Mus musculus

77 known processes

Tle4

transducin-like enhancer of split 4, homolog of Drosophila E(spl)

(Aliases: X83333,X83332,Grg4,Bce1,Bce-1,ESTM14,AA792082,ESTM13,5730411M05Rik)

Tle4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin cytoskeleton organization GO:0030036 220 0.299
Fly
organelle assembly GO:0070925 177 0.243
multicellular organism growth GO:0035264 161 0.198
cell type specific apoptotic process GO:0097285 268 0.196
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.181
regulation of neuron projection development GO:0010975 169 0.167
Worm
regulation of neuron differentiation GO:0045664 281 0.160
Mouse Worm
compound eye development GO:0048749 1 0.151
chromatin modification GO:0016568 187 0.149
histone modification GO:0016570 159 0.147
neuron apoptotic process GO:0051402 142 0.143
germ cell development GO:0007281 185 0.137
Worm
regulation of cellular amine metabolic process GO:0033238 20 0.130
cytoplasmic transport GO:0016482 234 0.122
regulation of cellular amino acid metabolic process GO:0006521 5 0.119
regulation of membrane potential GO:0042391 192 0.119
neuron death GO:0070997 154 0.119
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.115
regulation of cellular component biogenesis GO:0044087 181 0.114
positive regulation of apoptotic process GO:0043065 217 0.109
negative regulation of cell proliferation GO:0008285 296 0.109
regulation of cellular ketone metabolic process GO:0010565 66 0.101
regulation of neuron apoptotic process GO:0043523 122 0.101
regulation of organelle organization GO:0033043 289 0.092
regulation of cell cycle GO:0051726 281 0.090
digestive tract development GO:0048565 190 0.090
protein localization to nucleus GO:0034504 121 0.089
wnt signaling pathway GO:0016055 188 0.089
cellular ketone metabolic process GO:0042180 84 0.087
male gamete generation GO:0048232 285 0.086
leukocyte differentiation GO:0002521 342 0.086
protein modification by small protein conjugation GO:0032446 187 0.086
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.086
urogenital system development GO:0001655 261 0.084
muscle cell differentiation GO:0042692 261 0.084
spermatogenesis GO:0007283 284 0.084
gastrulation GO:0007369 116 0.079
epidermis development GO:0008544 187 0.079
regulation of cell division GO:0051302 76 0.078
ras protein signal transduction GO:0007265 77 0.078
respiratory system development GO:0060541 190 0.077
digestive system development GO:0055123 200 0.077
negative regulation of intracellular signal transduction GO:1902532 167 0.076
peptidyl amino acid modification GO:0018193 336 0.075
developmental maturation GO:0021700 193 0.074
cellular amino acid metabolic process GO:0006520 103 0.073
adaptive immune response GO:0002250 155 0.072
cation transport GO:0006812 399 0.071
innate immune response GO:0045087 157 0.071
muscle tissue development GO:0060537 308 0.070
amine metabolic process GO:0009308 45 0.070
regulation of cell projection organization GO:0031344 206 0.070
Worm
camera type eye development GO:0043010 266 0.069
negative regulation of neuron apoptotic process GO:0043524 92 0.068
dendrite development GO:0016358 115 0.068
Fly
covalent chromatin modification GO:0016569 163 0.068
microtubule based process GO:0007017 236 0.067
regulation of defense response GO:0031347 233 0.066
protein modification by small protein conjugation or removal GO:0070647 207 0.066
digestive tract morphogenesis GO:0048546 147 0.065
regulation of cellular catabolic process GO:0031329 242 0.065
cell division GO:0051301 120 0.065
response to lipopolysaccharide GO:0032496 128 0.064
cellular amine metabolic process GO:0044106 44 0.064
wound healing GO:0042060 157 0.064
sensory perception GO:0007600 245 0.064
axonogenesis GO:0007409 274 0.063
Worm
protein localization to organelle GO:0033365 185 0.063
positive regulation of programmed cell death GO:0043068 218 0.061
skin development GO:0043588 220 0.061
b cell activation GO:0042113 161 0.061
sensory perception of mechanical stimulus GO:0050954 107 0.061
rhythmic process GO:0048511 174 0.060
myotube differentiation GO:0014902 105 0.060
small gtpase mediated signal transduction GO:0007264 97 0.060
regulation of neuron death GO:1901214 134 0.060
negative regulation of cellular component organization GO:0051129 194 0.059
negative regulation of cellular amine metabolic process GO:0033239 1 0.059
regulation of secretion by cell GO:1903530 249 0.058
