Mus musculus

0 known processes

Gzmd

granzyme D

(Aliases: Ctla5,CCP5,Ctla-5)

Gzmd biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transforming growth factor beta secretion GO:2001203 1 0.859
transforming growth factor beta secretion GO:0038044 1 0.709
regulation of transforming growth factor beta secretion GO:2001201 1 0.626
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.598
Mouse
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.466
Mouse
regulation of interleukin 10 secretion GO:2001179 4 0.173
regulation of microvillus organization GO:0032530 3 0.161
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.154
Mouse
negative regulation of endothelial cell migration GO:0010596 4 0.126
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.125
Mouse
regulation of angiotensin metabolic process GO:0060177 4 0.125
Mouse
regulation of microvillus assembly GO:0032534 3 0.114
regulation of blood pressure GO:0008217 93 0.106
Mouse
cell adhesion GO:0007155 329 0.103
lymphocyte mediated immunity GO:0002449 139 0.092
Mouse
interleukin 10 secretion GO:0072608 4 0.087
regulation of angiotensin levels in blood GO:0002002 4 0.075
Mouse
lipid biosynthetic process GO:0008610 179 0.067
regulation of cellular ketone metabolic process GO:0010565 66 0.060
defense response to gram positive bacterium GO:0050830 50 0.059
Mouse
adaptive immune response GO:0002250 155 0.054
Mouse
killing by host of symbiont cells GO:0051873 11 0.050
Mouse
cellular response to hormone stimulus GO:0032870 150 0.049
spermatogenesis GO:0007283 284 0.048
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.047
Mouse
t cell mediated cytotoxicity GO:0001913 26 0.046
Mouse
cytokine production GO:0001816 319 0.046
cellular carbohydrate metabolic process GO:0044262 119 0.045
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.043
cellular response to organonitrogen compound GO:0071417 145 0.041
medium chain fatty acid metabolic process GO:0051791 1 0.041
regulation of kinase activity GO:0043549 249 0.041
cellular ketone metabolic process GO:0042180 84 0.041
calcitriol biosynthetic process from calciol GO:0036378 3 0.041
positive regulation of cellular amine metabolic process GO:0033240 5 0.040
response to nutrient levels GO:0031667 109 0.040
blood circulation GO:0008015 195 0.040
Mouse
regulation of cell projection organization GO:0031344 206 0.039
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.038
regulation of protein transport GO:0051223 163 0.038
response to molecule of bacterial origin GO:0002237 143 0.037
Mouse
regulation of hydrolase activity GO:0051336 246 0.036
response to lipopolysaccharide GO:0032496 128 0.036
Mouse
protein catabolic process GO:0030163 221 0.036
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.036
Mouse
regulation of hormone levels GO:0010817 211 0.035
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
cell killing GO:0001906 67 0.035
Mouse
response to inorganic substance GO:0010035 96 0.035
brown fat cell proliferation GO:0070342 1 0.035
cellular response to lipid GO:0071396 145 0.035
immune effector process GO:0002252 321 0.034
Mouse
cellular alcohol metabolic process GO:0044107 3 0.034
oxidation reduction process GO:0055114 342 0.034
regulation of transferase activity GO:0051338 263 0.033
fat cell differentiation GO:0045444 160 0.033
male gamete generation GO:0048232 285 0.032
defense response to bacterium GO:0042742 119 0.032
Mouse
growth of symbiont involved in interaction with host GO:0044116 23 0.032
Mouse
alcohol metabolic process GO:0006066 116 0.031
myeloid leukocyte mediated immunity GO:0002444 42 0.031
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.031
hormone metabolic process GO:0042445 86 0.031
vitamin d3 metabolic process GO:0070640 3 0.030
organic hydroxy compound metabolic process GO:1901615 203 0.030
regulation of cellular amine metabolic process GO:0033238 20 0.030
myotube differentiation GO:0014902 105 0.029
cytoplasmic transport GO:0016482 234 0.029
midgut development GO:0007494 4 0.029
regulation of feeding behavior GO:0060259 3 0.029
negative regulation of protein processing GO:0010955 79 0.029
multicellular organism growth GO:0035264 161 0.029
leukocyte mediated immunity GO:0002443 174 0.029
Mouse
