Mus musculus

81 known processes

Pfn1

profilin 1

(Aliases: Pfn)

Pfn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skeletal myofibril assembly GO:0014866 4 0.996
regulation of actin filament polymerization GO:0030833 38 0.779
Human Mouse
skeletal muscle thin filament assembly GO:0030240 2 0.769
actin polymerization or depolymerization GO:0008154 54 0.751
Human Mouse
regulation of actin filament length GO:0030832 45 0.725
Human Mouse
actin filament polymerization GO:0030041 44 0.723
Human Mouse
actin cytoskeleton organization GO:0030036 220 0.648
Human Mouse
actin filament organization GO:0007015 113 0.614
Human Mouse
muscle fiber development GO:0048747 76 0.573
regulation of actin polymerization or depolymerization GO:0008064 45 0.537
Human Mouse
positive regulation of cell death GO:0010942 224 0.537
actin filament depolymerization GO:0030042 15 0.508
cytokinesis GO:0000910 17 0.424
dna repair GO:0006281 107 0.421
regulation of protein complex disassembly GO:0043244 28 0.419
regulation of nucleotide metabolic process GO:0006140 169 0.413
Human
regulation of protein depolymerization GO:1901879 26 0.409
cellular response to dna damage stimulus GO:0006974 207 0.379
negative regulation of cell cycle GO:0045786 123 0.312
regulation of actin cytoskeleton organization GO:0032956 84 0.306
Human Mouse
positive regulation of actin filament depolymerization GO:0030836 5 0.295
cardiac myofibril assembly GO:0055003 12 0.293
mitotic cell cycle GO:0000278 195 0.293
dendritic spine organization GO:0097061 26 0.286
negative regulation of protein complex disassembly GO:0043242 22 0.280
myosin filament organization GO:0031033 3 0.271
myosin filament assembly GO:0031034 2 0.261
apoptotic signaling pathway GO:0097190 306 0.254
regulation of actin filament depolymerization GO:0030834 13 0.248
cytoplasmic transport GO:0016482 234 0.246
heterocycle catabolic process GO:0046700 280 0.230
Human
tube formation GO:0035148 140 0.230
positive regulation of cytoskeleton organization GO:0051495 49 0.226
Human Mouse
regionalization GO:0003002 337 0.225
regulation of cellular component size GO:0032535 121 0.223
Human Mouse
heart contraction GO:0060047 93 0.213
positive regulation of protein complex disassembly GO:0043243 5 0.211
organelle assembly GO:0070925 177 0.210
regulation of cell projection organization GO:0031344 206 0.209
Human Mouse
cell adhesion GO:0007155 329 0.199
response to organonitrogen compound GO:0010243 246 0.195
cell division GO:0051301 120 0.186
skeletal muscle organ development GO:0060538 163 0.185
muscle cell differentiation GO:0042692 261 0.184
myofibril assembly GO:0030239 34 0.182
cellular protein complex disassembly GO:0043624 36 0.175
actomyosin structure organization GO:0031032 56 0.175
Human Mouse
skeletal muscle fiber development GO:0048741 58 0.173
regulation of protein localization GO:0032880 231 0.171
regulation of cytoskeleton organization GO:0051493 122 0.168
Human Mouse
regulation of ion transport GO:0043269 215 0.167
nucleobase containing small molecule metabolic process GO:0055086 352 0.162
Human
positive regulation of actin filament polymerization GO:0030838 26 0.162
Human Mouse
cytokinetic process GO:0032506 2 0.158
establishment or maintenance of cell polarity GO:0007163 86 0.154
regulation of organelle organization GO:0033043 289 0.153
Human Mouse
actin filament based movement GO:0030048 23 0.152
cation transport GO:0006812 399 0.148
striated muscle tissue development GO:0014706 293 0.147
stem cell development GO:0048864 219 0.146
striated muscle cell development GO:0055002 125 0.142
microtubule cytoskeleton organization GO:0000226 157 0.141
cellular chemical homeostasis GO:0055082 215 0.141
regulation of cellular catabolic process GO:0031329 242 0.140
Human
epithelial tube formation GO:0072175 130 0.138
heart morphogenesis GO:0003007 178 0.136
mitotic cytokinesis GO:0000281 4 0.135
