Mus musculus

97 known processes

Prmt5

protein arginine N-methyltransferase 5

(Aliases: Jbp1,Skb1)

Prmt5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin disassembly GO:0031498 1 0.957
protein dna complex disassembly GO:0032986 1 0.956
nucleosome disassembly GO:0006337 1 0.944
pole plasm assembly GO:0007315 2 0.543
Fly
chromatin organization GO:0006325 206 0.391
meiotic nuclear division GO:0007126 115 0.281
protein dna complex subunit organization GO:0071824 28 0.245
regulation of cell cycle GO:0051726 281 0.223
regulation of cell cycle process GO:0010564 160 0.219
oocyte anterior posterior axis specification GO:0007314 2 0.204
Fly
macromolecule methylation GO:0043414 120 0.159
spermatogenesis GO:0007283 284 0.152
male gamete generation GO:0048232 285 0.131
meiotic cell cycle GO:0051321 122 0.113
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.112
nuclear division GO:0000280 158 0.097
regulation of mitotic cell cycle phase transition GO:1901990 73 0.094
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.091
apoptotic signaling pathway GO:0097190 306 0.080
Worm
regionalization GO:0003002 337 0.079
Fly
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.077
Human
chromatin remodeling GO:0006338 32 0.077
rna splicing via transesterification reactions GO:0000375 43 0.076
Human
snrna processing GO:0016180 1 0.073
negative regulation of cell proliferation GO:0008285 296 0.072
protein complex disassembly GO:0043241 40 0.070
macromolecular complex disassembly GO:0032984 43 0.067
mrna splicing via spliceosome GO:0000398 43 0.059
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.059
Worm
regulation of cell cycle phase transition GO:1901987 77 0.057
rna processing GO:0006396 105 0.057
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.056
oligosaccharide catabolic process GO:0009313 2 0.053
genitalia development GO:0048806 37 0.052
carbohydrate metabolic process GO:0005975 230 0.052
methylation GO:0032259 134 0.051
establishment of protein localization to organelle GO:0072594 118 0.051
oocyte axis specification GO:0007309 2 0.051
Fly
positive regulation of chromosome segregation GO:0051984 4 0.047
blastocyst development GO:0001824 80 0.047
regulation of wnt signaling pathway GO:0030111 123 0.047
mitotic cell cycle process GO:1903047 159 0.044
peptidyl lysine modification GO:0018205 77 0.044
muscle cell differentiation GO:0042692 261 0.042
atp dependent chromatin remodeling GO:0043044 9 0.040
endocytosis GO:0006897 168 0.040
nls bearing protein import into nucleus GO:0006607 2 0.040
multi multicellular organism process GO:0044706 109 0.039
purine nucleotide catabolic process GO:0006195 211 0.039
snrna 3 end processing GO:0034472 1 0.038
regulation of mitotic sister chromatid segregation GO:0033047 12 0.037
receptor mediated endocytosis GO:0006898 51 0.035
rna splicing GO:0008380 54 0.035
Human
positive regulation of cell cycle GO:0045787 92 0.035
g1 s transition of mitotic cell cycle GO:0000082 57 0.032
chromatin modification GO:0016568 187 0.031
gonad development GO:0008406 141 0.031
organism emergence from protective structure GO:0071684 4 0.030
meiosis i GO:0007127 60 0.030
positive regulation of programmed cell death GO:0043068 218 0.029
atp catabolic process GO:0006200 55 0.029
blastocyst hatching GO:0001835 4 0.029
membrane organization GO:0061024 245 0.028
hatching GO:0035188 4 0.028
regulation of protein catabolic process GO:0042176 108 0.028
histone modification GO:0016570 159 0.028
viral transcription GO:0019083 3 0.027
regulation of proteasomal protein catabolic process GO:0061136 46 0.027
mrna metabolic process GO:0016071 84 0.027
Human
regulation of cell cycle g2 m phase transition GO:1902749 10 0.027
maintenance of location GO:0051235 89 0.026
male meiosis GO:0007140 37 0.026
maturation of lsu rrna GO:0000470 1 0.026
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.025
metaphase plate congression GO:0051310 2 0.025
chromatin remodeling at centromere GO:0031055 2 0.025
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.025
chromosome segregation GO:0007059 48 0.024
