Mus musculus

32 known processes

Cdk4

cyclin-dependent kinase 4

(Aliases: Crk3)

Cdk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle process GO:0010564 160 0.996
Human Worm
dna integrity checkpoint GO:0031570 28 0.993
regulation of mitotic cell cycle phase transition GO:1901990 73 0.993
Human Worm
cell cycle checkpoint GO:0000075 47 0.979
dna metabolic process GO:0006259 303 0.976
cellular response to dna damage stimulus GO:0006974 207 0.972
regulation of mitotic cell cycle GO:0007346 126 0.967
Human Worm
positive regulation of cell cycle GO:0045787 92 0.965
Human Worm
dna damage checkpoint GO:0000077 26 0.963
regulation of cell cycle GO:0051726 281 0.956
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 6 0.953
regulation of cellular response to stress GO:0080135 159 0.951
re entry into mitotic cell cycle GO:0000320 3 0.942
cell growth GO:0016049 130 0.937
Fly
wnt signaling pathway GO:0016055 188 0.931
response to endoplasmic reticulum stress GO:0034976 53 0.929
cellular response to topologically incorrect protein GO:0035967 25 0.915
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.899
cell cycle g1 s phase transition GO:0044843 57 0.886
Human Worm
negative regulation of cell cycle GO:0045786 123 0.862
Human
positive regulation of cell cycle phase transition GO:1901989 17 0.862
Human Worm
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.857
response to iron ion GO:0010039 4 0.852
mitotic cell cycle GO:0000278 195 0.849
Human Worm Fly
axon guidance GO:0007411 141 0.847
positive regulation of protein modification process GO:0031401 299 0.827
negative regulation of cell cycle arrest GO:0071157 1 0.815
Human
heterocycle catabolic process GO:0046700 280 0.805
stem cell differentiation GO:0048863 268 0.802
Mouse
neuron projection guidance GO:0097485 141 0.795
mitotic cell cycle process GO:1903047 159 0.787
Human Worm
response to uv a GO:0070141 1 0.783
positive regulation of mitotic cell cycle GO:0045931 41 0.780
Human Worm
regionalization GO:0003002 337 0.777
Fly
negative regulation of cellular protein metabolic process GO:0032269 247 0.776
dna repair GO:0006281 107 0.763
leukocyte proliferation GO:0070661 172 0.763
t cell proliferation GO:0042098 120 0.760
response to unfolded protein GO:0006986 21 0.759
regulation of wnt signaling pathway GO:0030111 123 0.746
chromatin organization GO:0006325 206 0.740
chromatin modification GO:0016568 187 0.739
mitotic cell cycle checkpoint GO:0007093 31 0.738
mrna metabolic process GO:0016071 84 0.731
histone modification GO:0016570 159 0.721
negative regulation of molecular function GO:0044092 258 0.700
apoptotic signaling pathway GO:0097190 306 0.698
circadian regulation of gene expression GO:0032922 48 0.695
negative regulation of response to dna damage stimulus GO:2001021 10 0.685
regulation of cell division GO:0051302 76 0.684
fat cell differentiation GO:0045444 160 0.676
negative regulation of mitotic cell cycle GO:0045930 58 0.668
positive regulation of mammary gland epithelial cell proliferation GO:0033601 5 0.658
mitotic g1 dna damage checkpoint GO:0031571 4 0.656
aromatic compound catabolic process GO:0019439 286 0.653
macromolecule catabolic process GO:0009057 281 0.650
meiotic nuclear division GO:0007126 115 0.648
Worm
cellular macromolecule catabolic process GO:0044265 206 0.640
negative regulation of cell cycle phase transition GO:1901988 48 0.640
regulation of cell cycle phase transition GO:1901987 77 0.638
Human Worm
g1 s transition of mitotic cell cycle GO:0000082 57 0.637
Human Worm
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.634
endoplasmic reticulum unfolded protein response GO:0030968 19 0.634
regulation of protein kinase activity GO:0045859 232 0.631
gland development GO:0048732 330 0.624
lactation GO:0007595 25 0.623
positive regulation of programmed cell death GO:0043068 218 0.622