regulation of ras protein signal transduction GO:0046578 114 0.058
response to molecule of bacterial origin GO:0002237 143 0.058
nuclear transport GO:0051169 139 0.058
lymphocyte differentiation GO:0030098 242 0.058
maintenance of location GO:0051235 89 0.057
cellular macromolecule catabolic process GO:0044265 206 0.057
chromatin organization GO:0006325 206 0.056
developmental growth involved in morphogenesis GO:0060560 138 0.056
cellular component assembly involved in morphogenesis GO:0010927 139 0.056
mapk cascade GO:0000165 281 0.055
positive regulation of defense response GO:0031349 124 0.055
inorganic cation transmembrane transport GO:0098662 207 0.055
leukocyte mediated immunity GO:0002443 174 0.055
regulation of secretion GO:0051046 274 0.055
heterocycle catabolic process GO:0046700 280 0.054
protein ubiquitination GO:0016567 171 0.054
spermatid development GO:0007286 108 0.054
establishment of protein localization to organelle GO:0072594 118 0.054
blastocyst development GO:0001824 80 0.053
spermatid differentiation GO:0048515 115 0.053
gland development GO:0048732 330 0.053
intracellular protein transport GO:0006886 204 0.053
striated muscle tissue development GO:0014706 293 0.052
leukocyte proliferation GO:0070661 172 0.052
stem cell development GO:0048864 219 0.052
protein catabolic process GO:0030163 221 0.052
negative regulation of cell development GO:0010721 169 0.051
positive regulation of dna templated transcription elongation GO:0032786 2 0.051
organonitrogen compound catabolic process GO:1901565 264 0.051
nucleocytoplasmic transport GO:0006913 139 0.051
positive regulation of cell death GO:0010942 224 0.050
forebrain development GO:0030900 302 0.050
apoptotic signaling pathway GO:0097190 306 0.050
cellular response to lipid GO:0071396 145 0.049
cellular protein catabolic process GO:0044257 155 0.048
negative regulation of cellular protein metabolic process GO:0032269 247 0.048
mesoderm development GO:0007498 100 0.048
nucleotide metabolic process GO:0009117 332 0.047
epithelial cell proliferation GO:0050673 174 0.047
homeostasis of number of cells GO:0048872 210 0.047
regulation of cytokine production GO:0001817 266 0.047
heart morphogenesis GO:0003007 178 0.047
myeloid cell differentiation GO:0030099 233 0.047
embryonic epithelial tube formation GO:0001838 130 0.047
ribonucleoside metabolic process GO:0009119 245 0.046
immune effector process GO:0002252 321 0.046
cellular nitrogen compound catabolic process GO:0044270 280 0.046
oogenesis GO:0048477 56 0.045
Worm
blood vessel morphogenesis GO:0048514 285 0.045
posttranscriptional regulation of gene expression GO:0010608 155 0.045
sensory organ morphogenesis GO:0090596 242 0.045
epithelial tube morphogenesis GO:0060562 303 0.045
purine nucleotide metabolic process GO:0006163 302 0.045
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.045
aromatic compound catabolic process GO:0019439 286 0.045
negative regulation of protein metabolic process GO:0051248 282 0.045
purine containing compound metabolic process GO:0072521 311 0.045
protein import into nucleus GO:0006606 95 0.044
sensory perception of sound GO:0007605 97 0.044
protein kinase b signaling GO:0043491 74 0.044
neuroblast differentiation GO:0014016 2 0.044
regulation of transferase activity GO:0051338 263 0.044
nucleoside phosphate catabolic process GO:1901292 222 0.044
nucleoside catabolic process GO:0009164 206 0.044
negative regulation of neuron death GO:1901215 98 0.043
renal system development GO:0072001 225 0.043
regulation of cell migration GO:0030334 219 0.043
protein import GO:0017038 101 0.042
keratinocyte differentiation GO:0030216 48 0.042
purine nucleotide catabolic process GO:0006195 211 0.042
nucleoside triphosphate metabolic process GO:0009141 230 0.042
organic cyclic compound catabolic process GO:1901361 295 0.042
purine nucleoside metabolic process GO:0042278 241 0.042
cellular lipid metabolic process GO:0044255 323 0.041
guanosine containing compound catabolic process GO:1901069 144 0.041
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.041
circadian rhythm GO:0007623 114 0.041
negative regulation of molecular function GO:0044092 258 0.040
transmembrane transport GO:0055085 412 0.040
regulation of apoptotic signaling pathway GO:2001233 197 0.040
stem cell maintenance GO:0019827 130 0.040
cellular homeostasis GO:0019725 240 0.040
