Mus musculus

24 known processes

Irak4

interleukin-1 receptor-associated kinase 4

(Aliases: 9330209D03Rik,8430405M07Rik,IRAK-4,NY-REN-64)

Irak4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of interleukin 6 production GO:0032715 17 0.951
regulation of interleukin 6 production GO:0032675 55 0.883
interleukin 1 mediated signaling pathway GO:0070498 4 0.762
regulation of innate immune response GO:0045088 91 0.700
response to molecule of fungal origin GO:0002238 4 0.597
toll like receptor signaling pathway GO:0002224 38 0.544
innate immune response activating signal transduction GO:0002758 50 0.538
cellular response to biotic stimulus GO:0071216 92 0.530
interleukin 6 production GO:0032635 58 0.512
detection of molecule of bacterial origin GO:0032490 2 0.477
regulation of toll like receptor signaling pathway GO:0034121 20 0.463
interferon beta biosynthetic process GO:0045350 4 0.451
interleukin 23 production GO:0032627 2 0.435
pattern recognition receptor signaling pathway GO:0002221 47 0.429
response to peptidoglycan GO:0032494 9 0.400
negative regulation of map kinase activity GO:0043407 34 0.393
cytokine mediated signaling pathway GO:0019221 115 0.381
positive regulation of innate immune response GO:0045089 80 0.346
response to host immune response GO:0052572 3 0.345
regulation of macrophage cytokine production GO:0010935 8 0.343
regulation of jnk cascade GO:0046328 62 0.340
regulation of mapk cascade GO:0043408 248 0.335
immune response activating signal transduction GO:0002757 116 0.333
chemokine metabolic process GO:0050755 10 0.321
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.321
i kappab kinase nf kappab signaling GO:0007249 85 0.321
Human
regulation of response to cytokine stimulus GO:0060759 23 0.319
regulation of chemokine production GO:0032642 30 0.315
immune response regulating signaling pathway GO:0002764 125 0.310
cellular response to molecule of bacterial origin GO:0071219 83 0.306
macrophage cytokine production GO:0010934 9 0.303
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.296
positive regulation of jnk cascade GO:0046330 46 0.282
positive regulation of chemokine production GO:0032722 22 0.277
stress activated mapk cascade GO:0051403 80 0.272
regulation of interferon beta biosynthetic process GO:0045357 4 0.265
positive regulation of mapk cascade GO:0043410 170 0.264
cellular response to peptidoglycan GO:0071224 4 0.257
positive regulation of chemokine biosynthetic process GO:0045080 6 0.254
negative regulation of phosphate metabolic process GO:0045936 184 0.250
negative regulation of phosphorus metabolic process GO:0010563 184 0.246
activation of innate immune response GO:0002218 56 0.243
response to dsrna GO:0043331 30 0.239
positive regulation of cytokine biosynthetic process GO:0042108 40 0.236
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.229
positive regulation of stress activated mapk cascade GO:0032874 48 0.226
response to organonitrogen compound GO:0010243 246 0.224
response to interleukin 1 GO:0070555 11 0.221
stress activated protein kinase signaling cascade GO:0031098 81 0.219
jnk cascade GO:0007254 72 0.216
negative regulation of immune system process GO:0002683 209 0.216
cellular response to lipopolysaccharide GO:0071222 77 0.215
negative regulation of kinase activity GO:0033673 81 0.214
negative regulation of cytokine production GO:0001818 84 0.213
cytokine biosynthetic process GO:0042089 68 0.212
positive regulation of interleukin 6 production GO:0032755 37 0.212
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.210
mapk cascade GO:0000165 281 0.210
activation of immune response GO:0002253 138 0.209
regulation of kinase activity GO:0043549 249 0.208
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.203
regulation of interleukin 23 production GO:0032667 2 0.199
positive regulation of defense response GO:0031349 124 0.195
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.187
multicellular organismal homeostasis GO:0048871 164 0.184
negative regulation of intracellular signal transduction GO:1902532 167 0.182
interleukin 6 biosynthetic process GO:0042226 12 0.180
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070434 2 0.175
positive regulation of interleukin 18 production GO:0032741 2 0.174
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.169
chemokine biosynthetic process GO:0042033 8 0.168
signal transduction in absence of ligand GO:0038034 55 0.167
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.166
positive regulation of interleukin 6 biosynthetic process GO:0045410 6 0.166
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.161