leukocyte mediated cytotoxicity GO:0001909 62 0.028
Mouse
cellular amino acid metabolic process GO:0006520 103 0.028
positive regulation of cytokine production GO:0001819 174 0.028
macromolecule catabolic process GO:0009057 281 0.028
negative regulation of molecular function GO:0044092 258 0.028
negative regulation of phosphorylation GO:0042326 166 0.028
disruption by host of symbiont cells GO:0051852 11 0.028
Mouse
cellular response to organic cyclic compound GO:0071407 87 0.027
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.027
Mouse
regulation of establishment of protein localization GO:0070201 181 0.027
protein secretion GO:0009306 111 0.027
protein maturation GO:0051604 176 0.026
regulation of secretion by cell GO:1903530 249 0.026
olfactory learning GO:0008355 2 0.026
response to organic cyclic compound GO:0014070 198 0.026
regulation of defense response GO:0031347 233 0.026
positive regulation of cell projection organization GO:0031346 95 0.025
negative regulation of protein phosphorylation GO:0001933 126 0.025
regulation of lipid metabolic process GO:0019216 118 0.025
endocrine process GO:0050886 39 0.025
Mouse
regulation of angiogenesis GO:0045765 81 0.025
negative regulation of phosphorus metabolic process GO:0010563 184 0.025
nitrogen compound transport GO:0071705 271 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
organophosphate biosynthetic process GO:0090407 122 0.024
regulation of protein localization GO:0032880 231 0.024
response to peptide hormone GO:0043434 127 0.024
axonogenesis GO:0007409 274 0.024
carboxylic acid transport GO:0046942 100 0.024
regulation of peptidase activity GO:0052547 96 0.024
muscle tissue development GO:0060537 308 0.023
organic anion transport GO:0015711 137 0.023
regulation of brown fat cell proliferation GO:0070347 1 0.023
regulation of systemic arterial blood pressure GO:0003073 61 0.022
Mouse
growth of symbiont in host GO:0044117 23 0.022
Mouse
cellular alcohol biosynthetic process GO:0044108 3 0.022
striated muscle tissue development GO:0014706 293 0.022
regulation of proteolysis GO:0030162 164 0.022
response to organonitrogen compound GO:0010243 246 0.022
transmembrane transport GO:0055085 412 0.022
glucose metabolic process GO:0006006 92 0.022
cellular nitrogen compound catabolic process GO:0044270 280 0.022
regulation of cytokine production GO:0001817 266 0.022
circulatory system process GO:0003013 197 0.022
Mouse
anion transport GO:0006820 177 0.022
reactive nitrogen species metabolic process GO:2001057 0 0.022
sprouting angiogenesis GO:0002040 26 0.021
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.021
Mouse
negative regulation of protein modification process GO:0031400 163 0.021
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.021
Mouse
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.020
protein modification by small protein conjugation or removal GO:0070647 207 0.020
cellular protein catabolic process GO:0044257 155 0.020
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.020
placenta development GO:0001890 140 0.020
regulation of secretion GO:0051046 274 0.020
renal system process involved in regulation of blood volume GO:0001977 4 0.020
monosaccharide metabolic process GO:0005996 106 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
g protein coupled receptor signaling pathway GO:0007186 243 0.020
defense response to other organism GO:0098542 197 0.019
Mouse
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.019
Mouse
regulation of lipid biosynthetic process GO:0046890 54 0.019
cell substrate adhesion GO:0031589 130 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.019
membrane organization GO:0061024 245 0.018
positive regulation of angiogenesis GO:0045766 46 0.018
regulation of carbohydrate metabolic process GO:0006109 75 0.018
dephosphorylation GO:0016311 129 0.018
regulation of myotube differentiation GO:0010830 62 0.018
purine ribonucleotide metabolic process GO:0009150 290 0.018
response to steroid hormone GO:0048545 56 0.018
ribose phosphate metabolic process GO:0019693 291 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
cellular response to peptide hormone stimulus GO:0071375 92 0.018
organic hydroxy compound biosynthetic process GO:1901617 77 0.018