macromolecule catabolic process GO:0009057 281 0.040
embryonic organ morphogenesis GO:0048562 276 0.040
formation of primary germ layer GO:0001704 77 0.039
mitotic cell cycle process GO:1903047 159 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
negative regulation of protein modification process GO:0031400 163 0.039
glycosyl compound metabolic process GO:1901657 246 0.039
regulation of protein kinase activity GO:0045859 232 0.039
kidney epithelium development GO:0072073 121 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.039
action potential GO:0001508 78 0.039
striated muscle cell development GO:0055002 125 0.038
positive regulation of protein modification process GO:0031401 299 0.038
positive regulation of innate immune response GO:0045089 80 0.038
single organism nuclear import GO:1902593 95 0.038
regulation of vesicle mediated transport GO:0060627 139 0.038
neuronal action potential GO:0019228 54 0.038
cellular response to organonitrogen compound GO:0071417 145 0.038
production of molecular mediator of immune response GO:0002440 103 0.038
regulation of mapk cascade GO:0043408 248 0.038
epithelial cell development GO:0002064 159 0.038
regulation of cell motility GO:2000145 236 0.037
regulation of wnt signaling pathway GO:0030111 123 0.037
Fly
regulation of kinase activity GO:0043549 249 0.037
circulatory system process GO:0003013 197 0.037
purine nucleoside catabolic process GO:0006152 205 0.037
developmental cell growth GO:0048588 84 0.036
kidney development GO:0001822 213 0.036
nucleoside phosphate metabolic process GO:0006753 338 0.036
rho protein signal transduction GO:0007266 32 0.036
negative regulation of protein phosphorylation GO:0001933 126 0.036
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.035
purine nucleoside triphosphate metabolic process GO:0009144 226 0.035
lymphocyte mediated immunity GO:0002449 139 0.035
ribonucleoside triphosphate metabolic process GO:0009199 220 0.035
regulation of hormone levels GO:0010817 211 0.035
regulation of epithelial cell proliferation GO:0050678 141 0.035
chromosome segregation GO:0007059 48 0.035
actin filament organization GO:0007015 113 0.035
Fly
peptidyl serine phosphorylation GO:0018105 74 0.035
morphogenesis of embryonic epithelium GO:0016331 159 0.035
multicellular organismal signaling GO:0035637 91 0.034
activation of immune response GO:0002253 138 0.034
regulation of hydrolase activity GO:0051336 246 0.034
peptidyl lysine modification GO:0018205 77 0.034
neural tube development GO:0021915 160 0.034
stem cell differentiation GO:0048863 268 0.033
cell maturation GO:0048469 127 0.033
purine containing compound catabolic process GO:0072523 213 0.033
b cell proliferation GO:0042100 53 0.033
ion transmembrane transport GO:0034220 361 0.033
neural precursor cell proliferation GO:0061351 121 0.033
nucleoside triphosphate catabolic process GO:0009143 205 0.033
telencephalon development GO:0021537 186 0.033
organic hydroxy compound metabolic process GO:1901615 203 0.032
organelle localization GO:0051640 179 0.032
Worm
purine nucleoside triphosphate catabolic process GO:0009146 203 0.032
skeletal system development GO:0001501 356 0.032
lymphocyte proliferation GO:0046651 164 0.032
cell fate commitment GO:0045165 210 0.032
Fly
cation transmembrane transport GO:0098655 266 0.032
tube formation GO:0035148 140 0.032
erythrocyte differentiation GO:0030218 88 0.032
renal tubule development GO:0061326 87 0.032
blastocyst formation GO:0001825 33 0.032
blastocyst growth GO:0001832 23 0.032
development of primary sexual characteristics GO:0045137 143 0.032
Worm
positive regulation of apoptotic signaling pathway GO:2001235 95 0.031
purine ribonucleoside catabolic process GO:0046130 205 0.031
chemotaxis GO:0006935 247 0.031
nephron development GO:0072006 109 0.031
protein targeting GO:0006605 143 0.031
cellular response to lipopolysaccharide GO:0071222 77 0.031
central nervous system neuron differentiation GO:0021953 162 0.031
cell growth GO:0016049 130 0.031
intrinsic apoptotic signaling pathway GO:0097193 132 0.030
glycerolipid metabolic process GO:0046486 122 0.030
protein polymerization GO:0051258 57 0.030
protein maturation GO:0051604 176 0.030
nucleoside metabolic process GO:0009116 246 0.030
nerve development GO:0021675 67 0.030
branching morphogenesis of an epithelial tube GO:0048754 159 0.030
defense response to other organism GO:0098542 197 0.030
