Mus musculus

32 known processes

Kpna2

karyopherin (importin) alpha 2

(Aliases: Rch1,MGC91246,2410044B12Rik,IPOA1)

Kpna2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mrna metabolic process GO:0016071 84 0.673
mitotic cell cycle process GO:1903047 159 0.644
nuclear division GO:0000280 158 0.598
macromolecule catabolic process GO:0009057 281 0.384
posttranscriptional regulation of gene expression GO:0010608 155 0.321
chromatin modification GO:0016568 187 0.310
protein catabolic process GO:0030163 221 0.286
microtubule based process GO:0007017 236 0.274
posttranscriptional gene silencing by rna GO:0035194 10 0.267
mitotic cell cycle GO:0000278 195 0.265
gene silencing by rna GO:0031047 19 0.261
microtubule cytoskeleton organization GO:0000226 157 0.254
regulation of mitotic cell cycle GO:0007346 126 0.230
posttranscriptional gene silencing GO:0016441 10 0.225
nuclear transport GO:0051169 139 0.224
mitotic nuclear division GO:0007067 48 0.206
cellular macromolecule catabolic process GO:0044265 206 0.200
cytoplasmic transport GO:0016482 234 0.189
dna replication independent nucleosome assembly GO:0006336 1 0.183
mrna 3 end processing GO:0031124 16 0.183
nitrogen compound transport GO:0071705 271 0.179
regulation of ras protein signal transduction GO:0046578 114 0.174
mitotic cell cycle embryonic GO:0045448 5 0.171
gonad development GO:0008406 141 0.166
negative regulation of cellular protein metabolic process GO:0032269 247 0.163
cellular response to dna damage stimulus GO:0006974 207 0.161
organelle assembly GO:0070925 177 0.151
protein complex disassembly GO:0043241 40 0.150
regulation of cell cycle GO:0051726 281 0.148
meiotic cell cycle GO:0051321 122 0.146
cellular nitrogen compound catabolic process GO:0044270 280 0.143
male gamete generation GO:0048232 285 0.143
development of primary sexual characteristics GO:0045137 143 0.138
nucleic acid transport GO:0050657 18 0.137
regulation of cellular catabolic process GO:0031329 242 0.137
regulation of embryonic development GO:0045995 71 0.132
meiotic cell cycle process GO:1903046 77 0.128
spermatogenesis GO:0007283 284 0.127
response to oxidative stress GO:0006979 123 0.124
Mouse
intracellular protein transport GO:0006886 204 0.122
rna processing GO:0006396 105 0.122
modification dependent protein catabolic process GO:0019941 133 0.118
germ cell development GO:0007281 185 0.116
regulation of hydrolase activity GO:0051336 246 0.107
dna metabolic process GO:0006259 303 0.104
spermatid differentiation GO:0048515 115 0.103
small gtpase mediated signal transduction GO:0007264 97 0.103
rna 3 end processing GO:0031123 20 0.102
mitotic cytokinesis GO:0000281 4 0.102
organic cyclic compound catabolic process GO:1901361 295 0.099
rna interference GO:0016246 2 0.098
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.097
regulation of intracellular protein transport GO:0033157 82 0.095
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051439 1 0.094
glycerophospholipid biosynthetic process GO:0046474 32 0.093
spindle assembly involved in mitosis GO:0090307 4 0.092
negative regulation of protein maturation GO:1903318 79 0.090
organelle fission GO:0048285 170 0.088
nucleotide metabolic process GO:0009117 332 0.086
glycerolipid biosynthetic process GO:0045017 50 0.085
cellular amine metabolic process GO:0044106 44 0.085
spindle organization GO:0007051 28 0.084
positive regulation of hydrolase activity GO:0051345 148 0.083
lipid biosynthetic process GO:0008610 179 0.083
covalent chromatin modification GO:0016569 163 0.082
ribonucleoside catabolic process GO:0042454 206 0.082
regulation of protein maturation GO:1903317 96 0.081
modification dependent macromolecule catabolic process GO:0043632 133 0.080
aromatic compound catabolic process GO:0019439 286 0.078
histone acetylation GO:0016573 41 0.078
mrna processing GO:0006397 63 0.077
endocytosis GO:0006897 168 0.076
cellular lipid metabolic process GO:0044255 323 0.074
nucleoside phosphate metabolic process GO:0006753 338 0.074
spindle assembly involved in female meiosis i GO:0007057 2 0.074
carbohydrate metabolic process GO:0005975 230 0.073
spermatid development GO:0007286 108 0.070
gene silencing GO:0016458 38 0.070
fertilization GO:0009566 127 0.070
regulation of rna splicing GO:0043484 37 0.069
regulation of organelle organization GO:0033043 289 0.069
negative regulation of protein metabolic process GO:0051248 282 0.067
ubiquitin dependent protein catabolic process GO:0006511 129 0.067
protein localization to chromosome centromeric region GO:0071459 1 0.063
amine metabolic process GO:0009308 45 0.062
cell division GO:0051301 120 0.061
regulation of protein complex disassembly GO:0043244 28 0.061
cellular protein catabolic process GO:0044257 155 0.061
chromatin organization GO:0006325 206 0.061