muscle cell differentiation GO:0042692 261 0.018
response to acid chemical GO:0001101 111 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
cellular response to steroid hormone stimulus GO:0071383 33 0.018
fat soluble vitamin biosynthetic process GO:0042362 4 0.018
inflammatory response GO:0006954 244 0.017
skin development GO:0043588 220 0.017
glycerolipid metabolic process GO:0046486 122 0.017
modification by host of symbiont morphology or physiology GO:0051851 12 0.017
Mouse
spermatid development GO:0007286 108 0.017
protein processing GO:0016485 163 0.017
amino acid transmembrane transport GO:0003333 37 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
cytokine secretion GO:0050663 72 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
mapk cascade GO:0000165 281 0.017
negative regulation of feeding behavior GO:2000252 1 0.017
peptidyl serine modification GO:0018209 83 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
cellular response to molecule of fungal origin GO:0071226 2 0.017
regulation of cellular amino acid metabolic process GO:0006521 5 0.017
regulation of lymphocyte activation GO:0051249 240 0.016
cellular response to molecule of bacterial origin GO:0071219 83 0.016
negative regulation of growth GO:0045926 99 0.016
Mouse
small molecule biosynthetic process GO:0044283 132 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.016
steroid metabolic process GO:0008202 119 0.016
negative regulation of proteolysis GO:0045861 74 0.016
secondary alcohol metabolic process GO:1902652 3 0.016
erk1 and erk2 cascade GO:0070371 77 0.016
small gtpase mediated signal transduction GO:0007264 97 0.016
cellular amine metabolic process GO:0044106 44 0.016
dna metabolic process GO:0006259 303 0.016
cellular response to biotic stimulus GO:0071216 92 0.016
neutrophil mediated cytotoxicity GO:0070942 8 0.016
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.016
carbohydrate metabolic process GO:0005975 230 0.016
alcohol biosynthetic process GO:0046165 43 0.016
neutrophil mediated immunity GO:0002446 19 0.016
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.016
disruption of cells of other organism GO:0044364 13 0.015
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.015
positive regulation of protein secretion GO:0050714 52 0.015
energy derivation by oxidation of organic compounds GO:0015980 77 0.015
nuclear transport GO:0051169 139 0.015
regulation of protein maturation GO:1903317 96 0.015
positive regulation of secretion GO:0051047 130 0.015
single fertilization GO:0007338 82 0.015
visual perception GO:0007601 52 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
gonad development GO:0008406 141 0.015
organic acid transport GO:0015849 101 0.015
regulation of protein secretion GO:0050708 82 0.015
growth involved in symbiotic interaction GO:0044110 23 0.015
Mouse
androgen biosynthetic process GO:0006702 4 0.015
angiogenesis GO:0001525 201 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
positive regulation of innate immune response GO:0045089 80 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
regulation of endopeptidase activity GO:0052548 89 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
positive regulation of defense response GO:0031349 124 0.015
calcium ion dependent exocytosis GO:0017156 35 0.014
regulation of innate immune response GO:0045088 91 0.014
response to oxidative stress GO:0006979 123 0.014
glycerolipid biosynthetic process GO:0045017 50 0.014
cellular response to peptide GO:1901653 92 0.014
response to vitamin d GO:0033280 3 0.014
regulation of skeletal muscle fiber development GO:0048742 36 0.014
anatomical structure homeostasis GO:0060249 145 0.014
digestive system development GO:0055123 200 0.014
skeletal muscle organ development GO:0060538 163 0.014
t cell mediated immunity GO:0002456 50 0.014
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.014
positive regulation of protein transport GO:0051222 93 0.014
segmentation GO:0035282 93 0.014
organelle localization GO:0051640 179 0.014
renal system process GO:0003014 48 0.014
regulation of system process GO:0044057 200 0.014
regulation of cell migration GO:0030334 219 0.014
positive regulation of immune effector process GO:0002699 107 0.014