chronological cell aging GO:0001300 1 0.132
aromatic compound catabolic process GO:0019439 286 0.130
Human
actin mediated cell contraction GO:0070252 15 0.123
regulation of homeostatic process GO:0032844 182 0.122
oocyte construction GO:0007308 2 0.119
regulation of dendritic spine morphogenesis GO:0061001 17 0.117
multicellular organism growth GO:0035264 161 0.116
maintenance of location GO:0051235 89 0.114
primary neural tube formation GO:0014020 95 0.113
muscle tissue morphogenesis GO:0060415 53 0.109
oocyte axis specification GO:0007309 2 0.109
cation homeostasis GO:0055080 212 0.108
regulation of cell cycle process GO:0010564 160 0.107
dna metabolic process GO:0006259 303 0.107
pole plasm assembly GO:0007315 2 0.106
nucleoside triphosphate metabolic process GO:0009141 230 0.105
Human
mesenchymal cell development GO:0014031 93 0.105
muscle cell development GO:0055001 133 0.104
protein localization to organelle GO:0033365 185 0.103
negative regulation of cytoskeleton organization GO:0051494 36 0.102
Human Mouse
organophosphate catabolic process GO:0046434 232 0.102
Human
muscle tissue development GO:0060537 308 0.100
multi multicellular organism process GO:0044706 109 0.099
myotube cell development GO:0014904 60 0.095
ribonucleoside metabolic process GO:0009119 245 0.093
Human
negative regulation of cell size GO:0045792 3 0.090
positive regulation of cell development GO:0010720 237 0.089
regulation of anatomical structure size GO:0090066 178 0.089
Human Mouse
purine ribonucleotide metabolic process GO:0009150 290 0.088
Human
negative regulation of actin filament polymerization GO:0030837 11 0.087
Human Mouse
peptidyl amino acid modification GO:0018193 336 0.086
Mouse
modification dependent macromolecule catabolic process GO:0043632 133 0.085
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.085
Human
cellular amino acid metabolic process GO:0006520 103 0.084
cell aging GO:0007569 35 0.083
mesenchyme development GO:0060485 152 0.083
negative regulation of purine nucleotide catabolic process GO:0033122 9 0.082
reproductive behavior GO:0019098 32 0.081
purine nucleotide metabolic process GO:0006163 302 0.081
Human
nucleotide metabolic process GO:0009117 332 0.081
Human
cellular response to oxidative stress GO:0034599 76 0.081
endocytosis GO:0006897 168 0.081
blood circulation GO:0008015 195 0.081
myotube differentiation GO:0014902 105 0.080
multicellular organismal reproductive behavior GO:0033057 23 0.080
regulation of nucleoside metabolic process GO:0009118 130 0.077
Human
positive regulation of apoptotic process GO:0043065 217 0.077
purine ribonucleotide catabolic process GO:0009154 208 0.077
Human
positive regulation of organelle organization GO:0010638 128 0.076
Human Mouse
glucose homeostasis GO:0042593 128 0.075
oocyte anterior posterior axis specification GO:0007314 2 0.075
muscle contraction GO:0006936 101 0.073
positive regulation of nervous system development GO:0051962 221 0.073
purine containing compound metabolic process GO:0072521 311 0.073
Human
cellular protein complex assembly GO:0043623 116 0.073
Human Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.072
Human
gonad development GO:0008406 141 0.072
barbed end actin filament capping GO:0051016 6 0.072
purine ribonucleoside catabolic process GO:0046130 205 0.070
Human
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.068
regulation of lamellipodium assembly GO:0010591 3 0.068
regulation of cellular component biogenesis GO:0044087 181 0.068
Human Mouse
organic cyclic compound catabolic process GO:1901361 295 0.067
Human
chromatin modification GO:0016568 187 0.067
mitotic cell cycle process GO:1903047 159 0.065
positive regulation of programmed cell death GO:0043068 218 0.063
negative regulation of cellular component organization GO:0051129 194 0.063
Human Mouse
nitrogen compound transport GO:0071705 271 0.063
