Mus musculus

129 known processes

Dnmt3b

DNA methyltransferase 3B

(Aliases: MGC124407)

Dnmt3b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna methylation involved in gamete generation GO:0043046 15 1.000
Mouse
chorion development GO:0060717 7 0.999
Mouse
dna hypermethylation GO:0044026 3 0.998
Mouse
dna methylation involved in embryo development GO:0043045 6 0.986
dna modification GO:0006304 50 0.983
macromolecule methylation GO:0043414 120 0.981
dna methylation GO:0006306 43 0.977
methylation dependent chromatin silencing GO:0006346 6 0.951
methylation GO:0032259 134 0.945
response to amino acid GO:0043200 37 0.877
cellular response to amino acid stimulus GO:0071230 29 0.838
dna methylation on cytosine GO:0032776 5 0.816
dna alkylation GO:0006305 43 0.808
changes to dna methylation involved in embryo development GO:1901538 6 0.805
regulation of gene expression by genetic imprinting GO:0006349 15 0.767
chromatin modification GO:0016568 187 0.766
dosage compensation by inactivation of x chromosome GO:0009048 7 0.750
hypermethylation of cpg island GO:0044027 3 0.750
Mouse
chromatin silencing GO:0006342 15 0.632
cellular response to acid chemical GO:0071229 68 0.575
dna metabolic process GO:0006259 303 0.529
regulation of dna methylation GO:0044030 12 0.524
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.505
gene silencing GO:0016458 38 0.482
response to acid chemical GO:0001101 111 0.422
genetic imprinting GO:0071514 27 0.406
covalent chromatin modification GO:0016569 163 0.386
spermatogenesis GO:0007283 284 0.367
Mouse
response to organonitrogen compound GO:0010243 246 0.333
male gamete generation GO:0048232 285 0.197
Mouse
chromatin organization GO:0006325 206 0.180
protein methylation GO:0006479 81 0.174
Human Zebrafish
protein complex localization GO:0031503 19 0.166
negative regulation of gene expression epigenetic GO:0045814 15 0.158
intrinsic apoptotic signaling pathway GO:0097193 132 0.140
apoptotic signaling pathway GO:0097190 306 0.122
placenta development GO:0001890 140 0.122
Mouse
protein alkylation GO:0008213 81 0.120
Human Zebrafish
regulation of apoptotic signaling pathway GO:2001233 197 0.118
negative regulation of intracellular signal transduction GO:1902532 167 0.099
histone methylation GO:0016571 71 0.095
Human Zebrafish
leukocyte proliferation GO:0070661 172 0.082
histone lysine methylation GO:0034968 50 0.074
Human Zebrafish
heterochromatin organization GO:0070828 4 0.073
histone h3 k9 methylation GO:0051567 17 0.071
Human Zebrafish
urogenital system development GO:0001655 261 0.070
chromatin remodeling at centromere GO:0031055 2 0.058
nucleoside phosphate metabolic process GO:0006753 338 0.057
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.049
protein dna complex subunit organization GO:0071824 28 0.049
cellular response to dna damage stimulus GO:0006974 207 0.049
cellular macromolecule catabolic process GO:0044265 206 0.049
purine nucleoside triphosphate catabolic process GO:0009146 203 0.047
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.043
b cell activation GO:0042113 161 0.042
regulation of proteolysis GO:0030162 164 0.042
purine ribonucleotide metabolic process GO:0009150 290 0.041
ribose phosphate metabolic process GO:0019693 291 0.041
lymphocyte proliferation GO:0046651 164 0.040
glycosyl compound metabolic process GO:1901657 246 0.039
reactive oxygen species metabolic process GO:0072593 84 0.038
negative regulation of protein metabolic process GO:0051248 282 0.038
Human
ribonucleoside catabolic process GO:0042454 206 0.037
nucleoside metabolic process GO:0009116 246 0.037
centromere complex assembly GO:0034508 3 0.036
leukocyte differentiation GO:0002521 342 0.036
germ cell development GO:0007281 185 0.033
oxidation reduction process GO:0055114 342 0.033
cellular amino acid metabolic process GO:0006520 103 0.033
ribonucleoside triphosphate metabolic process GO:0009199 220 0.033
nucleoside triphosphate metabolic process GO:0009141 230 0.033
purine ribonucleoside metabolic process GO:0046128 241 0.033
positive regulation of cell death GO:0010942 224 0.033
chromatin assembly or disassembly GO:0006333 16 0.032
carbohydrate derivative catabolic process GO:1901136 231 0.032
synapsis GO:0007129 34 0.032
positive regulation of programmed cell death GO:0043068 218 0.032
blastocyst development GO:0001824 80 0.031
meiosis i GO:0007127 60 0.031
negative regulation of cell proliferation GO:0008285 296 0.030