regulation of cell activation GO:0050865 289 0.161
positive regulation of protein modification process GO:0031401 299 0.158
leukocyte proliferation GO:0070661 172 0.157
toll like receptor 4 signaling pathway GO:0034142 9 0.155
regulation of transferase activity GO:0051338 263 0.153
regulation of cytokine production GO:0001817 266 0.150
regulation of cytokine biosynthetic process GO:0042035 59 0.144
regulation of protein kinase activity GO:0045859 232 0.144
response to molecule of bacterial origin GO:0002237 143 0.142
blood vessel morphogenesis GO:0048514 285 0.142
innate immune response GO:0045087 157 0.140
negative regulation of protein metabolic process GO:0051248 282 0.140
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.140
regulation of cellular response to stress GO:0080135 159 0.139
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.137
cytokine metabolic process GO:0042107 71 0.137
wound healing GO:0042060 157 0.134
negative regulation of transferase activity GO:0051348 85 0.132
response to bacterial lipoprotein GO:0032493 4 0.132
regulation of chemokine biosynthetic process GO:0045073 8 0.131
apoptotic signaling pathway GO:0097190 306 0.129
positive regulation of interferon alpha production GO:0032727 4 0.128
toll like receptor 2 signaling pathway GO:0034134 6 0.127
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.127
negative regulation of protein phosphorylation GO:0001933 126 0.126
regulation of map kinase activity GO:0043405 120 0.126
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.124
carboxylic acid transport GO:0046942 100 0.123
regulation of lipid transport GO:0032368 36 0.123
lipid transport GO:0006869 98 0.122
inflammatory response GO:0006954 244 0.122
negative regulation of protein modification process GO:0031400 163 0.119
negative regulation of cholesterol transport GO:0032375 4 0.119
interleukin 17 production GO:0032620 11 0.119
response to defense related host nitric oxide production GO:0052565 2 0.118
chemokine production GO:0032602 34 0.113
negative regulation of phosphorylation GO:0042326 166 0.110
modulation by symbiont of defense related host nitric oxide production GO:0052163 1 0.109
positive regulation of kinase activity GO:0033674 155 0.109
regulation of glutamate secretion GO:0014048 3 0.108
cellular response to bacterial lipopeptide GO:0071221 3 0.108
response to defenses of other organism involved in symbiotic interaction GO:0052173 3 0.107
type i interferon production GO:0032606 29 0.105
amino acid transport GO:0006865 61 0.104
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.104
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.103
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.101
positive regulation of map kinase activity GO:0043406 84 0.100
cell adhesion GO:0007155 329 0.100
positive regulation of jun kinase activity GO:0043507 30 0.100
positive regulation of interleukin 8 production GO:0032757 2 0.100
negative regulation of cellular protein metabolic process GO:0032269 247 0.097
negative regulation of membrane potential GO:0045837 4 0.097
regulation of jun kinase activity GO:0043506 40 0.097
immune effector process GO:0002252 321 0.097
regulation of defense response GO:0031347 233 0.095
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.095
lipid localization GO:0010876 126 0.094
negative regulation of tumor necrosis factor production GO:0032720 17 0.094
response to organic cyclic compound GO:0014070 198 0.092
macromolecule catabolic process GO:0009057 281 0.091
response to atp GO:0033198 8 0.091
positive regulation of protein phosphorylation GO:0001934 242 0.091
lipid catabolic process GO:0016042 69 0.090
positive regulation of protein kinase activity GO:0045860 144 0.090
response to immune response of other organism involved in symbiotic interaction GO:0052564 3 0.089
regulation of protein complex disassembly GO:0043244 28 0.089
cognition GO:0050890 149 0.088
cellular lipid metabolic process GO:0044255 323 0.086
modulation by symbiont of host immune response GO:0052553 1 0.085
positive regulation by symbiont of host immune response GO:0052556 1 0.084
response to host GO:0075136 3 0.083
regulation of protein serine threonine kinase activity GO:0071900 157 0.083
positive regulation of transferase activity GO:0051347 167 0.082
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.082
regulation of cellular ketone metabolic process GO:0010565 66 0.082
protein complex disassembly GO:0043241 40 0.082
angiogenesis GO:0001525 201 0.082
regulation of b cell proliferation GO:0030888 39 0.082
