Mus musculus

202 known processes

Blm

Bloom syndrome, RecQ helicase-like

Blm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.877
dna metabolic process GO:0006259 303 0.809
nuclear division GO:0000280 158 0.776
Worm Fly
organelle fission GO:0048285 170 0.758
Worm Fly
microtubule cytoskeleton organization GO:0000226 157 0.756
dna recombination GO:0006310 92 0.741
male meiosis GO:0007140 37 0.678
mitotic cell cycle GO:0000278 195 0.663
Human Worm
meiotic nuclear division GO:0007126 115 0.626
Worm Fly
mitotic cell cycle process GO:1903047 159 0.618
Human Worm
regulation of mitotic cell cycle GO:0007346 126 0.528
Human
dna repair GO:0006281 107 0.521
regulation of cell division GO:0051302 76 0.447
Human
meiotic cell cycle process GO:1903046 77 0.438
Worm Fly
meiotic cell cycle GO:0051321 122 0.433
Worm Fly
microtubule based process GO:0007017 236 0.388
recombinational repair GO:0000725 21 0.384
Fly
negative regulation of cell cycle GO:0045786 123 0.379
Human
double strand break repair via homologous recombination GO:0000724 21 0.350
Fly
chromatin organization GO:0006325 206 0.347
meiosis i GO:0007127 60 0.306
Worm Fly
negative regulation of cellular component organization GO:0051129 194 0.285
female meiosis chromosome segregation GO:0016321 1 0.272
mitotic nuclear division GO:0007067 48 0.243
Worm
microtubule organizing center organization GO:0031023 28 0.236
negative regulation of cell cycle phase transition GO:1901988 48 0.227
Human
development of primary sexual characteristics GO:0045137 143 0.214
centrosome cycle GO:0007098 23 0.209
regulation of cell cycle GO:0051726 281 0.201
Human
meiotic chromosome segregation GO:0045132 19 0.199
Worm
negative regulation of organelle organization GO:0010639 90 0.188
mitotic sister chromatid segregation GO:0000070 14 0.181
regulation of organelle organization GO:0033043 289 0.171
double strand break repair GO:0006302 48 0.155
Human Fly
regulation of chromosome organization GO:0033044 83 0.155
regulation of mitosis GO:0007088 29 0.153
male gamete generation GO:0048232 285 0.153
dna endoreduplication GO:0042023 4 0.149
regulation of cell cycle process GO:0010564 160 0.148
Human
cellular amino acid metabolic process GO:0006520 103 0.146
organelle assembly GO:0070925 177 0.145
centrosome organization GO:0051297 26 0.143
synapsis GO:0007129 34 0.142
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.132
Human
spindle assembly involved in mitosis GO:0090307 4 0.119
spermatogenesis GO:0007283 284 0.111
blastocyst growth GO:0001832 23 0.110
male meiosis i GO:0007141 16 0.109
cellular macromolecule catabolic process GO:0044265 206 0.109
Human
regulation of mitotic cell cycle phase transition GO:1901990 73 0.108
Human
response to radiation GO:0009314 165 0.107
Human Worm
chromosome segregation GO:0007059 48 0.104
Worm
gonad development GO:0008406 141 0.100
establishment of organelle localization GO:0051656 122 0.100
negative regulation of nuclear division GO:0051784 19 0.098
histone modification GO:0016570 159 0.090
cell division GO:0051301 120 0.086
Human
chromatin modification GO:0016568 187 0.083
maintenance of location GO:0051235 89 0.083
regulation of protein localization GO:0032880 231 0.082
inner cell mass cell proliferation GO:0001833 15 0.081
regulation of nuclear division GO:0051783 56 0.078
mitotic chromosome condensation GO:0007076 1 0.078
cell cycle checkpoint GO:0000075 47 0.077
Human Worm
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.076
Human
centriole assembly GO:0098534 6 0.074
centrosome duplication GO:0051298 16 0.072
membrane organization GO:0061024 245 0.064
mitotic sister chromatid cohesion GO:0007064 1 0.064
positive regulation of cell cycle GO:0045787 92 0.062
histone threonine phosphorylation GO:0035405 1 0.061
purine nucleotide metabolic process GO:0006163 302 0.061
negative regulation of mitosis GO:0045839 10 0.060
regulation of cell cycle g2 m phase transition GO:1902749 10 0.059
nucleoside phosphate catabolic process GO:1901292 222 0.059
dna replication GO:0006260 52 0.059
Human
regulation of cellular amine metabolic process GO:0033238 20 0.054
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.053
negative regulation of protein metabolic process GO:0051248 282 0.051
heterochromatin organization GO:0070828 4 0.051
macromolecule methylation GO:0043414 120 0.051
reciprocal meiotic recombination GO:0007131 16 0.050
Worm Fly
negative regulation of mitotic cell cycle GO:0045930 58 0.050
Human
regulation of microtubule based process GO:0032886 52 0.049
regulation of cytoskeleton organization GO:0051493 122 0.049
