Mus musculus

53 known processes

Pak1

p21 protein (Cdc42/Rac)-activated kinase 1

(Aliases: PAK-1,AW045634,Paka)

Pak1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
sensory perception of touch GO:0050975 2 0.991
regulation of lamellipodium assembly GO:0010591 3 0.904
keratinocyte development GO:0003334 10 0.902
cell junction maintenance GO:0034331 4 0.820
retina vasculature morphogenesis in camera type eye GO:0061299 10 0.725
regulation of hair follicle cell proliferation GO:0071336 2 0.701
hyperosmotic response GO:0006972 4 0.700
positive regulation of lamellipodium organization GO:1902745 3 0.697
positive regulation of lamellipodium assembly GO:0010592 2 0.690
regulation of ruffle assembly GO:1900027 8 0.685
exocyst localization GO:0051601 2 0.679
engulfment of apoptotic cell GO:0043652 3 0.671
positive regulation of cellular amine metabolic process GO:0033240 5 0.566
regulation of substrate adhesion dependent cell spreading GO:1900024 12 0.562
rho protein signal transduction GO:0007266 32 0.556
cellular amine metabolic process GO:0044106 44 0.546
small gtpase mediated signal transduction GO:0007264 97 0.533
regulation of protein heterodimerization activity GO:0043497 2 0.532
regulation of exocyst localization GO:0060178 2 0.519
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 5 0.518
lateral inhibition GO:0046331 1 0.512
ruffle organization GO:0031529 16 0.511
regulation of neutrophil chemotaxis GO:0090022 14 0.506
lamellipodium organization GO:0097581 29 0.499
oocyte anterior posterior axis specification GO:0007314 2 0.493
amine metabolic process GO:0009308 45 0.475
positive regulation of filopodium assembly GO:0051491 10 0.474
ras protein signal transduction GO:0007265 77 0.465
ruffle assembly GO:0097178 13 0.464
phospholipid metabolic process GO:0006644 87 0.462
positive regulation of lipid kinase activity GO:0090218 11 0.452
non canonical wnt signaling pathway GO:0035567 33 0.447
response to osmotic stress GO:0006970 21 0.426
Yeast
positive regulation of substrate adhesion dependent cell spreading GO:1900026 8 0.426
asymmetric stem cell division GO:0098722 3 0.423
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.422
regulation of synapse structural plasticity GO:0051823 4 0.415
regulation of cellular amine metabolic process GO:0033238 20 0.400
dorsal ventral axon guidance GO:0033563 3 0.394
secondary metabolic process GO:0019748 18 0.387
guanosine containing compound catabolic process GO:1901069 144 0.374
cell adhesion GO:0007155 329 0.373
cerebral cortex radially oriented cell migration GO:0021799 31 0.371
cellular amino acid metabolic process GO:0006520 103 0.366
positive regulation of neutrophil migration GO:1902624 12 0.363
hair follicle cell proliferation GO:0071335 3 0.358
positive regulation of actin filament polymerization GO:0030838 26 0.357
regulation of cellular amino acid metabolic process GO:0006521 5 0.357
cellular ketone metabolic process GO:0042180 84 0.353
regulation of ras gtpase activity GO:0032318 88 0.343
regulation of nucleotide catabolic process GO:0030811 122 0.335
golgi localization GO:0051645 4 0.329
peptidyl serine modification GO:0018209 83 0.326
Human Yeast
regulation of cell adhesion GO:0030155 154 0.314
regulation of establishment of planar polarity GO:0090175 28 0.301
gtp catabolic process GO:0006184 143 0.300
dendritic cell migration GO:0036336 12 0.291
establishment of planar polarity GO:0001736 28 0.281
regulation of endocytosis GO:0030100 69 0.280
regulation of gtp catabolic process GO:0033124 113 0.279
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.278
regulation of cell substrate adhesion GO:0010810 73 0.276
positive regulation of metalloenzyme activity GO:0048554 3 0.276
protein catabolic process GO:0030163 221 0.275
guanosine containing compound metabolic process GO:1901068 144 0.273
positive regulation of neutrophil chemotaxis GO:0090023 12 0.272
immune response regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002433 1 0.268
