Mus musculus

7 known processes

Gzma

granzyme A

(Aliases: Ctla-3,Ctla3,SE1,TSP1,TSP-1,AW494114,Hf)

Gzma biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.999
detection of fungus GO:0016046 2 0.992
detection of yeast GO:0001879 2 0.961
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.931
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.897
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.856
adaptive immune response GO:0002250 155 0.853
Mouse
cytokine production GO:0001816 319 0.851
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.837
tumor necrosis factor production GO:0032640 50 0.830
response to molecule of fungal origin GO:0002238 4 0.821
cell killing GO:0001906 67 0.806
Mouse
regulation of natural killer cell mediated immunity GO:0002715 19 0.802
defense response to other organism GO:0098542 197 0.751
Mouse
lymphocyte mediated immunity GO:0002449 139 0.725
Mouse
innate immune response GO:0045087 157 0.711
immune effector process GO:0002252 321 0.700
Mouse
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.691
Mouse
regulation of adaptive immune response GO:0002819 90 0.687
regulation of cytokine production GO:0001817 266 0.685
positive regulation of leukocyte mediated immunity GO:0002705 70 0.672
regulation of leukocyte mediated immunity GO:0002703 104 0.651
positive regulation of defense response GO:0031349 124 0.644
cellular response to molecule of fungal origin GO:0071226 2 0.644
regulation of lymphocyte activation GO:0051249 240 0.638
positive regulation of cell killing GO:0031343 33 0.638
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.625
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.621
regulation of innate immune response GO:0045088 91 0.615
activation of immune response GO:0002253 138 0.586
negative regulation of immune system process GO:0002683 209 0.581
detection of other organism GO:0098543 8 0.574
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.558
natural killer cell mediated cytotoxicity GO:0042267 29 0.555
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.552
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.540
single organism cell adhesion GO:0098602 156 0.538
positive regulation of interferon gamma production GO:0032729 39 0.523
regulation of lymphocyte mediated immunity GO:0002706 84 0.510
regulation of defense response GO:0031347 233 0.486
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.485
single organismal cell cell adhesion GO:0016337 131 0.480
positive regulation of monocyte chemotaxis GO:0090026 2 0.477
regulation of cell killing GO:0031341 40 0.475
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.448
cdc42 protein signal transduction GO:0032488 0 0.442
regulation of ion homeostasis GO:2000021 64 0.426
positive regulation of cytokine production GO:0001819 174 0.423
positive regulation of thymocyte migration GO:2000412 2 0.422
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.421
interleukin 12 secretion GO:0072610 3 0.410
immune response activating signal transduction GO:0002757 116 0.409
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.407
Mouse
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.401
granulocyte chemotaxis GO:0071621 39 0.399
cytokine secretion GO:0050663 72 0.393
positive regulation of immune effector process GO:0002699 107 0.385
response to molecule of bacterial origin GO:0002237 143 0.379
Mouse
natural killer cell chemotaxis GO:0035747 1 0.378
regulation of angiotensin metabolic process GO:0060177 4 0.374
Mouse
alpha beta t cell activation GO:0046631 91 0.367
leukocyte differentiation GO:0002521 342 0.364
interferon gamma production GO:0032609 67 0.364
regulation of vesicle mediated transport GO:0060627 139 0.361
natural killer cell mediated immunity GO:0002228 29 0.357
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.354
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.352
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.348
defense response to gram positive bacterium GO:0050830 50 0.346
Mouse
cellular amine metabolic process GO:0044106 44 0.345
