Mus musculus

45 known processes

Top2b

topoisomerase (DNA) II beta

(Aliases: D230016L12Rik,Top-2)

Top2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oocyte construction GO:0007308 2 0.215
regulation of cytoskeleton organization GO:0051493 122 0.162
gonad development GO:0008406 141 0.153
microtubule cytoskeleton organization GO:0000226 157 0.148
Fly
regulation of organelle organization GO:0033043 289 0.124
mitotic nuclear division GO:0007067 48 0.106
Fly
dna metabolic process GO:0006259 303 0.105
Human Yeast Mouse Fly
chromatin assembly or disassembly GO:0006333 16 0.099
Yeast
myeloid cell homeostasis GO:0002262 114 0.099
regulation of actin cytoskeleton organization GO:0032956 84 0.098
nuclear division GO:0000280 158 0.097
Yeast Fly
cell division GO:0051301 120 0.093
Mouse
peptidyl amino acid modification GO:0018193 336 0.086
regulation of cellular component biogenesis GO:0044087 181 0.082
cellular response to dna damage stimulus GO:0006974 207 0.081
Fly
oocyte axis specification GO:0007309 2 0.080
cell adhesion GO:0007155 329 0.071
regulation of chromosome organization GO:0033044 83 0.070
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.069
response to molecule of bacterial origin GO:0002237 143 0.066
histone modification GO:0016570 159 0.066
natural killer cell differentiation GO:0001779 21 0.063
chromosome segregation GO:0007059 48 0.061
Mouse Fly
regulation of neuron differentiation GO:0045664 281 0.060
regulation of cell activation GO:0050865 289 0.056
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.056
regulation of cell cycle GO:0051726 281 0.056
Yeast Fly
development of primary sexual characteristics GO:0045137 143 0.055
chemotaxis GO:0006935 247 0.054
Zebrafish
axon guidance GO:0007411 141 0.053
Zebrafish
germ cell development GO:0007281 185 0.052
gene silencing GO:0016458 38 0.052
Worm Fly
neuron projection guidance GO:0097485 141 0.052
Zebrafish
inorganic cation transmembrane transport GO:0098662 207 0.051
mrna metabolic process GO:0016071 84 0.050
positive regulation of neuron differentiation GO:0045666 141 0.047
neuron projection extension GO:1990138 64 0.046
rhythmic process GO:0048511 174 0.046
small gtpase mediated signal transduction GO:0007264 97 0.045
multi organism reproductive behavior GO:0044705 29 0.045
cellular nitrogen compound catabolic process GO:0044270 280 0.045
Human Yeast Mouse Fly
protein dna complex subunit organization GO:0071824 28 0.045
negative regulation of nervous system development GO:0051961 156 0.044
natural killer cell activation GO:0030101 44 0.043
regulation of cell substrate adhesion GO:0010810 73 0.042
regulation of cellular amino acid metabolic process GO:0006521 5 0.041
protein digestion GO:0044256 1 0.041
covalent chromatin modification GO:0016569 163 0.040
meiotic nuclear division GO:0007126 115 0.039
Yeast
organelle localization GO:0051640 179 0.038
Fly
spindle assembly involved in meiosis GO:0090306 4 0.038
regulation of mrna splicing via spliceosome GO:0048024 32 0.038
macromolecule catabolic process GO:0009057 281 0.038
multi multicellular organism process GO:0044706 109 0.037
positive regulation of cell development GO:0010720 237 0.036
endocytosis GO:0006897 168 0.036
regulation of apoptotic signaling pathway GO:2001233 197 0.035
regulation of mitotic sister chromatid segregation GO:0033047 12 0.033
cell growth GO:0016049 130 0.033
muscle cell differentiation GO:0042692 261 0.033
nucleus localization GO:0051647 20 0.032
protein polymerization GO:0051258 57 0.032
mitotic cell cycle GO:0000278 195 0.032
Yeast Fly
cellular lipid metabolic process GO:0044255 323 0.032
organic hydroxy compound metabolic process GO:1901615 203 0.032
metaphase plate congression GO:0051310 2 0.031
Fly
regulation of sister chromatid segregation GO:0033045 13 0.031
regulation of cell cycle process GO:0010564 160 0.031
Yeast Fly
response to lipopolysaccharide GO:0032496 128 0.031
microtubule nucleation GO:0007020 2 0.030
