Mus musculus

67 known processes

Tle1

transducin-like enhancer of split 1, homolog of Drosophila E(spl)

(Aliases: Estm14,Tle4l,C230057C06Rik,Grg1)

Tle1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular ketone metabolic process GO:0010565 66 0.376
amine metabolic process GO:0009308 45 0.264
regulation of cellular amino acid metabolic process GO:0006521 5 0.244
positive regulation of protein phosphorylation GO:0001934 242 0.241
cellular amine metabolic process GO:0044106 44 0.236
positive regulation of cellular amine metabolic process GO:0033240 5 0.228
cellular ketone metabolic process GO:0042180 84 0.210
myeloid cell differentiation GO:0030099 233 0.155
cellular amino acid metabolic process GO:0006520 103 0.154
positive regulation of protein modification process GO:0031401 299 0.153
cytokine production GO:0001816 319 0.150
negative regulation of protein metabolic process GO:0051248 282 0.149
negative regulation of cellular protein metabolic process GO:0032269 247 0.143
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.142
positive regulation of cellular catabolic process GO:0031331 148 0.135
negative regulation of protein modification process GO:0031400 163 0.133
cellular response to arsenic containing substance GO:0071243 4 0.133
negative regulation of phosphate metabolic process GO:0045936 184 0.123
skeletal system development GO:0001501 356 0.115
regulation of cellular amine metabolic process GO:0033238 20 0.114
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.110
ras protein signal transduction GO:0007265 77 0.110
respiratory tube development GO:0030323 167 0.107
bmp signaling pathway GO:0030509 93 0.107
leukocyte differentiation GO:0002521 342 0.107
oxidation reduction process GO:0055114 342 0.102
germ cell development GO:0007281 185 0.096
negative regulation of phosphorus metabolic process GO:0010563 184 0.093
negative regulation of cellular amine metabolic process GO:0033239 1 0.092
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.090
regulation of bmp signaling pathway GO:0030510 60 0.087
peptidyl amino acid modification GO:0018193 336 0.087
positive regulation of nervous system development GO:0051962 221 0.087
Mouse
respiratory system development GO:0060541 190 0.086
b cell activation GO:0042113 161 0.086
positive regulation of cell development GO:0010720 237 0.080
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.079
canonical wnt signaling pathway GO:0060070 130 0.079
Fly
microtubule based process GO:0007017 236 0.076
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.075
negative regulation of phosphorylation GO:0042326 166 0.075
spermatogenesis GO:0007283 284 0.070
mapk cascade GO:0000165 281 0.068
gland development GO:0048732 330 0.066
wound healing GO:0042060 157 0.065
regulation of mapk cascade GO:0043408 248 0.065
positive regulation of transferase activity GO:0051347 167 0.065
negative regulation of molecular function GO:0044092 258 0.065
negative regulation of bmp signaling pathway GO:0030514 35 0.064
regulation of cellular catabolic process GO:0031329 242 0.061
angiogenesis GO:0001525 201 0.061
cell adhesion GO:0007155 329 0.060
negative regulation of immune system process GO:0002683 209 0.059
regulation of protein kinase activity GO:0045859 232 0.059
organelle assembly GO:0070925 177 0.058
skin development GO:0043588 220 0.056
regulation of cell projection organization GO:0031344 206 0.056
intracellular protein transport GO:0006886 204 0.055
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.055
ribonucleoside triphosphate catabolic process GO:0009203 199 0.055
positive regulation of cytokine production GO:0001819 174 0.055
cellular response to cytokine stimulus GO:0071345 189 0.054
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.054
wnt signaling pathway GO:0016055 188 0.053
Mouse Fly
regulation of secretion by cell GO:1903530 249 0.053
axonogenesis GO:0007409 274 0.053
lymphocyte differentiation GO:0030098 242 0.052
regulation of cytokine production GO:0001817 266 0.052
negative regulation of cell proliferation GO:0008285 296 0.052
nucleoside metabolic process GO:0009116 246 0.051
nucleobase containing small molecule metabolic process GO:0055086 352 0.051
forebrain development GO:0030900 302 0.050
regulation of wnt signaling pathway GO:0030111 123 0.049
Fly
ribonucleoside triphosphate metabolic process GO:0009199 220 0.048
positive regulation of protein kinase activity GO:0045860 144 0.048