cellular response to drug GO:0035690 15 0.344
antigen processing and presentation GO:0019882 47 0.337
cell recognition GO:0008037 83 0.333
immune response regulating signaling pathway GO:0002764 125 0.324
negative regulation of macrophage apoptotic process GO:2000110 3 0.321
activation of innate immune response GO:0002218 56 0.316
mature dendritic cell differentiation GO:0097029 3 0.315
defense response to bacterium GO:0042742 119 0.314
Mouse
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.313
reactive nitrogen species metabolic process GO:2001057 0 0.307
positive regulation of tumor necrosis factor production GO:0032760 30 0.303
positive regulation of lymphocyte activation GO:0051251 140 0.282
regulation of tumor necrosis factor production GO:0032680 49 0.280
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.280
regulation of t cell proliferation GO:0042129 92 0.276
leukocyte proliferation GO:0070661 172 0.269
cellular response to lipopolysaccharide GO:0071222 77 0.266
positive regulation of t cell activation GO:0050870 101 0.266
positive regulation of innate immune response GO:0045089 80 0.264
leukocyte mediated cytotoxicity GO:0001909 62 0.253
Mouse
cellular response to biotic stimulus GO:0071216 92 0.245
neutrophil chemotaxis GO:0030593 36 0.244
positive regulation of lymphocyte proliferation GO:0050671 70 0.237
regulation of dendritic cell dendrite assembly GO:2000547 2 0.234
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.230
regulation of antigen processing and presentation GO:0002577 10 0.229
cytokine mediated signaling pathway GO:0019221 115 0.225
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.224
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.224
regulation of cellular amino acid metabolic process GO:0006521 5 0.224
t cell activation GO:0042110 289 0.222
regulation of t cell activation GO:0050863 170 0.220
positive regulation of secretion GO:0051047 130 0.220
blood vessel morphogenesis GO:0048514 285 0.219
production of molecular mediator of immune response GO:0002440 103 0.218
t helper 2 cell cytokine production GO:0035745 4 0.218
regulation of t helper 2 cell cytokine production GO:2000551 3 0.217
leukocyte mediated immunity GO:0002443 174 0.216
Mouse
eosinophil migration GO:0072677 3 0.215
regulation of alpha beta t cell proliferation GO:0046640 18 0.213
t cell mediated immunity GO:0002456 50 0.211
Mouse
response to lipopolysaccharide GO:0032496 128 0.211
Mouse
neutrophil migration GO:1990266 37 0.208
positive regulation of phagocytosis GO:0050766 26 0.208
angiogenesis GO:0001525 201 0.206
killing of cells of other organism GO:0031640 13 0.202
Mouse
lymphocyte differentiation GO:0030098 242 0.197
positive regulation of eosinophil migration GO:2000418 2 0.196
regulation of neutrophil chemotaxis GO:0090022 14 0.196
regulation of multi organism process GO:0043900 111 0.194
Mouse
myeloid cell differentiation GO:0030099 233 0.193
positive regulation of granulocyte chemotaxis GO:0071624 12 0.192
sequestering of calcium ion GO:0051208 18 0.192
positive regulation of endocytosis GO:0045807 42 0.190
t cell differentiation GO:0030217 174 0.189
cell type specific apoptotic process GO:0097285 268 0.187
t cell costimulation GO:0031295 14 0.185
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.184
t helper 1 cell cytokine production GO:0035744 1 0.184
regulation of endocytosis GO:0030100 69 0.183
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.182
natural killer cell inhibitory signaling pathway GO:0002769 2 0.181
eosinophil activation involved in immune response GO:0002278 1 0.181
regulation of alpha beta t cell activation GO:0046634 53 0.180
g protein coupled receptor signaling pathway GO:0007186 243 0.176
regulation of leukocyte proliferation GO:0070663 121 0.176
reactive oxygen species biosynthetic process GO:1903409 8 0.175
positive regulation of alpha beta t cell activation GO:0046635 39 0.175
organ or tissue specific immune response GO:0002251 13 0.173
positive regulation of b cell mediated immunity GO:0002714 26 0.173
positive regulation of t cell costimulation GO:2000525 2 0.168