protein oligomerization GO:0051259 67 0.030
regulation of neuron projection development GO:0010975 169 0.030
male gamete generation GO:0048232 285 0.029
regulation of cellular catabolic process GO:0031329 242 0.029
organophosphate catabolic process GO:0046434 232 0.029
Human Yeast Mouse Fly
ras protein signal transduction GO:0007265 77 0.028
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.028
developmental growth involved in morphogenesis GO:0060560 138 0.028
establishment or maintenance of cell polarity GO:0007163 86 0.028
protein ubiquitination GO:0016567 171 0.028
regulation of neural precursor cell proliferation GO:2000177 70 0.028
negative regulation of protein depolymerization GO:1901880 21 0.028
multicellular organismal macromolecule catabolic process GO:0044266 1 0.028
lymphocyte differentiation GO:0030098 242 0.027
maintenance of location GO:0051235 89 0.027
body morphogenesis GO:0010171 45 0.027
actin filament organization GO:0007015 113 0.027
aromatic compound catabolic process GO:0019439 286 0.026
Human Yeast Mouse Fly
regulation of cellular ketone metabolic process GO:0010565 66 0.026
epithelial cell development GO:0002064 159 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
positive regulation of organelle organization GO:0010638 128 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
development of primary female sexual characteristics GO:0046545 73 0.025
nucleoside phosphate catabolic process GO:1901292 222 0.025
Human Yeast Mouse Fly
t cell activation GO:0042110 289 0.025
erythrocyte differentiation GO:0030218 88 0.025
female gamete generation GO:0007292 74 0.025
mitotic sister chromatid cohesion GO:0007064 1 0.025
microtubule based process GO:0007017 236 0.025
Fly
stem cell differentiation GO:0048863 268 0.025
ovarian follicle development GO:0001541 40 0.025
negative regulation of chromatin silencing GO:0031936 1 0.024
regulation of actin polymerization or depolymerization GO:0008064 45 0.024
mitochondrion distribution GO:0048311 4 0.024
mitotic sister chromatid segregation GO:0000070 14 0.024
Fly
cellular amino acid metabolic process GO:0006520 103 0.024
compound eye development GO:0048749 1 0.024
negative regulation of synapse assembly GO:0051964 3 0.024
response to insulin GO:0032868 100 0.024
epithelial cell proliferation GO:0050673 174 0.023
organic cyclic compound catabolic process GO:1901361 295 0.023
Human Yeast Mouse Fly
histone h3 k4 trimethylation GO:0080182 5 0.023
neural tube development GO:0021915 160 0.022
glycosyl compound metabolic process GO:1901657 246 0.022
Human Yeast Mouse Fly
blastocyst development GO:0001824 80 0.022
ossification GO:0001503 216 0.022
cellular amine metabolic process GO:0044106 44 0.022
positive regulation of gtpase activity GO:0043547 85 0.022
cellular ketone metabolic process GO:0042180 84 0.022
regulation of b cell activation GO:0050864 81 0.021
circulatory system process GO:0003013 197 0.021
nitrogen compound transport GO:0071705 271 0.021
spermatogenesis GO:0007283 284 0.021
centrosome cycle GO:0007098 23 0.021
regulation of system process GO:0044057 200 0.020
spindle assembly involved in female meiosis i GO:0007057 2 0.020
intracellular mrna localization GO:0008298 4 0.020
regulation of mapk cascade GO:0043408 248 0.020
positive regulation of mapk cascade GO:0043410 170 0.020
regulation of epithelial cell proliferation GO:0050678 141 0.020
microtubule polymerization or depolymerization GO:0031109 26 0.020
positive regulation of gtp catabolic process GO:0033126 85 0.020
regulation of cellular component size GO:0032535 121 0.020
regulation of protein localization GO:0032880 231 0.020
leukocyte differentiation GO:0002521 342 0.020
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.019
digestive tract development GO:0048565 190 0.019
leukocyte migration GO:0050900 124 0.019
chromatin organization GO:0006325 206 0.019
Yeast
regulation of cellular response to stress GO:0080135 159 0.019