nucleobase containing small molecule metabolic process GO:0055086 352 0.616
negative regulation of wnt signaling pathway GO:0030178 73 0.616
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 5 0.615
Human
response to testosterone GO:0033574 3 0.605
intrinsic apoptotic signaling pathway GO:0097193 132 0.603
negative regulation of phosphorylation GO:0042326 166 0.599
lymphocyte proliferation GO:0046651 164 0.590
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.586
signal transduction by p53 class mediator GO:0072331 51 0.583
negative regulation of growth GO:0045926 99 0.581
regulation of epithelial cell proliferation GO:0050678 141 0.574
regulation of response to dna damage stimulus GO:2001020 34 0.573
negative regulation of cell proliferation GO:0008285 296 0.563
response to alcohol GO:0097305 48 0.552
positive regulation of apoptotic signaling pathway GO:2001235 95 0.547
mrna processing GO:0006397 63 0.547
organophosphate biosynthetic process GO:0090407 122 0.542
cellular nitrogen compound catabolic process GO:0044270 280 0.541
response to topologically incorrect protein GO:0035966 25 0.540
chemotaxis GO:0006935 247 0.540
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.540
Worm
regulation of nuclear cell cycle dna replication GO:0033262 2 0.538
modification dependent macromolecule catabolic process GO:0043632 133 0.538
germ cell development GO:0007281 185 0.538
negative regulation of phosphorus metabolic process GO:0010563 184 0.536
g2 dna damage checkpoint GO:0031572 8 0.536
epithelial cell proliferation GO:0050673 174 0.531
development of primary sexual characteristics GO:0045137 143 0.527
Worm
regulation of transferase activity GO:0051338 263 0.523
homeostasis of number of cells GO:0048872 210 0.511
cellular ketone metabolic process GO:0042180 84 0.497
nucleoside phosphate biosynthetic process GO:1901293 79 0.486
regulation of body fluid levels GO:0050878 162 0.482
non recombinational repair GO:0000726 10 0.482
regulation of cell growth GO:0001558 91 0.480
positive regulation of protein phosphorylation GO:0001934 242 0.478
dna dependent dna replication GO:0006261 24 0.477
mitochondrion organization GO:0007005 134 0.474
Fly
nuclear transport GO:0051169 139 0.474
cellular chemical homeostasis GO:0055082 215 0.467
regulation of protein serine threonine kinase activity GO:0071900 157 0.466
cellular homeostasis GO:0019725 240 0.461
regulation of double strand break repair via homologous recombination GO:0010569 2 0.458
regulation of organelle organization GO:0033043 289 0.453
organonitrogen compound biosynthetic process GO:1901566 192 0.449
methylation GO:0032259 134 0.449
er nucleus signaling pathway GO:0006984 27 0.446
regulation of apoptotic signaling pathway GO:2001233 197 0.446
organ regeneration GO:0031100 2 0.444
regulation of kinase activity GO:0043549 249 0.441
organic cyclic compound catabolic process GO:1901361 295 0.440
mitotic g2 dna damage checkpoint GO:0007095 8 0.438
response to uv GO:0009411 44 0.433
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.430
myeloid cell differentiation GO:0030099 233 0.412
microtubule cytoskeleton organization GO:0000226 157 0.412
meiotic cell cycle GO:0051321 122 0.409
Worm
signal transduction in absence of ligand GO:0038034 55 0.407
protein localization to organelle GO:0033365 185 0.393
protein processing GO:0016485 163 0.393
protein methylation GO:0006479 81 0.390
rhythmic process GO:0048511 174 0.390
response to steroid hormone GO:0048545 56 0.389
dna catabolic process GO:0006308 19 0.385
positive regulation of transferase activity GO:0051347 167 0.381
regulation of cellular catabolic process GO:0031329 242 0.375
nuclear division GO:0000280 158 0.375
Worm
protein localization to chromosome centromeric region GO:0071459 1 0.374
cytoplasmic transport GO:0016482 234 0.371
nitrogen compound transport GO:0071705 271 0.368
regulation of cytoplasmic transport GO:1903649 112 0.365