cellular amino acid metabolic process GO:0006520 103 0.168
activation of jun kinase activity GO:0007257 15 0.168
regulation of monocyte chemotaxis GO:0090025 3 0.167
regulation of cellular ketone metabolic process GO:0010565 66 0.167
mapk cascade GO:0000165 281 0.166
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.164
endocytosis GO:0006897 168 0.163
regulation of angiotensin levels in blood GO:0002002 4 0.162
Mouse
astrocyte cell migration GO:0043615 3 0.159
regulation of interferon gamma production GO:0032649 57 0.157
chemokine mediated signaling pathway GO:0070098 17 0.156
regulation of establishment of protein localization GO:0070201 181 0.154
detection of biotic stimulus GO:0009595 10 0.153
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.153
divalent inorganic cation transport GO:0072511 178 0.151
lymphocyte proliferation GO:0046651 164 0.149
dendritic cell antigen processing and presentation GO:0002468 7 0.149
striated muscle tissue development GO:0014706 293 0.149
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.148
regulation of mapk cascade GO:0043408 248 0.148
positive regulation of cytokine secretion GO:0050715 41 0.147
regulation of interleukin 1 beta secretion GO:0050706 15 0.147
cation transport GO:0006812 399 0.144
regulation of phagocytosis GO:0050764 33 0.142
regulation of natural killer cell chemotaxis GO:2000501 1 0.140
response to yeast GO:0001878 6 0.140
regulation of reactive oxygen species metabolic process GO:2000377 40 0.140
regulation of cellular amine metabolic process GO:0033238 20 0.140
leukocyte activation involved in immune response GO:0002366 126 0.138
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.138
positive regulation of type 2 immune response GO:0002830 9 0.138
positive regulation of neutrophil chemotaxis GO:0090023 12 0.137
calcium ion homeostasis GO:0055074 127 0.136
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.136
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.135
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.134
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.134
regulation of b cell chemotaxis GO:2000537 2 0.132
pattern recognition receptor signaling pathway GO:0002221 47 0.132
positive regulation of cell migration GO:0030335 109 0.132
regulation of eosinophil migration GO:2000416 2 0.131
regulation of thymocyte migration GO:2000410 2 0.130
regulation of secretion by cell GO:1903530 249 0.128
release of sequestered calcium ion into cytosol GO:0051209 42 0.128
regulation of cytokine biosynthetic process GO:0042035 59 0.125
interleukin 1 beta secretion GO:0050702 16 0.123
amine metabolic process GO:0009308 45 0.123
regulation of cytokine secretion GO:0050707 61 0.122
nitrogen compound transport GO:0071705 271 0.121
positive regulation of cellular amine metabolic process GO:0033240 5 0.121
regulation of t helper 1 cell cytokine production GO:2000554 1 0.118
jnk cascade GO:0007254 72 0.117
immunoglobulin mediated immune response GO:0016064 69 0.116
positive regulation of behavior GO:0048520 40 0.115
second messenger mediated signaling GO:0019932 73 0.115
mature natural killer cell chemotaxis GO:0035782 1 0.115
cell activation involved in immune response GO:0002263 126 0.115
positive regulation of adaptive immune response GO:0002821 61 0.114
epithelial tube morphogenesis GO:0060562 303 0.114
peptidyl amino acid modification GO:0018193 336 0.113
regulation of cell activation GO:0050865 289 0.110
positive regulation of jnk cascade GO:0046330 46 0.109
positive regulation of b cell chemotaxis GO:2000538 2 0.109
sequestering of metal ion GO:0051238 19 0.109
natural killer cell activation GO:0030101 44 0.109
muscle tissue development GO:0060537 308 0.108
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.107
membrane organization GO:0061024 245 0.107
regulation of t cell costimulation GO:2000523 2 0.106
apoptotic signaling pathway GO:0097190 306 0.106
Mouse
positive regulation of inflammatory response GO:0050729 47 0.105
muscle fiber development GO:0048747 76 0.105
carbohydrate derivative biosynthetic process GO:1901137 183 0.105
