Mus musculus

16 known processes

Uba1

ubiquitin-like modifier activating enzyme 1

(Aliases: Ube1x,A1S9,AA989744,Ube-1,Sbx)

Uba1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.090
cytoplasmic transport GO:0016482 234 0.076
nucleobase containing small molecule metabolic process GO:0055086 352 0.075
endocytosis GO:0006897 168 0.074
protein complex disassembly GO:0043241 40 0.060
protein localization to organelle GO:0033365 185 0.057
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.055
protein modification by small protein conjugation GO:0032446 187 0.052
nucleoside phosphate metabolic process GO:0006753 338 0.052
maintenance of location GO:0051235 89 0.051
nuclear transport GO:0051169 139 0.049
macromolecular complex disassembly GO:0032984 43 0.049
ribose phosphate metabolic process GO:0019693 291 0.048
nucleotide metabolic process GO:0009117 332 0.048
membrane organization GO:0061024 245 0.048
intracellular protein transport GO:0006886 204 0.047
positive regulation of protein modification process GO:0031401 299 0.044
cation transport GO:0006812 399 0.044
mrna metabolic process GO:0016071 84 0.043
glycosyl compound metabolic process GO:1901657 246 0.043
posttranscriptional regulation of gene expression GO:0010608 155 0.042
response to organonitrogen compound GO:0010243 246 0.042
cellular ketone metabolic process GO:0042180 84 0.041
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.041
nucleoside triphosphate catabolic process GO:0009143 205 0.041
cellular amine metabolic process GO:0044106 44 0.040
oocyte axis specification GO:0007309 2 0.039
regulation of cellular ketone metabolic process GO:0010565 66 0.039
ras protein signal transduction GO:0007265 77 0.039
purine containing compound metabolic process GO:0072521 311 0.038
nucleocytoplasmic transport GO:0006913 139 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
germ cell development GO:0007281 185 0.037
oxidation reduction process GO:0055114 342 0.037
macromolecule catabolic process GO:0009057 281 0.036
ribonucleotide metabolic process GO:0009259 291 0.036
organonitrogen compound catabolic process GO:1901565 264 0.036
organophosphate catabolic process GO:0046434 232 0.036
regulation of neuron differentiation GO:0045664 281 0.035
oocyte construction GO:0007308 2 0.035
aromatic compound catabolic process GO:0019439 286 0.035
regulation of protein localization GO:0032880 231 0.034
regulation of cellular amino acid metabolic process GO:0006521 5 0.034
regulation of transferase activity GO:0051338 263 0.034
ribonucleotide catabolic process GO:0009261 208 0.034
cellular protein complex disassembly GO:0043624 36 0.034
negative regulation of synapse assembly GO:0051964 3 0.034
negative regulation of molecular function GO:0044092 258 0.033
pole plasm assembly GO:0007315 2 0.033
endomembrane system organization GO:0010256 147 0.032
protein import into nucleus GO:0006606 95 0.032
negative regulation of protein metabolic process GO:0051248 282 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
small gtpase mediated signal transduction GO:0007264 97 0.031
nuclear import GO:0051170 95 0.031
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.031
mrna processing GO:0006397 63 0.030
cellular response to hormone stimulus GO:0032870 150 0.030
cellular nitrogen compound catabolic process GO:0044270 280 0.030
retrograde transport endosome to golgi GO:0042147 2 0.030
rna splicing GO:0008380 54 0.029
axonogenesis GO:0007409 274 0.029
amine metabolic process GO:0009308 45 0.029
nucleoside metabolic process GO:0009116 246 0.029
purine nucleoside metabolic process GO:0042278 241 0.028
mrna splicing via spliceosome GO:0000398 43 0.028
carbohydrate metabolic process GO:0005975 230 0.028
negative regulation of cellular component organization GO:0051129 194 0.028
developmental maturation GO:0021700 193 0.028
ribonucleoside triphosphate catabolic process GO:0009203 199 0.027
oocyte anterior posterior axis specification GO:0007314 2 0.027
protein modification by small protein conjugation or removal GO:0070647 207 0.027
protein localization to nucleus GO:0034504 121 0.027
regulation of cellular component biogenesis GO:0044087 181 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.027
nucleotide catabolic process GO:0009166 217 0.026
nucleoside phosphate catabolic process GO:1901292 222 0.026
inclusion body assembly GO:0070841 3 0.026
molting cycle GO:0042303 90 0.026
synaptic transmission GO:0007268 329 0.026
ribonucleoside metabolic process GO:0009119 245 0.026
regulation of organelle organization GO:0033043 289 0.026
covalent chromatin modification GO:0016569 163 0.026
purine containing compound catabolic process GO:0072523 213 0.026
nucleoside catabolic process GO:0009164 206 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
protein import GO:0017038 101 0.025
regulation of proteolysis GO:0030162 164 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
lipid localization GO:0010876 126 0.025
purine ribonucleotide metabolic process GO:0009150 290 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