positive regulation of cell death GO:0010942 224 0.364
regulation of cell cycle g1 s phase transition GO:1902806 35 0.363
Worm
mammary gland epithelial cell proliferation GO:0033598 24 0.348
negative regulation of nuclear division GO:0051784 19 0.342
generation of precursor metabolites and energy GO:0006091 103 0.341
glycogen metabolic process GO:0005977 32 0.339
positive regulation of cell cycle process GO:0090068 61 0.336
Human Worm
negative regulation of cellular component organization GO:0051129 194 0.334
covalent chromatin modification GO:0016569 163 0.332
spermatogenesis GO:0007283 284 0.332
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.327
cellular response to lipid GO:0071396 145 0.324
response to corticosteroid GO:0031960 20 0.318
body fluid secretion GO:0007589 53 0.317
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.315
response to organic cyclic compound GO:0014070 198 0.315
positive regulation of cellular catabolic process GO:0031331 148 0.311
cellular amino acid metabolic process GO:0006520 103 0.301
rna processing GO:0006396 105 0.300
cellular response to oxidative stress GO:0034599 76 0.293
negative regulation of protein modification process GO:0031400 163 0.293
cellular protein catabolic process GO:0044257 155 0.293
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.285
ribonucleotide metabolic process GO:0009259 291 0.285
mammary gland alveolus development GO:0060749 22 0.285
negative regulation of transferase activity GO:0051348 85 0.284
regulation of cellular amino acid metabolic process GO:0006521 5 0.281
t cell activation GO:0042110 289 0.278
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.277
positive regulation of kinase activity GO:0033674 155 0.274
energy derivation by oxidation of organic compounds GO:0015980 77 0.272
positive regulation of apoptotic process GO:0043065 217 0.272
protein import into nucleus GO:0006606 95 0.271
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.271
regulation of cellular amine metabolic process GO:0033238 20 0.268
positive regulation of epithelial cell proliferation GO:0050679 68 0.266
regulation of hydrolase activity GO:0051336 246 0.261
pole plasm assembly GO:0007315 2 0.260
cellular response to cytokine stimulus GO:0071345 189 0.259
gene silencing GO:0016458 38 0.258
purine nucleoside triphosphate metabolic process GO:0009144 226 0.256
nucleocytoplasmic transport GO:0006913 139 0.256
axonogenesis GO:0007409 274 0.251
hexose metabolic process GO:0019318 98 0.248
mammary gland epithelium development GO:0061180 65 0.247
viral process GO:0016032 41 0.242
regulation of mapk cascade GO:0043408 248 0.242
nucleotide metabolic process GO:0009117 332 0.242
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.241
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.241
cell cycle arrest GO:0007050 37 0.240
Human
positive regulation of mitochondrion organization GO:0010822 17 0.238
positive regulation of growth GO:0045927 104 0.237
carbohydrate derivative biosynthetic process GO:1901137 183 0.234
endocytosis GO:0006897 168 0.234
ribonucleoside metabolic process GO:0009119 245 0.234
negative regulation of phosphate metabolic process GO:0045936 184 0.229
ribose phosphate metabolic process GO:0019693 291 0.228
response to light stimulus GO:0009416 135 0.226
macromolecule methylation GO:0043414 120 0.226
negative regulation of kinase activity GO:0033673 81 0.226
nucleotide biosynthetic process GO:0009165 78 0.226
regulation of intracellular protein transport GO:0033157 82 0.224
regulation of intracellular transport GO:0032386 159 0.224
extrinsic apoptotic signaling pathway GO:0097191 126 0.224
response to ethanol GO:0045471 18 0.222
positive regulation of organelle organization GO:0010638 128 0.217
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.217
cellular ion homeostasis GO:0006873 165 0.216