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.063
regulation of cell migration GO:0030334 219 0.063
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.062
macromolecular complex disassembly GO:0032984 43 0.062
negative regulation of actin filament depolymerization GO:0030835 9 0.062
striated muscle myosin thick filament assembly GO:0071688 1 0.062
negative regulation of cell cycle process GO:0010948 69 0.061
vascular smooth muscle contraction GO:0014829 5 0.061
embryonic epithelial tube formation GO:0001838 130 0.060
cellular response to organonitrogen compound GO:0071417 145 0.060
epithelial cell migration GO:0010631 63 0.059
Human Mouse
glycoprotein metabolic process GO:0009100 116 0.059
negative regulation of organelle organization GO:0010639 90 0.059
Human Mouse
purine ribonucleoside metabolic process GO:0046128 241 0.059
Human
negative regulation of cell proliferation GO:0008285 296 0.059
negative regulation of protein depolymerization GO:1901880 21 0.058
purine nucleoside metabolic process GO:0042278 241 0.058
Human
mesenchymal cell differentiation GO:0048762 107 0.057
development of primary sexual characteristics GO:0045137 143 0.057
female gamete generation GO:0007292 74 0.057
regulation of establishment of protein localization GO:0070201 181 0.056
cell type specific apoptotic process GO:0097285 268 0.056
cytosolic calcium ion transport GO:0060401 48 0.056
protein polymerization GO:0051258 57 0.056
Human Mouse
response to oxidative stress GO:0006979 123 0.056
stem cell differentiation GO:0048863 268 0.055
negative regulation of nucleoside metabolic process GO:0045978 11 0.055
cell substrate adhesion GO:0031589 130 0.054
regulation of hydrolase activity GO:0051336 246 0.054
Human
smooth muscle contraction GO:0006939 44 0.053
regulation of actin nucleation GO:0051125 4 0.052
cellular lipid metabolic process GO:0044255 323 0.052
glycosyl compound catabolic process GO:1901658 206 0.051
Human
ameboidal type cell migration GO:0001667 128 0.051
Human Mouse
intracellular protein transport GO:0006886 204 0.050
regulation of protein complex assembly GO:0043254 83 0.050
Human Mouse
cellular response to monosaccharide stimulus GO:0071326 47 0.050
vacuole organization GO:0007033 38 0.050
axon guidance GO:0007411 141 0.050
regulation of peptidyl serine phosphorylation GO:0033135 39 0.049
Mouse
regulation of neuron differentiation GO:0045664 281 0.049
circadian rhythm GO:0007623 114 0.049
protein depolymerization GO:0051261 34 0.049
regulation of cell cycle GO:0051726 281 0.048
histone modification GO:0016570 159 0.048
regulation of cellular response to stress GO:0080135 159 0.048
regulation of membrane potential GO:0042391 192 0.047
compound eye development GO:0048749 1 0.047
poly a mrna export from nucleus GO:0016973 4 0.047
regulation of endocytosis GO:0030100 69 0.047
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.046
negative regulation of cellular protein metabolic process GO:0032269 247 0.046
epidermis development GO:0008544 187 0.045
nucleoside metabolic process GO:0009116 246 0.045
Human
calcium ion homeostasis GO:0055074 127 0.045
regulation of blood vessel size GO:0050880 56 0.045
cellular response to hormone stimulus GO:0032870 150 0.044
gtp catabolic process GO:0006184 143 0.044
multi organism behavior GO:0051705 62 0.044
membrane organization GO:0061024 245 0.044
skin development GO:0043588 220 0.044
neural tube formation GO:0001841 108 0.044
nucleocytoplasmic transport GO:0006913 139 0.044
carbohydrate derivative catabolic process GO:1901136 231 0.044
Human
necrotic cell death GO:0070265 30 0.043
neural precursor cell proliferation GO:0061351 121 0.043
single organism cell adhesion GO:0098602 156 0.043
regulation of mitotic cell cycle GO:0007346 126 0.043
g protein coupled receptor signaling pathway GO:0007186 243 0.043
negative regulation of phosphate metabolic process GO:0045936 184 0.043
