Mus musculus

0 known processes

D2hgdh

D-2-hydroxyglutarate dehydrogenase

(Aliases: AI325464,AA408776,AA408778)

D2hgdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.074
Rat
cellular amino acid metabolic process GO:0006520 103 0.073
cellular ketone metabolic process GO:0042180 84 0.046
regulation of cellular ketone metabolic process GO:0010565 66 0.043
cellular amine metabolic process GO:0044106 44 0.040
cellular lipid metabolic process GO:0044255 323 0.039
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
carboxylic acid biosynthetic process GO:0046394 86 0.037
amine metabolic process GO:0009308 45 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
cellular nitrogen compound catabolic process GO:0044270 280 0.035
cytokine production GO:0001816 319 0.033
nucleoside phosphate metabolic process GO:0006753 338 0.033
organic cyclic compound catabolic process GO:1901361 295 0.033
aromatic compound catabolic process GO:0019439 286 0.033
cation transport GO:0006812 399 0.032
nucleobase containing small molecule metabolic process GO:0055086 352 0.032
dna metabolic process GO:0006259 303 0.032
cellular response to lipid GO:0071396 145 0.032
response to organonitrogen compound GO:0010243 246 0.032
organic acid biosynthetic process GO:0016053 86 0.031
nitrogen compound transport GO:0071705 271 0.030
heterocycle catabolic process GO:0046700 280 0.030
regulation of cytokine production GO:0001817 266 0.029
transmembrane transport GO:0055085 412 0.028
regulation of cellular amine metabolic process GO:0033238 20 0.028
cellular response to organonitrogen compound GO:0071417 145 0.026
lipid biosynthetic process GO:0008610 179 0.025
nucleotide metabolic process GO:0009117 332 0.025
alpha amino acid metabolic process GO:1901605 59 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
cofactor metabolic process GO:0051186 80 0.024
ribonucleoside metabolic process GO:0009119 245 0.023
purine ribonucleoside metabolic process GO:0046128 241 0.023
nucleoside triphosphate metabolic process GO:0009141 230 0.023
cellular response to dna damage stimulus GO:0006974 207 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
small molecule biosynthetic process GO:0044283 132 0.022
fatty acid metabolic process GO:0006631 121 0.021
coenzyme metabolic process GO:0006732 52 0.021
ribonucleotide metabolic process GO:0009259 291 0.021
immune effector process GO:0002252 321 0.020
regulation of cell activation GO:0050865 289 0.020
regulation of transferase activity GO:0051338 263 0.020
multicellular organismal homeostasis GO:0048871 164 0.020
regulation of lymphocyte activation GO:0051249 240 0.020
regulation of defense response GO:0031347 233 0.020
homeostasis of number of cells GO:0048872 210 0.020
protein localization to organelle GO:0033365 185 0.020
purine nucleotide metabolic process GO:0006163 302 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
macromolecule catabolic process GO:0009057 281 0.020
organic anion transport GO:0015711 137 0.020
peptidyl amino acid modification GO:0018193 336 0.019
organic acid transport GO:0015849 101 0.019
response to molecule of bacterial origin GO:0002237 143 0.019
ion transmembrane transport GO:0034220 361 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
carboxylic acid catabolic process GO:0046395 51 0.018
ribose phosphate metabolic process GO:0019693 291 0.018
cation transmembrane transport GO:0098655 266 0.018
regulation of protein transport GO:0051223 163 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.018
spermatogenesis GO:0007283 284 0.018
positive regulation of protein modification process GO:0031401 299 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
response to lipopolysaccharide GO:0032496 128 0.018
sulfur compound metabolic process GO:0006790 100 0.018
purine containing compound metabolic process GO:0072521 311 0.018
dna repair GO:0006281 107 0.018
cellular response to cytokine stimulus GO:0071345 189 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
leukocyte differentiation GO:0002521 342 0.017
t cell activation GO:0042110 289 0.017
protein modification by small protein conjugation or removal GO:0070647 207 0.017
innate immune response GO:0045087 157 0.017
negative regulation of immune system process GO:0002683 209 0.017
cell type specific apoptotic process GO:0097285 268 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
nucleoside metabolic process GO:0009116 246 0.017
response to peptide hormone GO:0043434 127 0.016
purine nucleoside catabolic process GO:0006152 205 0.016
anatomical structure homeostasis GO:0060249 145 0.016