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.081
negative regulation of multi organism process GO:0043901 68 0.080
protein catabolic process GO:0030163 221 0.078
cellular response to organonitrogen compound GO:0071417 145 0.075
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.074
regulation of leukocyte proliferation GO:0070663 121 0.073
regulation of tumor necrosis factor production GO:0032680 49 0.073
b cell activation GO:0042113 161 0.073
regulation of interleukin 8 production GO:0032677 3 0.073
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.073
learning or memory GO:0007611 148 0.073
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.070
cellular response to bacterial lipoprotein GO:0071220 3 0.069
inflammatory response to wounding GO:0090594 4 0.068
regulation of lymphocyte activation GO:0051249 240 0.068
sterol transport GO:0015918 38 0.068
cytokine production GO:0001816 319 0.067
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.066
regulation of insulin receptor signaling pathway GO:0046626 21 0.066
dicarboxylic acid transport GO:0006835 29 0.065
coagulation GO:0050817 78 0.065
regulation of reactive oxygen species metabolic process GO:2000377 40 0.065
myeloid leukocyte cytokine production GO:0061082 12 0.064
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.064
organic anion transport GO:0015711 137 0.064
lymphocyte proliferation GO:0046651 164 0.062
homeostasis of number of cells GO:0048872 210 0.062
posttranscriptional regulation of gene expression GO:0010608 155 0.061
antibiotic transport GO:0042891 1 0.060
b cell proliferation GO:0042100 53 0.059
regulation of interleukin 17 production GO:0032660 8 0.059
positive regulation of cell activation GO:0050867 158 0.058
glycosyl compound catabolic process GO:1901658 206 0.058
cellular response to lipoteichoic acid GO:0071223 6 0.058
digestive system development GO:0055123 200 0.058
response to extracellular stimulus GO:0009991 127 0.058
induction by symbiont of host immune response GO:0052559 1 0.057
temperature homeostasis GO:0001659 26 0.057
cellular amino acid metabolic process GO:0006520 103 0.057
modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 1 0.056
intestinal epithelial structure maintenance GO:0060729 4 0.056
regulation of cell adhesion GO:0030155 154 0.055
reactive oxygen species metabolic process GO:0072593 84 0.055
negative regulation of immune effector process GO:0002698 55 0.054
positive regulation of b cell activation GO:0050871 49 0.054
heterocycle catabolic process GO:0046700 280 0.054
regulation of anion transport GO:0044070 27 0.053
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.053
interferon beta production GO:0032608 16 0.052
defense response to bacterium GO:0042742 119 0.051
digestive tract development GO:0048565 190 0.050
sensory perception GO:0007600 245 0.050
nik nf kappab signaling GO:0038061 14 0.050
wound healing involved in inflammatory response GO:0002246 4 0.050
type i interferon biosynthetic process GO:0045351 9 0.050
t cell activation GO:0042110 289 0.050
regulation of type i interferon production GO:0032479 22 0.050
organic acid transport GO:0015849 101 0.049
negative regulation of defense response GO:0031348 77 0.049
modulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052302 1 0.049
response to host defenses GO:0052200 3 0.049
negative regulation of lipid metabolic process GO:0045833 30 0.048
response to lipopolysaccharide GO:0032496 128 0.047
induction by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052263 1 0.047
response to peptide hormone GO:0043434 127 0.047
nucleotide metabolic process GO:0009117 332 0.047
aromatic compound catabolic process GO:0019439 286 0.047
negative regulation of cellular component organization GO:0051129 194 0.046
positive regulation of macrophage cytokine production GO:0060907 7 0.046
single organism cell adhesion GO:0098602 156 0.045
cellular response to peptide GO:1901653 92 0.045
nucleoside catabolic process GO:0009164 206 0.045
cellular response to lipid GO:0071396 145 0.045
nucleoside triphosphate metabolic process GO:0009141 230 0.044
regulation of hormone levels GO:0010817 211 0.044
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070430 1 0.044
detection of lipopolysaccharide GO:0032497 1 0.044
induction by organism of defense response of other organism involved in symbiotic interaction GO:0052251 1 0.044
regulation of protein catabolic process GO:0042176 108 0.044
protein autophosphorylation GO:0046777 61 0.044
Fly
sensory perception of pain GO:0019233 47 0.043
regulation of membrane potential GO:0042391 192 0.043
