Mus musculus

0 known processes

Sh2d4a

SH2 domain containing 4A

(Aliases: 2210402M20Rik,SH2A)

Sh2d4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transport GO:0006812 399 0.083
cellular ketone metabolic process GO:0042180 84 0.067
cellular amino acid metabolic process GO:0006520 103 0.065
regulation of cellular amino acid metabolic process GO:0006521 5 0.059
regulation of cellular ketone metabolic process GO:0010565 66 0.058
cellular amine metabolic process GO:0044106 44 0.058
amine metabolic process GO:0009308 45 0.057
regulation of cellular amine metabolic process GO:0033238 20 0.053
nucleotide metabolic process GO:0009117 332 0.046
transmembrane transport GO:0055085 412 0.046
ion transmembrane transport GO:0034220 361 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
cellular lipid metabolic process GO:0044255 323 0.042
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
cell adhesion GO:0007155 329 0.040
oxidation reduction process GO:0055114 342 0.039
regulation of membrane potential GO:0042391 192 0.038
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.038
negative regulation of protein metabolic process GO:0051248 282 0.038
cation transmembrane transport GO:0098655 266 0.037
nucleoside phosphate metabolic process GO:0006753 338 0.036
immune effector process GO:0002252 321 0.035
inorganic ion transmembrane transport GO:0098660 234 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
negative regulation of phosphorus metabolic process GO:0010563 184 0.035
Human
cellular nitrogen compound catabolic process GO:0044270 280 0.034
aromatic compound catabolic process GO:0019439 286 0.033
heterocycle catabolic process GO:0046700 280 0.032
inorganic cation transmembrane transport GO:0098662 207 0.032
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
ribonucleotide metabolic process GO:0009259 291 0.032
purine containing compound metabolic process GO:0072521 311 0.031
cytokine production GO:0001816 319 0.030
regulation of hydrolase activity GO:0051336 246 0.030
Human
organic cyclic compound catabolic process GO:1901361 295 0.030
sensory perception GO:0007600 245 0.029
small gtpase mediated signal transduction GO:0007264 97 0.029
purine ribonucleotide metabolic process GO:0009150 290 0.029
multicellular organismal signaling GO:0035637 91 0.029
regulation of protein localization GO:0032880 231 0.029
positive regulation of protein modification process GO:0031401 299 0.028
regulation of secretion GO:0051046 274 0.028
inflammatory response GO:0006954 244 0.028
nucleoside metabolic process GO:0009116 246 0.028
purine nucleotide metabolic process GO:0006163 302 0.028
organic hydroxy compound metabolic process GO:1901615 203 0.027
monocarboxylic acid metabolic process GO:0032787 191 0.027
negative regulation of phosphate metabolic process GO:0045936 184 0.027
Human
glycosyl compound metabolic process GO:1901657 246 0.027
response to organonitrogen compound GO:0010243 246 0.027
negative regulation of cell proliferation GO:0008285 296 0.027
ras protein signal transduction GO:0007265 77 0.027
spermatogenesis GO:0007283 284 0.027
ribose phosphate metabolic process GO:0019693 291 0.026
regulation of organelle organization GO:0033043 289 0.026
male gamete generation GO:0048232 285 0.026
gland development GO:0048732 330 0.026
purine ribonucleoside metabolic process GO:0046128 241 0.026
apoptotic signaling pathway GO:0097190 306 0.026
circulatory system process GO:0003013 197 0.025
purine nucleoside metabolic process GO:0042278 241 0.025
ribonucleoside metabolic process GO:0009119 245 0.025
regulation of cellular catabolic process GO:0031329 242 0.025
urogenital system development GO:0001655 261 0.025
ribonucleoside triphosphate metabolic process GO:0009199 220 0.025
anion transport GO:0006820 177 0.025
nucleotide catabolic process GO:0009166 217 0.025
nitrogen compound transport GO:0071705 271 0.025
purine ribonucleotide catabolic process GO:0009154 208 0.024
purine nucleotide catabolic process GO:0006195 211 0.024
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.024
organophosphate catabolic process GO:0046434 232 0.024
purine nucleoside triphosphate metabolic process GO:0009144 226 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