hair follicle placode formation GO:0060789 5 0.267
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.265
purine nucleoside catabolic process GO:0006152 205 0.263
ribonucleoside triphosphate catabolic process GO:0009203 199 0.263
purine nucleotide catabolic process GO:0006195 211 0.263
ribonucleoside metabolic process GO:0009119 245 0.263
purine containing compound catabolic process GO:0072523 213 0.262
pole plasm assembly GO:0007315 2 0.258
ectodermal digestive tract development GO:0007439 1 0.257
pigment metabolic process GO:0042440 32 0.256
positive regulation of hair follicle cell proliferation GO:0071338 1 0.256
mesodermal cell migration GO:0008078 4 0.255
organic cyclic compound catabolic process GO:1901361 295 0.254
purine ribonucleoside metabolic process GO:0046128 241 0.254
morphogenesis of a polarized epithelium GO:0001738 37 0.254
single organismal cell cell adhesion GO:0016337 131 0.254
positive regulation of cell adhesion GO:0045785 80 0.253
cardiac conduction system development GO:0003161 12 0.250
g protein coupled receptor signaling pathway GO:0007186 243 0.249
Yeast
nucleus localization GO:0051647 20 0.249
positive regulation of cell projection organization GO:0031346 95 0.248
anatomical structure arrangement GO:0048532 20 0.247
regulation of ras protein signal transduction GO:0046578 114 0.246
neuromuscular process controlling balance GO:0050885 59 0.246
granulocyte chemotaxis GO:0071621 39 0.244
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.244
nucleotide catabolic process GO:0009166 217 0.243
protein localization to membrane GO:0072657 108 0.241
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.239
regulation of protein binding GO:0043393 60 0.238
axonogenesis GO:0007409 274 0.236
Mouse
immune effector process GO:0002252 321 0.234
regulation of response to wounding GO:1903034 189 0.234
positive regulation of ras gtpase activity GO:0032320 65 0.231
ribonucleotide catabolic process GO:0009261 208 0.230
endocytosis GO:0006897 168 0.230
asymmetric neuroblast division GO:0055059 1 0.230
regulation of neuron projection development GO:0010975 169 0.229
nucleoside catabolic process GO:0009164 206 0.228
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.225
positive regulation of cellular component biogenesis GO:0044089 94 0.224
Human
actin filament bundle assembly GO:0051017 40 0.222
Human
cellular lipid metabolic process GO:0044255 323 0.217
substrate adhesion dependent cell spreading GO:0034446 30 0.216
positive regulation of gtp catabolic process GO:0033126 85 0.213
glycosyl compound catabolic process GO:1901658 206 0.213
glycosyl compound metabolic process GO:1901657 246 0.210
stress activated mapk cascade GO:0051403 80 0.210
Human
regulation of vacuole organization GO:0044088 4 0.210
nucleobase containing small molecule metabolic process GO:0055086 352 0.209
oocyte axis specification GO:0007309 2 0.207
macromolecule catabolic process GO:0009057 281 0.207
establishment of tissue polarity GO:0007164 28 0.206
nucleoside phosphate catabolic process GO:1901292 222 0.204
purine nucleoside metabolic process GO:0042278 241 0.203
purine ribonucleotide catabolic process GO:0009154 208 0.203
synapse organization GO:0050808 125 0.203
purine ribonucleotide metabolic process GO:0009150 290 0.203
nucleoside metabolic process GO:0009116 246 0.203
actin filament polymerization GO:0030041 44 0.201
regulation of exit from mitosis GO:0007096 1 0.199
Yeast
plasma membrane organization GO:0007009 90 0.198
nucleoside triphosphate catabolic process GO:0009143 205 0.197
regulation of transferase activity GO:0051338 263 0.197
Human Yeast
nucleotide metabolic process GO:0009117 332 0.196
olfactory lobe development GO:0021988 32 0.194
intracellular mrna localization GO:0008298 4 0.194
purine nucleoside triphosphate metabolic process GO:0009144 226 0.193
purine containing compound metabolic process GO:0072521 311 0.193
