscle tissue development GO:0014706 293 0.067
meiotic nuclear division GO:0007126 115 0.066
heart process GO:0003015 94 0.066
positive regulation of myeloid cell differentiation GO:0045639 43 0.066
meiotic cell cycle GO:0051321 122 0.065
proximal tubule development GO:0072014 5 0.065
humoral immune response GO:0006959 57 0.065
negative regulation of oligodendrocyte differentiation GO:0048715 11 0.064
cation homeostasis GO:0055080 212 0.064
regulation of calcium ion dependent exocytosis GO:0017158 16 0.064
ciliary body morphogenesis GO:0061073 3 0.063
negative regulation of striated muscle cell differentiation GO:0051154 14 0.063
regulation of neuron differentiation GO:0045664 281 0.063
Mouse
regulation of filopodium assembly GO:0051489 13 0.063
cellular lipid metabolic process GO:0044255 323 0.063
myoblast differentiation GO:0045445 52 0.063
homeostasis of number of cells GO:0048872 210 0.062
negative regulation of anoikis GO:2000811 2 0.062
neuroblast differentiation GO:0014016 2 0.062
organic hydroxy compound transport GO:0015850 93 0.061
Mouse
angiogenesis GO:0001525 201 0.061
cell cell adhesion GO:0098609 41 0.061
epithelial cell proliferation GO:0050673 174 0.060
Mouse
regulation of myotube differentiation GO:0010830 62 0.060
activation of immune response GO:0002253 138 0.060
muscle system process GO:0003012 141 0.060
ubiquitin dependent protein catabolic process GO:0006511 129 0.059
endothelium development GO:0003158 45 0.059
protein modification by small protein conjugation or removal GO:0070647 207 0.059
gland development GO:0048732 330 0.059
response to growth factor GO:0070848 198 0.059
segment specification GO:0007379 15 0.059
cardiac chamber development GO:0003205 108 0.059
notch signaling involved in heart development GO:0061314 5 0.058
inflammatory response to antigenic stimulus GO:0002437 30 0.058
hair follicle development GO:0001942 85 0.058
cell type specific apoptotic process GO:0097285 268 0.058
Mouse
autophagy GO:0006914 45 0.058
Mouse
regulation of cell cycle phase transition GO:1901987 77 0.057
organelle assembly GO:0070925 177 0.057
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.056
coronary vein morphogenesis GO:0003169 2 0.056
cellular calcium ion homeostasis GO:0006874 119 0.055
cellular response to inorganic substance GO:0071241 37 0.055
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.055
glomerular capillary formation GO:0072104 6 0.055
cation transmembrane transport GO:0098655 266 0.055
renal system vasculature development GO:0061437 15 0.055
cellular amine metabolic process GO:0044106 44 0.054
response to oxygen levels GO:0070482 62 0.054
spermatogenesis GO:0007283 284 0.054
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.054
cell fate commitment involved in pattern specification GO:0060581 14 0.054
acidic amino acid transport GO:0015800 16 0.054
Mouse
placenta development GO:0001890 140 0.053
auditory receptor cell differentiation GO:0042491 37 0.053
epithelial tube morphogenesis GO:0060562 303 0.053
Mouse
regulation of meiotic cell cycle GO:0051445 34 0.053
morphogenesis of an endothelium GO:0003159 2 0.053
skeletal muscle fiber development GO:0048741 58 0.052
peptidyl amino acid modification GO:0018193 336 0.052
cellular ketone metabolic process GO:0042180 84 0.052
protein ubiquitination GO:0016567 171 0.052
cellular chemical homeostasis GO:0055082 215 0.052
canonical wnt signaling pathway GO:0060070 130 0.052
regulation of neurotransmitter levels GO:0001505 87 0.052
Mouse
macromolecule catabolic process GO:0009057 281 0.051
regulation of endothelial cell chemotaxis GO:2001026 1 0.051
bmp signaling pathway GO:0030509 93 0.051
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.051
regulation of cell projection assembly GO:0060491 38 0.051
segmentation GO:0035282 93 0.050
response to oxidative stress GO:0006979 123 0.050
Mouse
regulation of exocytosis GO:0017157 61 0.050
cognition GO:0050890 149 0.049
negative regulation of receptor activity GO:2000272 5 0.049
regulation of nuclear division GO:0051783 56 0.048
regulation of auditory receptor cell differentiation GO:0045607 4 0.048
