Mus musculus

0 known processes

Spg11

spastic paraplegia 11

(Aliases: A330015I11,6030465E24Rik,C530005A01Rik)

Spg11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside phosphate metabolic process GO:0006753 338 0.060
nucleobase containing small molecule metabolic process GO:0055086 352 0.055
ribonucleoside metabolic process GO:0009119 245 0.053
cellular nitrogen compound catabolic process GO:0044270 280 0.049
covalent chromatin modification GO:0016569 163 0.049
nucleotide metabolic process GO:0009117 332 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
purine nucleotide catabolic process GO:0006195 211 0.045
purine containing compound metabolic process GO:0072521 311 0.044
heterocycle catabolic process GO:0046700 280 0.044
cellular ketone metabolic process GO:0042180 84 0.043
cellular amine metabolic process GO:0044106 44 0.043
aromatic compound catabolic process GO:0019439 286 0.043
organic cyclic compound catabolic process GO:1901361 295 0.043
ribonucleoside triphosphate catabolic process GO:0009203 199 0.042
carbohydrate derivative catabolic process GO:1901136 231 0.042
macromolecule catabolic process GO:0009057 281 0.041
ribonucleotide metabolic process GO:0009259 291 0.041
nucleotide catabolic process GO:0009166 217 0.040
regulation of cellular amino acid metabolic process GO:0006521 5 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.038
negative regulation of cell proliferation GO:0008285 296 0.038
nucleoside phosphate catabolic process GO:1901292 222 0.037
ribonucleoside triphosphate metabolic process GO:0009199 220 0.037
purine ribonucleotide metabolic process GO:0009150 290 0.036
organophosphate catabolic process GO:0046434 232 0.036
organonitrogen compound catabolic process GO:1901565 264 0.035
glycosyl compound catabolic process GO:1901658 206 0.035
ribonucleotide catabolic process GO:0009261 208 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.034
nucleoside metabolic process GO:0009116 246 0.034
purine ribonucleoside catabolic process GO:0046130 205 0.034
regulation of membrane potential GO:0042391 192 0.034
regulation of cellular amine metabolic process GO:0033238 20 0.034
amine metabolic process GO:0009308 45 0.033
nucleoside triphosphate metabolic process GO:0009141 230 0.033
chromatin organization GO:0006325 206 0.033
purine containing compound catabolic process GO:0072523 213 0.032
purine nucleoside catabolic process GO:0006152 205 0.032
purine nucleoside triphosphate catabolic process GO:0009146 203 0.032
purine nucleotide metabolic process GO:0006163 302 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.031
chromatin modification GO:0016568 187 0.031
transmembrane transport GO:0055085 412 0.031
purine ribonucleoside metabolic process GO:0046128 241 0.030
regulation of cellular ketone metabolic process GO:0010565 66 0.030
intracellular protein transport GO:0006886 204 0.030
compound eye development GO:0048749 1 0.030
positive regulation of apoptotic process GO:0043065 217 0.030
regulation of hydrolase activity GO:0051336 246 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.029
ribonucleoside catabolic process GO:0042454 206 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
nucleoside triphosphate catabolic process GO:0009143 205 0.028
cellular amino acid metabolic process GO:0006520 103 0.028
ribose phosphate metabolic process GO:0019693 291 0.027
regulation of neuron differentiation GO:0045664 281 0.027
cellular macromolecule catabolic process GO:0044265 206 0.026
membrane organization GO:0061024 245 0.026
positive regulation of hydrolase activity GO:0051345 148 0.025
glycosyl compound metabolic process GO:1901657 246 0.025
cation transport GO:0006812 399 0.025
positive regulation of cell death GO:0010942 224 0.025
positive regulation of protein modification process GO:0031401 299 0.025
ras protein signal transduction GO:0007265 77 0.025
cell adhesion GO:0007155 329 0.024
purine nucleoside metabolic process GO:0042278 241 0.024
purine ribonucleotide catabolic process GO:0009154 208 0.023
multicellular organismal signaling GO:0035637 91 0.023
epithelial tube formation GO:0072175 130 0.023
positive regulation of programmed cell death GO:0043068 218 0.023
nucleoside catabolic process GO:0009164 206 0.023
protein maturation GO:0051604 176 0.023
leukocyte differentiation GO:0002521 342 0.023
regulation of cellular catabolic process GO:0031329 242 0.022
ion transmembrane transport GO:0034220 361 0.022
embryonic organ morphogenesis GO:0048562 276 0.022
cation transmembrane transport GO:0098655 266 0.021
epithelial tube morphogenesis GO:0060562 303 0.021
small gtpase mediated signal transduction GO:0007264 97 0.021
dna metabolic process GO:0006259 303 0.021
male gamete generation GO:0048232 285 0.021
positive regulation of protein phosphorylation GO:0001934 242 0.021
protein ubiquitination GO:0016567 171 0.021
regulation of organelle organization GO:0033043 289 0.021
protein processing GO:0016485 163 0.021
methylation GO:0032259 134 0.021
apoptotic signaling pathway GO:0097190 306 0.021
cellular response to dna damage stimulus GO:0006974 207 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
action potential GO:0001508 78 0.020
regulation of proteolysis GO:0030162 164 0.020
neuronal action potential GO:0019228 54 0.020
peptidyl amino acid modification GO:0018193 336 0.020
tube formation GO:0035148 140 0.020
response to growth factor GO:0070848 198 0.020
nitrogen compound transport GO:0071705 271 0.019
dna repair GO:0006281 107 0.019