establishment of neuroblast polarity GO:0045200 1 0.192
embryonic olfactory bulb interneuron precursor migration GO:0021831 2 0.192
positive regulation of mapk cascade GO:0043410 170 0.191
Human Yeast
oocyte construction GO:0007308 2 0.188
ribose phosphate metabolic process GO:0019693 291 0.188
sensory perception of mechanical stimulus GO:0050954 107 0.187
neutrophil chemotaxis GO:0030593 36 0.186
organophosphate catabolic process GO:0046434 232 0.186
positive regulation of rho gtpase activity GO:0032321 41 0.185
defense response to bacterium GO:0042742 119 0.185
positive regulation of kinase activity GO:0033674 155 0.181
Human Yeast
heterocycle catabolic process GO:0046700 280 0.181
purine nucleoside triphosphate catabolic process GO:0009146 203 0.180
melanin metabolic process GO:0006582 12 0.178
organic hydroxy compound metabolic process GO:1901615 203 0.177
organonitrogen compound catabolic process GO:1901565 264 0.176
carbohydrate derivative catabolic process GO:1901136 231 0.176
regulation of cell projection assembly GO:0060491 38 0.175
inner ear receptor cell development GO:0060119 39 0.175
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.175
regulation of cellular response to stress GO:0080135 159 0.174
Human
aromatic compound catabolic process GO:0019439 286 0.174
positive regulation of organelle organization GO:0010638 128 0.173
Human
myeloid leukocyte migration GO:0097529 57 0.173
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.172
cell chemotaxis GO:0060326 81 0.172
nucleoside triphosphate metabolic process GO:0009141 230 0.171
peptidyl serine phosphorylation GO:0018105 74 0.171
Human Yeast
positive regulation of granulocyte chemotaxis GO:0071624 12 0.170
positive regulation of protein complex assembly GO:0031334 45 0.170
ribonucleoside triphosphate metabolic process GO:0009199 220 0.170
ribonucleoside catabolic process GO:0042454 206 0.169
cytokine production GO:0001816 319 0.169
regulation of cell projection organization GO:0031344 206 0.169
posttranscriptional regulation of gene expression GO:0010608 155 0.167
granulocyte migration GO:0097530 43 0.167
cell growth GO:0016049 130 0.167
Yeast
positive regulation of response to wounding GO:1903036 66 0.165
nucleoside phosphate metabolic process GO:0006753 338 0.165
mechanoreceptor differentiation GO:0042490 67 0.164
mapk cascade GO:0000165 281 0.161
Human Yeast
protein polymerization GO:0051258 57 0.159
retina development in camera type eye GO:0060041 119 0.158
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.157
Human
regulation of neuron differentiation GO:0045664 281 0.157
neutrophil migration GO:1990266 37 0.157
gtp metabolic process GO:0046039 144 0.157
positive regulation of protein phosphorylation GO:0001934 242 0.156
Human Yeast
neuron death GO:0070997 154 0.155
ear development GO:0043583 200 0.155
cell substrate adhesion GO:0031589 130 0.153
forebrain cell migration GO:0021885 58 0.152
purine ribonucleoside catabolic process GO:0046130 205 0.152
establishment or maintenance of neuroblast polarity GO:0045196 1 0.151
regulation of filopodium assembly GO:0051489 13 0.151
localization within membrane GO:0051668 4 0.150
regulation of cellular ketone metabolic process GO:0010565 66 0.150
neuromuscular process GO:0050905 99 0.150
regulation of neutrophil migration GO:1902622 14 0.149
bone resorption GO:0045453 38 0.149
cellular nitrogen compound catabolic process GO:0044270 280 0.146
regulation of nuclear division GO:0051783 56 0.146
Yeast
jnk cascade GO:0007254 72 0.144
Human
positive regulation of gtpase activity GO:0043547 85 0.143
regulation of cellular component size GO:0032535 121 0.142
regulation of chemotaxis GO:0050920 53 0.141
leukocyte chemotaxis GO:0030595 69 0.140
regulation of rho gtpase activity GO:0032319 58 0.138
regulation of actin filament length GO:0030832 45 0.137
axon guidance GO:0007411 141 0.137
olfactory bulb interneuron development GO:0021891 7 0.136
regulation of binding GO:0051098 111 0.135