cellular lipid metabolic process GO:0044255 323 0.047
regulation of binding GO:0051098 111 0.047
regulation of lymphocyte activation GO:0051249 240 0.046
digestive system development GO:0055123 200 0.046
regulation of secretion GO:0051046 274 0.046
regulation of canonical wnt signaling pathway GO:0060828 82 0.046
Fly
blood vessel morphogenesis GO:0048514 285 0.046
monosaccharide metabolic process GO:0005996 106 0.046
developmental maturation GO:0021700 193 0.045
i kappab kinase nf kappab signaling GO:0007249 85 0.045
Human
ephrin receptor signaling pathway GO:0048013 20 0.045
placenta development GO:0001890 140 0.044
cellular response to cadmium ion GO:0071276 3 0.044
fat cell differentiation GO:0045444 160 0.044
macromolecule catabolic process GO:0009057 281 0.044
connective tissue development GO:0061448 179 0.044
regulation of transferase activity GO:0051338 263 0.044
negative regulation of kinase activity GO:0033673 81 0.043
intra s dna damage checkpoint GO:0031573 4 0.043
negative regulation of protein phosphorylation GO:0001933 126 0.043
myeloid cell homeostasis GO:0002262 114 0.043
organophosphate catabolic process GO:0046434 232 0.043
striated muscle tissue development GO:0014706 293 0.042
p38mapk cascade GO:0038066 4 0.042
response to growth factor GO:0070848 198 0.042
positive regulation of kinase activity GO:0033674 155 0.042
response to lipopolysaccharide GO:0032496 128 0.041
hepaticobiliary system development GO:0061008 67 0.041
telencephalon development GO:0021537 186 0.041
male gamete generation GO:0048232 285 0.041
t cell activation GO:0042110 289 0.041
regulation of purine nucleotide catabolic process GO:0033121 122 0.041
aromatic compound catabolic process GO:0019439 286 0.040
regulation of hydrolase activity GO:0051336 246 0.040
regulation of apoptotic signaling pathway GO:2001233 197 0.040
purine ribonucleoside metabolic process GO:0046128 241 0.039
epidermis development GO:0008544 187 0.039
muscle tissue development GO:0060537 308 0.039
response to organic cyclic compound GO:0014070 198 0.039
nucleoside phosphate metabolic process GO:0006753 338 0.039
stem cell maintenance GO:0019827 130 0.039
regulation of vesicle mediated transport GO:0060627 139 0.038
response to molecule of bacterial origin GO:0002237 143 0.038
muscle cell differentiation GO:0042692 261 0.038
myeloid leukocyte differentiation GO:0002573 119 0.038
regulation of cell migration GO:0030334 219 0.038
transforming growth factor beta2 production GO:0032906 2 0.038
regulation of nucleoside metabolic process GO:0009118 130 0.038
regulation of cellular component biogenesis GO:0044087 181 0.037
multicellular organism growth GO:0035264 161 0.037
purine containing compound catabolic process GO:0072523 213 0.037
purine ribonucleotide catabolic process GO:0009154 208 0.037
peptidyl lysine modification GO:0018205 77 0.037
ossification GO:0001503 216 0.037
digestive tract development GO:0048565 190 0.037
chromatin organization GO:0006325 206 0.037
organic cyclic compound catabolic process GO:1901361 295 0.037
negative regulation of myeloid cell differentiation GO:0045638 38 0.037
regulation of organelle organization GO:0033043 289 0.037
gtp metabolic process GO:0046039 144 0.036
labyrinthine layer blood vessel development GO:0060716 21 0.036
protein import into nucleus GO:0006606 95 0.036
purine nucleoside metabolic process GO:0042278 241 0.036
developmental growth involved in morphogenesis GO:0060560 138 0.036
regulation of membrane potential GO:0042391 192 0.035
guanosine containing compound metabolic process GO:1901068 144 0.035
protein localization to organelle GO:0033365 185 0.035
regulation of cell motility GO:2000145 236 0.035
embryonic placenta development GO:0001892 98 0.035
nucleoside triphosphate metabolic process GO:0009141 230 0.034
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.034
protein ubiquitination GO:0016567 171 0.034
ribose phosphate metabolic process GO:0019693 291 0.034
nucleotide metabolic process GO:0009117 332 0.034
microtubule cytoskeleton organization GO:0000226 157 0.034
ribonucleoside metabolic process GO:0009119 245 0.034
homeostasis of number of cells GO:0048872 210 0.033
apoptotic signaling pathway GO:0097190 306 0.033
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.033
purine nucleoside triphosphate catabolic process GO:0009146 203 0.033
regulation of ras gtpase activity GO:0032318 88 0.033
regulation of nucleotide metabolic process GO:0006140 169 0.033
