Mus musculus

0 known processes

Shmt1

serine hydroxymethyltransferase 1 (soluble)

(Aliases: AI385541,mshmt2,mshmt,Shmt,AI324848,C81125,mshmt1)

Shmt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.194
Human
heterocycle catabolic process GO:0046700 280 0.113
organic cyclic compound catabolic process GO:1901361 295 0.107
cellular nitrogen compound catabolic process GO:0044270 280 0.100
purine containing compound metabolic process GO:0072521 311 0.097
Human
oxidation reduction process GO:0055114 342 0.092
nucleotide metabolic process GO:0009117 332 0.091
purine nucleotide metabolic process GO:0006163 302 0.087
purine nucleoside metabolic process GO:0042278 241 0.085
purine nucleoside triphosphate metabolic process GO:0009144 226 0.084
serine family amino acid metabolic process GO:0009069 7 0.082
Human
organic acid biosynthetic process GO:0016053 86 0.080
nucleoside phosphate metabolic process GO:0006753 338 0.079
ribonucleoside metabolic process GO:0009119 245 0.077
organonitrogen compound catabolic process GO:1901565 264 0.076
Human
glycosyl compound metabolic process GO:1901657 246 0.075
nucleobase containing small molecule metabolic process GO:0055086 352 0.073
Human
cellular ketone metabolic process GO:0042180 84 0.070
regulation of cellular amino acid metabolic process GO:0006521 5 0.069
ribose phosphate metabolic process GO:0019693 291 0.067
regulation of cellular ketone metabolic process GO:0010565 66 0.066
ion transmembrane transport GO:0034220 361 0.062
nucleoside metabolic process GO:0009116 246 0.061
amine metabolic process GO:0009308 45 0.060
alpha amino acid biosynthetic process GO:1901607 15 0.060
transmembrane transport GO:0055085 412 0.059
aromatic compound catabolic process GO:0019439 286 0.056
purine ribonucleotide metabolic process GO:0009150 290 0.056
nucleoside triphosphate metabolic process GO:0009141 230 0.054
organonitrogen compound biosynthetic process GO:1901566 192 0.054
Human
l serine metabolic process GO:0006563 2 0.053
Human
carboxylic acid biosynthetic process GO:0046394 86 0.052
alpha amino acid metabolic process GO:1901605 59 0.051
Human
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.046
cellular response to dna damage stimulus GO:0006974 207 0.046
regulation of cellular amine metabolic process GO:0033238 20 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.045
dna metabolic process GO:0006259 303 0.045
purine ribonucleoside metabolic process GO:0046128 241 0.045
ribonucleoside triphosphate metabolic process GO:0009199 220 0.044
cellular amino acid biosynthetic process GO:0008652 22 0.044
organophosphate catabolic process GO:0046434 232 0.042
positive regulation of cellular amine metabolic process GO:0033240 5 0.041
cellular amine metabolic process GO:0044106 44 0.040
membrane organization GO:0061024 245 0.040
regulation of defense response GO:0031347 233 0.040
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
purine ribonucleoside catabolic process GO:0046130 205 0.038
apoptotic signaling pathway GO:0097190 306 0.038
small molecule biosynthetic process GO:0044283 132 0.038
regulation of organelle organization GO:0033043 289 0.038
intrinsic apoptotic signaling pathway GO:0097193 132 0.037
nucleoside triphosphate catabolic process GO:0009143 205 0.037
protein oligomerization GO:0051259 67 0.037
Human
spermatogenesis GO:0007283 284 0.037
nucleoside phosphate catabolic process GO:1901292 222 0.036
ribonucleotide metabolic process GO:0009259 291 0.036
dna repair GO:0006281 107 0.036
nucleoside catabolic process GO:0009164 206 0.036
ribonucleoside catabolic process GO:0042454 206 0.034
action potential GO:0001508 78 0.032
anion transport GO:0006820 177 0.032
nucleotide catabolic process GO:0009166 217 0.032
cytokine production GO:0001816 319 0.032
purine nucleoside triphosphate catabolic process GO:0009146 203 0.032
negative regulation of cellular component organization GO:0051129 194 0.032
ribonucleotide catabolic process GO:0009261 208 0.031
immune effector process GO:0002252 321 0.031
cellular lipid metabolic process GO:0044255 323 0.030
ribonucleoside triphosphate catabolic process GO:0009203 199 0.029
peptidyl amino acid modification GO:0018193 336 0.028
cation transport GO:0006812 399 0.028
gland development GO:0048732 330 0.028