regulation of actin filament polymerization GO:0030833 38 0.135
regulation of lipid metabolic process GO:0019216 118 0.134
regulation of rho protein signal transduction GO:0035023 71 0.133
olfactory bulb development GO:0021772 30 0.133
regulation of vesicle mediated transport GO:0060627 139 0.133
stress activated protein kinase signaling cascade GO:0031098 81 0.133
Human
auditory receptor cell differentiation GO:0042491 37 0.132
olfactory bulb interneuron differentiation GO:0021889 12 0.131
keratinocyte differentiation GO:0030216 48 0.130
regulation of anatomical structure size GO:0090066 178 0.130
chemotaxis GO:0006935 247 0.130
regulation of purine nucleotide catabolic process GO:0033121 122 0.127
sensory perception GO:0007600 245 0.127
ribonucleotide metabolic process GO:0009259 291 0.127
positive regulation of cell development GO:0010720 237 0.127
neuron projection extension GO:1990138 64 0.126
positive regulation of behavior GO:0048520 40 0.126
single organism cell adhesion GO:0098602 156 0.126
telencephalon cell migration GO:0022029 55 0.125
regulation of protein stability GO:0031647 52 0.124
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.123
synaptic transmission GO:0007268 329 0.122
positive regulation of protein kinase activity GO:0045860 144 0.122
Human Yeast
membrane invagination GO:0010324 17 0.121
nuclear division GO:0000280 158 0.121
Yeast
regulation of actin filament based process GO:0032970 99 0.121
Human Rat
hair cell differentiation GO:0035315 40 0.121
cell cell junction organization GO:0045216 72 0.121
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.120
developmental cell growth GO:0048588 84 0.119
ear morphogenesis GO:0042471 118 0.119
gland development GO:0048732 330 0.118
male gamete generation GO:0048232 285 0.118
positive regulation of actin filament bundle assembly GO:0032233 11 0.117
Human
sensory organ morphogenesis GO:0090596 242 0.117
innate immune response GO:0045087 157 0.116
regulation of neuron death GO:1901214 134 0.115
phagocytosis GO:0006909 66 0.113
negative regulation of cell projection organization GO:0031345 56 0.113
gonad development GO:0008406 141 0.112
Worm
positive regulation of cellular catabolic process GO:0031331 148 0.110
inner ear receptor cell differentiation GO:0060113 61 0.109
epidermis development GO:0008544 187 0.108
determination of digestive tract left right asymmetry GO:0071907 1 0.108
endomembrane system organization GO:0010256 147 0.108
cochlea development GO:0090102 35 0.108
positive regulation of protein modification process GO:0031401 299 0.108
Human Yeast
leukocyte migration GO:0050900 124 0.107
muscle tissue development GO:0060537 308 0.107
filopodium assembly GO:0046847 19 0.106
microtubule based movement GO:0007018 84 0.106
germ cell development GO:0007281 185 0.106
actin filament branching GO:0090135 1 0.104
membrane organization GO:0061024 245 0.104
developmental maturation GO:0021700 193 0.103
regulation of cell cycle process GO:0010564 160 0.102
Yeast
negative regulation of cellular component organization GO:0051129 194 0.102
regulation of cytoskeleton organization GO:0051493 122 0.101
Human Rat
microtubule based process GO:0007017 236 0.101
striated muscle tissue development GO:0014706 293 0.100
actin filament organization GO:0007015 113 0.100
Human
regulation of actin filament bundle assembly GO:0032231 18 0.099
Human
organelle localization GO:0051640 179 0.099
positive regulation of chemotaxis GO:0050921 38 0.099
regulation of phagocytosis GO:0050764 33 0.098
epithelial cell development GO:0002064 159 0.097
retina vasculature development in camera type eye GO:0061298 17 0.097
regulation of membrane potential GO:0042391 192 0.097
auditory receptor cell morphogenesis GO:0002093 15 0.097
forebrain development GO:0030900 302 0.097
hair follicle development GO:0001942 85 0.096
cochlea morphogenesis GO:0090103 22 0.095
exocrine system development GO:0035272 45 0.095