organonitrogen compound catabolic process GO:1901565 264 0.033
regulation of leukocyte differentiation GO:1902105 159 0.033
glial cell differentiation GO:0010001 131 0.033
regulation of ossification GO:0030278 112 0.033
asymmetric stem cell division GO:0098722 3 0.032
regulation of ras protein signal transduction GO:0046578 114 0.032
ribonucleotide metabolic process GO:0009259 291 0.032
negative regulation of cellular component organization GO:0051129 194 0.032
protein targeting GO:0006605 143 0.032
purine ribonucleoside catabolic process GO:0046130 205 0.032
regulation of purine nucleotide metabolic process GO:1900542 169 0.032
negative regulation of transferase activity GO:0051348 85 0.032
negative regulation of phagocytosis GO:0050765 4 0.032
rho protein signal transduction GO:0007266 32 0.032
regulation of establishment of protein localization GO:0070201 181 0.032
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.032
regulation of nucleotide catabolic process GO:0030811 122 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.031
establishment of protein localization to organelle GO:0072594 118 0.031
negative regulation of nervous system development GO:0051961 156 0.031
fatty acid metabolic process GO:0006631 121 0.031
monocarboxylic acid metabolic process GO:0032787 191 0.031
endocytosis GO:0006897 168 0.031
oocyte axis specification GO:0007309 2 0.031
nucleoside catabolic process GO:0009164 206 0.031
b cell differentiation GO:0030183 78 0.030
carbohydrate metabolic process GO:0005975 230 0.030
regulation of cell cycle GO:0051726 281 0.030
pallium development GO:0021543 120 0.030
innate immune response GO:0045087 157 0.030
positive regulation of ras gtpase activity GO:0032320 65 0.030
regulation of neuron projection development GO:0010975 169 0.030
positive regulation of programmed cell death GO:0043068 218 0.030
dna metabolic process GO:0006259 303 0.030
actin filament organization GO:0007015 113 0.029
Fly
neuron projection guidance GO:0097485 141 0.029
histone modification GO:0016570 159 0.029
camera type eye development GO:0043010 266 0.029
glucose metabolic process GO:0006006 92 0.029
guanosine containing compound catabolic process GO:1901069 144 0.029
protein acylation GO:0043543 64 0.029
purine nucleoside catabolic process GO:0006152 205 0.029
limb morphogenesis GO:0035108 149 0.029
embryonic organ morphogenesis GO:0048562 276 0.029
response to organonitrogen compound GO:0010243 246 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.029
nuclear import GO:0051170 95 0.029
ribonucleoside catabolic process GO:0042454 206 0.028
erythrocyte differentiation GO:0030218 88 0.028
labyrinthine layer development GO:0060711 49 0.028
regulation of myeloid cell differentiation GO:0045637 96 0.028
lung development GO:0030324 164 0.028
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.028
placenta blood vessel development GO:0060674 31 0.028
regulation of gtp catabolic process GO:0033124 113 0.028
glycosyl compound catabolic process GO:1901658 206 0.028
covalent chromatin modification GO:0016569 163 0.028
negative regulation of cell cycle GO:0045786 123 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
synapse organization GO:0050808 125 0.027
response to extracellular stimulus GO:0009991 127 0.027
regulation of protein transport GO:0051223 163 0.027
purine nucleoside triphosphate metabolic process GO:0009144 226 0.027
cell division GO:0051301 120 0.027
nitrogen compound transport GO:0071705 271 0.027
purine ribonucleotide metabolic process GO:0009150 290 0.027
phagocytosis GO:0006909 66 0.027
stem cell development GO:0048864 219 0.027
gtp catabolic process GO:0006184 143 0.027
positive regulation of transforming growth factor beta2 production GO:0032915 2 0.026
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.026
peptidyl tyrosine phosphorylation GO:0018108 143 0.026
cellular response to growth factor stimulus GO:0071363 197 0.026
regulation of protein serine threonine kinase activity GO:0071900 157 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.026
positive regulation of apoptotic process GO:0043065 217 0.026
regulation of defense response GO:0031347 233 0.026
regionalization GO:0003002 337 0.026
neuronal action potential GO:0019228 54 0.026
regulation of response to wounding GO:1903034 189 0.026
regulation of protein localization GO:0032880 231 0.025
immune effector process GO:0002252 321 0.025
