Mus musculus

42 known processes

Psme2

proteasome (prosome, macropain) 28 subunit, beta

(Aliases: AA589371,PA28b,AI788882)

Psme2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of proteolysis GO:0045862 85 0.792
antigen processing and presentation GO:0019882 47 0.727
positive regulation of peptidase activity GO:0010952 49 0.705
antigen processing and presentation of exogenous antigen GO:0019884 26 0.679
cellular macromolecule catabolic process GO:0044265 206 0.510
positive regulation of endopeptidase activity GO:0010950 43 0.508
regulation of peptidase activity GO:0052547 96 0.475
positive regulation of hydrolase activity GO:0051345 148 0.363
t cell proliferation GO:0042098 120 0.348
cellular response to dna damage stimulus GO:0006974 207 0.339
regulation of endopeptidase activity GO:0052548 89 0.200
regulation of defense response GO:0031347 233 0.183
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.173
modification dependent protein catabolic process GO:0019941 133 0.164
regulation of t cell activation GO:0050863 170 0.133
interspecies interaction between organisms GO:0044419 83 0.132
lymphocyte proliferation GO:0046651 164 0.126
ubiquitin dependent protein catabolic process GO:0006511 129 0.117
regulation of intracellular transport GO:0032386 159 0.117
fat cell differentiation GO:0045444 160 0.111
regulation of lymphocyte activation GO:0051249 240 0.110
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.105
innate immune response GO:0045087 157 0.103
protein catabolic process GO:0030163 221 0.098
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 3 0.093
macromolecule catabolic process GO:0009057 281 0.091
apoptotic signaling pathway GO:0097190 306 0.089
leukocyte differentiation GO:0002521 342 0.071
positive regulation of cellular component biogenesis GO:0044089 94 0.062
modification dependent macromolecule catabolic process GO:0043632 133 0.061
oxidation reduction process GO:0055114 342 0.060
cellular amino acid metabolic process GO:0006520 103 0.059
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.053
regulation of t cell proliferation GO:0042129 92 0.052
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 9 0.050
response to lipopolysaccharide GO:0032496 128 0.050
organic cyclic compound catabolic process GO:1901361 295 0.048
muscle tissue development GO:0060537 308 0.043
t cell activation GO:0042110 289 0.042
arp2 3 complex mediated actin nucleation GO:0034314 3 0.042
negative regulation of protein modification process GO:0031400 163 0.040
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.040
positive regulation of apoptotic signaling pathway GO:2001235 95 0.038
blood vessel morphogenesis GO:0048514 285 0.038
cellular protein complex assembly GO:0043623 116 0.037
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.036
negative regulation of molecular function GO:0044092 258 0.035
nicotinamide nucleotide biosynthetic process GO:0019359 4 0.035
intracellular protein transport GO:0006886 204 0.034
negative regulation of immune system process GO:0002683 209 0.034
cellular amine metabolic process GO:0044106 44 0.034
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.033
i kappab kinase nf kappab signaling GO:0007249 85 0.033
metal ion homeostasis GO:0055065 189 0.032
regulation of cellular ketone metabolic process GO:0010565 66 0.032
nucleobase containing small molecule metabolic process GO:0055086 352 0.031
response to organic cyclic compound GO:0014070 198 0.031
cellular ketone metabolic process GO:0042180 84 0.030
cation transport GO:0006812 399 0.030
inflammatory response GO:0006954 244 0.030
ras protein signal transduction GO:0007265 77 0.030
cytoplasmic transport GO:0016482 234 0.030
gland development GO:0048732 330 0.030
epidermis development GO:0008544 187 0.030
male gamete generation GO:0048232 285 0.029
regulation of interleukin 1 alpha secretion GO:0050705 3 0.029
extrinsic apoptotic signaling pathway GO:0097191 126 0.028
type i interferon production GO:0032606 29 0.028
aromatic compound catabolic process GO:0019439 286 0.028
protein polymerization GO:0051258 57 0.028
sequestering of metal ion GO:0051238 19 0.027
regulation of cellular amino acid metabolic process GO:0006521 5 0.027
maintenance of location GO:0051235 89 0.027
superoxide metabolic process GO:0006801 27 0.027
cellular protein catabolic process GO:0044257 155 0.027
regulation of protein kinase activity GO:0045859 232 0.027
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.027
nucleoside phosphate metabolic process GO:0006753 338 0.026