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.095
epithelial cell morphogenesis GO:0003382 41 0.094
cerebral cortex development GO:0021987 86 0.093
peptidyl amino acid modification GO:0018193 336 0.093
Human Yeast
regulation of respiratory burst GO:0060263 2 0.093
regulation of mapk cascade GO:0043408 248 0.092
Human Yeast
positive regulation of wound healing GO:0090303 17 0.092
actin cytoskeleton reorganization GO:0031532 21 0.092
Human
positive regulation of rac gtpase activity GO:0032855 14 0.091
epithelial cell cell adhesion GO:0090136 6 0.091
positive regulation of cell substrate adhesion GO:0010811 47 0.091
protein modification by small protein conjugation GO:0032446 187 0.091
cerebral cortex cell migration GO:0021795 44 0.091
positive regulation of lipid metabolic process GO:0045834 40 0.091
cellular response to dna damage stimulus GO:0006974 207 0.090
embryonic organ morphogenesis GO:0048562 276 0.089
pallium development GO:0021543 120 0.089
inner ear morphogenesis GO:0042472 101 0.089
regulation of interleukin 23 production GO:0032667 2 0.088
regulation of lipid kinase activity GO:0043550 14 0.087
neuron migration GO:0001764 122 0.087
spermatogenesis GO:0007283 284 0.087
microtubule cytoskeleton organization GO:0000226 157 0.087
regulation of lamellipodium organization GO:1902743 5 0.087
regulation of hydrolase activity GO:0051336 246 0.086
positive regulation of apoptotic process GO:0043065 217 0.086
Yeast
ectodermal placode morphogenesis GO:0071697 16 0.085
cell junction organization GO:0034330 77 0.085
Worm
regulation of protein localization GO:0032880 231 0.085
Yeast
multicellular organismal homeostasis GO:0048871 164 0.084
regulation of actin polymerization or depolymerization GO:0008064 45 0.084
synapse assembly GO:0007416 56 0.084
microtubule based transport GO:0010970 50 0.084
developmental growth involved in morphogenesis GO:0060560 138 0.084
regulation of organ morphogenesis GO:2000027 144 0.082
canonical wnt signaling pathway GO:0060070 130 0.082
regulation of intracellular transport GO:0032386 159 0.081
Yeast
submandibular salivary gland formation GO:0060661 1 0.080
neuron projection guidance GO:0097485 141 0.080
regulation of organelle organization GO:0033043 289 0.079
Human Yeast Rat
central nervous system neuron development GO:0021954 67 0.079
multicellular organism growth GO:0035264 161 0.079
regulation of jnk cascade GO:0046328 62 0.078
Human
regulation of cell migration GO:0030334 219 0.078
camera type eye development GO:0043010 266 0.077
heart contraction GO:0060047 93 0.077
central nervous system neuron differentiation GO:0021953 162 0.077
dna replication GO:0006260 52 0.076
regulation of protein serine threonine kinase activity GO:0071900 157 0.074
Human Yeast
semaphorin plexin signaling pathway GO:0071526 21 0.073
regulation of t cell activation GO:0050863 170 0.073
regulation of protein kinase activity GO:0045859 232 0.073
Human Yeast
positive regulation of neuron apoptotic process GO:0043525 25 0.073
regulation of granulocyte chemotaxis GO:0071622 17 0.072
dna metabolic process GO:0006259 303 0.072
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.072
cation transmembrane transport GO:0098655 266 0.071
positive regulation of transferase activity GO:0051347 167 0.071
Human Yeast
circulatory system process GO:0003013 197 0.070
hair follicle morphogenesis GO:0031069 29 0.070
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.070
adherens junction organization GO:0034332 28 0.070
neuron apoptotic process GO:0051402 142 0.069
positive regulation of jnk cascade GO:0046330 46 0.069
Human
axonal fasciculation GO:0007413 15 0.068
cell fate commitment GO:0045165 210 0.068
morphogenesis of embryonic epithelium GO:0016331 159 0.067
regulation of protein catabolic process GO:0042176 108 0.067
heart process GO:0003015 94 0.066
digestive tract morphogenesis GO:0048546 147 0.066
skin development GO:0043588 220 0.066
wnt signaling pathway GO:0016055 188 0.066