negative regulation of lymphocyte activation GO:0051250 91 0.025
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.025
glycosyl compound metabolic process GO:1901657 246 0.025
regulation of neuron differentiation GO:0045664 281 0.025
Mouse
ribonucleotide catabolic process GO:0009261 208 0.025
regulation of fat cell differentiation GO:0045598 81 0.025
cell maturation GO:0048469 127 0.025
multicellular organismal signaling GO:0035637 91 0.024
nucleoside triphosphate catabolic process GO:0009143 205 0.024
cell type specific apoptotic process GO:0097285 268 0.024
nucleotide catabolic process GO:0009166 217 0.024
regulation of feeding behavior GO:0060259 3 0.024
organic hydroxy compound metabolic process GO:1901615 203 0.024
cytoplasmic transport GO:0016482 234 0.024
regulation of striated muscle cell differentiation GO:0051153 81 0.024
negative regulation of cell activation GO:0050866 111 0.024
heart morphogenesis GO:0003007 178 0.024
cell junction maintenance GO:0034331 4 0.024
positive regulation of hydrolase activity GO:0051345 148 0.024
positive regulation of mapk cascade GO:0043410 170 0.023
positive regulation of nucleotide catabolic process GO:0030813 88 0.023
amide transport GO:0042886 138 0.023
lipid biosynthetic process GO:0008610 179 0.023
negative regulation of apoptotic signaling pathway GO:2001234 104 0.023
mitotic cytokinesis GO:0000281 4 0.023
epithelial cell proliferation GO:0050673 174 0.023
cellular nitrogen compound catabolic process GO:0044270 280 0.023
spermatid differentiation GO:0048515 115 0.023
regulation of kinase activity GO:0043549 249 0.023
stem cell differentiation GO:0048863 268 0.023
organelle localization GO:0051640 179 0.023
protein catabolic process GO:0030163 221 0.023
cellular response to molecule of bacterial origin GO:0071219 83 0.023
negative regulation of growth GO:0045926 99 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
chromatin modification GO:0016568 187 0.023
cellular response to biotic stimulus GO:0071216 92 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
oocyte construction GO:0007308 2 0.022
striated muscle cell development GO:0055002 125 0.022
cellular response to lipid GO:0071396 145 0.022
stem cell proliferation GO:0072089 117 0.022
nucleocytoplasmic transport GO:0006913 139 0.022
segmentation GO:0035282 93 0.022
cartilage development GO:0051216 140 0.022
cell fate commitment GO:0045165 210 0.021
Fly
myeloid leukocyte activation GO:0002274 83 0.021
response to radiation GO:0009314 165 0.021
actin filament based movement GO:0030048 23 0.021
transmission of nerve impulse GO:0019226 76 0.021
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.021
membrane organization GO:0061024 245 0.021
regulation of actin filament based process GO:0032970 99 0.021
positive regulation of protein transport GO:0051222 93 0.021
skeletal muscle organ development GO:0060538 163 0.021
negative regulation of intracellular signal transduction GO:1902532 167 0.021
Human
endomembrane system organization GO:0010256 147 0.021
t cell differentiation GO:0030217 174 0.021
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.021
Fly
ubiquitin dependent protein catabolic process GO:0006511 129 0.021
regulation of epithelial cell proliferation GO:0050678 141 0.020
gliogenesis GO:0042063 141 0.020
positive regulation of nucleoside metabolic process GO:0045979 91 0.020
response to oxidative stress GO:0006979 123 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
glycerolipid metabolic process GO:0046486 122 0.020
spermatid development GO:0007286 108 0.020
regulation of t cell activation GO:0050863 170 0.020
insulin secretion GO:0030073 89 0.020
microglial cell activation GO:0001774 3 0.020
negative regulation of synapse assembly GO:0051964 3 0.020
regulation of peptide transport GO:0090087 91 0.020
regulation of cytoskeleton organization GO:0051493 122 0.020
nuclear division GO:0000280 158 0.020
regulation of gliogenesis GO:0014013 50 0.020
positive regulation of neuron differentiation GO:0045666 141 0.020
Mouse
cellular response to oxidative stress GO:0034599 76 0.020
heterocycle catabolic process GO:0046700 280 0.020
protein autophosphorylation GO:0046777 61 0.019
mitotic cell cycle process GO:1903047 159 0.019
negative regulation of neuron differentiation GO:0045665 101 0.019
positive regulation of cell projection organization GO:0031346 95 0.019
defense response to other organism GO:0098542 197 0.019