dna metabolic process GO:0006259 303 0.030
regulation of response to drug GO:2001023 2 0.030
organophosphate catabolic process GO:0046434 232 0.030
endodermal cell fate commitment GO:0001711 12 0.030
cytokine production GO:0001816 319 0.029
regulation of exocytosis GO:0017157 61 0.029
ribonucleoside catabolic process GO:0042454 206 0.029
lens morphogenesis in camera type eye GO:0002089 24 0.029
cardiac muscle tissue development GO:0048738 130 0.029
rna processing GO:0006396 105 0.029
purine ribonucleoside metabolic process GO:0046128 241 0.029
response to organonitrogen compound GO:0010243 246 0.029
regulation of cell cycle process GO:0010564 160 0.029
positive regulation of ras gtpase activity GO:0032320 65 0.029
negative regulation of phosphate metabolic process GO:0045936 184 0.029
negative regulation of wnt signaling pathway GO:0030178 73 0.029
Fly
cellular response to molecule of bacterial origin GO:0071219 83 0.028
cellular chemical homeostasis GO:0055082 215 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
negative regulation of nervous system development GO:0051961 156 0.028
engulfment of apoptotic cell GO:0043652 3 0.028
regulation of innate immune response GO:0045088 91 0.028
negative regulation of phosphorylation GO:0042326 166 0.028
cellular response to biotic stimulus GO:0071216 92 0.028
organelle fission GO:0048285 170 0.028
nuclear division GO:0000280 158 0.028
metal ion homeostasis GO:0055065 189 0.027
rna interference GO:0016246 2 0.027
glycosyl compound catabolic process GO:1901658 206 0.027
cellular carbohydrate metabolic process GO:0044262 119 0.027
regulation of system process GO:0044057 200 0.027
exocytosis GO:0006887 121 0.027
nephron epithelium development GO:0072009 92 0.027
cellular ion homeostasis GO:0006873 165 0.027
placenta development GO:0001890 140 0.027
endocytosis GO:0006897 168 0.027
gliogenesis GO:0042063 141 0.027
myeloid cell homeostasis GO:0002262 114 0.026
neuron projection extension GO:1990138 64 0.026
synapse organization GO:0050808 125 0.026
positive regulation of nervous system development GO:0051962 221 0.026
Mouse
immune response regulating signaling pathway GO:0002764 125 0.026
morphogenesis of a branching epithelium GO:0061138 193 0.026
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.026
regulation of intracellular transport GO:0032386 159 0.026
positive regulation of growth GO:0045927 104 0.026
cell adhesion GO:0007155 329 0.026
regulation of purine nucleotide metabolic process GO:1900542 169 0.026
myelination GO:0042552 74 0.026
nucleotide catabolic process GO:0009166 217 0.025
gtp metabolic process GO:0046039 144 0.025
protein acylation GO:0043543 64 0.025
regulation of protein transport GO:0051223 163 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.025
Worm
mesoderm morphogenesis GO:0048332 64 0.025
regulation of ras gtpase activity GO:0032318 88 0.025
ribonucleotide catabolic process GO:0009261 208 0.025
retina development in camera type eye GO:0060041 119 0.025
cellular protein complex assembly GO:0043623 116 0.025
immune response activating signal transduction GO:0002757 116 0.025
ribonucleotide metabolic process GO:0009259 291 0.025
cardiac chamber development GO:0003205 108 0.025
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.025
cellular response to organic cyclic compound GO:0071407 87 0.025
morphogenesis of a branching structure GO:0001763 203 0.025
sequestering of metal ion GO:0051238 19 0.025
regulation of actin filament based process GO:0032970 99 0.024
muscle cell development GO:0055001 133 0.024
regulation of gtp catabolic process GO:0033124 113 0.024
regionalization GO:0003002 337 0.024
nephron tubule development GO:0072080 84 0.024
response to organic cyclic compound GO:0014070 198 0.024
regulation of lymphocyte activation GO:0051249 240 0.024
regulation of cytoskeleton organization GO:0051493 122 0.024
skeletal muscle organ development GO:0060538 163 0.024
neuron projection guidance GO:0097485 141 0.024
negative regulation of phosphorus metabolic process GO:0010563 184 0.024
negative regulation of neuron differentiation GO:0045665 101 0.023
organophosphate biosynthetic process GO:0090407 122 0.023
mitotic cell cycle GO:0000278 195 0.023
positive regulation of cell migration GO:0030335 109 0.023
glial cell differentiation GO:0010001 131 0.023
canonical wnt signaling pathway GO:0060070 130 0.023
Fly