feeding behavior GO:0007631 62 0.065
attachment of spindle microtubules to kinetochore GO:0008608 4 0.065
regulation of peptidyl serine phosphorylation GO:0033135 39 0.064
Human
genitalia development GO:0048806 37 0.064
telencephalon development GO:0021537 186 0.064
ectodermal placode formation GO:0060788 16 0.063
interleukin 23 production GO:0032627 2 0.063
regulation of cell activation GO:0050865 289 0.062
substantia nigra development GO:0021762 2 0.062
substrate independent telencephalic tangential migration GO:0021826 8 0.061
transmembrane transport GO:0055085 412 0.061
Yeast
myoblast proliferation GO:0051450 11 0.061
purine nucleotide metabolic process GO:0006163 302 0.061
positive regulation of cell death GO:0010942 224 0.061
Yeast
organelle fission GO:0048285 170 0.061
Yeast
actin polymerization or depolymerization GO:0008154 54 0.060
regulation of cell motility GO:2000145 236 0.060
negative regulation of cytokine production GO:0001818 84 0.060
inorganic cation transmembrane transport GO:0098662 207 0.060
phenol containing compound metabolic process GO:0018958 60 0.059
tissue homeostasis GO:0001894 115 0.058
mitotic nuclear division GO:0007067 48 0.058
Yeast
motor neuron axon guidance GO:0008045 26 0.058
positive regulation of cell motility GO:2000147 116 0.057
keratinization GO:0031424 9 0.057
cardiac muscle tissue development GO:0048738 130 0.056
positive regulation of neuron death GO:1901216 28 0.056
regulation of kinase activity GO:0043549 249 0.056
Human Yeast
neuron projection extension involved in neuron projection guidance GO:1902284 14 0.056
positive regulation of cell migration GO:0030335 109 0.055
segmentation GO:0035282 93 0.055
anatomical structure homeostasis GO:0060249 145 0.055
ion transmembrane transport GO:0034220 361 0.055
neuron projection regeneration GO:0031102 14 0.055
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.055
Human Yeast
positive regulation of protein transport GO:0051222 93 0.054
Yeast
spermatid differentiation GO:0048515 115 0.054
regulation of synapse assembly GO:0051963 29 0.054
positive regulation of protein catabolic process GO:0045732 60 0.054
tissue remodeling GO:0048771 102 0.054
negative regulation of interleukin 23 production GO:0032707 1 0.053
axon extension involved in axon guidance GO:0048846 14 0.053
regulation of neuron apoptotic process GO:0043523 122 0.052
regulation of protein transport GO:0051223 163 0.052
Yeast
regulation of microtubule cytoskeleton organization GO:0070507 37 0.052
regulation of wound healing GO:0061041 40 0.051
muscle cell differentiation GO:0042692 261 0.051
establishment of organelle localization GO:0051656 122 0.050
regulation of lymphocyte activation GO:0051249 240 0.050
regionalization GO:0003002 337 0.049
positive regulation of stress activated mapk cascade GO:0032874 48 0.049
Human
digestive system development GO:0055123 200 0.049
substrate independent telencephalic tangential interneuron migration GO:0021843 8 0.048
forebrain neuron development GO:0021884 30 0.048
epithelial mesenchymal cell signaling GO:0060684 7 0.048
cellular protein complex assembly GO:0043623 116 0.048
regulation of stress fiber assembly GO:0051492 15 0.047
Human
neural nucleus development GO:0048857 22 0.047
forebrain neuron differentiation GO:0021879 52 0.046
inflammatory response GO:0006954 244 0.046
syncytium formation by plasma membrane fusion GO:0000768 42 0.046
regulation of microtubule based process GO:0032886 52 0.046
blood circulation GO:0008015 195 0.046
negative regulation of phosphate metabolic process GO:0045936 184 0.045
positive regulation of endocytosis GO:0045807 42 0.045
gliogenesis GO:0042063 141 0.045
cellular component maintenance GO:0043954 11 0.045
regulation of cellular component biogenesis GO:0044087 181 0.045
Human
skeletal muscle organ development GO:0060538 163 0.045
molting cycle GO:0042303 90 0.044
positive regulation of synapse structural plasticity GO:0051835 1 0.044