carbohydrate derivative biosynthetic process GO:1901137 183 0.024
peptidyl amino acid modification GO:0018193 336 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
nucleoside triphosphate catabolic process GO:0009143 205 0.023
epithelial cell development GO:0002064 159 0.023
carbohydrate derivative catabolic process GO:1901136 231 0.023
regulation of system process GO:0044057 200 0.023
fatty acid metabolic process GO:0006631 121 0.022
blood circulation GO:0008015 195 0.022
action potential GO:0001508 78 0.022
nucleoside phosphate catabolic process GO:1901292 222 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.022
leukocyte differentiation GO:0002521 342 0.022
macromolecule catabolic process GO:0009057 281 0.022
actin cytoskeleton organization GO:0030036 220 0.022
mapk cascade GO:0000165 281 0.022
cytoplasmic transport GO:0016482 234 0.021
regulation of cell cycle GO:0051726 281 0.021
dna metabolic process GO:0006259 303 0.021
glycosyl compound catabolic process GO:1901658 206 0.021
rho protein signal transduction GO:0007266 32 0.021
divalent inorganic cation transport GO:0072511 178 0.021
regulation of mapk cascade GO:0043408 248 0.021
response to organic cyclic compound GO:0014070 198 0.021
g protein coupled receptor signaling pathway GO:0007186 243 0.021
ribonucleotide catabolic process GO:0009261 208 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
negative regulation of phosphorylation GO:0042326 166 0.021
kidney development GO:0001822 213 0.021
homeostasis of number of cells GO:0048872 210 0.021
renal system development GO:0072001 225 0.021
cellular homeostasis GO:0019725 240 0.021
t cell activation GO:0042110 289 0.020
Mouse
skin development GO:0043588 220 0.020
nucleoside catabolic process GO:0009164 206 0.020
ribonucleoside catabolic process GO:0042454 206 0.020
divalent metal ion transport GO:0070838 172 0.020
regulation of hormone levels GO:0010817 211 0.020
positive regulation of nervous system development GO:0051962 221 0.020
negative regulation of cellular amine metabolic process GO:0033239 1 0.020
mitotic cell cycle GO:0000278 195 0.020
purine containing compound catabolic process GO:0072523 213 0.020
regulation of neuron differentiation GO:0045664 281 0.020
regulation of establishment of protein localization GO:0070201 181 0.020
negative regulation of molecular function GO:0044092 258 0.020
Human
posttranscriptional regulation of gene expression GO:0010608 155 0.020
negative regulation of protein modification process GO:0031400 163 0.020
transmission of nerve impulse GO:0019226 76 0.020
lipid biosynthetic process GO:0008610 179 0.020
protein ubiquitination GO:0016567 171 0.020
response to molecule of bacterial origin GO:0002237 143 0.020
regulation of anatomical structure size GO:0090066 178 0.020
regulation of cytokine production GO:0001817 266 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
response to lipopolysaccharide GO:0032496 128 0.019
cation homeostasis GO:0055080 212 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
epithelial tube morphogenesis GO:0060562 303 0.019
regulation of cell projection organization GO:0031344 206 0.019
meiotic cell cycle GO:0051321 122 0.019
positive regulation of cell development GO:0010720 237 0.019
regulation of secretion by cell GO:1903530 249 0.019
cellular response to lipid GO:0071396 145 0.019
myeloid cell differentiation GO:0030099 233 0.019
regulation of homeostatic process GO:0032844 182 0.019
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.019
striated muscle tissue development GO:0014706 293 0.019
metal ion homeostasis GO:0055065 189 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
organelle fission GO:0048285 170 0.018
sensory organ morphogenesis GO:0090596 242 0.018
cellular ion homeostasis GO:0006873 165 0.018
regulation of ion transport GO:0043269 215 0.018
regulation of cell activation GO:0050865 289 0.018
synaptic transmission GO:0007268 329 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
developmental maturation GO:0021700 193 0.018
purine nucleoside triphosphate catabolic process GO:0009146 203 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
membrane organization GO:0061024 245 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
positive regulation of cell death GO:0010942 224 0.018