cellular response to dna damage stimulus GO:0006974 207 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
regulation of neuron death GO:1901214 134 0.019
mitochondrion organization GO:0007005 134 0.019
cellular response to extracellular stimulus GO:0031668 81 0.019
response to peptide GO:1901652 136 0.019
renal system development GO:0072001 225 0.019
regulation of intracellular transport GO:0032386 159 0.019
regulation of cytoplasmic transport GO:1903649 112 0.019
response to nutrient levels GO:0031667 109 0.019
morphogenesis of a branching structure GO:0001763 203 0.019
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.019
rhythmic process GO:0048511 174 0.019
regulation of reactive oxygen species metabolic process GO:2000377 40 0.018
purine containing compound metabolic process GO:0072521 311 0.018
regulation of hormone levels GO:0010817 211 0.018
regulation of lymphocyte differentiation GO:0045619 107 0.018
chemotaxis GO:0006935 247 0.018
positive regulation of lymphocyte activation GO:0051251 140 0.018
lateral inhibition GO:0046331 1 0.018
Fly
asymmetric neuroblast division GO:0055059 1 0.018
peptide hormone secretion GO:0030072 109 0.018
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.018
cellular protein complex assembly GO:0043623 116 0.018
negative regulation of leukocyte differentiation GO:1902106 51 0.018
maternal determination of anterior posterior axis embryo GO:0008358 2 0.018
positive regulation of ossification GO:0045778 47 0.018
regulation of cell activation GO:0050865 289 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.018
digestive tract morphogenesis GO:0048546 147 0.018
action potential GO:0001508 78 0.018
cellular carbohydrate metabolic process GO:0044262 119 0.018
kidney development GO:0001822 213 0.018
positive regulation of secretion GO:0051047 130 0.018
response to drug GO:0042493 75 0.018
response to acid chemical GO:0001101 111 0.017
ensheathment of neurons GO:0007272 76 0.017
cellular homeostasis GO:0019725 240 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
appendage development GO:0048736 166 0.017
muscle cell development GO:0055001 133 0.017
regulation of actin cytoskeleton organization GO:0032956 84 0.017
negative regulation of mapk cascade GO:0043409 65 0.017
positive regulation of intracellular transport GO:0032388 70 0.017
regulation of osteoblast differentiation GO:0045667 67 0.017
regulation of erythrocyte differentiation GO:0045646 23 0.017
lymphocyte proliferation GO:0046651 164 0.017
leukocyte proliferation GO:0070661 172 0.017
regulation of endocytosis GO:0030100 69 0.017
cell cycle checkpoint GO:0000075 47 0.017
protein deacetylation GO:0006476 32 0.017
organ growth GO:0035265 117 0.017
protein localization to membrane GO:0072657 108 0.017
activation of immune response GO:0002253 138 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
cellular response to starvation GO:0009267 57 0.017
peptidyl lysine acetylation GO:0018394 45 0.016
morphogenesis of a branching epithelium GO:0061138 193 0.016
extrinsic apoptotic signaling pathway GO:0097191 126 0.016
response to epidermal growth factor GO:0070849 4 0.016
development of primary male sexual characteristics GO:0046546 88 0.016
maintenance of location GO:0051235 89 0.016
pancreas development GO:0031016 57 0.016
immune response regulating signaling pathway GO:0002764 125 0.016
actin cytoskeleton organization GO:0030036 220 0.016
Fly
carbohydrate derivative catabolic process GO:1901136 231 0.016
blastocyst development GO:0001824 80 0.016
positive regulation of cell activation GO:0050867 158 0.016
peptidyl serine phosphorylation GO:0018105 74 0.016
fibroblast proliferation GO:0048144 35 0.016
osteoblast development GO:0002076 17 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
positive regulation of map kinase activity GO:0043406 84 0.016
organelle fission GO:0048285 170 0.016
modification dependent protein catabolic process GO:0019941 133 0.016
positive regulation of immune effector process GO:0002699 107 0.016
lipid localization GO:0010876 126 0.016
positive regulation of epithelial cell proliferation GO:0050679 68 0.016
cellular response to nitric oxide GO:0071732 4 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.016
cellular component assembly involved in morphogenesis GO:0010927 139 0.016
peptidyl serine modification GO:0018209 83 0.016
urogenital system development GO:0001655 261 0.015
engulfment of apoptotic cell GO:0043652 3 0.015
energy derivation by oxidation of organic compounds GO:0015980 77 0.015