cell division GO:0051301 120 0.044
Yeast
lipid biosynthetic process GO:0008610 179 0.044
syncytium formation GO:0006949 43 0.043
hair cycle GO:0042633 90 0.043
positive regulation of cell division GO:0051781 31 0.042
development of primary sexual characteristics GO:0045137 143 0.042
Worm
ectodermal placode development GO:0071696 16 0.042
glycerolipid metabolic process GO:0046486 122 0.042
cell type specific apoptotic process GO:0097285 268 0.041
muscle fiber development GO:0048747 76 0.041
salivary gland morphogenesis GO:0007435 33 0.041
peripheral nervous system development GO:0007422 53 0.041
regulation of secretion by cell GO:1903530 249 0.041
regulation of dna replication GO:0006275 17 0.041
axon regeneration GO:0031103 12 0.041
regulation of mitotic cell cycle GO:0007346 126 0.040
Yeast
positive regulation of dna replication GO:0045740 9 0.039
establishment or maintenance of cell polarity GO:0007163 86 0.039
Yeast
regulation of secretion GO:0051046 274 0.039
mitotic cell cycle process GO:1903047 159 0.039
Yeast
positive regulation of exocytosis GO:0045921 20 0.039
ossification GO:0001503 216 0.038
dendrite development GO:0016358 115 0.038
regulation of metalloenzyme activity GO:0048552 4 0.038
protein localization to plasma membrane GO:0072659 57 0.038
cellular component assembly involved in morphogenesis GO:0010927 139 0.038
positive regulation of secretion GO:0051047 130 0.037
defense response to other organism GO:0098542 197 0.037
action potential GO:0001508 78 0.037
regulation of metal ion transport GO:0010959 106 0.037
rna localization GO:0006403 23 0.037
cytokinetic process GO:0032506 2 0.037
Yeast
multicellular organismal signaling GO:0035637 91 0.037
skin morphogenesis GO:0043589 38 0.037
transmission of nerve impulse GO:0019226 76 0.037
bone remodeling GO:0046849 53 0.036
actin cytoskeleton organization GO:0030036 220 0.036
Human Rat
spermatid development GO:0007286 108 0.036
midbrain development GO:0030901 35 0.035
regulation of protein complex assembly GO:0043254 83 0.035
cell matrix adhesion GO:0007160 68 0.035
nuclear migration GO:0007097 6 0.035
maternal determination of anterior posterior axis embryo GO:0008358 2 0.034
lipid localization GO:0010876 126 0.034
Yeast
anion transport GO:0006820 177 0.033
positive regulation of lymphocyte activation GO:0051251 140 0.033
negative regulation of phosphorus metabolic process GO:0010563 184 0.033
cell substrate junction assembly GO:0007044 24 0.032
Worm
neuron fate determination GO:0048664 9 0.032
determination of left right symmetry GO:0007368 80 0.032
epidermis morphogenesis GO:0048730 33 0.032
response to oxidative stress GO:0006979 123 0.031
skeletal system development GO:0001501 356 0.031
negative regulation of phosphorylation GO:0042326 166 0.031
receptor mediated endocytosis GO:0006898 51 0.031
myotube differentiation GO:0014902 105 0.031
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.031
regulation of mitosis GO:0007088 29 0.030
Yeast
neuromuscular synaptic transmission GO:0007274 16 0.030
regulation of lipid storage GO:0010883 20 0.030
t cell activation GO:0042110 289 0.030
ameboidal type cell migration GO:0001667 128 0.030
response to peptide GO:1901652 136 0.030
Rat
positive regulation of cell activation GO:0050867 158 0.030
regulation of pseudopodium assembly GO:0031272 1 0.030
response to peptide hormone GO:0043434 127 0.029
Rat
maintenance of location GO:0051235 89 0.029
digestive tract development GO:0048565 190 0.028
regulation of cell growth GO:0001558 91 0.028
monocarboxylic acid metabolic process GO:0032787 191 0.028
regulation of cell shape GO:0008360 39 0.028
protein processing GO:0016485 163 0.028
embryonic digestive tract development GO:0048566 27 0.027
forebrain generation of neurons GO:0021872 63 0.027
negative regulation of cellular protein metabolic process GO:0032269 247 0.027
protein ubiquitination GO:0016567 171 0.027

Pak1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org