modification by symbiont of host morphology or physiology GO:0044003 4 0.043
regulation of sterol transport GO:0032371 17 0.042
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.042
regulation of cell migration GO:0030334 219 0.042
macromolecular complex disassembly GO:0032984 43 0.042
response to lipoteichoic acid GO:0070391 6 0.041
negative regulation of sterol transport GO:0032372 4 0.041
anion transport GO:0006820 177 0.041
regulation of leukocyte differentiation GO:1902105 159 0.041
response to catecholamine GO:0071869 4 0.041
purine ribonucleoside metabolic process GO:0046128 241 0.041
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.041
carbohydrate derivative catabolic process GO:1901136 231 0.041
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.039
interleukin 18 mediated signaling pathway GO:0035655 2 0.039
positive regulation of lipid transport GO:0032370 22 0.039
positive regulation of type i interferon production GO:0032481 14 0.038
ribonucleoside triphosphate catabolic process GO:0009203 199 0.038
cholesterol transport GO:0030301 38 0.038
regulation of cytokine production involved in immune response GO:0002718 26 0.038
reactive nitrogen species metabolic process GO:2001057 0 0.038
regulation of cellular amino acid metabolic process GO:0006521 5 0.037
response to insulin GO:0032868 100 0.037
tumor necrosis factor production GO:0032640 50 0.037
ribonucleoside catabolic process GO:0042454 206 0.037
nitrogen compound transport GO:0071705 271 0.037
transmembrane transport GO:0055085 412 0.037
regulation of interleukin 18 production GO:0032661 3 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.036
ras protein signal transduction GO:0007265 77 0.036
positive regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070426 2 0.036
regulation of lipid catabolic process GO:0050994 15 0.035
negative regulation of cell migration GO:0030336 59 0.035
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.035
regulation of tolerance induction GO:0002643 10 0.035
response to peptide GO:1901652 136 0.035
regulation of cell motility GO:2000145 236 0.035
ribonucleoside metabolic process GO:0009119 245 0.035
hormone secretion GO:0046879 128 0.035
tissue remodeling GO:0048771 102 0.034
carbohydrate transport GO:0008643 62 0.034
membrane organization GO:0061024 245 0.034
production of molecular mediator of immune response GO:0002440 103 0.034
response to interleukin 12 GO:0070671 2 0.034
regulation of hemostasis GO:1900046 28 0.034
regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070432 3 0.034
membrane lipid biosynthetic process GO:0046467 32 0.033
peptidyl amino acid modification GO:0018193 336 0.033
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.033
cellular response to external stimulus GO:0071496 88 0.033
cellular ketone metabolic process GO:0042180 84 0.033
cellular nitrogen compound catabolic process GO:0044270 280 0.032
cellular response to hormone stimulus GO:0032870 150 0.032
glycosyl compound metabolic process GO:1901657 246 0.032
regulation of stress activated mapk cascade GO:0032872 69 0.032
cation transmembrane transport GO:0098655 266 0.032
cholesterol efflux GO:0033344 24 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
interspecies interaction between organisms GO:0044419 83 0.031
purine containing compound catabolic process GO:0072523 213 0.031
positive regulation of tolerance induction GO:0002645 8 0.031
cellular response to monoamine stimulus GO:0071868 3 0.030
purine nucleotide catabolic process GO:0006195 211 0.030
purine nucleoside triphosphate metabolic process GO:0009144 226 0.030
negative regulation of interleukin 23 production GO:0032707 1 0.030
glutamate secretion GO:0014047 8 0.030
toll like receptor 7 signaling pathway GO:0034154 4 0.030
negative regulation of protein complex disassembly GO:0043242 22 0.030
toll like receptor 9 signaling pathway GO:0034162 6 0.029
regulation of amine transport GO:0051952 21 0.029
heterotypic cell cell adhesion GO:0034113 7 0.029
organelle localization GO:0051640 179 0.029
monosaccharide transport GO:0015749 58 0.029
regulation of cholesterol transport GO:0032374 17 0.029
negative regulation of lymphocyte proliferation GO:0050672 45 0.029
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052345 1 0.028
regulation of system process GO:0044057 200 0.028
forebrain development GO:0030900 302 0.028
glucose transport GO:0015758 56 0.028
hexose transport GO:0008645 56 0.028
response to starvation GO:0042594 65 0.028
memory GO:0007613 58 0.028
defense response to other organism GO:0098542 197 0.028
Fly