apoptotic signaling pathway GO:0097190 306 0.014
Mouse
hexose metabolic process GO:0019318 98 0.014
positive regulation of secretion by cell GO:1903532 114 0.014
response to peptide GO:1901652 136 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
oocyte construction GO:0007308 2 0.014
rhodopsin mediated signaling pathway GO:0016056 4 0.014
negative regulation of protein maturation GO:1903318 79 0.014
regulation of protein processing GO:0070613 96 0.014
actin mediated cell contraction GO:0070252 15 0.014
c21 steroid hormone biosynthetic process GO:0006700 3 0.014
negative regulation of growth of symbiont in host GO:0044130 19 0.014
Mouse
sympathetic neuron projection guidance GO:0097491 4 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
regulation of body fluid levels GO:0050878 162 0.013
carbohydrate biosynthetic process GO:0016051 74 0.013
regulation of nucleotide metabolic process GO:0006140 169 0.013
ear morphogenesis GO:0042471 118 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
regulation of cell motility GO:2000145 236 0.013
regulation of anatomical structure size GO:0090066 178 0.013
response to oxygen levels GO:0070482 62 0.013
regulation of cell activation GO:0050865 289 0.013
ribonucleoside metabolic process GO:0009119 245 0.013
lipid transport GO:0006869 98 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
vitamin d biosynthetic process GO:0042368 3 0.013
cellular lipid metabolic process GO:0044255 323 0.013
endocytosis GO:0006897 168 0.013
stem cell proliferation GO:0072089 117 0.013
positive regulation of neuron differentiation GO:0045666 141 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
sperm motility GO:0030317 47 0.013
defense response to fungus GO:0050832 12 0.013
Mouse
epidermis development GO:0008544 187 0.013
protein ubiquitination GO:0016567 171 0.013
regionalization GO:0003002 337 0.013
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 4 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
Mouse
neutrophil mediated killing of bacterium GO:0070944 6 0.013
Mouse
endomembrane system organization GO:0010256 147 0.013
sulfur compound metabolic process GO:0006790 100 0.013
regulation of cellular component biogenesis GO:0044087 181 0.012
mesodermal cell migration GO:0008078 4 0.012
regulation of homeostatic process GO:0032844 182 0.012
fertilization GO:0009566 127 0.012
regulation of response to wounding GO:1903034 189 0.012
positive regulation of cell development GO:0010720 237 0.012
purine nucleoside metabolic process GO:0042278 241 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
innate immune response activating signal transduction GO:0002758 50 0.012
regulation of muscle system process GO:0090257 80 0.012
isoprenoid metabolic process GO:0006720 29 0.012
aromatic compound catabolic process GO:0019439 286 0.012
regulation of vasculature development GO:1901342 88 0.012
regulation of protein catabolic process GO:0042176 108 0.012
response to drug GO:0042493 75 0.012
negative regulation of brown fat cell proliferation GO:0070348 1 0.012
plasma membrane organization GO:0007009 90 0.012
multicellular organismal signaling GO:0035637 91 0.012
gland development GO:0048732 330 0.012
neutrophil mediated killing of symbiont cell GO:0070943 8 0.012
Mouse
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.012
amine metabolic process GO:0009308 45 0.012
negative regulation of muscle cell differentiation GO:0051148 33 0.012
sterol homeostasis GO:0055092 45 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
response to molecule of fungal origin GO:0002238 4 0.012
negative regulation of hydrolase activity GO:0051346 71 0.012
fat cell proliferation GO:0070341 4 0.012
response to extracellular stimulus GO:0009991 127 0.012
regulation of action potential GO:0098900 4 0.012
generation of precursor metabolites and energy GO:0006091 103 0.012
ion transmembrane transport GO:0034220 361 0.012
regulation of myoblast differentiation GO:0045661 29 0.012
cell type specific apoptotic process GO:0097285 268 0.012
maintenance of location GO:0051235 89 0.012
compound eye development GO:0048749 1 0.012
nucleoside metabolic process GO:0009116 246 0.012
regulation of cellular response to stress GO:0080135 159 0.012