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.043
ribose phosphate metabolic process GO:0019693 291 0.043
Human
ribonucleotide catabolic process GO:0009261 208 0.042
Human
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.042
chromatin organization GO:0006325 206 0.042
covalent chromatin modification GO:0016569 163 0.042
response to amino acid GO:0043200 37 0.041
molting cycle GO:0042303 90 0.041
negative regulation of phagocytosis GO:0050765 4 0.041
response to extracellular stimulus GO:0009991 127 0.041
morphogenesis of an epithelial fold GO:0060571 28 0.040
calcium ion transport GO:0006816 159 0.040
receptor mediated endocytosis GO:0006898 51 0.040
regulation of body fluid levels GO:0050878 162 0.040
metal ion homeostasis GO:0055065 189 0.040
neural tube development GO:0021915 160 0.040
cellular amine metabolic process GO:0044106 44 0.040
regulation of cell substrate adhesion GO:0010810 73 0.039
heart process GO:0003015 94 0.038
regulation of secretion by cell GO:1903530 249 0.038
Mouse
gliogenesis GO:0042063 141 0.038
regulation of transferase activity GO:0051338 263 0.037
cellular response to nutrient levels GO:0031669 64 0.037
positive regulation of cellular amine metabolic process GO:0033240 5 0.037
establishment of protein localization to organelle GO:0072594 118 0.037
regulation of intracellular transport GO:0032386 159 0.037
macromolecule catabolic process GO:0009057 281 0.037
cellular ketone metabolic process GO:0042180 84 0.037
single organism nuclear import GO:1902593 95 0.036
positive regulation of protein modification process GO:0031401 299 0.036
Mouse
meiotic nuclear division GO:0007126 115 0.036
ribonucleotide metabolic process GO:0009259 291 0.035
Human
purine nucleotide catabolic process GO:0006195 211 0.035
Human
peptidyl lysine modification GO:0018205 77 0.035
regulation of nucleotide catabolic process GO:0030811 122 0.035
Human
small gtpase mediated signal transduction GO:0007264 97 0.035
cellular homeostasis GO:0019725 240 0.035
regulation of glycogen catabolic process GO:0005981 2 0.035
wound healing GO:0042060 157 0.035
ubiquitin dependent protein catabolic process GO:0006511 129 0.034
protein localization to membrane GO:0072657 108 0.034
extrinsic apoptotic signaling pathway GO:0097191 126 0.034
protein complex disassembly GO:0043241 40 0.033
morphogenesis of embryonic epithelium GO:0016331 159 0.033
forebrain development GO:0030900 302 0.033
actin filament capping GO:0051693 6 0.033
t cell activation GO:0042110 289 0.032
organic acid transport GO:0015849 101 0.032
regulation of translation GO:0006417 71 0.032
glycosyl compound metabolic process GO:1901657 246 0.032
Human
negative regulation of molecular function GO:0044092 258 0.032
cellular macromolecule catabolic process GO:0044265 206 0.032
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.032
cell communication by chemical coupling GO:0010643 2 0.032
dna recombination GO:0006310 92 0.032
regulation of response to wounding GO:1903034 189 0.031
regulation of apoptotic signaling pathway GO:2001233 197 0.031
regulation of purine nucleotide catabolic process GO:0033121 122 0.031
Human
microtubule based process GO:0007017 236 0.031
guanosine containing compound metabolic process GO:1901068 144 0.031
myeloid cell differentiation GO:0030099 233 0.031
leukocyte proliferation GO:0070661 172 0.031
regulation of cell cycle phase transition GO:1901987 77 0.030
inflammatory response GO:0006954 244 0.030
regulation of kinase activity GO:0043549 249 0.030
plasma membrane organization GO:0007009 90 0.030
nucleotide catabolic process GO:0009166 217 0.030
Human
regulation of multi organism process GO:0043900 111 0.030
cardiac muscle tissue development GO:0048738 130 0.030
protein targeting GO:0006605 143 0.030
organic anion transport GO:0015711 137 0.030
translation GO:0006412 93 0.029
ras protein signal transduction GO:0007265 77 0.029