activation of mapkk activity GO:0000186 15 0.048
Mouse
negative regulation of secretion GO:0051048 61 0.048
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.048
positive regulation of proteolysis GO:0045862 85 0.048
interleukin 4 production GO:0032633 24 0.048
carbohydrate metabolic process GO:0005975 230 0.048
Mouse
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.047
regulation of myeloid cell differentiation GO:0045637 96 0.047
cellular homeostasis GO:0019725 240 0.047
muscle cell development GO:0055001 133 0.047
regulation of ossification GO:0030278 112 0.047
embryonic appendage morphogenesis GO:0035113 126 0.047
negative regulation of ossification GO:0030279 49 0.047
lymphocyte activation involved in immune response GO:0002285 93 0.047
regulation of organelle organization GO:0033043 289 0.046
response to hypoxia GO:0001666 58 0.046
rhombomere morphogenesis GO:0021593 2 0.046
blood vessel morphogenesis GO:0048514 285 0.046
response to decreased oxygen levels GO:0036293 59 0.046
lung development GO:0030324 164 0.046
positive regulation of cellular catabolic process GO:0031331 148 0.045
regulation of hematopoietic progenitor cell differentiation GO:1901532 18 0.045
positive regulation of glial cell differentiation GO:0045687 21 0.045
positive regulation of epidermal cell differentiation GO:0045606 6 0.045
organonitrogen compound biosynthetic process GO:1901566 192 0.045
muscle cell differentiation GO:0042692 261 0.044
response to muramyl dipeptide GO:0032495 9 0.044
organelle fission GO:0048285 170 0.044
cellular response to dna damage stimulus GO:0006974 207 0.044
Mouse
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 20 0.044
heart contraction GO:0060047 93 0.044
respiratory system development GO:0060541 190 0.044
kidney vasculature development GO:0061440 15 0.043
somite development GO:0061053 81 0.043
venous blood vessel development GO:0060841 13 0.043
regulation of glial cell differentiation GO:0045685 41 0.043
immune response regulating signaling pathway GO:0002764 125 0.043
negative regulation of protein processing GO:0010955 79 0.043
apoptotic process involved in morphogenesis GO:0060561 25 0.042
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.042
osteoclast differentiation GO:0030316 62 0.042
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.042
response to organic cyclic compound GO:0014070 198 0.042
negative regulation of secretion by cell GO:1903531 54 0.041
rhombomere formation GO:0021594 1 0.041
response to inorganic substance GO:0010035 96 0.041
cellular protein catabolic process GO:0044257 155 0.040
heart morphogenesis GO:0003007 178 0.040
Mouse
regulation of cell cycle process GO:0010564 160 0.040
regulation of gliogenesis GO:0014013 50 0.040
cardiac left ventricle morphogenesis GO:0003214 9 0.040
hair follicle morphogenesis GO:0031069 29 0.040
chemotaxis GO:0006935 247 0.040
cellular response to starvation GO:0009267 57 0.040
Mouse
modification dependent protein catabolic process GO:0019941 133 0.039
ovulation cycle GO:0042698 59 0.039
cellular response to hormone stimulus GO:0032870 150 0.039
regulation of blood vessel endothelial cell migration GO:0043535 12 0.039
peptidyl tyrosine modification GO:0018212 145 0.039
positive regulation of cell development GO:0010720 237 0.039
hair cell differentiation GO:0035315 40 0.039
positive regulation of mitotic cell cycle GO:0045931 41 0.039
mapk cascade GO:0000165 281 0.038
Mouse
positive regulation of cell motility GO:2000147 116 0.038
negative regulation of cellular protein metabolic process GO:0032269 247 0.038
protein modification by small protein conjugation GO:0032446 187 0.038
stem cell maintenance GO:0019827 130 0.038
regulation of dna templated transcription in response to stress GO:0043620 9 0.038
cellular response to gonadotropin stimulus GO:0071371 4 0.038
regulation of cell cycle GO:0051726 281 0.038
myotube cell development GO:0014904 60 0.038
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.037
Mouse
regulation of organ morphogenesis GO:2000027 144 0.037
endocytosis GO:0006897 168 0.037