nucleotide catabolic process GO:0009166 217 0.030
nucleobase containing small molecule metabolic process GO:0055086 352 0.030
muscle cell differentiation GO:0042692 261 0.030
ribonucleotide metabolic process GO:0009259 291 0.029
purine nucleoside metabolic process GO:0042278 241 0.029
purine nucleotide metabolic process GO:0006163 302 0.029
cellular amine metabolic process GO:0044106 44 0.029
mitotic recombination GO:0006312 3 0.029
negative regulation of protein processing GO:0010955 79 0.029
regulation of ossification GO:0030278 112 0.029
purine nucleoside triphosphate metabolic process GO:0009144 226 0.029
negative regulation of cellular component organization GO:0051129 194 0.028
Human
protein processing GO:0016485 163 0.028
maintenance of location GO:0051235 89 0.028
organic hydroxy compound metabolic process GO:1901615 203 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
regulation of cellular ketone metabolic process GO:0010565 66 0.028
cellular ketone metabolic process GO:0042180 84 0.028
macromolecule catabolic process GO:0009057 281 0.028
negative regulation of apoptotic signaling pathway GO:2001234 104 0.028
aromatic compound catabolic process GO:0019439 286 0.028
nucleoside catabolic process GO:0009164 206 0.027
ribonucleotide catabolic process GO:0009261 208 0.026
purine nucleoside catabolic process GO:0006152 205 0.026
hematopoietic progenitor cell differentiation GO:0002244 143 0.025
heterocycle catabolic process GO:0046700 280 0.025
immune effector process GO:0002252 321 0.025
negative regulation of osteoblast proliferation GO:0033689 4 0.025
ossification GO:0001503 216 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.024
regulation of reactive oxygen species metabolic process GO:2000377 40 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
response to radiation GO:0009314 165 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.024
dna recombination GO:0006310 92 0.023
purine containing compound metabolic process GO:0072521 311 0.023
regulation of neuron differentiation GO:0045664 281 0.023
anion transport GO:0006820 177 0.023
maintenance of dna methylation GO:0010216 4 0.023
ribonucleoside monophosphate metabolic process GO:0009161 80 0.023
modification dependent macromolecule catabolic process GO:0043632 133 0.022
rhythmic process GO:0048511 174 0.022
innate immune response GO:0045087 157 0.022
ion transmembrane transport GO:0034220 361 0.022
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.021
dna repair GO:0006281 107 0.021
nucleoside monophosphate metabolic process GO:0009123 85 0.021
ribonucleoside metabolic process GO:0009119 245 0.021
regulation of cellular amine metabolic process GO:0033238 20 0.021
monocarboxylic acid metabolic process GO:0032787 191 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.021
small molecule biosynthetic process GO:0044283 132 0.020
protein modification by small protein conjugation GO:0032446 187 0.020
atp metabolic process GO:0046034 75 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
purine ribonucleotide catabolic process GO:0009154 208 0.020
response to inorganic substance GO:0010035 96 0.020
protein maturation GO:0051604 176 0.020
proteasomal protein catabolic process GO:0010498 98 0.020
intracellular receptor signaling pathway GO:0030522 74 0.020
spermatid differentiation GO:0048515 115 0.020
membrane organization GO:0061024 245 0.020
negative regulation of protein maturation GO:1903318 79 0.019
purine nucleoside monophosphate metabolic process GO:0009126 81 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
lipid biosynthetic process GO:0008610 179 0.019
response to organic cyclic compound GO:0014070 198 0.019
sensory perception GO:0007600 245 0.018
positive regulation of cell development GO:0010720 237 0.018
cytoplasmic transport GO:0016482 234 0.018
transmission of nerve impulse GO:0019226 76 0.018
production of molecular mediator of immune response GO:0002440 103 0.018
segmentation GO:0035282 93 0.018
regulation of multi organism process GO:0043900 111 0.018
stem cell maintenance GO:0019827 130 0.017
trunk segmentation GO:0035290 4 0.017
spermatid development GO:0007286 108 0.017
biomineral tissue development GO:0031214 64 0.017
regulation of histone methylation GO:0031060 30 0.017
Human Zebrafish
peptidyl lysine methylation GO:0018022 29 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
potassium ion homeostasis GO:0055075 4 0.017