chromatin modification GO:0016568 187 0.025
nucleoside triphosphate metabolic process GO:0009141 230 0.025
cellular lipid metabolic process GO:0044255 323 0.024
positive regulation of protein phosphorylation GO:0001934 242 0.024
regulation of peptidase activity GO:0052547 96 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
negative regulation of protein depolymerization GO:1901880 21 0.024
regulation of cell cycle GO:0051726 281 0.024
skin development GO:0043588 220 0.024
positive regulation of cell death GO:0010942 224 0.024
translation GO:0006412 93 0.024
autophagy GO:0006914 45 0.023
protein maturation GO:0051604 176 0.023
regulation of hydrolase activity GO:0051336 246 0.023
single organism nuclear import GO:1902593 95 0.023
ribonucleoside triphosphate metabolic process GO:0009199 220 0.023
protein ubiquitination GO:0016567 171 0.023
peptidyl amino acid modification GO:0018193 336 0.023
spermatogenesis GO:0007283 284 0.023
heterocycle catabolic process GO:0046700 280 0.023
protein catabolic process GO:0030163 221 0.023
protein targeting GO:0006605 143 0.023
cell type specific apoptotic process GO:0097285 268 0.023
mitotic cell cycle GO:0000278 195 0.023
regulation of kinase activity GO:0043549 249 0.023
response to peptide hormone GO:0043434 127 0.023
organelle assembly GO:0070925 177 0.023
protein processing GO:0016485 163 0.022
positive regulation of cell development GO:0010720 237 0.022
regulation of protein kinase activity GO:0045859 232 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
regulation of cellular amine metabolic process GO:0033238 20 0.022
regulation of mapk cascade GO:0043408 248 0.022
microtubule cytoskeleton organization GO:0000226 157 0.022
circadian rhythm GO:0007623 114 0.022
rna interference GO:0016246 2 0.022
development of primary sexual characteristics GO:0045137 143 0.022
cellular carbohydrate metabolic process GO:0044262 119 0.022
epithelial tube morphogenesis GO:0060562 303 0.022
response to extracellular stimulus GO:0009991 127 0.022
regulation of vesicle mediated transport GO:0060627 139 0.022
rhythmic process GO:0048511 174 0.022
rna processing GO:0006396 105 0.022
regulation of endocytosis GO:0030100 69 0.021
synapse organization GO:0050808 125 0.021
response to acid chemical GO:0001101 111 0.021
carbohydrate biosynthetic process GO:0016051 74 0.021
ribonucleoside catabolic process GO:0042454 206 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
cellular homeostasis GO:0019725 240 0.021
mapk cascade GO:0000165 281 0.021
regulation of intracellular transport GO:0032386 159 0.021
male gamete generation GO:0048232 285 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
cell growth GO:0016049 130 0.021
negative regulation of cell size GO:0045792 3 0.021
microtubule based process GO:0007017 236 0.020
response to peptide GO:1901652 136 0.020
regulation of cell motility GO:2000145 236 0.020
purine ribonucleoside catabolic process GO:0046130 205 0.020
protein localization to membrane GO:0072657 108 0.020
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.020
purine nucleoside triphosphate catabolic process GO:0009146 203 0.020
nitrogen compound transport GO:0071705 271 0.020
regulation of cell migration GO:0030334 219 0.020
regulation of anatomical structure size GO:0090066 178 0.020
regulation of nucleotide metabolic process GO:0006140 169 0.020
regulation of cell projection organization GO:0031344 206 0.020
cellular response to organonitrogen compound GO:0071417 145 0.020
positive regulation of organelle organization GO:0010638 128 0.020
regulation of cellular catabolic process GO:0031329 242 0.019
ribonucleoprotein complex subunit organization GO:0071826 28 0.019
modification dependent protein catabolic process GO:0019941 133 0.019
ameboidal type cell migration GO:0001667 128 0.019
purine nucleoside catabolic process GO:0006152 205 0.019
rna splicing via transesterification reactions GO:0000375 43 0.019
receptor mediated endocytosis GO:0006898 51 0.019
cellular protein catabolic process GO:0044257 155 0.019
organelle fission GO:0048285 170 0.019
carbohydrate derivative catabolic process GO:1901136 231 0.019
regulation of cell growth GO:0001558 91 0.019
regulation of secretion by cell GO:1903530 249 0.019
muscle cell differentiation GO:0042692 261 0.019
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.019
glycosyl compound catabolic process GO:1901658 206 0.019
positive regulation of hydrolase activity GO:0051345 148 0.019
ion transmembrane transport GO:0034220 361 0.019
positive regulation of nucleotide metabolic process GO:0045981 114 0.019
apoptotic signaling pathway GO:0097190 306 0.019
regulation of clathrin mediated endocytosis GO:2000369 4 0.019
hexose metabolic process GO:0019318 98 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
cellular response to external stimulus GO:0071496 88 0.018
regulation of translation GO:0006417 71 0.018
fatty acid metabolic process GO:0006631 121 0.018
response to insulin GO:0032868 100 0.018
regulation of endopeptidase activity GO:0052548 89 0.018