regulation of lipid metabolic process GO:0019216 118 0.028
insulin receptor signaling pathway GO:0008286 49 0.028
nucleoside phosphate metabolic process GO:0006753 338 0.028
epithelial cell development GO:0002064 159 0.028
natural killer cell proliferation GO:0001787 3 0.027
organophosphate catabolic process GO:0046434 232 0.027
regulation of secretion GO:0051046 274 0.027
cellular response to organic cyclic compound GO:0071407 87 0.027
insulin secretion GO:0030073 89 0.027
inorganic ion transmembrane transport GO:0098660 234 0.027
positive regulation of interleukin 17 production GO:0032740 3 0.027
regulation of embryonic development GO:0045995 71 0.027
negative regulation of mapk cascade GO:0043409 65 0.027
cellular amine metabolic process GO:0044106 44 0.027
regulation of mrna stability GO:0043488 23 0.026
cellular response to catecholamine stimulus GO:0071870 3 0.026
carbohydrate metabolic process GO:0005975 230 0.026
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.025
extrinsic apoptotic signaling pathway GO:0097191 126 0.025
compound eye development GO:0048749 1 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.025
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.025
wnt signaling pathway GO:0016055 188 0.025
positive regulation of secretion GO:0051047 130 0.025
lateral inhibition GO:0046331 1 0.025
response to bacterial lipopeptide GO:0070339 3 0.025
regulation of cell cycle GO:0051726 281 0.025
organonitrogen compound catabolic process GO:1901565 264 0.025
hematopoietic progenitor cell differentiation GO:0002244 143 0.024
negative regulation of glucose transport GO:0010829 9 0.024
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.024
response to exogenous dsrna GO:0043330 22 0.024
cellular response to insulin stimulus GO:0032869 78 0.024
fatty acid transport GO:0015908 28 0.024
induction by symbiont of defense related host nitric oxide production GO:0052063 1 0.024
negative regulation of translational initiation GO:0045947 4 0.024
negative regulation of nervous system development GO:0051961 156 0.024
negative regulation of response to cytokine stimulus GO:0060761 9 0.023
urogenital system development GO:0001655 261 0.023
chemotaxis GO:0006935 247 0.023
amine metabolic process GO:0009308 45 0.023
small gtpase mediated signal transduction GO:0007264 97 0.023
negative regulation of cell adhesion GO:0007162 45 0.022
inorganic cation transmembrane transport GO:0098662 207 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
sensory organ morphogenesis GO:0090596 242 0.022
b cell proliferation involved in immune response GO:0002322 5 0.022
exocytosis GO:0006887 121 0.022
cellular response to peptide hormone stimulus GO:0071375 92 0.022
response to arsenic containing substance GO:0046685 5 0.022
regulation of neuron differentiation GO:0045664 281 0.022
negative regulation of molecular function GO:0044092 258 0.021
chloramphenicol transport GO:0042892 1 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
digestive tract morphogenesis GO:0048546 147 0.021
membrane lipid metabolic process GO:0006643 53 0.021
negative regulation of cell motility GO:2000146 61 0.021
regulation of production of molecular mediator of immune response GO:0002700 65 0.021
response to activity GO:0014823 13 0.021
nucleobase containing small molecule metabolic process GO:0055086 352 0.021
positive regulation of organic acid transport GO:0032892 11 0.021
nucleoside monophosphate metabolic process GO:0009123 85 0.021
regulation of angiogenesis GO:0045765 81 0.021
endomembrane system organization GO:0010256 147 0.021
erk1 and erk2 cascade GO:0070371 77 0.020
growth involved in symbiotic interaction GO:0044110 23 0.020
ribose phosphate metabolic process GO:0019693 291 0.020
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.020
hemostasis GO:0007599 78 0.020
regulation of binding GO:0051098 111 0.020
nitric oxide production involved in inflammatory response GO:0002537 2 0.020
establishment of vesicle localization GO:0051650 81 0.020
negative regulation of leukocyte proliferation GO:0070664 46 0.020
glycosylation GO:0070085 62 0.020
peptide hormone secretion GO:0030072 109 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.019
organic hydroxy compound transport GO:0015850 93 0.019
gastrulation GO:0007369 116 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
regulation of ion transport GO:0043269 215 0.019
ion transmembrane transport GO:0034220 361 0.019
fatty acid derivative transport GO:1901571 14 0.019
regulation of response to biotic stimulus GO:0002831 38 0.019
growth of symbiont involved in interaction with host GO:0044116 23 0.019