cellular homeostasis GO:0019725 240 0.019
regulation of kinase activity GO:0043549 249 0.019
guanosine containing compound metabolic process GO:1901068 144 0.019
renal system development GO:0072001 225 0.019
regulation of cellular component biogenesis GO:0044087 181 0.018
cytoplasmic transport GO:0016482 234 0.018
protein catabolic process GO:0030163 221 0.018
protein alkylation GO:0008213 81 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
spermatogenesis GO:0007283 284 0.018
regulation of protein localization GO:0032880 231 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
regulation of cytokine production GO:0001817 266 0.018
negative regulation of molecular function GO:0044092 258 0.018
neural tube formation GO:0001841 108 0.018
regulation of cell activation GO:0050865 289 0.017
forebrain development GO:0030900 302 0.017
fertilization GO:0009566 127 0.017
response to organonitrogen compound GO:0010243 246 0.017
kidney development GO:0001822 213 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
endocytosis GO:0006897 168 0.017
gtp metabolic process GO:0046039 144 0.017
negative regulation of protein metabolic process GO:0051248 282 0.017
muscle cell differentiation GO:0042692 261 0.017
negative regulation of cell development GO:0010721 169 0.017
cellular lipid metabolic process GO:0044255 323 0.017
histone modification GO:0016570 159 0.017
stem cell development GO:0048864 219 0.016
glycoprotein metabolic process GO:0009100 116 0.016
regulation of vesicle mediated transport GO:0060627 139 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
regulation of protein kinase activity GO:0045859 232 0.016
microtubule based process GO:0007017 236 0.016
embryonic epithelial tube formation GO:0001838 130 0.016
establishment of protein localization to organelle GO:0072594 118 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
cell type specific apoptotic process GO:0097285 268 0.016
positive regulation of apoptotic signaling pathway GO:2001235 95 0.016
response to light stimulus GO:0009416 135 0.016
anatomical structure homeostasis GO:0060249 145 0.016
regulation of transferase activity GO:0051338 263 0.016
organelle localization GO:0051640 179 0.016
b cell activation GO:0042113 161 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
sensory organ morphogenesis GO:0090596 242 0.015
protein localization to organelle GO:0033365 185 0.015
regulation of mapk cascade GO:0043408 248 0.015
cellular response to organonitrogen compound GO:0071417 145 0.015
gtp catabolic process GO:0006184 143 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.015
endomembrane system organization GO:0010256 147 0.015
protein targeting GO:0006605 143 0.015
regulation of gtp catabolic process GO:0033124 113 0.015
carbohydrate metabolic process GO:0005975 230 0.015
dephosphorylation GO:0016311 129 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
sensory perception GO:0007600 245 0.015
rho protein signal transduction GO:0007266 32 0.015
cognition GO:0050890 149 0.015
cellular chemical homeostasis GO:0055082 215 0.015
negative regulation of nervous system development GO:0051961 156 0.015
response to radiation GO:0009314 165 0.015
reactive oxygen species metabolic process GO:0072593 84 0.015
rhythmic process GO:0048511 174 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
cytokine production GO:0001816 319 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
urogenital system development GO:0001655 261 0.014
divalent inorganic cation transport GO:0072511 178 0.014
positive regulation of nervous system development GO:0051962 221 0.014
regulation of cell cycle GO:0051726 281 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
skin development GO:0043588 220 0.014
regulation of cell motility GO:2000145 236 0.014
macromolecule methylation GO:0043414 120 0.014
transmission of nerve impulse GO:0019226 76 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
ubiquitin dependent protein catabolic process GO:0006511 129 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
mapk cascade GO:0000165 281 0.014
myeloid cell differentiation GO:0030099 233 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
regulation of secretion GO:0051046 274 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
cellular response to hormone stimulus GO:0032870 150 0.013
epidermis development GO:0008544 187 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
lung development GO:0030324 164 0.013
response to oxidative stress GO:0006979 123 0.013
developmental maturation GO:0021700 193 0.013
response to peptide hormone GO:0043434 127 0.013
positive regulation of proteolysis GO:0045862 85 0.013
t cell activation GO:0042110 289 0.013
positive regulation of kinase activity GO:0033674 155 0.013
lipid biosynthetic process GO:0008610 179 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
modification dependent macromolecule catabolic process GO:0043632 133 0.013
hexose metabolic process GO:0019318 98 0.013
protein autophosphorylation GO:0046777 61 0.013
glycoprotein biosynthetic process GO:0009101 89 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
positive regulation of gtp catabolic process GO:0033126 85 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
protein methylation GO:0006479 81 0.013
positive regulation of gtpase activity GO:0043547 85 0.013
regulation of t cell activation GO:0050863 170 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
dna recombination GO:0006310 92 0.012
negative regulation of immune system process GO:0002683 209 0.012