b cell chemotaxis GO:0035754 3 0.105
negative regulation of growth GO:0045926 99 0.102
Mouse
regulation of muscle tissue development GO:1901861 97 0.102
regulation of chemotaxis GO:0050920 53 0.102
leukocyte migration GO:0050900 124 0.101
small gtpase mediated signal transduction GO:0007264 97 0.101
regulation of cell migration GO:0030334 219 0.101
cellular homeostasis GO:0019725 240 0.101
regulation of type 2 immune response GO:0002828 18 0.101
dendritic cell dendrite assembly GO:0097026 2 0.101
organic cyclic compound catabolic process GO:1901361 295 0.101
Human
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.100
t cell proliferation GO:0042098 120 0.100
receptor mediated endocytosis GO:0006898 51 0.099
metal ion homeostasis GO:0055065 189 0.098
immunoglobulin production in mucosal tissue GO:0002426 3 0.098
antigen receptor mediated signaling pathway GO:0050851 64 0.097
cellular response to molecule of bacterial origin GO:0071219 83 0.097
lymphocyte activation involved in immune response GO:0002285 93 0.097
cytosolic calcium ion transport GO:0060401 48 0.097
thymocyte migration GO:0072679 2 0.096
t cell activation involved in immune response GO:0002286 43 0.094
positive regulation of chemotaxis GO:0050921 38 0.094
regulation of protein secretion GO:0050708 82 0.094
nitric oxide biosynthetic process GO:0006809 25 0.093
membrane invagination GO:0010324 17 0.093
regulation of leukocyte apoptotic process GO:2000106 56 0.093
regulation of protein transport GO:0051223 163 0.092
response to transforming growth factor beta GO:0071559 88 0.092
negative regulation of eosinophil degranulation GO:0043310 1 0.091
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.091
regulation of neutrophil migration GO:1902622 14 0.090
interleukin 1 production GO:0032612 31 0.090
regulation of cell projection organization GO:0031344 206 0.089
platelet morphogenesis GO:0036344 13 0.088
positive regulation of antigen processing and presentation GO:0002579 10 0.087
positive regulation of protein modification process GO:0031401 299 0.087
divalent metal ion transport GO:0070838 172 0.086
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.086
regulation of skeletal muscle fiber development GO:0048742 36 0.085
negative regulation of leukocyte mediated immunity GO:0002704 29 0.085
granulocyte migration GO:0097530 43 0.085
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.084
Mouse
cellular metal ion homeostasis GO:0006875 151 0.084
t cell anergy GO:0002870 4 0.084
leukocyte chemotaxis GO:0030595 69 0.084
interspecies interaction between organisms GO:0044419 83 0.084
Mouse
regulation of cdc42 protein signal transduction GO:0032489 5 0.083
cell adhesion GO:0007155 329 0.083
positive regulation of cytokine biosynthetic process GO:0042108 40 0.081
regulation of purine nucleotide metabolic process GO:1900542 169 0.081
cell chemotaxis GO:0060326 81 0.081
regulation of calcium mediated signaling GO:0050848 19 0.080
positive regulation of cell death GO:0010942 224 0.080
Human
interaction with symbiont GO:0051702 14 0.080
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.080
positive regulation of protein secretion GO:0050714 52 0.080
cytokine production involved in immune response GO:0002367 34 0.080
regulation of stress activated mapk cascade GO:0032872 69 0.079
regulation of t cell mediated immunity GO:0002709 34 0.079
innate immune response activating signal transduction GO:0002758 50 0.079
cellular response to lipid GO:0071396 145 0.078
cellular ion homeostasis GO:0006873 165 0.076
peptidyl tyrosine phosphorylation GO:0018108 143 0.076
lymphocyte costimulation GO:0031294 15 0.075
chemotaxis GO:0006935 247 0.075
regulation of leukocyte differentiation GO:1902105 159 0.075
t helper 1 type immune response GO:0042088 25 0.075
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.074
regulation of homeostatic process GO:0032844 182 0.073
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.073
negative regulation of myoblast differentiation GO:0045662 18 0.073
regulation of protein localization GO:0032880 231 0.073