regulation of organelle organization GO:0033043 289 0.024
cellular protein complex assembly GO:0043623 116 0.024
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.023
intracellular mrna localization GO:0008298 4 0.023
Fly
biofilm formation GO:0042710 1 0.023
macromolecule catabolic process GO:0009057 281 0.023
oocyte development GO:0048599 33 0.023
Fly
stem cell differentiation GO:0048863 268 0.022
regulation of cell motility GO:2000145 236 0.022
cellularization GO:0007349 1 0.022
lipid localization GO:0010876 126 0.021
myeloid cell differentiation GO:0030099 233 0.021
single species biofilm formation GO:0044010 1 0.021
organelle fission GO:0048285 170 0.021
homeostasis of number of cells GO:0048872 210 0.021
t cell proliferation GO:0042098 120 0.021
viral gene expression GO:0019080 3 0.021
megakaryocyte differentiation GO:0030219 26 0.020
mitotic nuclear division GO:0007067 48 0.020
cellular amino acid metabolic process GO:0006520 103 0.020
ribonucleoside monophosphate metabolic process GO:0009161 80 0.020
response to uv GO:0009411 44 0.020
regulation of reproductive process GO:2000241 66 0.020
proteasomal protein catabolic process GO:0010498 98 0.020
mitochondrial calcium ion homeostasis GO:0051560 7 0.019
regulation of cell substrate adhesion GO:0010810 73 0.019
maturation of 5 8s rrna GO:0000460 1 0.019
purine nucleoside triphosphate catabolic process GO:0009146 203 0.019
positive regulation of cell cycle phase transition GO:1901989 17 0.019
regulation of cell cycle g1 s phase transition GO:1902806 35 0.019
oocyte construction GO:0007308 2 0.019
Fly
cell cycle g1 s phase transition GO:0044843 57 0.019
muscle cell development GO:0055001 133 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.018
microtubule cytoskeleton organization GO:0000226 157 0.018
cellular response to lipid GO:0071396 145 0.018
Fly
response to extracellular stimulus GO:0009991 127 0.018
female gamete generation GO:0007292 74 0.017
Fly
protein localization to organelle GO:0033365 185 0.017
snrna metabolic process GO:0016073 1 0.017
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.017
Worm
negative regulation of cell cycle GO:0045786 123 0.017
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.017
protein localization to chromosome centromeric region GO:0071459 1 0.017
rrna transcription GO:0009303 9 0.016
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.016
regulation of mitotic cell cycle GO:0007346 126 0.016
purine nucleoside monophosphate catabolic process GO:0009128 58 0.016
ncrna 3 end processing GO:0043628 2 0.016
response to peptide hormone GO:0043434 127 0.016
positive regulation of growth GO:0045927 104 0.016
response to organonitrogen compound GO:0010243 246 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
Worm
wnt signaling pathway GO:0016055 188 0.015
purine nucleoside monophosphate metabolic process GO:0009126 81 0.015
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.015
ubiquitin dependent protein catabolic process GO:0006511 129 0.015
protein processing GO:0016485 163 0.015
snorna metabolic process GO:0016074 1 0.015
regulation of transferase activity GO:0051338 263 0.015
histone demethylation GO:0016577 13 0.015
cellular protein catabolic process GO:0044257 155 0.015
regulation of protein maturation GO:1903317 96 0.015
mitochondrion organization GO:0007005 134 0.014
positive regulation of cell activation GO:0050867 158 0.014
positive regulation of protein modification process GO:0031401 299 0.014
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 1 0.014
purine nucleotide metabolic process GO:0006163 302 0.014
positive regulation of cell substrate adhesion GO:0010811 47 0.014
regulation of body fluid levels GO:0050878 162 0.014
aspartate family amino acid metabolic process GO:0009066 10 0.014
positive regulation of cell cycle process GO:0090068 61 0.014
regulation of androgen receptor signaling pathway GO:0060765 3 0.014
purine nucleoside triphosphate metabolic process GO:0009144 226 0.014
response to organic cyclic compound GO:0014070 198 0.014