regulation of proteolysis GO:0030162 164 0.060
ras protein signal transduction GO:0007265 77 0.059
regulation of protein import into nucleus GO:0042306 52 0.058
cellular protein complex disassembly GO:0043624 36 0.057
nucleobase containing compound transport GO:0015931 27 0.054
proteasomal protein catabolic process GO:0010498 98 0.054
regulation of kinase activity GO:0043549 249 0.053
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.052
rna splicing GO:0008380 54 0.051
protein ubiquitination GO:0016567 171 0.051
regulation of nucleocytoplasmic transport GO:0046822 73 0.051
dna templated transcription termination GO:0006353 4 0.049
positive regulation of gtp catabolic process GO:0033126 85 0.048
protein targeting GO:0006605 143 0.048
gene silencing by mirna GO:0035195 10 0.047
regulation of transferase activity GO:0051338 263 0.045
female meiosis i GO:0007144 7 0.045
spindle assembly involved in meiosis GO:0090306 4 0.044
regulation of exit from mitosis GO:0007096 1 0.044
axonogenesis GO:0007409 274 0.043
mrna catabolic process GO:0006402 22 0.043
positive regulation of cellular catabolic process GO:0031331 148 0.043
response to organic cyclic compound GO:0014070 198 0.042
ribose phosphate metabolic process GO:0019693 291 0.041
dna packaging GO:0006323 30 0.041
regulation of cellular response to stress GO:0080135 159 0.040
dna conformation change GO:0071103 37 0.040
regulation of protein kinase activity GO:0045859 232 0.040
positive regulation of protein kinase activity GO:0045860 144 0.040
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.039
response to inorganic substance GO:0010035 96 0.038
Mouse
cellularization GO:0007349 1 0.038
nucleoside catabolic process GO:0009164 206 0.038
rna splicing via transesterification reactions GO:0000375 43 0.037
organelle localization GO:0051640 179 0.037
negative regulation of phosphate metabolic process GO:0045936 184 0.037
protein modification by small protein conjugation or removal GO:0070647 207 0.036
cellular response to lipid GO:0071396 145 0.036
rna localization GO:0006403 23 0.036
internal protein amino acid acetylation GO:0006475 42 0.035
chromosome segregation GO:0007059 48 0.035
chemotaxis GO:0006935 247 0.035
regulation of leukocyte differentiation GO:1902105 159 0.035
nucleocytoplasmic transport GO:0006913 139 0.034
protein localization to nucleus GO:0034504 121 0.034
regulation of glucose metabolic process GO:0010906 60 0.034
regulation of cytoplasmic transport GO:1903649 112 0.034
organophosphate biosynthetic process GO:0090407 122 0.034
forebrain development GO:0030900 302 0.033
single fertilization GO:0007338 82 0.033
phospholipid biosynthetic process GO:0008654 36 0.033
female meiotic division GO:0007143 21 0.033
cellular response to metal ion GO:0071248 31 0.033
positive regulation of nfat protein import into nucleus GO:0051533 1 0.033
nucleoside phosphate catabolic process GO:1901292 222 0.032
cell fate commitment GO:0045165 210 0.032
positive regulation of intracellular protein transport GO:0090316 42 0.032
cell cycle checkpoint GO:0000075 47 0.032
protein import into nucleus GO:0006606 95 0.032
cell type specific apoptotic process GO:0097285 268 0.031
regulation of cell cycle process GO:0010564 160 0.030
regulation of protein catabolic process GO:0042176 108 0.030
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.030
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.030
homeostasis of number of cells GO:0048872 210 0.029
ameboidal type cell migration GO:0001667 128 0.029
negative regulation of leukocyte differentiation GO:1902106 51 0.029
respiratory system development GO:0060541 190 0.028
regulation of protein processing GO:0070613 96 0.028
positive regulation of cell division GO:0051781 31 0.028
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.028
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.028
cyclin catabolic process GO:0008054 1 0.028
mitotic chromosome condensation GO:0007076 1 0.028
ribonucleotide metabolic process GO:0009259 291 0.028
cell growth GO:0016049 130 0.027
regulation of purine nucleotide catabolic process GO:0033121 122 0.027
heterocycle catabolic process GO:0046700 280 0.027
peptidyl amino acid modification GO:0018193 336 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.027
centrosome separation GO:0051299 4 0.027
regulation of mapk cascade GO:0043408 248 0.026
protein localization to organelle GO:0033365 185 0.026
positive regulation of transferase activity GO:0051347 167 0.026
regulation of body fluid levels GO:0050878 162 0.026
positive regulation of cell development GO:0010720 237 0.026
negative regulation of molecular function GO:0044092 258 0.026
establishment of organelle localization GO:0051656 122 0.025
organophosphate catabolic process GO:0046434 232 0.025