hepaticobiliary system development GO:0061008 67 0.215
cellular carbohydrate metabolic process GO:0044262 119 0.215
purine ribonucleoside catabolic process GO:0046130 205 0.214
purine containing compound biosynthetic process GO:0072522 70 0.212
positive regulation of fibroblast proliferation GO:0048146 20 0.211
Human
negative regulation of epithelial cell proliferation GO:0050680 64 0.211
muscle cell differentiation GO:0042692 261 0.211
female gamete generation GO:0007292 74 0.210
leukocyte apoptotic process GO:0071887 71 0.210
purine containing compound metabolic process GO:0072521 311 0.210
cellular amine metabolic process GO:0044106 44 0.209
regulation of cellular ketone metabolic process GO:0010565 66 0.207
negative regulation of cellular catabolic process GO:0031330 47 0.204
nucleoside triphosphate metabolic process GO:0009141 230 0.204
regulation of double strand break repair via nonhomologous end joining GO:2001032 2 0.203
protein modification by small protein conjugation or removal GO:0070647 207 0.203
microtubule based process GO:0007017 236 0.202
leukocyte differentiation GO:0002521 342 0.200
Mouse
response to estrogen GO:0043627 24 0.200
amine metabolic process GO:0009308 45 0.199
cell division GO:0051301 120 0.198
negative regulation of protein phosphorylation GO:0001933 126 0.197
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.193
dna replication GO:0006260 52 0.190
regulation of neuron differentiation GO:0045664 281 0.188
meiotic cell cycle process GO:1903046 77 0.188
negative regulation of intracellular signal transduction GO:1902532 167 0.187
response to inorganic substance GO:0010035 96 0.185
negative regulation of protein metabolic process GO:0051248 282 0.185
carbohydrate metabolic process GO:0005975 230 0.182
purine nucleoside triphosphate catabolic process GO:0009146 203 0.182
positive regulation of protein kinase activity GO:0045860 144 0.180
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.179
viral life cycle GO:0019058 36 0.176
proteasomal protein catabolic process GO:0010498 98 0.175
positive regulation of cell growth GO:0030307 33 0.174
jak stat cascade GO:0007259 42 0.173
Fly
canonical wnt signaling pathway GO:0060070 130 0.173
regulation of nucleoside metabolic process GO:0009118 130 0.173
oxidation reduction process GO:0055114 342 0.171
liver development GO:0001889 66 0.166
purine nucleotide biosynthetic process GO:0006164 65 0.165
receptor mediated endocytosis GO:0006898 51 0.165
posttranscriptional regulation of gene expression GO:0010608 155 0.162
protein localization to nucleus GO:0034504 121 0.158
epithelial tube morphogenesis GO:0060562 303 0.157
membrane organization GO:0061024 245 0.154
camera type eye development GO:0043010 266 0.154
regulation of dna dependent dna replication GO:0090329 8 0.154
development of primary male sexual characteristics GO:0046546 88 0.154
nucleoside phosphate metabolic process GO:0006753 338 0.153
mitotic nuclear division GO:0007067 48 0.152
Worm
deoxyribonucleotide biosynthetic process GO:0009263 6 0.151
interspecies interaction between organisms GO:0044419 83 0.150
regulation of lipid metabolic process GO:0019216 118 0.149
positive regulation of cytoplasmic transport GO:1903651 40 0.148
peptidyl amino acid modification GO:0018193 336 0.148
gonad development GO:0008406 141 0.148
Worm
negative regulation of apoptotic signaling pathway GO:2001234 104 0.148
regulation of nucleocytoplasmic transport GO:0046822 73 0.148
innate immune response GO:0045087 157 0.146
striated muscle tissue development GO:0014706 293 0.146
protein modification by small protein conjugation GO:0032446 187 0.146
cell type specific apoptotic process GO:0097285 268 0.145
double strand break repair via nonhomologous end joining GO:0006303 10 0.143
oocyte anterior posterior axis specification GO:0007314 2 0.142
mapk cascade GO:0000165 281 0.142