mrna processing GO:0006397 63 0.019
cytokine production GO:0001816 319 0.019
cellular response to insulin stimulus GO:0032869 78 0.019
female gonad development GO:0008585 71 0.019
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
Human Yeast Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
female sex differentiation GO:0046660 84 0.018
regulation of rna splicing GO:0043484 37 0.018
chromatin modification GO:0016568 187 0.018
Yeast
positive regulation of protein phosphorylation GO:0001934 242 0.017
leukocyte proliferation GO:0070661 172 0.017
regulation of b cell differentiation GO:0045577 23 0.017
peptidyl lysine trimethylation GO:0018023 12 0.017
cell fate commitment GO:0045165 210 0.017
regulation of ras protein signal transduction GO:0046578 114 0.017
regulation of neurotransmitter levels GO:0001505 87 0.017
protein catabolic process GO:0030163 221 0.017
mrna localization resulting in posttranscriptional regulation of gene expression GO:0010609 2 0.017
peptidyl lysine modification GO:0018205 77 0.017
regulation of mrna processing GO:0050684 41 0.017
cell matrix adhesion GO:0007160 68 0.017
phagocytosis GO:0006909 66 0.016
establishment of organelle localization GO:0051656 122 0.016
Fly
negative regulation of rna splicing GO:0033119 12 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
Human Yeast Mouse Fly
mapk cascade GO:0000165 281 0.016
dendrite development GO:0016358 115 0.016
regulation of leukocyte differentiation GO:1902105 159 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
embryonic limb morphogenesis GO:0030326 126 0.016
response to organonitrogen compound GO:0010243 246 0.016
peyer s patch development GO:0048541 12 0.016
ribonucleoprotein complex subunit organization GO:0071826 28 0.016
single organism cell adhesion GO:0098602 156 0.016
mrna transport GO:0051028 13 0.015
mesoderm development GO:0007498 100 0.015
negative regulation of immune system process GO:0002683 209 0.015
negative regulation of gene expression epigenetic GO:0045814 15 0.015
Fly
t cell differentiation GO:0030217 174 0.015
homeostasis of number of cells GO:0048872 210 0.015
positive regulation of cell cycle process GO:0090068 61 0.015
blood circulation GO:0008015 195 0.015
regulation of mitotic cell cycle GO:0007346 126 0.015
Yeast Fly
positive regulation of protein modification process GO:0031401 299 0.015
organelle assembly GO:0070925 177 0.015
b cell proliferation GO:0042100 53 0.015
photoreceptor cell development GO:0042461 40 0.015
positive regulation of nervous system development GO:0051962 221 0.015
regulation of mitosis GO:0007088 29 0.014
positive regulation of glucose metabolic process GO:0010907 21 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
megakaryocyte differentiation GO:0030219 26 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.014
cellular polysaccharide metabolic process GO:0044264 38 0.014
cation transmembrane transport GO:0098655 266 0.014
negative regulation of organelle organization GO:0010639 90 0.014
neuroblast differentiation GO:0014016 2 0.014
developmental maturation GO:0021700 193 0.014
regulation of cytokine production GO:0001817 266 0.014
response to peptide hormone GO:0043434 127 0.014
regulation of chromosome segregation GO:0051983 21 0.014
regulation of leukocyte proliferation GO:0070663 121 0.013
lateral mesodermal cell fate commitment GO:0048372 2 0.013
actin polymerization or depolymerization GO:0008154 54 0.013
regulation of microtubule cytoskeleton organization GO:0070507 37 0.013
blastocyst formation GO:0001825 33 0.013
oocyte differentiation GO:0009994 35 0.013
formation of primary germ layer GO:0001704 77 0.013
ovulation cycle GO:0042698 59 0.013
liver development GO:0001889 66 0.013
centrosome organization GO:0051297 26 0.013
nucleoside catabolic process GO:0009164 206 0.013
Human Yeast Mouse Fly
meiotic cell cycle process GO:1903046 77 0.013
Yeast
spindle assembly involved in female meiosis GO:0007056 3 0.013