spindle organization GO:0007051 28 0.049
negative regulation of cell cycle process GO:0010948 69 0.047
Human
apoptotic signaling pathway GO:0097190 306 0.047
attachment of spindle microtubules to kinetochore GO:0008608 4 0.047
regulation of mitotic sister chromatid segregation GO:0033047 12 0.046
chromosome organization involved in meiosis GO:0070192 39 0.046
negative regulation of chromosome organization GO:2001251 30 0.046
ribonucleotide metabolic process GO:0009259 291 0.045
histone lysine methylation GO:0034968 50 0.044
metaphase plate congression GO:0051310 2 0.044
organelle localization GO:0051640 179 0.043
translesion synthesis GO:0019985 1 0.042
chromosome separation GO:0051304 14 0.041
Worm
genitalia development GO:0048806 37 0.041
protein catabolic process GO:0030163 221 0.040
dna dependent dna replication GO:0006261 24 0.039
Human
double strand break repair via nonhomologous end joining GO:0006303 10 0.039
Fly
cellular ketone metabolic process GO:0042180 84 0.039
blastocyst development GO:0001824 80 0.038
regulation of cell cycle phase transition GO:1901987 77 0.038
Human
mitotic recombination GO:0006312 3 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.036
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.035
amine metabolic process GO:0009308 45 0.035
protein maturation GO:0051604 176 0.033
spindle assembly GO:0051225 13 0.033
cellular nitrogen compound catabolic process GO:0044270 280 0.033
nucleocytoplasmic transport GO:0006913 139 0.033
purine nucleoside catabolic process GO:0006152 205 0.032
multicellular organism growth GO:0035264 161 0.032
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.031
purine nucleoside triphosphate catabolic process GO:0009146 203 0.031
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.031
protein processing GO:0016485 163 0.030
cellular amine metabolic process GO:0044106 44 0.030
positive regulation of organelle organization GO:0010638 128 0.030
ribose phosphate metabolic process GO:0019693 291 0.030
regulation of centriole replication GO:0046599 1 0.029
nucleobase containing small molecule metabolic process GO:0055086 352 0.029
peptidyl amino acid modification GO:0018193 336 0.029
cellular protein catabolic process GO:0044257 155 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
regulation of dna recombination GO:0000018 34 0.028
regulation of cellular catabolic process GO:0031329 242 0.028
endomembrane system organization GO:0010256 147 0.027
sister chromatid segregation GO:0000819 20 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.026
mitotic sister chromatid separation GO:0051306 9 0.026
histone acetylation GO:0016573 41 0.026
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.026
dna packaging GO:0006323 30 0.026
protein methylation GO:0006479 81 0.026
germ cell development GO:0007281 185 0.026
nucleoside triphosphate catabolic process GO:0009143 205 0.025
nuclear transport GO:0051169 139 0.025
glycosyl compound metabolic process GO:1901657 246 0.025
internal protein amino acid acetylation GO:0006475 42 0.025
peptidyl lysine modification GO:0018205 77 0.025
regulation of protein catabolic process GO:0042176 108 0.025
methylation GO:0032259 134 0.025
regulation of cellular ketone metabolic process GO:0010565 66 0.025
cellular response to organonitrogen compound GO:0071417 145 0.025
Human
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.025
Human
regulation of chromosome segregation GO:0051983 21 0.024
female meiotic division GO:0007143 21 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
body morphogenesis GO:0010171 45 0.024
replication fork protection GO:0048478 1 0.024
intracellular protein transport GO:0006886 204 0.024
purine nucleoside triphosphate metabolic process GO:0009144 226 0.024
protein modification by small protein conjugation or removal GO:0070647 207 0.024
positive regulation of protein modification process GO:0031401 299 0.024
anatomical structure homeostasis GO:0060249 145 0.023
covalent chromatin modification GO:0016569 163 0.023
spindle checkpoint GO:0031577 12 0.023
negative regulation of cell division GO:0051782 24 0.022
Human
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.022
purine ribonucleotide catabolic process GO:0009154 208 0.022
negative regulation of protein catabolic process GO:0042177 36 0.022
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.022
regulation of double strand break repair via homologous recombination GO:0010569 2 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.022
positive regulation of mitotic cell cycle GO:0045931 41 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