response to organic cyclic compound GO:0014070 198 0.012
regulation of ras gtpase activity GO:0032318 88 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.012
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
protein localization to membrane GO:0072657 108 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
regulation of cell migration GO:0030334 219 0.012
response to nutrient levels GO:0031667 109 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
skeletal system development GO:0001501 356 0.012
inflammatory response GO:0006954 244 0.012
cellular response to lipid GO:0071396 145 0.012
regulation of cell adhesion GO:0030155 154 0.012
positive regulation of transferase activity GO:0051347 167 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
b cell differentiation GO:0030183 78 0.012
sensory perception of sound GO:0007605 97 0.012
regulation of secretion by cell GO:1903530 249 0.012
myelination GO:0042552 74 0.012
protein polyubiquitination GO:0000209 33 0.012
vacuole organization GO:0007033 38 0.012
learning or memory GO:0007611 148 0.012
protein oligomerization GO:0051259 67 0.012
gland development GO:0048732 330 0.012
response to extracellular stimulus GO:0009991 127 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
respiratory system development GO:0060541 190 0.012
stem cell differentiation GO:0048863 268 0.012
blood vessel morphogenesis GO:0048514 285 0.012
negative regulation of protein modification process GO:0031400 163 0.012
positive regulation of secretion GO:0051047 130 0.012
immune effector process GO:0002252 321 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
tube closure GO:0060606 91 0.012
neural tube development GO:0021915 160 0.012
maintenance of location GO:0051235 89 0.012
sequestering of metal ion GO:0051238 19 0.012
establishment of organelle localization GO:0051656 122 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
ossification GO:0001503 216 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
mitotic cell cycle GO:0000278 195 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
lipid localization GO:0010876 126 0.011
nuclear transport GO:0051169 139 0.011
divalent metal ion transport GO:0070838 172 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
ear development GO:0043583 200 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
response to lipopolysaccharide GO:0032496 128 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
wnt signaling pathway GO:0016055 188 0.011
blood circulation GO:0008015 195 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
locomotory behavior GO:0007626 195 0.011
histone methylation GO:0016571 71 0.011
telencephalon development GO:0021537 186 0.011
muscle tissue development GO:0060537 308 0.011
canonical wnt signaling pathway GO:0060070 130 0.011
regulation of anatomical structure size GO:0090066 178 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
chemotaxis GO:0006935 247 0.011
single organism cell adhesion GO:0098602 156 0.011
regulation of defense response GO:0031347 233 0.011
purine nucleoside monophosphate metabolic process GO:0009126 81 0.011
regulation of rho protein signal transduction GO:0035023 71 0.011
camera type eye development GO:0043010 266 0.011
adult behavior GO:0030534 135 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
sequestering of calcium ion GO:0051208 18 0.011
glucose homeostasis GO:0042593 128 0.011
lateral inhibition GO:0046331 1 0.011
cellular carbohydrate metabolic process GO:0044262 119 0.011
negative regulation of synapse assembly GO:0051964 3 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
stem cell proliferation GO:0072089 117 0.011
ribonucleoside monophosphate catabolic process GO:0009158 57 0.011
dendrite development GO:0016358 115 0.010
microtubule cytoskeleton organization GO:0000226 157 0.010
metal ion homeostasis GO:0055065 189 0.010
organelle assembly GO:0070925 177 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
synaptic transmission GO:0007268 329 0.010
nucleoside monophosphate catabolic process GO:0009125 59 0.010
regulation of cellular response to growth factor stimulus GO:0090287 82 0.010
lymphocyte differentiation GO:0030098 242 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.010
atp metabolic process GO:0046034 75 0.010
cellular ion homeostasis GO:0006873 165 0.010
purine nucleoside monophosphate catabolic process GO:0009128 58 0.010
wound healing GO:0042060 157 0.010
oxidation reduction process GO:0055114 342 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
atp catabolic process GO:0006200 55 0.010
striated muscle tissue development GO:0014706 293 0.010
axonogenesis GO:0007409 274 0.010
digestive tract development GO:0048565 190 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
skeletal system morphogenesis GO:0048705 203 0.010
regulation of homeostatic process GO:0032844 182 0.010
regionalization GO:0003002 337 0.010
multicellular organism growth GO:0035264 161 0.010
regulation of endocytosis GO:0030100 69 0.010
vesicle organization GO:0016050 60 0.010
epithelial cell proliferation GO:0050673 174 0.010
heart morphogenesis GO:0003007 178 0.010
response to acid chemical GO:0001101 111 0.010
cellular response to molecule of bacterial origin GO:0071219 83 0.010
positive regulation of ras gtpase activity GO:0032320 65 0.010

Spg11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
central nervous system disease DOID:331 0 0.018
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.013