endocrine system development GO:0035270 98 0.023
regulation of cytoplasmic transport GO:1903649 112 0.023
positive regulation of hydrolase activity GO:0051345 148 0.023
locomotory behavior GO:0007626 195 0.022
ascending thin limb development GO:0072021 2 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
calcium ion dependent exocytosis GO:0017156 35 0.022
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.022
purine ribonucleotide metabolic process GO:0009150 290 0.022
thymus development GO:0048538 41 0.022
regulation of nucleotide metabolic process GO:0006140 169 0.022
epithelial tube formation GO:0072175 130 0.022
calcium ion homeostasis GO:0055074 127 0.022
inner ear morphogenesis GO:0042472 101 0.022
microtubule cytoskeleton organization GO:0000226 157 0.022
regulation of cellular component size GO:0032535 121 0.022
cellular response to dna damage stimulus GO:0006974 207 0.022
cellularization GO:0007349 1 0.022
phagocytosis GO:0006909 66 0.022
regulation of chromatin organization GO:1902275 57 0.022
appendage development GO:0048736 166 0.022
cellular response to hormone stimulus GO:0032870 150 0.021
b cell differentiation GO:0030183 78 0.021
sequestering of calcium ion GO:0051208 18 0.021
regulation of nucleoside metabolic process GO:0009118 130 0.021
small molecule biosynthetic process GO:0044283 132 0.021
meiotic nuclear division GO:0007126 115 0.021
mesoderm formation GO:0001707 62 0.021
divalent inorganic cation transport GO:0072511 178 0.021
mrna processing GO:0006397 63 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.021
gonad development GO:0008406 141 0.021
Worm
glycerolipid biosynthetic process GO:0045017 50 0.021
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.021
regulation of lymphocyte proliferation GO:0050670 117 0.021
embryonic placenta development GO:0001892 98 0.021
actomyosin structure organization GO:0031032 56 0.021
cell activation involved in immune response GO:0002263 126 0.021
response to growth factor GO:0070848 198 0.021
regulation of actin cytoskeleton organization GO:0032956 84 0.021
mechanoreceptor differentiation GO:0042490 67 0.020
guanosine containing compound metabolic process GO:1901068 144 0.020
t cell activation GO:0042110 289 0.020
regulation of organ morphogenesis GO:2000027 144 0.020
neuron migration GO:0001764 122 0.020
angiogenesis GO:0001525 201 0.020
mrna metabolic process GO:0016071 84 0.020
nose development GO:0043584 12 0.020
regulation of cell activation GO:0050865 289 0.020
mitochondrion distribution GO:0048311 4 0.020
oocyte maturation GO:0001556 18 0.020
defense response to bacterium GO:0042742 119 0.020
ear development GO:0043583 200 0.020
alcohol metabolic process GO:0006066 116 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.019
immunoglobulin mediated immune response GO:0016064 69 0.019
cardiac chamber morphogenesis GO:0003206 93 0.019
nuclear import GO:0051170 95 0.019
transmission of nerve impulse GO:0019226 76 0.019
inner ear receptor cell differentiation GO:0060113 61 0.019
regulation of chromosome organization GO:0033044 83 0.019
forebrain neuron differentiation GO:0021879 52 0.019
histone acetylation GO:0016573 41 0.019
positive regulation of organelle organization GO:0010638 128 0.019
muscle contraction GO:0006936 101 0.019
negative regulation of synapse assembly GO:0051964 3 0.019
ossification GO:0001503 216 0.019
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.019
development of primary male sexual characteristics GO:0046546 88 0.019
regulation of anatomical structure size GO:0090066 178 0.019
blood circulation GO:0008015 195 0.019
male sex differentiation GO:0046661 109 0.019
peptidyl serine modification GO:0018209 83 0.019
myeloid leukocyte differentiation GO:0002573 119 0.019
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.019
immunoglobulin production GO:0002377 73 0.018
regulation of adaptive immune response GO:0002819 90 0.018
negative regulation of transferase activity GO:0051348 85 0.018
regulation of nucleotide catabolic process GO:0030811 122 0.018
regulation of high voltage gated calcium channel activity GO:1901841 2 0.018
axon guidance GO:0007411 141 0.018
lens development in camera type eye GO:0002088 62 0.018
t cell differentiation GO:0030217 174 0.018
positive regulation of cellular catabolic process GO:0031331 148 0.018
negative regulation of cell activation GO:0050866 111 0.018