ribonucleoside triphosphate metabolic process GO:0009199 220 0.021
dna replication independent nucleosome assembly GO:0006336 1 0.021
cytokinesis GO:0000910 17 0.021
regulation of protein maturation GO:1903317 96 0.021
protein modification by small protein conjugation GO:0032446 187 0.020
negative regulation of cellular catabolic process GO:0031330 47 0.020
intra s dna damage checkpoint GO:0031573 4 0.020
oocyte maturation GO:0001556 18 0.020
histone h3 k9 methylation GO:0051567 17 0.020
purine containing compound metabolic process GO:0072521 311 0.020
negative regulation of dna dependent dna replication GO:2000104 1 0.020
ribonucleoside catabolic process GO:0042454 206 0.020
intrinsic apoptotic signaling pathway GO:0097193 132 0.019
positive regulation of cellular catabolic process GO:0031331 148 0.019
fertilization GO:0009566 127 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
mitotic cytokinesis GO:0000281 4 0.019
proteasomal protein catabolic process GO:0010498 98 0.019
cilium assembly GO:0042384 81 0.019
sister chromatid cohesion GO:0007062 12 0.019
protein targeting GO:0006605 143 0.019
response to ionizing radiation GO:0010212 42 0.019
Human Worm
gland development GO:0048732 330 0.019
nucleoside metabolic process GO:0009116 246 0.019
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.018
purine nucleoside monophosphate metabolic process GO:0009126 81 0.018
protein import GO:0017038 101 0.018
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.018
regulation of kinase activity GO:0043549 249 0.018
Human
single organism nuclear import GO:1902593 95 0.018
response to light stimulus GO:0009416 135 0.018
positive regulation of kinase activity GO:0033674 155 0.018
negative regulation of proteolysis GO:0045861 74 0.018
regulation of proteasomal protein catabolic process GO:0061136 46 0.018
spindle assembly involved in female meiosis GO:0007056 3 0.018
regulation of meiotic cell cycle GO:0051445 34 0.017
meiotic cell cycle checkpoint GO:0033313 2 0.017
dna catabolic process endonucleolytic GO:0000737 15 0.017
actin filament based movement GO:0030048 23 0.017
muscle cell differentiation GO:0042692 261 0.017
dna catabolic process GO:0006308 19 0.017
Human
reciprocal dna recombination GO:0035825 16 0.017
Worm Fly
ribonucleoside metabolic process GO:0009119 245 0.017
cilium morphogenesis GO:0060271 102 0.017
nuclear dna replication GO:0033260 3 0.017
nuclear import GO:0051170 95 0.017
spermatid development GO:0007286 108 0.017
protein acylation GO:0043543 64 0.017
regulation of microtubule cytoskeleton organization GO:0070507 37 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
histone methylation GO:0016571 71 0.016
cellular protein complex assembly GO:0043623 116 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
maintenance of location in cell GO:0051651 24 0.016
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.016
regulation of nucleotide metabolic process GO:0006140 169 0.016
cytoplasmic transport GO:0016482 234 0.016
protein import into nucleus GO:0006606 95 0.016
positive regulation of cell death GO:0010942 224 0.016
heterocycle catabolic process GO:0046700 280 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
atp catabolic process GO:0006200 55 0.016
negative regulation of histone h3 k9 methylation GO:0051573 4 0.015
cellularization GO:0007349 1 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
regulation of protein processing GO:0070613 96 0.015
lymphocyte mediated immunity GO:0002449 139 0.015
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.015
somatic diversification of immune receptors GO:0002200 53 0.015
atp metabolic process GO:0046034 75 0.015
regulation of histone modification GO:0031056 56 0.015
immune effector process GO:0002252 321 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
regulation of cellular component biogenesis GO:0044087 181 0.015
cell fate commitment GO:0045165 210 0.015
protein alkylation GO:0008213 81 0.015
positive regulation of histone h3 k9 methylation GO:0051574 4 0.014
mitotic cell cycle checkpoint GO:0007093 31 0.014
Human
astral microtubule organization GO:0030953 3 0.014
single fertilization GO:0007338 82 0.014
regulation of chromatin modification GO:1903308 57 0.014
protein polyubiquitination GO:0000209 33 0.014
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.014
multi multicellular organism process GO:0044706 109 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
cell cycle switching GO:0060184 1 0.014
internal peptidyl lysine acetylation GO:0018393 42 0.014
cellular response to abiotic stimulus GO:0071214 56 0.014