spermatogenesis GO:0007283 284 0.026
cellular metal ion homeostasis GO:0006875 151 0.025
regulation of protein targeting GO:1903533 61 0.025
myeloid cell homeostasis GO:0002262 114 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
carbohydrate derivative catabolic process GO:1901136 231 0.023
glycosyl compound metabolic process GO:1901657 246 0.023
purine containing compound catabolic process GO:0072523 213 0.023
nuclear transport GO:0051169 139 0.022
regulation of homeostatic process GO:0032844 182 0.022
histone modification GO:0016570 159 0.022
homeostasis of number of cells GO:0048872 210 0.021
regulation of protein complex assembly GO:0043254 83 0.021
regulation of leukocyte proliferation GO:0070663 121 0.021
positive regulation of lymphocyte activation GO:0051251 140 0.021
multi multicellular organism process GO:0044706 109 0.021
monocarboxylic acid metabolic process GO:0032787 191 0.021
response to molecule of bacterial origin GO:0002237 143 0.020
proteasomal ubiquitin independent protein catabolic process GO:0010499 1 0.020
neuron death GO:0070997 154 0.020
regulation of cellular amine metabolic process GO:0033238 20 0.020
lymphocyte mediated immunity GO:0002449 139 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
phagocytosis GO:0006909 66 0.019
response to organonitrogen compound GO:0010243 246 0.019
leukocyte proliferation GO:0070661 172 0.019
regulation of transferase activity GO:0051338 263 0.019
regulation of protein localization GO:0032880 231 0.019
organophosphate biosynthetic process GO:0090407 122 0.019
protein localization to organelle GO:0033365 185 0.019
vesicle organization GO:0016050 60 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
cellular chemical homeostasis GO:0055082 215 0.019
sensory perception GO:0007600 245 0.018
positive regulation of cellular amine metabolic process GO:0033240 5 0.018
purine nucleoside metabolic process GO:0042278 241 0.018
cellular ion homeostasis GO:0006873 165 0.018
lymphocyte differentiation GO:0030098 242 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
regulation of membrane potential GO:0042391 192 0.018
regulation of secretion GO:0051046 274 0.018
protein maturation GO:0051604 176 0.018
protein localization to nucleus GO:0034504 121 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
nucleotide catabolic process GO:0009166 217 0.018
regulation of hormone levels GO:0010817 211 0.018
mapk cascade GO:0000165 281 0.018
cellular modified amino acid metabolic process GO:0006575 63 0.017
cellular homeostasis GO:0019725 240 0.017
regulation of neuron death GO:1901214 134 0.017
mitochondrion organization GO:0007005 134 0.017
myosin filament organization GO:0031033 3 0.017
zymogen activation GO:0031638 41 0.017
nitrogen compound transport GO:0071705 271 0.017
regulation of cytokine production GO:0001817 266 0.017
regulation of anatomical structure size GO:0090066 178 0.017
progesterone metabolic process GO:0042448 4 0.017
regulation of cell activation GO:0050865 289 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
regulation of body fluid levels GO:0050878 162 0.016
b cell activation GO:0042113 161 0.016
cellular lipid metabolic process GO:0044255 323 0.016
regulation of lymphocyte proliferation GO:0050670 117 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
ion transmembrane transport GO:0034220 361 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
regulation of interleukin 1 alpha production GO:0032650 4 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
microtubule based process GO:0007017 236 0.015
regulation of neuron apoptotic process GO:0043523 122 0.015
positive regulation of leukocyte proliferation GO:0070665 73 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
female sex differentiation GO:0046660 84 0.015
pyridine nucleotide biosynthetic process GO:0019363 4 0.015
apoptotic mitochondrial changes GO:0008637 48 0.015
regulation of mast cell differentiation GO:0060375 3 0.015
membrane organization GO:0061024 245 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
neuron apoptotic process GO:0051402 142 0.015
positive regulation of lymphocyte proliferation GO:0050671 70 0.015
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.014
synaptic transmission GO:0007268 329 0.014
cation homeostasis GO:0055080 212 0.014
regulation of organelle organization GO:0033043 289 0.014
carbohydrate catabolic process GO:0016052 32 0.014
cellular calcium ion homeostasis GO:0006874 119 0.014
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.014