regulation of cell activation GO:0050865 289 0.029
morphogenesis of a polarized epithelium GO:0001738 37 0.029
cardiac muscle tissue morphogenesis GO:0055008 44 0.029
maternal determination of anterior posterior axis embryo GO:0008358 2 0.029
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.029
rac protein signal transduction GO:0016601 13 0.029
oligodendrocyte differentiation GO:0048709 53 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
posttranscriptional regulation of gene expression GO:0010608 155 0.028
ribonucleoside catabolic process GO:0042454 206 0.028
Human
asymmetric neuroblast division GO:0055059 1 0.028
carbohydrate homeostasis GO:0033500 128 0.028
protein secretion GO:0009306 111 0.028
angiogenesis GO:0001525 201 0.028
proteasomal protein catabolic process GO:0010498 98 0.028
apoptotic process involved in mammary gland involution GO:0060057 4 0.028
cellular response to carbohydrate stimulus GO:0071322 50 0.028
protein localization to plasma membrane GO:0072659 57 0.028
positive regulation of endocytosis GO:0045807 42 0.027
regulation of tube size GO:0035150 57 0.027
arp2 3 complex mediated actin nucleation GO:0034314 3 0.027
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.027
tissue migration GO:0090130 68 0.027
Human Mouse
muscle system process GO:0003012 141 0.027
defense response to other organism GO:0098542 197 0.027
circulatory system process GO:0003013 197 0.027
wnt signaling pathway GO:0016055 188 0.026
neuron death GO:0070997 154 0.026
divalent inorganic cation homeostasis GO:0072507 138 0.026
cellular metal ion homeostasis GO:0006875 151 0.026
regulation of protein heterodimerization activity GO:0043497 2 0.026
cellular response to acid chemical GO:0071229 68 0.026
sulfur compound metabolic process GO:0006790 100 0.026
lateral inhibition GO:0046331 1 0.026
organonitrogen compound catabolic process GO:1901565 264 0.025
Human
multicellular organismal aging GO:0010259 24 0.025
regulation of secretion GO:0051046 274 0.025
Mouse
cellularization GO:0007349 1 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
Human
carbon catabolite activation of transcription GO:0045991 4 0.025
monocarboxylic acid metabolic process GO:0032787 191 0.025
negative regulation of phosphorus metabolic process GO:0010563 184 0.025
positive regulation of mammary gland involution GO:1903521 4 0.025
regulation of dendritic spine development GO:0060998 22 0.025
glycoprotein biosynthetic process GO:0009101 89 0.024
cardiac muscle contraction GO:0060048 32 0.024
cellular glucose homeostasis GO:0001678 52 0.024
inorganic ion transmembrane transport GO:0098660 234 0.024
regulation of gtp catabolic process GO:0033124 113 0.024
neuron apoptotic process GO:0051402 142 0.024
regulation of protein serine threonine kinase activity GO:0071900 157 0.024
protein oligomerization GO:0051259 67 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
carbohydrate derivative biosynthetic process GO:1901137 183 0.024
striated muscle contraction GO:0006941 45 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
negative regulation of neuron death GO:1901215 98 0.024
cellular component assembly involved in morphogenesis GO:0010927 139 0.023
protein glycosylation GO:0006486 55 0.023
vascular process in circulatory system GO:0003018 62 0.023
response to light stimulus GO:0009416 135 0.023
rna localization GO:0006403 23 0.023
peptidyl serine modification GO:0018209 83 0.023
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.023
sequestering of metal ion GO:0051238 19 0.023
epithelial tube morphogenesis GO:0060562 303 0.023
regulation of cell adhesion GO:0030155 154 0.022
negative regulation of purine nucleotide metabolic process GO:1900543 16 0.022
dorsal ventral axon guidance GO:0033563 3 0.022
rhythmic process GO:0048511 174 0.022
cellular response to lipid GO:0071396 145 0.022