myeloid cell differentiation GO:0030099 233 0.025
meiosis i GO:0007127 60 0.025
guanosine containing compound metabolic process GO:1901068 144 0.025
mapk cascade GO:0000165 281 0.025
organonitrogen compound biosynthetic process GO:1901566 192 0.025
positive regulation of intracellular transport GO:0032388 70 0.024
negative regulation of phosphorus metabolic process GO:0010563 184 0.024
cellular amino acid metabolic process GO:0006520 103 0.024
glycerophospholipid metabolic process GO:0006650 71 0.024
protein modification by small protein removal GO:0070646 21 0.024
organelle disassembly GO:1903008 2 0.023
protein modification by small protein conjugation GO:0032446 187 0.023
regulation of hormone levels GO:0010817 211 0.023
carbohydrate homeostasis GO:0033500 128 0.023
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
actin cytoskeleton organization GO:0030036 220 0.023
regulation of stress activated mapk cascade GO:0032872 69 0.023
glycosyl compound metabolic process GO:1901657 246 0.023
digestive system development GO:0055123 200 0.023
regulation of purine nucleotide metabolic process GO:1900542 169 0.023
regulation of intracellular transport GO:0032386 159 0.023
establishment of rna localization GO:0051236 18 0.022
regulation of nucleoside metabolic process GO:0009118 130 0.022
cellular response to inorganic substance GO:0071241 37 0.021
alcohol metabolic process GO:0006066 116 0.021
regulation of nucleotide metabolic process GO:0006140 169 0.021
body morphogenesis GO:0010171 45 0.021
small molecule biosynthetic process GO:0044283 132 0.021
insulin secretion GO:0030073 89 0.021
regulation of cellular protein catabolic process GO:1903362 61 0.021
negative regulation of phosphorylation GO:0042326 166 0.020
skin development GO:0043588 220 0.020
glycerolipid metabolic process GO:0046486 122 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.020
ribonucleoside triphosphate catabolic process GO:0009203 199 0.020
purine containing compound metabolic process GO:0072521 311 0.020
regulation of cell activation GO:0050865 289 0.020
polyamine biosynthetic process GO:0006596 2 0.019
dendrite development GO:0016358 115 0.019
macromolecular complex disassembly GO:0032984 43 0.019
positive regulation of protein modification process GO:0031401 299 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
regulation of cellular component size GO:0032535 121 0.019
ossification GO:0001503 216 0.019
single organism nuclear import GO:1902593 95 0.019
cell cycle g1 s phase transition GO:0044843 57 0.019
regulation of protein targeting GO:1903533 61 0.018
regulation of proteasomal protein catabolic process GO:0061136 46 0.018
positive regulation of cytoplasmic transport GO:1903651 40 0.018
cellular carbohydrate metabolic process GO:0044262 119 0.018
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.018
pore complex assembly GO:0046931 3 0.018
regulation of cell division GO:0051302 76 0.018
dephosphorylation GO:0016311 129 0.018
positive regulation of gtpase activity GO:0043547 85 0.018
cellular biogenic amine metabolic process GO:0006576 28 0.018
carbohydrate derivative catabolic process GO:1901136 231 0.018
positive regulation of nucleoside metabolic process GO:0045979 91 0.018
positive regulation of kinase activity GO:0033674 155 0.017
response to oxygen levels GO:0070482 62 0.017
oxidation reduction process GO:0055114 342 0.017
oogenesis GO:0048477 56 0.017
female gamete generation GO:0007292 74 0.017
purine nucleoside catabolic process GO:0006152 205 0.016
adult behavior GO:0030534 135 0.016
cellular response to calcium ion GO:0071277 14 0.016
positive regulation of cell cycle GO:0045787 92 0.016
regulation of translation GO:0006417 71 0.016
peptide hormone secretion GO:0030072 109 0.016
gland development GO:0048732 330 0.016
mrna splicing via spliceosome GO:0000398 43 0.016
epidermis development GO:0008544 187 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
regulation of lipid metabolic process GO:0019216 118 0.016
phospholipid metabolic process GO:0006644 87 0.015
regulation of chromosome organization GO:0033044 83 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
purine containing compound catabolic process GO:0072523 213 0.015
positive regulation of protein import into nucleus GO:0042307 26 0.015
histone modification GO:0016570 159 0.015
response to acid chemical GO:0001101 111 0.015
positive regulation of cell cycle process GO:0090068 61 0.015
purine nucleoside triphosphate metabolic process GO:0009144 226 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
generation of precursor metabolites and energy GO:0006091 103 0.015
cardiac muscle cell differentiation GO:0055007 69 0.015
regulation of protein transport GO:0051223 163 0.015
organ growth GO:0035265 117 0.015
positive regulation of mitotic cell cycle GO:0045931 41 0.015