Human
establishment of spindle localization GO:0051293 19 0.014
protein localization to organelle GO:0033365 185 0.014
positive regulation of hydrolase activity GO:0051345 148 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.013
adaptive immune response GO:0002250 155 0.013
positive regulation of chromatin modification GO:1903310 28 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.013
negative regulation of protein processing GO:0010955 79 0.013
folic acid containing compound metabolic process GO:0006760 3 0.013
cellular component assembly involved in morphogenesis GO:0010927 139 0.013
lateral inhibition GO:0046331 1 0.013
regulation of proteolysis GO:0030162 164 0.013
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.013
purine containing compound catabolic process GO:0072523 213 0.013
cell aging GO:0007569 35 0.013
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.013
cation transport GO:0006812 399 0.012
histone h3 acetylation GO:0043966 14 0.012
spindle localization GO:0051653 22 0.012
dna integrity checkpoint GO:0031570 28 0.012
Human Worm
production of molecular mediator of immune response GO:0002440 103 0.012
aromatic compound catabolic process GO:0019439 286 0.012
histone h3 k4 methylation GO:0051568 23 0.012
regulation of chromatin organization GO:1902275 57 0.012
positive regulation of transferase activity GO:0051347 167 0.012
cell adhesion GO:0007155 329 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
positive regulation of gtp catabolic process GO:0033126 85 0.012
nucleotide catabolic process GO:0009166 217 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
skeletal system development GO:0001501 356 0.012
regulation of cell activation GO:0050865 289 0.012
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.012
negative regulation of sister chromatid segregation GO:0033046 7 0.012
regulation of intracellular transport GO:0032386 159 0.011
leukocyte activation involved in immune response GO:0002366 126 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
neural precursor cell proliferation GO:0061351 121 0.011
stem cell development GO:0048864 219 0.011
negative regulation of dna replication GO:0008156 4 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
response to organic cyclic compound GO:0014070 198 0.011
Human
response to organonitrogen compound GO:0010243 246 0.011
Human
regulation of centrosome cycle GO:0046605 10 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
regulation of meiosis i GO:0060631 7 0.011
spermatid differentiation GO:0048515 115 0.011
dna biosynthetic process GO:0071897 22 0.011
Fly
centrosome separation GO:0051299 4 0.011
regulation of cellular component size GO:0032535 121 0.011
ras protein signal transduction GO:0007265 77 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
mitotic spindle assembly checkpoint GO:0007094 7 0.011
mitotic spindle checkpoint GO:0071174 9 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
regulation of protein complex assembly GO:0043254 83 0.011
organophosphate catabolic process GO:0046434 232 0.011
intracellular mrna localization GO:0008298 4 0.011
positive regulation of meiotic cell cycle GO:0051446 15 0.011
regulation of mitotic sister chromatid separation GO:0010965 12 0.011
protein autophosphorylation GO:0046777 61 0.010
cell type specific apoptotic process GO:0097285 268 0.010
protein secretion GO:0009306 111 0.010
wnt signaling pathway GO:0016055 188 0.010
regulation of neuron differentiation GO:0045664 281 0.010
regulation of nuclear cell cycle dna replication GO:0033262 2 0.010
negative regulation of histone methylation GO:0031061 10 0.010
positive regulation of nucleotide catabolic process GO:0030813 88 0.010
regulation of protein serine threonine kinase activity GO:0071900 157 0.010
Human
regulation of dna replication GO:0006275 17 0.010

Blm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.104
disease of cellular proliferation DOID:14566 0 0.104
immune system disease DOID:2914 0 0.071
disease of anatomical entity DOID:7 0 0.071
hematopoietic system disease DOID:74 0 0.071
breast cancer DOID:1612 0 0.039
thoracic cancer DOID:5093 0 0.039
organ system cancer DOID:0050686 0 0.039
congenital hypoplastic anemia DOID:1342 0 0.031
aplastic anemia DOID:12449 0 0.031
fanconi s anemia DOID:13636 0 0.031
bone marrow disease DOID:4961 0 0.031
anemia DOID:2355 0 0.031
physical disorder DOID:0080015 0 0.015
nervous system disease DOID:863 0 0.013
reproductive organ cancer DOID:193 0 0.013
male reproductive organ cancer DOID:3856 0 0.011
neuropathy DOID:870 0 0.010