regulation of hormone levels GO:0010817 211 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.018
response to nutrient levels GO:0031667 109 0.018
establishment of protein localization to membrane GO:0090150 54 0.018
locomotory behavior GO:0007626 195 0.018
negative regulation of nervous system development GO:0051961 156 0.018
monocarboxylic acid metabolic process GO:0032787 191 0.017
cellular protein complex assembly GO:0043623 116 0.017
regulation of cellular response to stress GO:0080135 159 0.017
regulation of neuron projection development GO:0010975 169 0.017
intracellular mrna localization GO:0008298 4 0.017
positive regulation of kinase activity GO:0033674 155 0.017
transmembrane transport GO:0055085 412 0.017
regulation of cell activation GO:0050865 289 0.017
response to light stimulus GO:0009416 135 0.017
stem cell differentiation GO:0048863 268 0.017
regulation of protein transport GO:0051223 163 0.017
protein oligomerization GO:0051259 67 0.017
gland development GO:0048732 330 0.017
response to radiation GO:0009314 165 0.017
organelle localization GO:0051640 179 0.016
asymmetric neuroblast division GO:0055059 1 0.016
histone modification GO:0016570 159 0.016
rho protein signal transduction GO:0007266 32 0.016
cellular response to lipid GO:0071396 145 0.016
positive regulation of nervous system development GO:0051962 221 0.016
gene silencing by rna GO:0031047 19 0.016
sensory perception GO:0007600 245 0.016
respiratory system development GO:0060541 190 0.016
lipid biosynthetic process GO:0008610 179 0.016
cellular response to peptide hormone stimulus GO:0071375 92 0.016
regulation of secretion GO:0051046 274 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
cellular chemical homeostasis GO:0055082 215 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
cellular response to peptide GO:1901653 92 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
protein secretion GO:0009306 111 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
cell fate commitment GO:0045165 210 0.016
inflammatory response GO:0006954 244 0.016
chromatin organization GO:0006325 206 0.015
cognition GO:0050890 149 0.015
blastocyst development GO:0001824 80 0.015
regulation of protein serine threonine kinase activity GO:0071900 157 0.015
cation transmembrane transport GO:0098655 266 0.015
meiotic nuclear division GO:0007126 115 0.015
adult behavior GO:0030534 135 0.015
lipid transport GO:0006869 98 0.015
striated muscle tissue development GO:0014706 293 0.015
negative regulation of growth GO:0045926 99 0.015
immune effector process GO:0002252 321 0.014
epidermis development GO:0008544 187 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
neuron migration GO:0001764 122 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
spermatid development GO:0007286 108 0.014
lateral line system development GO:0048925 1 0.014
guanosine containing compound metabolic process GO:1901068 144 0.014
wnt signaling pathway GO:0016055 188 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
sulfur compound metabolic process GO:0006790 100 0.014
regulation of protein targeting GO:1903533 61 0.014
dephosphorylation GO:0016311 129 0.014
monosaccharide metabolic process GO:0005996 106 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.014
regulation of ion transport GO:0043269 215 0.014
negative regulation of organelle organization GO:0010639 90 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
chemotaxis GO:0006935 247 0.014
lateral inhibition GO:0046331 1 0.014
regulation of glucose metabolic process GO:0010906 60 0.014
epithelial cell development GO:0002064 159 0.014
protein depolymerization GO:0051261 34 0.014
glucose metabolic process GO:0006006 92 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.013
response to inorganic substance GO:0010035 96 0.013
positive regulation of nucleotide catabolic process GO:0030813 88 0.013
olfactory learning GO:0008355 2 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
Human
cellular response to cytokine stimulus GO:0071345 189 0.013
maternal determination of anterior posterior axis embryo GO:0008358 2 0.013
fat cell differentiation GO:0045444 160 0.013
organic anion transport GO:0015711 137 0.013
positive regulation of transferase activity GO:0051347 167 0.013
adult locomotory behavior GO:0008344 91 0.013
cation homeostasis GO:0055080 212 0.013
response to organic cyclic compound GO:0014070 198 0.013
regulation of cysteine type endopeptidase activity GO:2000116 65 0.013
anion transport GO:0006820 177 0.013
negative regulation of protein modification process GO:0031400 163 0.013
regulation of mrna metabolic process GO:1903311 43 0.013
calcium ion homeostasis GO:0055074 127 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
forebrain development GO:0030900 302 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
dna metabolic process GO:0006259 303 0.013
regulation of ras gtpase activity GO:0032318 88 0.013
regulation of apoptotic signaling pathway GO:2001233 197 0.013
multicellular organismal homeostasis GO:0048871 164 0.013