regulation of glycoprotein biosynthetic process GO:0010559 12 0.072
cellular response to cytokine stimulus GO:0071345 189 0.072
regulation of jnk cascade GO:0046328 62 0.070
negative regulation of multi organism process GO:0043901 68 0.070
Mouse
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.070
regulation of myoblast differentiation GO:0045661 29 0.070
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.069
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.069
positive regulation of immunological synapse formation GO:2000522 1 0.068
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.068
regulation of cellular response to stress GO:0080135 159 0.067
regulation of granulocyte chemotaxis GO:0071622 17 0.067
regulation of gtp catabolic process GO:0033124 113 0.067
defense response to virus GO:0051607 68 0.066
positive regulation of leukocyte differentiation GO:1902107 86 0.066
positive regulation of neutrophil migration GO:1902624 12 0.066
interleukin 1 secretion GO:0050701 16 0.066
regulation of intracellular transport GO:0032386 159 0.065
positive regulation of programmed cell death GO:0043068 218 0.065
Human
stress activated mapk cascade GO:0051403 80 0.065
regulation of hormone levels GO:0010817 211 0.064
Mouse
dendritic cell chemotaxis GO:0002407 7 0.064
positive regulation of stress activated mapk cascade GO:0032874 48 0.064
ras protein signal transduction GO:0007265 77 0.064
developmental growth involved in morphogenesis GO:0060560 138 0.064
aromatic compound catabolic process GO:0019439 286 0.063
Human
muscle cell development GO:0055001 133 0.063
maintenance of location GO:0051235 89 0.063
regulation of ras protein signal transduction GO:0046578 114 0.063
cytokine biosynthetic process GO:0042089 68 0.063
regulation of cell motility GO:2000145 236 0.062
myeloid leukocyte migration GO:0097529 57 0.061
regulation of epithelial cell proliferation GO:0050678 141 0.061
calcium mediated signaling GO:0019722 46 0.061
reactive oxygen species metabolic process GO:0072593 84 0.061
positive regulation of t cell proliferation GO:0042102 52 0.061
myeloid leukocyte differentiation GO:0002573 119 0.060
cellular chemical homeostasis GO:0055082 215 0.060
phagocytosis GO:0006909 66 0.060
rho protein signal transduction GO:0007266 32 0.060
lymphocyte migration GO:0072676 26 0.060
nucleobase containing small molecule metabolic process GO:0055086 352 0.060
regulation of dendritic cell chemotaxis GO:2000508 1 0.060
macrophage apoptotic process GO:0071888 7 0.060
regulation of cytokine production involved in immune response GO:0002718 26 0.060
regulation of interleukin 1 secretion GO:0050704 15 0.060
calcium ion transport into cytosol GO:0060402 48 0.060
regulation of immunoglobulin production GO:0002637 42 0.059
positive regulation of map kinase activity GO:0043406 84 0.058
activation of mapk activity GO:0000187 59 0.058
detection of external biotic stimulus GO:0098581 9 0.058
macrophage chemotaxis GO:0048246 14 0.058
protein secretion GO:0009306 111 0.058
organonitrogen compound catabolic process GO:1901565 264 0.057
cellular ketone metabolic process GO:0042180 84 0.057
negative regulation of cell activation GO:0050866 111 0.057
cellular divalent inorganic cation homeostasis GO:0072503 127 0.056
response to drug GO:0042493 75 0.056
inflammatory response GO:0006954 244 0.056
regulation of production of molecular mediator of immune response GO:0002700 65 0.056
regulation of t helper 1 cell differentiation GO:0045625 7 0.056
purine ribonucleotide metabolic process GO:0009150 290 0.055
regulation of lymphocyte anergy GO:0002911 4 0.055
positive regulation of protein phosphorylation GO:0001934 242 0.055
b cell mediated immunity GO:0019724 71 0.054
dendritic cell differentiation GO:0097028 26 0.054
eosinophil mediated immunity GO:0002447 1 0.054
negative regulation of homeostatic process GO:0032845 71 0.054
cellular nitrogen compound catabolic process GO:0044270 280 0.054
Human
morphogenesis of a branching epithelium GO:0061138 193 0.054
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.053
positive regulation of secretion by cell GO:1903532 114 0.053