organic anion transport GO:0015711 137 0.018
innate immune response GO:0045087 157 0.018
endomembrane system organization GO:0010256 147 0.018
muscle cell differentiation GO:0042692 261 0.018
positive regulation of secretion GO:0051047 130 0.018
nuclear division GO:0000280 158 0.017
cellular chemical homeostasis GO:0055082 215 0.017
organonitrogen compound biosynthetic process GO:1901566 192 0.017
response to acid chemical GO:0001101 111 0.017
camera type eye development GO:0043010 266 0.017
protein maturation GO:0051604 176 0.017
sequestering of calcium ion GO:0051208 18 0.017
regulation of transferase activity GO:0051338 263 0.017
regulation of intracellular transport GO:0032386 159 0.017
maintenance of location GO:0051235 89 0.016
regulation of response to wounding GO:1903034 189 0.016
positive regulation of apoptotic process GO:0043065 217 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
negative regulation of immune system process GO:0002683 209 0.016
regulation of protein kinase activity GO:0045859 232 0.016
protein secretion GO:0009306 111 0.016
microtubule based process GO:0007017 236 0.016
meiotic cell cycle process GO:1903046 77 0.016
neuronal action potential GO:0019228 54 0.016
single organism cell adhesion GO:0098602 156 0.016
intracellular protein transport GO:0006886 204 0.016
cell type specific apoptotic process GO:0097285 268 0.016
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.016
regulation of cell motility GO:2000145 236 0.016
protein catabolic process GO:0030163 221 0.016
regulation of actin filament based process GO:0032970 99 0.016
actin filament organization GO:0007015 113 0.016
short chain fatty acid catabolic process GO:0019626 2 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.015
morphogenesis of embryonic epithelium GO:0016331 159 0.015
regulation of proteolysis GO:0030162 164 0.015
oocyte construction GO:0007308 2 0.015
locomotory behavior GO:0007626 195 0.015
axonogenesis GO:0007409 274 0.015
cell growth GO:0016049 130 0.015
leukocyte proliferation GO:0070661 172 0.015
fertilization GO:0009566 127 0.015
regulation of kinase activity GO:0043549 249 0.015
sequestering of metal ion GO:0051238 19 0.015
cellular metal ion homeostasis GO:0006875 151 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
skeletal system development GO:0001501 356 0.015
regulation of defense response GO:0031347 233 0.015
stem cell development GO:0048864 219 0.015
cofactor metabolic process GO:0051186 80 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
regulation of t cell activation GO:0050863 170 0.015
regulation of protein transport GO:0051223 163 0.015
regulation of cellular response to stress GO:0080135 159 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.014
heart morphogenesis GO:0003007 178 0.014
morphogenesis of a branching epithelium GO:0061138 193 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.014
ossification GO:0001503 216 0.014
ear development GO:0043583 200 0.014
oocyte axis specification GO:0007309 2 0.014
regulation of body fluid levels GO:0050878 162 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
glycoprotein metabolic process GO:0009100 116 0.014
regulation of cellular component size GO:0032535 121 0.014
positive regulation of neuron differentiation GO:0045666 141 0.014
regionalization GO:0003002 337 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
muscle system process GO:0003012 141 0.014
cell activation involved in immune response GO:0002263 126 0.014
organic acid transport GO:0015849 101 0.014
regulation of multi organism process GO:0043900 111 0.014
calcium ion transport GO:0006816 159 0.014
calcium ion homeostasis GO:0055074 127 0.014
germ cell development GO:0007281 185 0.014
lymphocyte differentiation GO:0030098 242 0.014
spermatid differentiation GO:0048515 115 0.014
compound eye development GO:0048749 1 0.014
epithelial cell proliferation GO:0050673 174 0.014
carbohydrate metabolic process GO:0005975 230 0.014
cellular response to hormone stimulus GO:0032870 150 0.014
cell junction organization GO:0034330 77 0.014
sulfur compound metabolic process GO:0006790 100 0.013
cellular protein complex assembly GO:0043623 116 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
microtubule cytoskeleton organization GO:0000226 157 0.013