positive regulation of dna repair GO:0045739 3 0.139
ribonucleoside catabolic process GO:0042454 206 0.139
regulation of cell migration GO:0030334 219 0.136
oocyte development GO:0048599 33 0.136
negative regulation of immune system process GO:0002683 209 0.136
ossification GO:0001503 216 0.135
cell cycle g2 m phase transition GO:0044839 20 0.135
Human
myeloid cell homeostasis GO:0002262 114 0.134
regulation of protein import into nucleus GO:0042306 52 0.131
metaphase plate congression GO:0051310 2 0.130
leydig cell differentiation GO:0033327 10 0.129
positive regulation of proteolysis GO:0045862 85 0.128
male gamete generation GO:0048232 285 0.128
response to nutrient levels GO:0031667 109 0.127
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.125
sister chromatid cohesion GO:0007062 12 0.125
response to estradiol GO:0032355 12 0.124
striated muscle cell development GO:0055002 125 0.123
small gtpase mediated signal transduction GO:0007264 97 0.123
histone methylation GO:0016571 71 0.122
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.121
response to transition metal nanoparticle GO:1990267 11 0.121
purine nucleoside catabolic process GO:0006152 205 0.121
regulation of dna dependent dna replication initiation GO:0030174 3 0.120
response to metal ion GO:0010038 47 0.116
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.115
regulation of microtubule based process GO:0032886 52 0.114
stem cell development GO:0048864 219 0.114
response to oxidative stress GO:0006979 123 0.114
response to glucocorticoid GO:0051384 20 0.113
oocyte construction GO:0007308 2 0.110
negative regulation of hydrolase activity GO:0051346 71 0.109
response to ketone GO:1901654 15 0.109
nucleoside metabolic process GO:0009116 246 0.109
neuron apoptotic process GO:0051402 142 0.108
sensory organ morphogenesis GO:0090596 242 0.108
dna dealkylation GO:0035510 11 0.107
protein catabolic process GO:0030163 221 0.105
regulation of cell motility GO:2000145 236 0.105
meiosis i GO:0007127 60 0.104
spindle assembly GO:0051225 13 0.103
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.102
mrna splicing via spliceosome GO:0000398 43 0.101
negative regulation of cell cycle process GO:0010948 69 0.100
Human
segmentation GO:0035282 93 0.099
Fly
regulation of binding GO:0051098 111 0.099
locomotory behavior GO:0007626 195 0.098
purine ribonucleotide metabolic process GO:0009150 290 0.098
intracellular receptor signaling pathway GO:0030522 74 0.097
lymphocyte homeostasis GO:0002260 64 0.097
protein ubiquitination GO:0016567 171 0.097
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.095
positive regulation of response to dna damage stimulus GO:2001022 14 0.095
neuron death GO:0070997 154 0.095
protein maturation GO:0051604 176 0.095
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.095
regulation of microtubule cytoskeleton organization GO:0070507 37 0.093
purine ribonucleoside metabolic process GO:0046128 241 0.092
response to radiation GO:0009314 165 0.092
chromatin silencing GO:0006342 15 0.091
regulation of g2 m transition of mitotic cell cycle GO:0010389 10 0.091
Human
purine nucleotide metabolic process GO:0006163 302 0.090
positive regulation of cellular amine metabolic process GO:0033240 5 0.090
branching morphogenesis of an epithelial tube GO:0048754 159 0.089
ras protein signal transduction GO:0007265 77 0.089
recombinational repair GO:0000725 21 0.088
response to x ray GO:0010165 11 0.088
polysaccharide metabolic process GO:0005976 39 0.088
oocyte differentiation GO:0009994 35 0.087
regulation of proteolysis GO:0030162 164 0.087
negative regulation of cellular amine metabolic process GO:0033239 1 0.087
monosaccharide metabolic process GO:0005996 106 0.087
dna templated transcription termination GO:0006353 4 0.085
replication fork processing GO:0031297 1 0.085
organelle fission GO:0048285 170 0.085
Worm