positive regulation of cell migration GO:0030335 109 0.037
calcium ion transmembrane transport GO:0070588 85 0.037
metal ion homeostasis GO:0055065 189 0.036
regulation of anoikis GO:2000209 2 0.036
chromatin organization GO:0006325 206 0.036
digestive system development GO:0055123 200 0.036
regulation of cellular amine metabolic process GO:0033238 20 0.036
hair cycle GO:0042633 90 0.036
regulation of osteoblast differentiation GO:0045667 67 0.036
regulation of oligodendrocyte differentiation GO:0048713 23 0.036
cardiac conduction system development GO:0003161 12 0.036
multi multicellular organism process GO:0044706 109 0.036
cardiac muscle tissue development GO:0048738 130 0.036
regulation of protein kinase activity GO:0045859 232 0.036
cellular response to external stimulus GO:0071496 88 0.036
Mouse
nuclear division GO:0000280 158 0.036
blood vessel lumenization GO:0072554 2 0.036
nucleobase containing small molecule metabolic process GO:0055086 352 0.035
response to lipopolysaccharide GO:0032496 128 0.035
response to nutrient levels GO:0031667 109 0.035
Mouse
wound healing GO:0042060 157 0.035
inner ear receptor cell fate commitment GO:0060120 6 0.035
sulfur compound metabolic process GO:0006790 100 0.035
urogenital system development GO:0001655 261 0.035
response to molecule of bacterial origin GO:0002237 143 0.035
regulation of canonical wnt signaling pathway GO:0060828 82 0.035
kidney vasculature morphogenesis GO:0061439 7 0.035
digestive tract development GO:0048565 190 0.035
regulation of body fluid levels GO:0050878 162 0.035
camera type eye development GO:0043010 266 0.034
sprouting angiogenesis GO:0002040 26 0.034
regulation of cellular catabolic process GO:0031329 242 0.034
actin cytoskeleton organization GO:0030036 220 0.034
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.034
cellular response to decreased oxygen levels GO:0036294 18 0.034
cardiac chamber morphogenesis GO:0003206 93 0.034
female gamete generation GO:0007292 74 0.034
regulation of binding GO:0051098 111 0.033
positive regulation of nervous system development GO:0051962 221 0.033
renal tubule development GO:0061326 87 0.033
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.032
cell chemotaxis GO:0060326 81 0.032
myeloid cell homeostasis GO:0002262 114 0.032
lymphocyte differentiation GO:0030098 242 0.032
nitrogen compound transport GO:0071705 271 0.032
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.032
regulation of chemotaxis GO:0050920 53 0.032
macromolecule glycosylation GO:0043413 55 0.032
Mouse
regulation of proteolysis GO:0030162 164 0.032
epidermis morphogenesis GO:0048730 33 0.032
anatomical structure homeostasis GO:0060249 145 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.032
negative regulation of nervous system development GO:0051961 156 0.032
Mouse
photoreceptor cell development GO:0042461 40 0.032
t cell activation involved in immune response GO:0002286 43 0.032
l amino acid transport GO:0015807 32 0.032
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.032
positive regulation of cytokine production GO:0001819 174 0.031
regulation of establishment of protein localization GO:0070201 181 0.031
male gamete generation GO:0048232 285 0.031
cellular response to metal ion GO:0071248 31 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.031
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.031
developmental programmed cell death GO:0010623 41 0.031
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.031
multi organism behavior GO:0051705 62 0.031
innate immune response GO:0045087 157 0.031
regulation of synaptic transmission glutamatergic GO:0051966 19 0.031
Mouse
g1 s transition of mitotic cell cycle GO:0000082 57 0.031
reactive oxygen species metabolic process GO:0072593 84 0.031
anion transport GO:0006820 177 0.031
Mouse
negative regulation of proteolysis GO:0045861 74 0.031
negative regulation of protein maturation GO:1903318 79 0.031
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.031
cardiac ventricle development GO:0003231 83 0.031
positive regulation of hydrolase activity GO:0051345 148 0.030