striated muscle tissue development GO:0014706 293 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
cellular response to lipopolysaccharide GO:0071222 77 0.014
dna repair GO:0006281 107 0.014
rhythmic process GO:0048511 174 0.014
rna interference GO:0016246 2 0.014
proteasomal protein catabolic process GO:0010498 98 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
positive regulation of cell death GO:0010942 224 0.014
cellular response to oxidative stress GO:0034599 76 0.014
organelle fission GO:0048285 170 0.013
positive regulation of organelle organization GO:0010638 128 0.013
neuromuscular process GO:0050905 99 0.013
cellular response to lipid GO:0071396 145 0.013
regulation of type i interferon mediated signaling pathway GO:0060338 7 0.013
positive regulation of secretion GO:0051047 130 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
nuclear import GO:0051170 95 0.013
carbohydrate homeostasis GO:0033500 128 0.013
leukocyte mediated cytotoxicity GO:0001909 62 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
locomotory behavior GO:0007626 195 0.013
regulation of protein ubiquitination GO:0031396 52 0.013
positive regulation of growth GO:0045927 104 0.013
protein import GO:0017038 101 0.013
regulation of cell motility GO:2000145 236 0.013
regulation of mapk cascade GO:0043408 248 0.013
negative regulation of cell activation GO:0050866 111 0.013
amine metabolic process GO:0009308 45 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.012
positive regulation of protein modification process GO:0031401 299 0.012
t cell differentiation GO:0030217 174 0.012
regulation of metal ion transport GO:0010959 106 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
respiratory system development GO:0060541 190 0.012
transmembrane transport GO:0055085 412 0.012
lymphocyte homeostasis GO:0002260 64 0.012
positive regulation of type i interferon production GO:0032481 14 0.012
negative regulation of lymphocyte proliferation GO:0050672 45 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
regulation of proteolysis GO:0030162 164 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.012
positive regulation of nervous system development GO:0051962 221 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
dna metabolic process GO:0006259 303 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
ribonucleoside metabolic process GO:0009119 245 0.012
myeloid cell differentiation GO:0030099 233 0.012
regulation of kinase activity GO:0043549 249 0.012
dephosphorylation GO:0016311 129 0.012
epithelial tube formation GO:0072175 130 0.011
heterocycle catabolic process GO:0046700 280 0.011
cytokine production GO:0001816 319 0.011
meiotic nuclear division GO:0007126 115 0.011
regulation of hydrolase activity GO:0051336 246 0.011
negative regulation of organelle organization GO:0010639 90 0.011
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.011
protein methylation GO:0006479 81 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
positive regulation of mitotic cell cycle GO:0045931 41 0.011
negative regulation of lymphocyte activation GO:0051250 91 0.011
actin cytoskeleton organization GO:0030036 220 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
positive regulation of cell cycle GO:0045787 92 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
membrane depolarization GO:0051899 64 0.011
calcium ion homeostasis GO:0055074 127 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
cell type specific apoptotic process GO:0097285 268 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.011
regulation of establishment of protein localization GO:0070201 181 0.011
signal transduction in absence of ligand GO:0038034 55 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
fertilization GO:0009566 127 0.011
purine deoxyribonucleoside triphosphate metabolic process GO:0009215 7 0.010
regulation of cellular component size GO:0032535 121 0.010
purine nucleoside catabolic process GO:0006152 205 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.010
nuclear division GO:0000280 158 0.010
cell substrate adhesion GO:0031589 130 0.010
protein processing GO:0016485 163 0.010
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.010
nucleoside phosphate biosynthetic process GO:1901293 79 0.010
peptidyl amino acid modification GO:0018193 336 0.010
circulatory system process GO:0003013 197 0.010

Psme2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.016
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
cancer DOID:162 0 0.013
gastrointestinal system cancer DOID:3119 0 0.013
organ system cancer DOID:0050686 0 0.013