calcium ion transport GO:0006816 159 0.053
regulation of jun kinase activity GO:0043506 40 0.052
regulation of secretion GO:0051046 274 0.052
striated muscle cell development GO:0055002 125 0.052
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.052
Mouse
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.051
Mouse
negative regulation of immune effector process GO:0002698 55 0.051
negative regulation of apoptotic signaling pathway GO:2001234 104 0.051
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.051
Mouse
neutrophil mediated killing of bacterium GO:0070944 6 0.051
Mouse
leukocyte apoptotic process GO:0071887 71 0.050
disruption of cells of other organism GO:0044364 13 0.050
Mouse
cellular calcium ion homeostasis GO:0006874 119 0.050
positive regulation of cell activation GO:0050867 158 0.049
response to acid chemical GO:0001101 111 0.049
positive regulation of gtp catabolic process GO:0033126 85 0.049
monocyte extravasation GO:0035696 2 0.049
positive regulation of epithelial cell proliferation GO:0050679 68 0.049
cytosolic calcium ion homeostasis GO:0051480 70 0.049
regulation of angiogenesis GO:0045765 81 0.048
negative regulation of cell proliferation GO:0008285 296 0.048
nucleotide metabolic process GO:0009117 332 0.048
regulation of cellular component biogenesis GO:0044087 181 0.048
interleukin 1 beta production GO:0032611 30 0.047
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.047
eosinophil activation GO:0043307 1 0.046
phagocytosis recognition GO:0006910 12 0.046
positive regulation of cytokine production involved in immune response GO:0002720 19 0.046
myeloid cell apoptotic process GO:0033028 22 0.046
negative regulation of protein metabolic process GO:0051248 282 0.046
glycoprotein metabolic process GO:0009100 116 0.046
regulation of cytoplasmic transport GO:1903649 112 0.046
t cell migration GO:0072678 19 0.046
t helper 17 cell chemotaxis GO:0035705 1 0.045
peptidyl tyrosine modification GO:0018212 145 0.045
positive regulation of response to wounding GO:1903036 66 0.045
divalent inorganic cation homeostasis GO:0072507 138 0.044
interleukin 2 production GO:0032623 33 0.044
negative regulation of innate immune response GO:0045824 17 0.044
hematopoietic stem cell migration GO:0035701 1 0.044
protein kinase b signaling GO:0043491 74 0.043
skeletal muscle fiber development GO:0048741 58 0.043
stress activated protein kinase signaling cascade GO:0031098 81 0.043
regulation of interleukin 2 production GO:0032663 28 0.043
epithelial cell proliferation GO:0050673 174 0.042
eosinophil degranulation GO:0043308 1 0.042
regulation of lymphocyte differentiation GO:0045619 107 0.042
regulation of peptide transport GO:0090087 91 0.042
helper t cell chemotaxis GO:0035704 1 0.042
blood circulation GO:0008015 195 0.041
Mouse
positive regulation of t helper 1 type immune response GO:0002827 12 0.041
purine nucleoside triphosphate catabolic process GO:0009146 203 0.041
microglial cell activation involved in immune response GO:0002282 1 0.041
regulation of regulated secretory pathway GO:1903305 20 0.040
positive regulation of cell motility GO:2000147 116 0.040
immunoglobulin production GO:0002377 73 0.040
myoblast differentiation GO:0045445 52 0.040
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.040
regulation of eosinophil degranulation GO:0043309 1 0.040
cd4 positive alpha beta t cell activation GO:0035710 45 0.040
cellular macromolecule catabolic process GO:0044265 206 0.040
Human
positive regulation of lymphocyte anergy GO:0002913 4 0.040
negative regulation of cellular amine metabolic process GO:0033239 1 0.039
purine containing compound metabolic process GO:0072521 311 0.039
t cell differentiation involved in immune response GO:0002292 30 0.039
negative regulation of phosphate metabolic process GO:0045936 184 0.039
nitric oxide metabolic process GO:0046209 25 0.039
positive regulation of apoptotic process GO:0043065 217 0.039
Human
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.039
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.038