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.084
dna biosynthetic process GO:0071897 22 0.082
response to ionizing radiation GO:0010212 42 0.082
positive regulation of cell migration GO:0030335 109 0.081
insemination GO:0007320 6 0.081
cellular response to growth factor stimulus GO:0071363 197 0.081
response to drug GO:0042493 75 0.081
Human
rna splicing GO:0008380 54 0.080
regulation of cell substrate adhesion GO:0010810 73 0.080
actomyosin structure organization GO:0031032 56 0.079
purine nucleoside metabolic process GO:0042278 241 0.078
regeneration GO:0031099 38 0.078
release of cytochrome c from mitochondria GO:0001836 23 0.077
i kappab kinase nf kappab signaling GO:0007249 85 0.077
purine ribonucleotide biosynthetic process GO:0009152 59 0.076
regulation of protein catabolic process GO:0042176 108 0.076
establishment of protein localization to organelle GO:0072594 118 0.076
regulation of reactive oxygen species metabolic process GO:2000377 40 0.076
base excision repair GO:0006284 9 0.075
dna modification GO:0006304 50 0.074
dephosphorylation GO:0016311 129 0.073
activation of cysteine type endopeptidase activity GO:0097202 27 0.071
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.071
lymphocyte apoptotic process GO:0070227 54 0.070
cellular polysaccharide metabolic process GO:0044264 38 0.070
regulation of myeloid cell differentiation GO:0045637 96 0.069
cellular response to organic cyclic compound GO:0071407 87 0.069
cellular response to hormone stimulus GO:0032870 150 0.069
morphogenesis of a branching epithelium GO:0061138 193 0.068
nucleotide catabolic process GO:0009166 217 0.068
cellular lipid metabolic process GO:0044255 323 0.068
metal ion homeostasis GO:0055065 189 0.066
cell substrate adhesion GO:0031589 130 0.065
negative regulation of neuron apoptotic process GO:0043524 92 0.065
purine containing compound catabolic process GO:0072523 213 0.064
response to corticosterone GO:0051412 1 0.064
ribonucleoside triphosphate catabolic process GO:0009203 199 0.063
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.063
regulation of mitochondrial membrane potential GO:0051881 17 0.062
purine ribonucleotide catabolic process GO:0009154 208 0.062
cellular response to peptide hormone stimulus GO:0071375 92 0.062
response to extracellular stimulus GO:0009991 127 0.061
multicellular organism growth GO:0035264 161 0.061
mitotic spindle organization GO:0007052 10 0.060
response to mineralocorticoid GO:0051385 1 0.060
positive regulation of chromosome organization GO:2001252 33 0.060
regulation of neuron death GO:1901214 134 0.059
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.059
urogenital system development GO:0001655 261 0.059
negative regulation of organelle organization GO:0010639 90 0.059
organ growth GO:0035265 117 0.058
regulation of carbohydrate metabolic process GO:0006109 75 0.058
notch signaling pathway GO:0007219 71 0.057
Mouse
multi multicellular organism process GO:0044706 109 0.057
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.056
hematopoietic progenitor cell differentiation GO:0002244 143 0.056
Mouse
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.056
positive regulation of lipid metabolic process GO:0045834 40 0.056
chromatin remodeling GO:0006338 32 0.056
regulation of feeding behavior GO:0060259 3 0.056
negative regulation of neuron death GO:1901215 98 0.056
establishment of rna localization GO:0051236 18 0.055
cellular response to extracellular stimulus GO:0031668 81 0.055
stem cell maintenance GO:0019827 130 0.055
gliogenesis GO:0042063 141 0.054
mesenchymal cell differentiation GO:0048762 107 0.054
defense response to bacterium GO:0042742 119 0.054
zymogen activation GO:0031638 41 0.054
negative regulation of cell growth GO:0030308 44 0.054
positive regulation of cell development GO:0010720 237 0.054
regulation of fibroblast proliferation GO:0048145 34 0.054