regulation of erk1 and erk2 cascade GO:0070372 71 0.011
negative regulation of angiogenesis GO:0016525 25 0.011
positive regulation of transferase activity GO:0051347 167 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
positive regulation of endothelial cell migration GO:0010595 12 0.011
substrate dependent cerebral cortex tangential migration GO:0021825 3 0.011
single organism nuclear import GO:1902593 95 0.011
negative regulation of lymphocyte activation GO:0051250 91 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
regulation of tube size GO:0035150 57 0.011
camera type eye development GO:0043010 266 0.011
sa node cell action potential GO:0086015 4 0.011
actin filament based movement GO:0030048 23 0.011
developmental maturation GO:0021700 193 0.011
peptide metabolic process GO:0006518 46 0.011
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
positive regulation of kinase activity GO:0033674 155 0.011
cellular homeostasis GO:0019725 240 0.011
oocyte axis specification GO:0007309 2 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
nucleotide metabolic process GO:0009117 332 0.011
cell maturation GO:0048469 127 0.011
regulation of striated muscle cell differentiation GO:0051153 81 0.011
insulin receptor signaling pathway GO:0008286 49 0.011
cardiac muscle cell contraction GO:0086003 7 0.011
response to light stimulus GO:0009416 135 0.011
regulation of hippo signaling GO:0035330 1 0.011
spermatid differentiation GO:0048515 115 0.011
interferon gamma production GO:0032609 67 0.011
feeding behavior GO:0007631 62 0.011
progesterone metabolic process GO:0042448 4 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
nucleobase containing small molecule metabolic process GO:0055086 352 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
amino acid transport GO:0006865 61 0.011
transmission of nerve impulse GO:0019226 76 0.011
cellular response to acid chemical GO:0071229 68 0.011
myoblast differentiation GO:0045445 52 0.011
peptide secretion GO:0002790 114 0.011
protein localization to organelle GO:0033365 185 0.011
heterocycle catabolic process GO:0046700 280 0.011
positive regulation of cytokine secretion GO:0050715 41 0.011
homeostasis of number of cells GO:0048872 210 0.011
response to testosterone GO:0033574 3 0.011
trunk segmentation GO:0035290 4 0.011
nuclear division GO:0000280 158 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
positive regulation of nervous system development GO:0051962 221 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
peptidyl serine phosphorylation GO:0018105 74 0.011
ubiquitin dependent protein catabolic process GO:0006511 129 0.011
skeletal muscle fiber development GO:0048741 58 0.011
natural killer cell activation GO:0030101 44 0.011
response to amino acid GO:0043200 37 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
cellular response to external stimulus GO:0071496 88 0.010
regulation of mapk cascade GO:0043408 248 0.010
anion transmembrane transport GO:0098656 71 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.010
purine ribonucleoside metabolic process GO:0046128 241 0.010
cholesterol homeostasis GO:0042632 44 0.010
intracellular protein transport GO:0006886 204 0.010
glycoprotein metabolic process GO:0009100 116 0.010
positive regulation of proteolysis GO:0045862 85 0.010
response to retinoic acid GO:0032526 56 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
blood coagulation GO:0007596 76 0.010
modification dependent macromolecule catabolic process GO:0043632 133 0.010
monosaccharide transport GO:0015749 58 0.010
detection of stimulus GO:0051606 84 0.010
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.010
positive regulation of protein modification process GO:0031401 299 0.010

Gzmd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
central nervous system disease DOID:331 0 0.021
neurodegenerative disease DOID:1289 0 0.018
sensory system disease DOID:0050155 0 0.015
cardiovascular system disease DOID:1287 0 0.015
eye and adnexa disease DOID:1492 0 0.014
retinal disease DOID:5679 0 0.014
eye disease DOID:5614 0 0.014
disease of metabolism DOID:0014667 0 0.013
retinal degeneration DOID:8466 0 0.011
motor neuron disease DOID:231 0 0.011
amyotrophic lateral sclerosis DOID:332 0 0.011