positive regulation of glycoprotein metabolic process GO:1903020 6 0.038
i kappab kinase nf kappab signaling GO:0007249 85 0.038
positive regulation of t cell anergy GO:0002669 4 0.038
branching morphogenesis of an epithelial tube GO:0048754 159 0.038
negative thymic t cell selection GO:0045060 12 0.038
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.037
regulation of neuron apoptotic process GO:0043523 122 0.037
thymic t cell selection GO:0045061 22 0.037
homeostasis of number of cells GO:0048872 210 0.037
regulation of protein kinase activity GO:0045859 232 0.037
b cell activation GO:0042113 161 0.037
negative regulation of leukocyte apoptotic process GO:2000107 31 0.037
regulation of dendritic cell antigen processing and presentation GO:0002604 7 0.037
ear development GO:0043583 200 0.036
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.036
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 16 0.036
regulation of lymphocyte apoptotic process GO:0070228 41 0.036
positive regulation of leukocyte proliferation GO:0070665 73 0.035
immune complex clearance by monocytes and macrophages GO:0002436 2 0.035
negative regulation of phosphorylation GO:0042326 166 0.035
positive regulation of calcium mediated signaling GO:0050850 15 0.035
positive regulation of immunoglobulin production GO:0002639 28 0.035
mucosal immune response GO:0002385 13 0.035
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.035
Mouse
guanosine containing compound metabolic process GO:1901068 144 0.035
cell cell recognition GO:0009988 44 0.035
t helper cell differentiation GO:0042093 28 0.035
positive regulation of homeostatic process GO:0032846 64 0.034
regulation of map kinase activity GO:0043405 120 0.034
response to interferon gamma GO:0034341 34 0.034
positive regulation of protein transport GO:0051222 93 0.034
macromolecule catabolic process GO:0009057 281 0.034
Human
positive regulation of jun kinase activity GO:0043507 30 0.034
positive regulation of cellular catabolic process GO:0031331 148 0.034
skeletal muscle organ development GO:0060538 163 0.033
positive regulation of mapk cascade GO:0043410 170 0.033
positive regulation of t cell mediated immunity GO:0002711 24 0.033
tissue remodeling GO:0048771 102 0.033
regulation of b cell mediated immunity GO:0002712 37 0.033
cellular response to acid chemical GO:0071229 68 0.033
regulation of t cell anergy GO:0002667 4 0.033
t cell receptor signaling pathway GO:0050852 46 0.033
regulation of cell projection assembly GO:0060491 38 0.033
myotube cell development GO:0014904 60 0.033
carbohydrate derivative catabolic process GO:1901136 231 0.033
neutrophil mediated cytotoxicity GO:0070942 8 0.032
Mouse
alpha beta t cell proliferation GO:0046633 21 0.032
viral gene expression GO:0019080 3 0.032
gland development GO:0048732 330 0.032
lymphocyte chemotaxis GO:0048247 10 0.032
negative regulation of hydrolase activity GO:0051346 71 0.032
Human
humoral immune response GO:0006959 57 0.031
negative regulation of cellular protein metabolic process GO:0032269 247 0.031
positive regulation of intracellular transport GO:0032388 70 0.031
myotube differentiation GO:0014902 105 0.031
regulation of cell adhesion GO:0030155 154 0.030
regulation of t helper 1 type immune response GO:0002825 17 0.030
positive regulation of t cell cytokine production GO:0002726 5 0.030
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.030
developmental maturation GO:0021700 193 0.030
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
ossification GO:0001503 216 0.030
regulation of nitric oxide biosynthetic process GO:0045428 18 0.030
regulation of growth of symbiont in host GO:0044126 19 0.029
Mouse
regulation of immunological synapse formation GO:2000520 2 0.029
negative regulation of lymphocyte activation GO:0051250 91 0.029
cytokine metabolic process GO:0042107 71 0.029
neuron death GO:0070997 154 0.029
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.029
response to organonitrogen compound GO:0010243 246 0.029
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.029

Gzma disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org