thymus development GO:0048538 41 0.030
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.030
striated muscle contraction GO:0006941 45 0.030
regulation of muscle tissue development GO:1901861 97 0.030
regulation of fat cell differentiation GO:0045598 81 0.030
appendage morphogenesis GO:0035107 149 0.030
regulation of cell migration GO:0030334 219 0.030
glomerulus vasculature development GO:0072012 14 0.030
neural precursor cell proliferation GO:0061351 121 0.029
wnt signaling pathway GO:0016055 188 0.029
negative regulation of neuron differentiation GO:0045665 101 0.029
Mouse
leukocyte proliferation GO:0070661 172 0.029
regulation of retina development in camera type eye GO:1902866 3 0.029
negative regulation of muscle cell differentiation GO:0051148 33 0.029
cellular response to oxygen levels GO:0071453 20 0.029
cardiac septum development GO:0003279 59 0.029
determination of left right symmetry GO:0007368 80 0.029
Mouse
cardiocyte differentiation GO:0035051 87 0.029
oligodendrocyte differentiation GO:0048709 53 0.029
cell activation involved in immune response GO:0002263 126 0.029
regulation of homeostatic process GO:0032844 182 0.029
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.029
regulation of epidermis development GO:0045682 33 0.028
embryonic hemopoiesis GO:0035162 23 0.028
female sex differentiation GO:0046660 84 0.028
epithalamus development GO:0021538 2 0.028
spinal cord development GO:0021510 81 0.028
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.028
regulation of neural retina development GO:0061074 3 0.028
peripheral nervous system development GO:0007422 53 0.028
cell substrate adhesion GO:0031589 130 0.028
macromolecule methylation GO:0043414 120 0.028
cardiac endothelial cell differentiation GO:0003348 4 0.027
protein catabolic process GO:0030163 221 0.027
blood circulation GO:0008015 195 0.027
endothelial cell differentiation GO:0045446 41 0.027
negative regulation of gliogenesis GO:0014014 23 0.027
regulation of vesicle mediated transport GO:0060627 139 0.027
positive regulation of cell cycle process GO:0090068 61 0.027
epithelium migration GO:0090132 63 0.027
regulation of endocytosis GO:0030100 69 0.027
positive regulation of cell fate commitment GO:0010455 8 0.027
neuron apoptotic process GO:0051402 142 0.026
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.026
neuron death GO:0070997 154 0.026
Mouse
fat cell differentiation GO:0045444 160 0.026
epithelial cell development GO:0002064 159 0.026
regulation of notch signaling pathway GO:0008593 35 0.026
Fly
nephron tubule development GO:0072080 84 0.026
cellular response to growth factor stimulus GO:0071363 197 0.026
odontogenesis GO:0042476 78 0.026
positive regulation of secretion GO:0051047 130 0.026
hindlimb morphogenesis GO:0035137 42 0.026
cellular metal ion homeostasis GO:0006875 151 0.026
negative regulation of cell cycle GO:0045786 123 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
muscle fiber development GO:0048747 76 0.025
mitral valve development GO:0003174 4 0.025

Psen2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.454
Human
disease of anatomical entity DOID:7 0 0.454
Human
cardiovascular system disease DOID:1287 0 0.454
Human
central nervous system disease DOID:331 0 0.234
Human
nervous system disease DOID:863 0 0.234
Human
disease of mental health DOID:150 0 0.232
Human
cognitive disorder DOID:1561 0 0.232
Human
myopathy DOID:423 0 0.189
Human
muscular disease DOID:0080000 0 0.189
Human
cardiomyopathy DOID:0050700 0 0.189
Human
musculoskeletal system disease DOID:17 0 0.189
Human
muscle tissue disease DOID:66 0 0.189
Human
skin disease DOID:37 0 0.154
integumentary system disease DOID:16 0 0.154
dementia DOID:1307 0 0.118
Human
neurodegenerative disease DOID:1289 0 0.107
Human
intrinsic cardiomyopathy DOID:0060036 0 0.097
Human
alzheimer s disease DOID:10652 0 0.075
Human
tauopathy DOID:680 0 0.075
Human
disease of metabolism DOID:0014667 0 0.039
inherited metabolic disorder DOID:655 0 0.027
brain disease DOID:936 0 0.027
gastrointestinal system disease DOID:77 0 0.026