satellite cell activation involved in skeletal muscle regeneration GO:0014901 3 0.022
amide transport GO:0042886 138 0.022
organic hydroxy compound metabolic process GO:1901615 203 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
Human
negative regulation of cell migration GO:0030336 59 0.022
Mouse
positive regulation of peptidase activity GO:0010952 49 0.022
cardiac muscle cell differentiation GO:0055007 69 0.022
regulation of heart contraction GO:0008016 77 0.022
nuclear import GO:0051170 95 0.022
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.021
divalent inorganic cation transport GO:0072511 178 0.021
positive regulation of protein depolymerization GO:1901881 5 0.021
response to metal ion GO:0010038 47 0.021
lamellipodium organization GO:0097581 29 0.021
cellular response to cytokine stimulus GO:0071345 189 0.021
zymogen activation GO:0031638 41 0.021
innate immune response GO:0045087 157 0.021
protein catabolic process GO:0030163 221 0.021
response to nutrient levels GO:0031667 109 0.021
canonical wnt signaling pathway GO:0060070 130 0.021
activation of adenylate cyclase activity GO:0007190 4 0.020
regulation of mrna metabolic process GO:1903311 43 0.020
positive regulation of apoptotic signaling pathway GO:2001235 95 0.020
positive regulation of secretion GO:0051047 130 0.020
regulation of proteolysis GO:0030162 164 0.020
neural tube closure GO:0001843 90 0.020
response to drug GO:0042493 75 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.020
Human
regulation of t cell activation GO:0050863 170 0.020
peptide hormone secretion GO:0030072 109 0.020
mating GO:0007618 27 0.020
negative regulation of kinase activity GO:0033673 81 0.019
gland development GO:0048732 330 0.019
regulation of protein transport GO:0051223 163 0.019
negative regulation of atpase activity GO:0032780 2 0.019
regulation of map kinase activity GO:0043405 120 0.019
oocyte development GO:0048599 33 0.019
negative regulation of cell motility GO:2000146 61 0.019
Mouse
neuromuscular process GO:0050905 99 0.019
negative regulation of cell development GO:0010721 169 0.019
regulation of cell projection assembly GO:0060491 38 0.019
Human Mouse
gtp metabolic process GO:0046039 144 0.019
regulation of synaptic plasticity GO:0048167 87 0.019
substrate dependent cell migration cell extension GO:0006930 4 0.019
regulation of cell motility GO:2000145 236 0.018
Human Mouse
cleavage furrow formation GO:0036089 2 0.018
organelle fission GO:0048285 170 0.018
cell junction assembly GO:0034329 52 0.018
cellular ion homeostasis GO:0006873 165 0.018
vasoconstriction GO:0042310 27 0.018
spermatogenesis GO:0007283 284 0.018
regulation of peptidase activity GO:0052547 96 0.018
camp metabolic process GO:0046058 40 0.018
uropod organization GO:0032796 2 0.018
negative regulation of neuron apoptotic process GO:0043524 92 0.018
morphogenesis of a branching structure GO:0001763 203 0.018
positive regulation of kinase activity GO:0033674 155 0.018
maternal placenta development GO:0001893 20 0.018
positive regulation of protein phosphorylation GO:0001934 242 0.018
Mouse
positive regulation of leukocyte proliferation GO:0070665 73 0.018
protein localization to nucleus GO:0034504 121 0.017
positive regulation of cell motility GO:2000147 116 0.017
Human
myeloid leukocyte differentiation GO:0002573 119 0.017
pigment metabolic process GO:0042440 32 0.017
positive regulation of growth GO:0045927 104 0.017
peptidyl tyrosine modification GO:0018212 145 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
Human
purine nucleoside catabolic process GO:0006152 205 0.017
Human
mitochondrion organization GO:0007005 134 0.017
signal transduction in absence of ligand GO:0038034 55 0.017
endomembrane system organization GO:0010256 147 0.017
negative regulation of nucleotide metabolic process GO:0045980 16 0.017
regulation of cytokine production GO:0001817 266 0.017