positive regulation of protein transport GO:0051222 93 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.012
neural tube development GO:0021915 160 0.012
stem cell development GO:0048864 219 0.012
cell maturation GO:0048469 127 0.012
response to amino acid GO:0043200 37 0.012
regulation of multi organism process GO:0043900 111 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
mitotic nuclear division GO:0007067 48 0.012
neural tube formation GO:0001841 108 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
protein localization to plasma membrane GO:0072659 57 0.012
plasma membrane organization GO:0007009 90 0.012
blood circulation GO:0008015 195 0.012
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
sequestering of calcium ion GO:0051208 18 0.012
dendrite development GO:0016358 115 0.012
cellular amide metabolic process GO:0043603 58 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
transmission of nerve impulse GO:0019226 76 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
regulation of protein maturation GO:1903317 96 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
regulation of nucleoside metabolic process GO:0009118 130 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.012
metal ion homeostasis GO:0055065 189 0.012
gonad development GO:0008406 141 0.012
mitochondrion organization GO:0007005 134 0.011
female gamete generation GO:0007292 74 0.011
telencephalon development GO:0021537 186 0.011
response to growth factor GO:0070848 198 0.011
multicellular organism growth GO:0035264 161 0.011
compound eye development GO:0048749 1 0.011
mitotic cell cycle process GO:1903047 159 0.011
response to oxygen levels GO:0070482 62 0.011
negative regulation of protein maturation GO:1903318 79 0.011
small molecule catabolic process GO:0044282 71 0.011
cell division GO:0051301 120 0.011
potassium ion transport GO:0006813 52 0.011
camera type eye development GO:0043010 266 0.011
cell adhesion GO:0007155 329 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
defense response to other organism GO:0098542 197 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
glucose homeostasis GO:0042593 128 0.011
negative regulation of cell development GO:0010721 169 0.011
spermatid differentiation GO:0048515 115 0.011
positive regulation of necrotic cell death GO:0010940 1 0.011
inorganic ion transmembrane transport GO:0098660 234 0.011
nuclear export GO:0051168 34 0.011
asymmetric stem cell division GO:0098722 3 0.011
hatching GO:0035188 4 0.011
skeletal muscle organ development GO:0060538 163 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.011
extracellular matrix organization GO:0030198 147 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
regulation of cellular component size GO:0032535 121 0.011
thermosensory behavior GO:0040040 1 0.011
carbohydrate homeostasis GO:0033500 128 0.011
innate immune response GO:0045087 157 0.011
nucleobase containing compound transport GO:0015931 27 0.011
regulation of system process GO:0044057 200 0.011
phagocytosis GO:0006909 66 0.011
lymphocyte differentiation GO:0030098 242 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
myosin filament assembly GO:0031034 2 0.011
regulation of membrane potential GO:0042391 192 0.011
synapse assembly GO:0007416 56 0.010
regulation of map kinase activity GO:0043405 120 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
cellular response to extracellular stimulus GO:0031668 81 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.010
nucleoside monophosphate metabolic process GO:0009123 85 0.010
localization within membrane GO:0051668 4 0.010
cellular response to insulin stimulus GO:0032869 78 0.010
nuclear division GO:0000280 158 0.010
learning or memory GO:0007611 148 0.010
digestive system development GO:0055123 200 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
regulation of carbohydrate metabolic process GO:0006109 75 0.010
positive regulation of proteolysis GO:0045862 85 0.010
response to temperature stimulus GO:0009266 55 0.010
oogenesis GO:0048477 56 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
defense response to bacterium GO:0042742 119 0.010
organic acid catabolic process GO:0016054 51 0.010
carbohydrate transport GO:0008643 62 0.010
regulation of synaptic plasticity GO:0048167 87 0.010
urogenital system development GO:0001655 261 0.010
positive regulation of secretion by cell GO:1903532 114 0.010
multicellular organismal signaling GO:0035637 91 0.010

Uba1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.067
nervous system disease DOID:863 0 0.067
sensory system disease DOID:0050155 0 0.027
eye and adnexa disease DOID:1492 0 0.027
neuropathy DOID:870 0 0.025
central nervous system disease DOID:331 0 0.022
neurodegenerative disease DOID:1289 0 0.018
retinal disease DOID:5679 0 0.016
retinal degeneration DOID:8466 0 0.016
retinitis pigmentosa DOID:10584 0 0.016
eye disease DOID:5614 0 0.016
disease of metabolism DOID:0014667 0 0.015
neuromuscular disease DOID:440 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
disease of cellular proliferation DOID:14566 0 0.010