Fly
nucleoside phosphate catabolic process GO:1901292 222 0.014
ribose phosphate metabolic process GO:0019693 291 0.014
transcription from rna polymerase i promoter GO:0006360 13 0.014
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.013
negative regulation of cell cycle arrest GO:0071157 1 0.013
cardiac chamber morphogenesis GO:0003206 93 0.013
transdifferentiation GO:0060290 1 0.013
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.013
disaccharide metabolic process GO:0005984 1 0.013
negative regulation of reproductive process GO:2000242 31 0.013
myosin filament assembly GO:0031034 2 0.013
urogenital system development GO:0001655 261 0.013
development of primary sexual characteristics GO:0045137 143 0.013
regulation of mrna metabolic process GO:1903311 43 0.013
regulation of cell division GO:0051302 76 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.012
cellular component assembly involved in morphogenesis GO:0010927 139 0.012
nucleolus organization GO:0007000 5 0.012
establishment of protein localization to membrane GO:0090150 54 0.012
negative regulation of cell cycle phase transition GO:1901988 48 0.012
protein catabolic process GO:0030163 221 0.012
histone lysine demethylation GO:0070076 13 0.012
nucleoside phosphate metabolic process GO:0006753 338 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
morphogenesis of an endothelium GO:0003159 2 0.012
midgut development GO:0007494 4 0.012
cellular nitrogen compound catabolic process GO:0044270 280 0.012
cytoplasmic transport GO:0016482 234 0.012
cellular response to radiation GO:0071478 28 0.012
meiotic cell cycle process GO:1903046 77 0.012
negative regulation of cell cycle process GO:0010948 69 0.012
positive regulation of mrna processing GO:0050685 16 0.012
positive regulation of b cell activation GO:0050871 49 0.012
nucleotide catabolic process GO:0009166 217 0.012
localization within membrane GO:0051668 4 0.012
tube closure GO:0060606 91 0.012
spliceosomal complex disassembly GO:0000390 1 0.012
actin cytoskeleton organization GO:0030036 220 0.012
cell division GO:0051301 120 0.011
regulation of mitochondrial translation GO:0070129 3 0.011
modification dependent protein catabolic process GO:0019941 133 0.011
response to light stimulus GO:0009416 135 0.011
positive regulation of cellular protein catabolic process GO:1903364 34 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
chromosome separation GO:0051304 14 0.011
response to insulin GO:0032868 100 0.011
glycosyl compound catabolic process GO:1901658 206 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
leukocyte proliferation GO:0070661 172 0.011
skeletal system development GO:0001501 356 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
positive regulation of immune effector process GO:0002699 107 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
stem cell development GO:0048864 219 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.011
gene silencing GO:0016458 38 0.011
leukocyte differentiation GO:0002521 342 0.010
nucleobase containing small molecule metabolic process GO:0055086 352 0.010
positive regulation of apoptotic process GO:0043065 217 0.010
striated muscle cell development GO:0055002 125 0.010
regulation of cellular catabolic process GO:0031329 242 0.010
cellular homeostasis GO:0019725 240 0.010
response to inorganic substance GO:0010035 96 0.010
purine ribonucleotide metabolic process GO:0009150 290 0.010
regulation of cell activation GO:0050865 289 0.010
rig i signaling pathway GO:0039529 4 0.010
positive regulation of cell adhesion GO:0045785 80 0.010

Prmt5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.027
sensory system disease DOID:0050155 0 0.027
disease of anatomical entity DOID:7 0 0.027
eye and adnexa disease DOID:1492 0 0.027
nervous system disease DOID:863 0 0.027
eye disease DOID:5614 0 0.027
retinal degeneration DOID:8466 0 0.021
immune system cancer DOID:0060083 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010
disease of metabolism DOID:0014667 0 0.010
inherited metabolic disorder DOID:655 0 0.010