stem cell differentiation GO:0048863 268 0.013
leukocyte migration GO:0050900 124 0.013
nucleoside monophosphate metabolic process GO:0009123 85 0.013
carboxylic acid biosynthetic process GO:0046394 86 0.013
regulation of feeding behavior GO:0060259 3 0.013
regulation of metal ion transport GO:0010959 106 0.013
intracellular mrna localization GO:0008298 4 0.013
regulation of cell migration GO:0030334 219 0.013
protein targeting GO:0006605 143 0.013
organelle assembly GO:0070925 177 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
positive regulation of cellular component biogenesis GO:0044089 94 0.013
gtp metabolic process GO:0046039 144 0.013
multicellular organismal homeostasis GO:0048871 164 0.013
respiratory system development GO:0060541 190 0.013
cellular response to molecule of bacterial origin GO:0071219 83 0.013
cell maturation GO:0048469 127 0.013
neural tube development GO:0021915 160 0.013
activation of immune response GO:0002253 138 0.013
placenta development GO:0001890 140 0.013
organelle localization GO:0051640 179 0.013
mitotic cell cycle process GO:1903047 159 0.013
regulation of cell cycle process GO:0010564 160 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
leukocyte mediated immunity GO:0002443 174 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
positive regulation of transferase activity GO:0051347 167 0.013
lymphocyte proliferation GO:0046651 164 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
amide transport GO:0042886 138 0.013
meiotic nuclear division GO:0007126 115 0.013
gtp catabolic process GO:0006184 143 0.013
exocytosis GO:0006887 121 0.013
lipid localization GO:0010876 126 0.013
protein localization to organelle GO:0033365 185 0.013
blood vessel morphogenesis GO:0048514 285 0.013
regulation of ion transmembrane transport GO:0034765 119 0.012
cell recognition GO:0008037 83 0.012
wound healing GO:0042060 157 0.012
epithelial tube formation GO:0072175 130 0.012
small molecule biosynthetic process GO:0044283 132 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
organic acid biosynthetic process GO:0016053 86 0.012
adaptive immune response GO:0002250 155 0.012
regulation of cell adhesion GO:0030155 154 0.012
carboxylic acid transport GO:0046942 100 0.012
multicellular organism growth GO:0035264 161 0.012
endocytosis GO:0006897 168 0.012
chemotaxis GO:0006935 247 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
cytokinetic process GO:0032506 2 0.012
protein processing GO:0016485 163 0.012
interleukin 8 production GO:0032637 4 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
wnt signaling pathway GO:0016055 188 0.012
positive regulation of organelle organization GO:0010638 128 0.012
response to inorganic substance GO:0010035 96 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
myelination GO:0042552 74 0.012
cell fate commitment GO:0045165 210 0.012
tube formation GO:0035148 140 0.012
hormone secretion GO:0046879 128 0.012
cellular alcohol metabolic process GO:0044107 3 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
blastocyst development GO:0001824 80 0.012
defense response to other organism GO:0098542 197 0.012
response to radiation GO:0009314 165 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
detection of stimulus GO:0051606 84 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.012
regulation of neuron projection development GO:0010975 169 0.012
positive regulation of secretion by cell GO:1903532 114 0.012
dephosphorylation GO:0016311 129 0.012
Human
actin filament based movement GO:0030048 23 0.012
carbohydrate homeostasis GO:0033500 128 0.012
establishment of blood nerve barrier GO:0008065 3 0.011
plasma membrane organization GO:0007009 90 0.011
multi multicellular organism process GO:0044706 109 0.011
positive regulation of immune effector process GO:0002699 107 0.011
regulation of transmembrane transport GO:0034762 128 0.011
glycoprotein biosynthetic process GO:0009101 89 0.011
tissue remodeling GO:0048771 102 0.011
regulation of mitotic cell cycle GO:0007346 126 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
angiogenesis GO:0001525 201 0.011
macromolecule glycosylation GO:0043413 55 0.011
adult behavior GO:0030534 135 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