glycosyl compound catabolic process GO:1901658 206 0.016
regulation of hormone levels GO:0010817 211 0.016
response to peptide GO:1901652 136 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
regulation of cellular catabolic process GO:0031329 242 0.016
sensory perception GO:0007600 245 0.016
protein maturation GO:0051604 176 0.016
regulation of organelle organization GO:0033043 289 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
regulation of homeostatic process GO:0032844 182 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
response to insulin GO:0032868 100 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
regulation of secretion GO:0051046 274 0.016
organophosphate catabolic process GO:0046434 232 0.016
intracellular protein transport GO:0006886 204 0.015
response to organic cyclic compound GO:0014070 198 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.015
carbohydrate homeostasis GO:0033500 128 0.015
cellular response to biotic stimulus GO:0071216 92 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
response to acid chemical GO:0001101 111 0.015
tissue homeostasis GO:0001894 115 0.015
carbohydrate derivative catabolic process GO:1901136 231 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
inflammatory response GO:0006954 244 0.015
protein modification by small protein conjugation GO:0032446 187 0.015
apoptotic signaling pathway GO:0097190 306 0.015
protein ubiquitination GO:0016567 171 0.015
cellular macromolecule catabolic process GO:0044265 206 0.015
nucleoside catabolic process GO:0009164 206 0.015
response to radiation GO:0009314 165 0.015
anion transport GO:0006820 177 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.015
negative regulation of cell proliferation GO:0008285 296 0.014
cellular response to molecule of bacterial origin GO:0071219 83 0.014
regulation of membrane potential GO:0042391 192 0.014
alpha amino acid biosynthetic process GO:1901607 15 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
organic acid catabolic process GO:0016054 51 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.014
regulation of kinase activity GO:0043549 249 0.014
ras protein signal transduction GO:0007265 77 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
glycoprotein metabolic process GO:0009100 116 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
protein targeting GO:0006605 143 0.014
cytoplasmic transport GO:0016482 234 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
carboxylic acid transport GO:0046942 100 0.014
male gamete generation GO:0048232 285 0.014
carbohydrate metabolic process GO:0005975 230 0.014
positive regulation of cytokine production GO:0001819 174 0.014
nuclear transport GO:0051169 139 0.013
regulation of cell cycle GO:0051726 281 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
ribonucleoside triphosphate metabolic process GO:0009199 220 0.013
gland development GO:0048732 330 0.013
mitochondrion organization GO:0007005 134 0.013
positive regulation of cell death GO:0010942 224 0.013
monocarboxylic acid biosynthetic process GO:0072330 61 0.013
limb development GO:0060173 166 0.013
regulation of protein localization GO:0032880 231 0.013
lymphocyte proliferation GO:0046651 164 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
fat cell differentiation GO:0045444 160 0.013
cation homeostasis GO:0055080 212 0.013
regulation of protein kinase activity GO:0045859 232 0.013
thermosensory behavior GO:0040040 1 0.013
regulation of t cell activation GO:0050863 170 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
microtubule based process GO:0007017 236 0.013
translation GO:0006412 93 0.013
regulation of response to wounding GO:1903034 189 0.013
protein localization to nucleus GO:0034504 121 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
nucleotide catabolic process GO:0009166 217 0.013
appendage development GO:0048736 166 0.013
cellular homeostasis GO:0019725 240 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
small gtpase mediated signal transduction GO:0007264 97 0.013
protein processing GO:0016485 163 0.013
regulation of intracellular transport GO:0032386 159 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of ion transport GO:0043269 215 0.012
fertilization GO:0009566 127 0.012
mitotic cell cycle GO:0000278 195 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
regulation of mapk cascade GO:0043408 248 0.012
compound eye development GO:0048749 1 0.012
cellular response to acid chemical GO:0071229 68 0.012
multicellular organism growth GO:0035264 161 0.012