positive regulation of cell migration GO:0030335 109 0.015
neural tube development GO:0021915 160 0.015
single organismal cell cell adhesion GO:0016337 131 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.015
cation transmembrane transport GO:0098655 266 0.015
response to inorganic substance GO:0010035 96 0.015
peptide secretion GO:0002790 114 0.015
immune response activating signal transduction GO:0002757 116 0.015
neuron migration GO:0001764 122 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
skeletal system morphogenesis GO:0048705 203 0.015
glycerophospholipid metabolic process GO:0006650 71 0.015
regulation of postsynaptic membrane potential GO:0060078 48 0.015
hormone secretion GO:0046879 128 0.015
positive regulation of cell death GO:0010942 224 0.015
neuron death GO:0070997 154 0.015
regulation of cellular component size GO:0032535 121 0.015
positive regulation of protein localization to nucleus GO:1900182 30 0.015
regulation of leukocyte proliferation GO:0070663 121 0.015
cellularization GO:0007349 1 0.015
myotube differentiation GO:0014902 105 0.015
single organism cell adhesion GO:0098602 156 0.015
t cell proliferation GO:0042098 120 0.015
branching morphogenesis of an epithelial tube GO:0048754 159 0.015
negative regulation of cell development GO:0010721 169 0.015
regulation of organ morphogenesis GO:2000027 144 0.015
cellular response to lipopolysaccharide GO:0071222 77 0.015
cofactor metabolic process GO:0051186 80 0.015
small molecule biosynthetic process GO:0044283 132 0.015
stress activated mapk cascade GO:0051403 80 0.015
rna interference GO:0016246 2 0.015
sensory perception GO:0007600 245 0.015
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.015
negative regulation of cell cycle process GO:0010948 69 0.015
meiotic nuclear division GO:0007126 115 0.015
positive regulation of t cell activation GO:0050870 101 0.014
regulation of carbohydrate metabolic process GO:0006109 75 0.014
liver development GO:0001889 66 0.014
regulation of protein complex assembly GO:0043254 83 0.014
single organism nuclear import GO:1902593 95 0.014
negative regulation of wnt signaling pathway GO:0030178 73 0.014
Fly
protein kinase b signaling GO:0043491 74 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
regulation of innate immune response GO:0045088 91 0.014
sequestering of calcium ion GO:0051208 18 0.014
apoptotic mitochondrial changes GO:0008637 48 0.014
cell cell junction organization GO:0045216 72 0.014
cytokine mediated signaling pathway GO:0019221 115 0.014
peptidyl threonine phosphorylation GO:0018107 31 0.014
regulation of map kinase activity GO:0043405 120 0.014
phospholipid metabolic process GO:0006644 87 0.014
tube formation GO:0035148 140 0.014
regulation of chromatin organization GO:1902275 57 0.014
adaptive immune response GO:0002250 155 0.014
protein polymerization GO:0051258 57 0.014
female gamete generation GO:0007292 74 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
regulation of b cell activation GO:0050864 81 0.014
sequestering of metal ion GO:0051238 19 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.014
cell fate specification GO:0001708 72 0.014
positive regulation of gtpase activity GO:0043547 85 0.014
actin polymerization or depolymerization GO:0008154 54 0.014
leukocyte activation involved in immune response GO:0002366 126 0.014
osmosensory signaling pathway GO:0007231 1 0.014
regulation of lipid metabolic process GO:0019216 118 0.014
morphogenesis of embryonic epithelium GO:0016331 159 0.013
endodermal cell fate specification GO:0001714 4 0.013
negative regulation of neuron death GO:1901215 98 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
neuron apoptotic process GO:0051402 142 0.013
protein localization to nucleus GO:0034504 121 0.013
germ line stem cell division GO:0042078 2 0.013
regulation of anatomical structure size GO:0090066 178 0.013
protein import GO:0017038 101 0.013
synaptic transmission GO:0007268 329 0.013
positive regulation of organelle organization GO:0010638 128 0.013
positive regulation of neuron projection development GO:0010976 79 0.013
regulation of translation GO:0006417 71 0.013
rab protein signal transduction GO:0032482 1 0.013
oogenesis GO:0048477 56 0.013
regulation of peptide secretion GO:0002791 77 0.013

Tle1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
musculoskeletal system disease DOID:17 0 0.015
connective tissue disease DOID:65 0 0.014