Human
purine nucleotide catabolic process GO:0006195 211 0.053
regulation of atp metabolic process GO:1903578 17 0.053
spindle organization GO:0007051 28 0.053
regulation of neuron apoptotic process GO:0043523 122 0.053
ribonucleotide biosynthetic process GO:0009260 59 0.052
response to oxygen levels GO:0070482 62 0.052
skeletal system development GO:0001501 356 0.051
embryonic appendage morphogenesis GO:0035113 126 0.051
oogenesis GO:0048477 56 0.051
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.051
cognition GO:0050890 149 0.051
blastoderm segmentation GO:0007350 13 0.050
Fly
protein complex disassembly GO:0043241 40 0.049
regulation of leukocyte apoptotic process GO:2000106 56 0.049
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.049
gene silencing by rna GO:0031047 19 0.049
regulation of protein stability GO:0031647 52 0.049
heart contraction GO:0060047 93 0.049
cellular calcium ion homeostasis GO:0006874 119 0.049
organelle assembly GO:0070925 177 0.048
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.048
cell maturation GO:0048469 127 0.047
regulation of establishment of protein localization GO:0070201 181 0.047
cation transport GO:0006812 399 0.047
blood vessel morphogenesis GO:0048514 285 0.047
ribose phosphate biosynthetic process GO:0046390 59 0.047
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 10 0.046
protein targeting GO:0006605 143 0.046
ribonucleotide catabolic process GO:0009261 208 0.046
regulation of striated muscle cell differentiation GO:0051153 81 0.046
sequestering of metal ion GO:0051238 19 0.045
positive regulation of triglyceride catabolic process GO:0010898 3 0.045
cellular response to radiation GO:0071478 28 0.045
regulation of protein localization GO:0032880 231 0.045
apoptotic mitochondrial changes GO:0008637 48 0.045
cellular response to steroid hormone stimulus GO:0071383 33 0.044
regulation of protein processing GO:0070613 96 0.044
regulation of cellular protein catabolic process GO:1903362 61 0.044
intracellular protein transport GO:0006886 204 0.044
transmembrane transport GO:0055085 412 0.044
cell aging GO:0007569 35 0.043
regulation of cysteine type endopeptidase activity GO:2000116 65 0.043
negative regulation of dna templated transcription termination GO:0060567 1 0.043
negative regulation of oxidative stress induced cell death GO:1903202 9 0.043
response to acid chemical GO:0001101 111 0.043
defense response to gram negative bacterium GO:0050829 28 0.042
positive regulation of peptidase activity GO:0010952 49 0.042
glucan metabolic process GO:0044042 32 0.042
maintenance of location GO:0051235 89 0.042
trna wobble uridine modification GO:0002098 2 0.041
nucleoside catabolic process GO:0009164 206 0.041
cell fate commitment GO:0045165 210 0.041
reactive oxygen species metabolic process GO:0072593 84 0.040
positive regulation of neuron differentiation GO:0045666 141 0.040
male sex differentiation GO:0046661 109 0.040
mesenchyme development GO:0060485 152 0.040
positive regulation of intracellular transport GO:0032388 70 0.040
positive regulation of cell division GO:0051781 31 0.040
response to transforming growth factor beta GO:0071559 88 0.040

Cdk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
large intestine cancer DOID:5672 0 0.913
colon cancer DOID:219 0 0.913
gastrointestinal system cancer DOID:3119 0 0.913
intestinal cancer DOID:10155 0 0.913
cancer DOID:162 0 0.913
disease of cellular proliferation DOID:14566 0 0.913
organ system cancer DOID:0050686 0 0.913
colorectal cancer DOID:9256 0 0.913
immune system cancer DOID:0060083 0 0.510
hematologic cancer DOID:2531 0 0.465
bone marrow cancer DOID:4960 0 0.278
cell type benign neoplasm DOID:0060084 0 0.217
benign neoplasm DOID:0060072 0 0.217
disease of metabolism DOID:0014667 0 0.090
inherited metabolic disorder DOID:655 0 0.061
colon carcinoma DOID:1520 0 0.061