interleukin 1 production GO:0032612 31 0.019
regulation of response to wounding GO:1903034 189 0.019
b cell homeostasis GO:0001782 34 0.019
positive regulation of interferon beta production GO:0032728 8 0.019
positive regulation of protein catabolic process GO:0045732 60 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
positive regulation by organism of defense response of other organism involved in symbiotic interaction GO:0052510 1 0.019
cellular response to dna damage stimulus GO:0006974 207 0.018
negative regulation of cell development GO:0010721 169 0.018
glycoprotein metabolic process GO:0009100 116 0.018
production of molecular mediator involved in inflammatory response GO:0002532 21 0.018
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.018
interleukin 8 production GO:0032637 4 0.018
striated muscle myosin thick filament assembly GO:0071688 1 0.018
mrna stabilization GO:0048255 9 0.018
positive regulation of fatty acid transport GO:2000193 8 0.018
peptide transport GO:0015833 133 0.018
negative regulation of ion transport GO:0043271 28 0.018
amine transport GO:0015837 21 0.018
nitric oxide synthase biosynthetic process GO:0051767 7 0.018
microglial cell activation GO:0001774 3 0.018
positive regulation of cytokine production GO:0001819 174 0.018
interaction with host GO:0051701 22 0.018
germ cell development GO:0007281 185 0.018
macromolecule glycosylation GO:0043413 55 0.017
anatomical structure homeostasis GO:0060249 145 0.017
positive regulation of hydrolase activity GO:0051345 148 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
organic hydroxy compound metabolic process GO:1901615 203 0.017
regulation of cellular amine metabolic process GO:0033238 20 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
mast cell proliferation GO:0070662 4 0.017
regulation of adiponectin secretion GO:0070163 2 0.017
response to monoamine GO:0071867 4 0.017
regulation of mast cell proliferation GO:0070666 4 0.017
lymphocyte apoptotic process GO:0070227 54 0.016
regulation of growth of symbiont in host GO:0044126 19 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
regulation of lymphocyte anergy GO:0002911 4 0.016
positive regulation of fever generation GO:0031622 6 0.016
organonitrogen compound biosynthetic process GO:1901566 192 0.016
myosin filament assembly GO:0031034 2 0.016
positive regulation of immune effector process GO:0002699 107 0.016
positive regulation of cell motility GO:2000147 116 0.016
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
nucleotide catabolic process GO:0009166 217 0.016
developmental programmed cell death GO:0010623 41 0.016
regulation of glucose transport GO:0010827 32 0.016
organelle assembly GO:0070925 177 0.016
response to organophosphorus GO:0046683 22 0.016
translation GO:0006412 93 0.016
negative regulation of macrophage cytokine production GO:0010936 1 0.016
regulation of fever generation GO:0031620 6 0.015
cellular response to abiotic stimulus GO:0071214 56 0.015
regulation of homeostatic process GO:0032844 182 0.015
negative regulation of necroptotic process GO:0060546 9 0.015
nitric oxide biosynthetic process GO:0006809 25 0.015
positive regulation by symbiont of host defense response GO:0052509 1 0.015
gland development GO:0048732 330 0.015
adiponectin secretion GO:0070162 2 0.015
regulation of b cell activation GO:0050864 81 0.015
platelet activation GO:0030168 40 0.015
lipid biosynthetic process GO:0008610 179 0.015
defense response to virus GO:0051607 68 0.015
cellular protein catabolic process GO:0044257 155 0.015
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.015
dna metabolic process GO:0006259 303 0.015
sphingolipid biosynthetic process GO:0030148 26 0.015
negative regulation of lipid transport GO:0032369 8 0.015
detection of external biotic stimulus GO:0098581 9 0.015
response to interleukin 4 GO:0070670 23 0.015
negative regulation of growth GO:0045926 99 0.015
positive regulation of cell migration GO:0030335 109 0.015
positive regulation of icosanoid secretion GO:0032305 7 0.015
cellularization GO:0007349 1 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.015

Irak4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.880
cancer DOID:162 0 0.685
organ system cancer DOID:0050686 0 0.648
gastrointestinal system cancer DOID:3119 0 0.113
immune system cancer DOID:0060083 0 0.037
hematologic cancer DOID:2531 0 0.037
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
disease of metabolism DOID:0014667 0 0.033
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.020
immune system disease DOID:2914 0 0.019