ear morphogenesis GO:0042471 118 0.018
positive regulation of nucleotide metabolic process GO:0045981 114 0.018
limb development GO:0060173 166 0.018
regulation of b cell proliferation GO:0030888 39 0.018
regulation of protein catabolic process GO:0042176 108 0.018
skeletal system morphogenesis GO:0048705 203 0.018
regulation of leukocyte proliferation GO:0070663 121 0.018
regulation of establishment of protein localization GO:0070201 181 0.017
nitrogen compound transport GO:0071705 271 0.017
regulation of rho protein signal transduction GO:0035023 71 0.017
sensory system development GO:0048880 3 0.017
positive regulation of cell development GO:0010720 237 0.017
Mouse
divalent metal ion transport GO:0070838 172 0.017
positive regulation of cytokine production GO:0001819 174 0.017
positive regulation of cell motility GO:2000147 116 0.017
positive regulation of immune effector process GO:0002699 107 0.017
regulation of ossification GO:0030278 112 0.017
internal protein amino acid acetylation GO:0006475 42 0.017
modification dependent macromolecule catabolic process GO:0043632 133 0.017
protein autophosphorylation GO:0046777 61 0.017
regulation of cellular response to stress GO:0080135 159 0.017
regulation of ion transport GO:0043269 215 0.017
response to radiation GO:0009314 165 0.017
endodermal cell fate specification GO:0001714 4 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.017
peptide transport GO:0015833 133 0.017
gene silencing GO:0016458 38 0.017
pallium development GO:0021543 120 0.017
positive regulation of cell cycle process GO:0090068 61 0.017
negative regulation of kinase activity GO:0033673 81 0.017
cranial nerve development GO:0021545 41 0.016
gtp catabolic process GO:0006184 143 0.016
positive regulation of cell cycle GO:0045787 92 0.016
lymphocyte activation involved in immune response GO:0002285 93 0.016
establishment of organelle localization GO:0051656 122 0.016
Worm
cellular divalent inorganic cation homeostasis GO:0072503 127 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
peptide hormone secretion GO:0030072 109 0.016
stem cell proliferation GO:0072089 117 0.016
response to peptide GO:1901652 136 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
ubiquitin dependent protein catabolic process GO:0006511 129 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.016
regulation of homeostatic process GO:0032844 182 0.016
cell differentiation involved in kidney development GO:0061005 33 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
positive regulation of protein phosphorylation GO:0001934 242 0.016
regulation of nuclear division GO:0051783 56 0.016
rna splicing GO:0008380 54 0.016
lipid biosynthetic process GO:0008610 179 0.016
mesodermal cell fate commitment GO:0001710 17 0.016
positive regulation of gtpase activity GO:0043547 85 0.016
connective tissue development GO:0061448 179 0.016
regulation of response to wounding GO:1903034 189 0.016
protein processing GO:0016485 163 0.015
regulation of synapse assembly GO:0051963 29 0.015
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.015
regulation of myeloid cell differentiation GO:0045637 96 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
limbic system development GO:0021761 72 0.015
organ growth GO:0035265 117 0.015
respiratory tube development GO:0030323 167 0.015
t cell proliferation GO:0042098 120 0.015
regulation of protein processing GO:0070613 96 0.015
cochlea development GO:0090102 35 0.015
cardiac muscle cell differentiation GO:0055007 69 0.015
positive regulation of neuron differentiation GO:0045666 141 0.015
Mouse
response to acid chemical GO:0001101 111 0.015
regulation of protein serine threonine kinase activity GO:0071900 157 0.015
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.015
feeding behavior GO:0007631 62 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
regulation of embryonic development GO:0045995 71 0.015
peptide secretion GO:0002790 114 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
female gamete generation GO:0007292 74 0.015
Worm
male sex determination GO:0030238 14 0.015
mesodermal cell differentiation GO:0048333 22 0.015
hindbrain development GO:0030902 128 0.015
male gonad development GO:0008584 88 0.015

Tle4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
organ system cancer DOID:0050686 0 0.019
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017