protein localization to membrane GO:0072657 108 0.011
leukocyte activation involved in immune response GO:0002366 126 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
positive regulation of cytokine production GO:0001819 174 0.011
glycerolipid metabolic process GO:0046486 122 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
forebrain development GO:0030900 302 0.011
cellular response to acid chemical GO:0071229 68 0.011
small molecule catabolic process GO:0044282 71 0.011
chromatin modification GO:0016568 187 0.011
peptide transport GO:0015833 133 0.011
cell cell junction organization GO:0045216 72 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
respiratory tube development GO:0030323 167 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
muscle tissue development GO:0060537 308 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
response to oxidative stress GO:0006979 123 0.011
cell substrate adhesion GO:0031589 130 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
neural tube formation GO:0001841 108 0.011
lipid catabolic process GO:0016042 69 0.011
t cell differentiation GO:0030217 174 0.011
extracellular structure organization GO:0043062 148 0.011
male sex differentiation GO:0046661 109 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
neuron death GO:0070997 154 0.011
cellular alcohol biosynthetic process GO:0044108 3 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
gonad development GO:0008406 141 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
glucose homeostasis GO:0042593 128 0.011
engulfment of apoptotic cell GO:0043652 3 0.011
chromatin organization GO:0006325 206 0.011
muscle contraction GO:0006936 101 0.011
tissue homeostasis GO:0001894 115 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
cellular modified amino acid metabolic process GO:0006575 63 0.011
regulation of ras protein signal transduction GO:0046578 114 0.011
negative regulation of cell development GO:0010721 169 0.011
protein localization to nucleus GO:0034504 121 0.011
immune response activating signal transduction GO:0002757 116 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
maternal determination of anterior posterior axis embryo GO:0008358 2 0.010
regulation of interleukin 8 production GO:0032677 3 0.010
response to growth factor GO:0070848 198 0.010
retina development in camera type eye GO:0060041 119 0.010
regulation of protein catabolic process GO:0042176 108 0.010
extrinsic apoptotic signaling pathway GO:0097191 126 0.010
regulation of leukocyte proliferation GO:0070663 121 0.010
regulation of binding GO:0051098 111 0.010
extracellular matrix organization GO:0030198 147 0.010
anatomical structure homeostasis GO:0060249 145 0.010
protein oligomerization GO:0051259 67 0.010
epidermis development GO:0008544 187 0.010
interspecies interaction between organisms GO:0044419 83 0.010
negative regulation of cell activation GO:0050866 111 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
digestive tract development GO:0048565 190 0.010
monocarboxylic acid biosynthetic process GO:0072330 61 0.010
regulation of cell growth GO:0001558 91 0.010
regulation of ion homeostasis GO:2000021 64 0.010
Mouse
ameboidal type cell migration GO:0001667 128 0.010
positive regulation of protein transport GO:0051222 93 0.010
lung development GO:0030324 164 0.010
regulation of peptidase activity GO:0052547 96 0.010
methylation GO:0032259 134 0.010
protein glycosylation GO:0006486 55 0.010
spermatid development GO:0007286 108 0.010
female meiosis chromosome segregation GO:0016321 1 0.010
synapse organization GO:0050808 125 0.010
lymphocyte mediated immunity GO:0002449 139 0.010
negative regulation of nervous system development GO:0051961 156 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010

Sh2d4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
musculoskeletal system disease DOID:17 0 0.020
nervous system disease DOID:863 0 0.018
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.015
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.013
central nervous system disease DOID:331 0 0.012
immune system disease DOID:2914 0 0.012
cardiovascular system disease DOID:1287 0 0.012
connective tissue disease DOID:65 0 0.011
bone disease DOID:0080001 0 0.010