negative regulation of phosphorylation GO:0042326 166 0.017
b cell activation GO:0042113 161 0.017
oxidation reduction process GO:0055114 342 0.017
negative regulation of translation GO:0017148 22 0.017
regulation of neuron apoptotic process GO:0043523 122 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
Human
regulation of muscle tissue development GO:1901861 97 0.017
regulation of ion homeostasis GO:2000021 64 0.017
amine metabolic process GO:0009308 45 0.017
cellular protein catabolic process GO:0044257 155 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
camera type eye development GO:0043010 266 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.016
Human
regulation of hormone levels GO:0010817 211 0.016
protein maturation GO:0051604 176 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.016
cardiocyte differentiation GO:0035051 87 0.016
response to ischemia GO:0002931 14 0.016
immune effector process GO:0002252 321 0.016
macromolecule glycosylation GO:0043413 55 0.016
activation of cysteine type endopeptidase activity GO:0097202 27 0.016
glycosylation GO:0070085 62 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
regulation of hematopoietic stem cell differentiation GO:1902036 1 0.016
divalent metal ion transport GO:0070838 172 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
mating behavior GO:0007617 20 0.016
mrna processing GO:0006397 63 0.016
response to peptide hormone GO:0043434 127 0.016
internal peptidyl lysine acetylation GO:0018393 42 0.016
regulation of neuron death GO:1901214 134 0.015
cellular response to gamma radiation GO:0071480 4 0.015
cytosolic calcium ion homeostasis GO:0051480 70 0.015
lipid storage GO:0019915 36 0.015
regulation of myeloid cell differentiation GO:0045637 96 0.015
positive regulation of mapk cascade GO:0043410 170 0.015
carbohydrate metabolic process GO:0005975 230 0.015
positive regulation of ion transport GO:0043270 65 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
neuron projection guidance GO:0097485 141 0.015
genitalia development GO:0048806 37 0.015
cellular calcium ion homeostasis GO:0006874 119 0.015
negative regulation of osteoblast proliferation GO:0033689 4 0.015
neurotransmitter transport GO:0006836 76 0.015
Mouse
protein import into nucleus GO:0006606 95 0.015
type b pancreatic cell proliferation GO:0044342 10 0.015
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 4 0.015
cellular response to extracellular stimulus GO:0031668 81 0.015
dendritic spine development GO:0060996 30 0.015
sensory organ morphogenesis GO:0090596 242 0.014
oocyte differentiation GO:0009994 35 0.014
regulation of synapse assembly GO:0051963 29 0.014
blood vessel morphogenesis GO:0048514 285 0.014
transmembrane transport GO:0055085 412 0.014
branching morphogenesis of an epithelial tube GO:0048754 159 0.014
establishment of organelle localization GO:0051656 122 0.014
Mouse
carboxylic acid transport GO:0046942 100 0.014
response to superoxide GO:0000303 16 0.014
lipid localization GO:0010876 126 0.014
negative regulation of cellular catabolic process GO:0031330 47 0.014
regulation of blood pressure GO:0008217 93 0.014
lymphocyte differentiation GO:0030098 242 0.014
release of sequestered calcium ion into cytosol GO:0051209 42 0.014
cardiac muscle cell development GO:0055013 39 0.014
establishment of tissue polarity GO:0007164 28 0.014
positive regulation of protein transport GO:0051222 93 0.014

Pfn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.038
disease of anatomical entity DOID:7 0 0.038
Human
nervous system disease DOID:863 0 0.038
Human
large intestine cancer DOID:5672 0 0.030
colon cancer DOID:219 0 0.030
gastrointestinal system cancer DOID:3119 0 0.030
intestinal cancer DOID:10155 0 0.030
cancer DOID:162 0 0.030
disease of cellular proliferation DOID:14566 0 0.030
organ system cancer DOID:0050686 0 0.030
colorectal cancer DOID:9256 0 0.030