dephosphorylation GO:0016311 129 0.012
establishment of protein localization to organelle GO:0072594 118 0.012
purine nucleotide catabolic process GO:0006195 211 0.012
purine containing compound catabolic process GO:0072523 213 0.012
regulation of secretion by cell GO:1903530 249 0.012
inorganic cation transmembrane transport GO:0098662 207 0.012
interleukin 8 production GO:0032637 4 0.012
regulation of cellular response to stress GO:0080135 159 0.012
ribonucleoside bisphosphate metabolic process GO:0033875 9 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
anion transmembrane transport GO:0098656 71 0.012
metal ion homeostasis GO:0055065 189 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
amide transport GO:0042886 138 0.012
divalent inorganic cation transport GO:0072511 178 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
wnt signaling pathway GO:0016055 188 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
rhythmic process GO:0048511 174 0.011
synaptic transmission GO:0007268 329 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
cellular chemical homeostasis GO:0055082 215 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
regulation of hydrolase activity GO:0051336 246 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
dicarboxylic acid metabolic process GO:0043648 18 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
protein import GO:0017038 101 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
dna catabolic process endonucleolytic GO:0000737 15 0.011
positive regulation of defense response GO:0031349 124 0.011
lateral inhibition GO:0046331 1 0.011
negative regulation of cellular component organization GO:0051129 194 0.011
membrane organization GO:0061024 245 0.011
maintenance of location GO:0051235 89 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
male anatomical structure morphogenesis GO:0090598 4 0.011
adult behavior GO:0030534 135 0.011
small molecule catabolic process GO:0044282 71 0.011
negative regulation of cell cycle GO:0045786 123 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
defense response to other organism GO:0098542 197 0.011
muscle tissue development GO:0060537 308 0.011
neuron death GO:0070997 154 0.011
lymphocyte differentiation GO:0030098 242 0.011
nuclear division GO:0000280 158 0.011
respiratory tube development GO:0030323 167 0.011
mapk cascade GO:0000165 281 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
germ cell development GO:0007281 185 0.011
rho protein signal transduction GO:0007266 32 0.011
cellular amino acid biosynthetic process GO:0008652 22 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
cellular response to peptide GO:1901653 92 0.011
skin development GO:0043588 220 0.011
tube formation GO:0035148 140 0.011
regulation of feeding behavior GO:0060259 3 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
glucose homeostasis GO:0042593 128 0.011
skeletal muscle organ development GO:0060538 163 0.011
protein catabolic process GO:0030163 221 0.010
striated muscle tissue development GO:0014706 293 0.010
methylation GO:0032259 134 0.010
positive regulation of cell activation GO:0050867 158 0.010
connective tissue development GO:0061448 179 0.010
response to light stimulus GO:0009416 135 0.010
regulation of inflammatory response GO:0050727 147 0.010
peptide transport GO:0015833 133 0.010
cellular amide metabolic process GO:0043603 58 0.010
cellular amino acid catabolic process GO:0009063 25 0.010
amino acid transport GO:0006865 61 0.010
steroid metabolic process GO:0008202 119 0.010
positive regulation of cell development GO:0010720 237 0.010
leukocyte proliferation GO:0070661 172 0.010
positive regulation of secretion by cell GO:1903532 114 0.010
alpha amino acid catabolic process GO:1901606 18 0.010
purine nucleoside triphosphate catabolic process GO:0009146 203 0.010
cellular modified amino acid metabolic process GO:0006575 63 0.010
negative regulation of phosphorylation GO:0042326 166 0.010
glycosylation GO:0070085 62 0.010
myeloid cell differentiation GO:0030099 233 0.010
locomotory behavior GO:0007626 195 0.010
positive regulation of interleukin 8 production GO:0032757 2 0.010
inorganic ion transmembrane transport GO:0098660 234 0.010

D2hgdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.030
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
disease of cellular proliferation DOID:14566 0 0.017
central nervous system disease DOID:331 0 0.016
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
inherited metabolic disorder DOID:655 0 0.015
sensory system disease DOID:0050155 0 0.015