modification dependent protein catabolic process GO:0019941 133 0.017
cation transmembrane transport GO:0098655 266 0.017
nucleocytoplasmic transport GO:0006913 139 0.017
transmembrane transport GO:0055085 412 0.017
t cell activation GO:0042110 289 0.017
response to peptide GO:1901652 136 0.016
cellular homeostasis GO:0019725 240 0.016
regulation of secretion by cell GO:1903530 249 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
organonitrogen compound catabolic process GO:1901565 264 0.016
regulation of asymmetric cell division GO:0009786 4 0.016
extracellular structure organization GO:0043062 148 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
regulation of cell activation GO:0050865 289 0.016
multicellular organismal signaling GO:0035637 91 0.016
chromosome organization involved in meiosis GO:0070192 39 0.016
negative regulation of cellular catabolic process GO:0031330 47 0.016
regulation of cell projection organization GO:0031344 206 0.016
amine metabolic process GO:0009308 45 0.015
carboxylic acid biosynthetic process GO:0046394 86 0.015
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
regulation of cytokine production GO:0001817 266 0.015
cation transport GO:0006812 399 0.015
nitrogen compound transport GO:0071705 271 0.015
protein modification by small protein conjugation or removal GO:0070647 207 0.015
skeletal system morphogenesis GO:0048705 203 0.015
cellular lipid metabolic process GO:0044255 323 0.015
positive regulation of immature t cell proliferation GO:0033091 4 0.015
neuron apoptotic process GO:0051402 142 0.015
regulation of hormone levels GO:0010817 211 0.015
gene silencing by rna GO:0031047 19 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.015
rna interference GO:0016246 2 0.014
divalent metal ion transport GO:0070838 172 0.014
negative regulation of cell development GO:0010721 169 0.014
lymphocyte differentiation GO:0030098 242 0.014
retrograde transport endosome to golgi GO:0042147 2 0.014
regulation of chromatin silencing GO:0031935 2 0.014
regulation of cellular response to stress GO:0080135 159 0.014
organic anion transport GO:0015711 137 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.014
peptidyl lysine modification GO:0018205 77 0.014
engulfment of apoptotic cell GO:0043652 3 0.014
response to iron ion GO:0010039 4 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
cellular protein complex assembly GO:0043623 116 0.014
microtubule cytoskeleton organization GO:0000226 157 0.014
oogenesis GO:0048477 56 0.013
myosin filament assembly GO:0031034 2 0.013
action potential GO:0001508 78 0.013
positive regulation of histone h3 k9 methylation GO:0051574 4 0.013
positive regulation of cell projection organization GO:0031346 95 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
regulation of secretion GO:0051046 274 0.013
gliogenesis GO:0042063 141 0.013
cell activation involved in immune response GO:0002263 126 0.013
organic acid biosynthetic process GO:0016053 86 0.013
cellularization GO:0007349 1 0.013
mrna transcription from rna polymerase ii promoter GO:0042789 4 0.013
negative regulation of proteolysis GO:0045861 74 0.013
regulation of defense response GO:0031347 233 0.013
regulation of nucleotide metabolic process GO:0006140 169 0.013
negative regulation of cellular protein metabolic process GO:0032269 247 0.013
Human
response to growth factor GO:0070848 198 0.013
extracellular matrix organization GO:0030198 147 0.013
cellular ion homeostasis GO:0006873 165 0.013
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.013
fat cell differentiation GO:0045444 160 0.013
camera type eye development GO:0043010 266 0.013
Zebrafish
positive regulation of secretion GO:0051047 130 0.013
homeostasis of number of cells GO:0048872 210 0.013
cytokine production GO:0001816 319 0.013
cellular response to oxidative stress GO:0034599 76 0.012
regulation of body fluid levels GO:0050878 162 0.012
lung development GO:0030324 164 0.012
regionalization GO:0003002 337 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
stem cell differentiation GO:0048863 268 0.012
stem cell development GO:0048864 219 0.012
response to ionizing radiation GO:0010212 42 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
regulation of protein processing GO:0070613 96 0.012
regulation of t cell activation GO:0050863 170 0.012
forebrain development GO:0030900 302 0.012
cellular protein catabolic process GO:0044257 155 0.012