protein maturation GO:0051604 176 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
peptide secretion GO:0002790 114 0.015
synaptic transmission GO:0007268 329 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
body fluid secretion GO:0007589 53 0.014
cytokinetic process GO:0032506 2 0.014
response to iron ion GO:0010039 4 0.014
regulation of cellular ketone metabolic process GO:0010565 66 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.014
cellular response to organic cyclic compound GO:0071407 87 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
nucleoside triphosphate catabolic process GO:0009143 205 0.014
cellular response to oxidative stress GO:0034599 76 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
lung development GO:0030324 164 0.014
regulation of protein stability GO:0031647 52 0.014
negative regulation of protein processing GO:0010955 79 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
amide transport GO:0042886 138 0.014
telencephalon development GO:0021537 186 0.014
regulation of nucleotide catabolic process GO:0030811 122 0.014
nucleus organization GO:0006997 45 0.013
response to radiation GO:0009314 165 0.013
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
base excision repair GO:0006284 9 0.013
spindle assembly involved in female meiosis GO:0007056 3 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
positive regulation of protein transport GO:0051222 93 0.013
neuron migration GO:0001764 122 0.013
developmental maturation GO:0021700 193 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
regulation of microtubule based process GO:0032886 52 0.013
hormone secretion GO:0046879 128 0.013
regulation of myeloid cell differentiation GO:0045637 96 0.013
protein processing GO:0016485 163 0.013
peptidyl lysine acetylation GO:0018394 45 0.013
positive regulation of growth GO:0045927 104 0.013
learning or memory GO:0007611 148 0.013
purine nucleotide metabolic process GO:0006163 302 0.013
nls bearing protein import into nucleus GO:0006607 2 0.012
Human
regulation of rho protein signal transduction GO:0035023 71 0.012
monosaccharide metabolic process GO:0005996 106 0.012
meiotic nuclear division GO:0007126 115 0.012
meiotic spindle organization GO:0000212 9 0.012
regulation of cell cycle phase transition GO:1901987 77 0.012
regulation of protein localization GO:0032880 231 0.012
membrane lipid metabolic process GO:0006643 53 0.012
regionalization GO:0003002 337 0.012
internal peptidyl lysine acetylation GO:0018393 42 0.012
cellular protein complex assembly GO:0043623 116 0.012
negative regulation of cellular protein catabolic process GO:1903363 22 0.012
negative regulation of proteolysis GO:0045861 74 0.012
response to decreased oxygen levels GO:0036293 59 0.012
positive regulation of protein localization to nucleus GO:1900182 30 0.012
regulation of histone modification GO:0031056 56 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
g1 s transition of mitotic cell cycle GO:0000082 57 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
cell fate specification GO:0001708 72 0.012
positive regulation of organelle organization GO:0010638 128 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
rna transport GO:0050658 18 0.011
positive regulation of cellular amine metabolic process GO:0033240 5 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
apoptotic signaling pathway GO:0097190 306 0.011
chromatin remodeling GO:0006338 32 0.011
oocyte differentiation GO:0009994 35 0.011
glucose homeostasis GO:0042593 128 0.011
urogenital system development GO:0001655 261 0.011
glucan metabolic process GO:0044042 32 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
cell maturation GO:0048469 127 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
anatomical structure homeostasis GO:0060249 145 0.011
microtubule depolymerization GO:0007019 15 0.011
sister chromatid segregation GO:0000819 20 0.011
wnt signaling pathway GO:0016055 188 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
striated muscle tissue development GO:0014706 293 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
response to light stimulus GO:0009416 135 0.010
regulation of neuron projection development GO:0010975 169 0.010
regulation of carbohydrate metabolic process GO:0006109 75 0.010
regulation of ubiquitin protein transferase activity GO:0051438 7 0.010
regulation of peptidase activity GO:0052547 96 0.010
leukocyte differentiation GO:0002521 342 0.010
glycosyl compound catabolic process GO:1901658 206 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.010
cellular polysaccharide metabolic process GO:0044264 38 0.010
regulation of cell projection organization GO:0031344 206 0.010

Kpna2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org