sperm individualization GO:0007291 1 0.013
multicellular organismal reproductive behavior GO:0033057 23 0.013
dna dependent dna replication GO:0006261 24 0.013
Yeast
oocyte development GO:0048599 33 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
Human Yeast Mouse Fly
hindbrain development GO:0030902 128 0.013
apoptotic signaling pathway GO:0097190 306 0.013
spermatid development GO:0007286 108 0.013
b cell differentiation GO:0030183 78 0.013
regulation of cell growth GO:0001558 91 0.012
regulation of cellular amine metabolic process GO:0033238 20 0.012
stem cell maintenance GO:0019827 130 0.012
mitotic cytokinesis GO:0000281 4 0.012
response to growth factor GO:0070848 198 0.012
protein polyubiquitination GO:0000209 33 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.012
mrna destabilization GO:0061157 4 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
Human Yeast Mouse Fly
calcium ion transport GO:0006816 159 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
regulation of actin filament based process GO:0032970 99 0.012
cellularization GO:0007349 1 0.012
regulation of cell shape GO:0008360 39 0.012
protein localization to organelle GO:0033365 185 0.012
regulation of protein depolymerization GO:1901879 26 0.012
cellular protein catabolic process GO:0044257 155 0.012
microtubule organizing center organization GO:0031023 28 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
mitotic sister chromatid separation GO:0051306 9 0.011
positive regulation of growth GO:0045927 104 0.011
digestive system development GO:0055123 200 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
Worm
macromolecule methylation GO:0043414 120 0.011
purine ribonucleoside catabolic process GO:0046130 205 0.011
Human Yeast Mouse Fly
purine ribonucleotide catabolic process GO:0009154 208 0.011
Human Yeast Mouse Fly
positive regulation of lymphocyte activation GO:0051251 140 0.011
cerebellum development GO:0021549 77 0.011
negative regulation of t cell proliferation GO:0042130 38 0.011
ribonucleotide catabolic process GO:0009261 208 0.011
Human Yeast Mouse Fly
cellular macromolecule catabolic process GO:0044265 206 0.011
regulation of rna stability GO:0043487 26 0.011
neural precursor cell proliferation GO:0061351 121 0.011
positive regulation of chromosome segregation GO:0051984 4 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
regulation of cellular response to hypoxia GO:1900037 2 0.011
regulation of t cell proliferation GO:0042129 92 0.011
digestive tract morphogenesis GO:0048546 147 0.011
myeloid cell differentiation GO:0030099 233 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
Human Yeast Mouse Fly
circadian rhythm GO:0007623 114 0.011
regulation of cell projection organization GO:0031344 206 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
Human Yeast Mouse Fly
multi organism behavior GO:0051705 62 0.011
regulation of translation GO:0006417 71 0.010
protein acylation GO:0043543 64 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
positive regulation of cell activation GO:0050867 158 0.010
leukocyte tethering or rolling GO:0050901 3 0.010
positive regulation of transferase activity GO:0051347 167 0.010
meiotic spindle organization GO:0000212 9 0.010
cation transport GO:0006812 399 0.010
regulation of cardiac cell fate specification GO:2000043 1 0.010
negative regulation of cell activation GO:0050866 111 0.010
negative regulation of hepatocyte proliferation GO:2000346 3 0.010
histone h3 k4 methylation GO:0051568 23 0.010

Top2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.245
nervous system disease DOID:863 0 0.245
central nervous system disease DOID:331 0 0.115
neurodegenerative disease DOID:1289 0 0.075
sensory system disease DOID:0050155 0 0.058
eye and adnexa disease DOID:1492 0 0.038
eye disease DOID:5614 0 0.023
x linked disease DOID:0050735 0 0.010
endocrine gland cancer DOID:170 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010