positive regulation of cell activation GO:0050867 158 0.012
regulation of cellular component size GO:0032535 121 0.012
bone mineralization GO:0030282 54 0.012
regulation of nuclear cell cycle dna replication GO:0033262 2 0.012
b cell differentiation GO:0030183 78 0.012
immunoglobulin production GO:0002377 73 0.012
embryonic placenta development GO:0001892 98 0.012
metal ion homeostasis GO:0055065 189 0.012
mesodermal cell migration GO:0008078 4 0.012
response to lipopolysaccharide GO:0032496 128 0.012
somitogenesis GO:0001756 69 0.012
rna processing GO:0006396 105 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
purine nucleoside monophosphate catabolic process GO:0009128 58 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
actin filament organization GO:0007015 113 0.012
erythrocyte differentiation GO:0030218 88 0.012
neuronal action potential GO:0019228 54 0.012
alcohol metabolic process GO:0006066 116 0.012
skeletal muscle organ development GO:0060538 163 0.012
protein localization to nucleus GO:0034504 121 0.012
multicellular organism growth GO:0035264 161 0.011
regulation of protein transport GO:0051223 163 0.011
response to oxidative stress GO:0006979 123 0.011
locomotory behavior GO:0007626 195 0.011
respiratory system development GO:0060541 190 0.011
female gamete generation GO:0007292 74 0.011
dna endoreduplication GO:0042023 4 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
regulation of cell cycle GO:0051726 281 0.011
fatty acid metabolic process GO:0006631 121 0.011
glycerolipid metabolic process GO:0046486 122 0.011
wound healing GO:0042060 157 0.011
regulation of protein localization GO:0032880 231 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.011
calcium ion homeostasis GO:0055074 127 0.011
blood vessel morphogenesis GO:0048514 285 0.011
protein ubiquitination GO:0016567 171 0.011
lipid localization GO:0010876 126 0.011
negative regulation of immune system process GO:0002683 209 0.011
regulation of osteoblast differentiation GO:0045667 67 0.011
regulation of organ morphogenesis GO:2000027 144 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
peptidyl amino acid modification GO:0018193 336 0.011
mitochondrion organization GO:0007005 134 0.011
positive regulation of osteoblast differentiation GO:0045669 34 0.011
positive regulation of cytokine production GO:0001819 174 0.011
blastocyst formation GO:0001825 33 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
renal water homeostasis GO:0003091 7 0.011
alpha beta t cell activation GO:0046631 91 0.011
mapk cascade GO:0000165 281 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
mitotic cell cycle process GO:1903047 159 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
n terminal protein amino acid modification GO:0031365 6 0.011
organ growth GO:0035265 117 0.011
muscle tissue development GO:0060537 308 0.011
gene silencing by mirna GO:0035195 10 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
regulation of ion transport GO:0043269 215 0.011
lateral inhibition GO:0046331 1 0.010
male meiosis GO:0007140 37 0.010
divalent inorganic cation transport GO:0072511 178 0.010
development of primary sexual characteristics GO:0045137 143 0.010
carbohydrate metabolic process GO:0005975 230 0.010
regulation of actin nucleation GO:0051125 4 0.010
development of primary male sexual characteristics GO:0046546 88 0.010
cell maturation GO:0048469 127 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
cell type specific apoptotic process GO:0097285 268 0.010
neuron death GO:0070997 154 0.010
male sex differentiation GO:0046661 109 0.010
organic acid transport GO:0015849 101 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
gonad development GO:0008406 141 0.010
ribonucleoside monophosphate catabolic process GO:0009158 57 0.010
glycerophospholipid metabolic process GO:0006650 71 0.010
regulation of neuron projection development GO:0010975 169 0.010
intracellular mrna localization GO:0008298 4 0.010
myosin filament organization GO:0031033 3 0.010
response to molecule of bacterial origin GO:0002237 143 0.010

Dnmt3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.017
immune system disease DOID:2914 0 0.015
disease of anatomical entity DOID:7 0 0.015
hematopoietic system disease DOID:74 0 0.015
nervous system disease DOID:863 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
musculoskeletal system disease DOID:17 0 0.011