purine nucleoside catabolic process GO:0006152 205 0.027
male gamete generation GO:0048232 285 0.027
locomotory behavior GO:0007626 195 0.027
aspartate family amino acid metabolic process GO:0009066 10 0.027
regulation of cytokine production GO:0001817 266 0.027
purine nucleotide catabolic process GO:0006195 211 0.026
positive regulation of apoptotic process GO:0043065 217 0.026
endomembrane system organization GO:0010256 147 0.026
organic hydroxy compound metabolic process GO:1901615 203 0.026
regulation of apoptotic signaling pathway GO:2001233 197 0.026
response to organonitrogen compound GO:0010243 246 0.025
posttranscriptional regulation of gene expression GO:0010608 155 0.025
protein maturation GO:0051604 176 0.025
cell adhesion GO:0007155 329 0.025
negative regulation of molecular function GO:0044092 258 0.025
multicellular organismal signaling GO:0035637 91 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
positive regulation of cell death GO:0010942 224 0.023
purine containing compound catabolic process GO:0072523 213 0.023
carbohydrate derivative catabolic process GO:1901136 231 0.023
regulation of membrane potential GO:0042391 192 0.023
nucleotide biosynthetic process GO:0009165 78 0.022
carbohydrate metabolic process GO:0005975 230 0.022
cellular carbohydrate metabolic process GO:0044262 119 0.022
generation of precursor metabolites and energy GO:0006091 103 0.022
organic anion transport GO:0015711 137 0.022
regulation of ion transmembrane transport GO:0034765 119 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
germ cell development GO:0007281 185 0.022
regulation of mapk cascade GO:0043408 248 0.021
cellular homeostasis GO:0019725 240 0.021
leukocyte differentiation GO:0002521 342 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
cellular response to lipid GO:0071396 145 0.021
monocarboxylic acid metabolic process GO:0032787 191 0.020
purine nucleoside biosynthetic process GO:0042451 19 0.020
organophosphate biosynthetic process GO:0090407 122 0.020
protein homooligomerization GO:0051260 43 0.020
mitochondrion organization GO:0007005 134 0.020
endocytosis GO:0006897 168 0.020
regulation of innate immune response GO:0045088 91 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
regulation of cell activation GO:0050865 289 0.020
ribonucleoside monophosphate metabolic process GO:0009161 80 0.020
energy derivation by oxidation of organic compounds GO:0015980 77 0.020
cellular response to cytokine stimulus GO:0071345 189 0.019
negative regulation of phosphorus metabolic process GO:0010563 184 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
histone modification GO:0016570 159 0.019
lipid biosynthetic process GO:0008610 179 0.019
cytoplasmic transport GO:0016482 234 0.018
small gtpase mediated signal transduction GO:0007264 97 0.018
regulation of response to wounding GO:1903034 189 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
sensory perception GO:0007600 245 0.018
innate immune response GO:0045087 157 0.018
carboxylic acid catabolic process GO:0046395 51 0.018
Human
nucleoside phosphate biosynthetic process GO:1901293 79 0.018
mapk cascade GO:0000165 281 0.017
blastocyst development GO:0001824 80 0.017
nucleoside monophosphate metabolic process GO:0009123 85 0.017
regulation of cellular response to stress GO:0080135 159 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
cellular ion homeostasis GO:0006873 165 0.017
nitrogen compound transport GO:0071705 271 0.017
protein processing GO:0016485 163 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
regulation of anatomical structure size GO:0090066 178 0.017
negative regulation of phosphate metabolic process GO:0045936 184 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
muscle cell differentiation GO:0042692 261 0.017
lymphocyte differentiation GO:0030098 242 0.017
small molecule catabolic process GO:0044282 71 0.017
Human
chromatin organization GO:0006325 206 0.017
cellular response to peptide hormone stimulus GO:0071375 92 0.017
carbohydrate derivative biosynthetic process GO:1901137 183 0.017
regulation of secretion GO:0051046 274 0.017
macromolecule catabolic process GO:0009057 281 0.016
heart process GO:0003015 94 0.016
protein targeting GO:0006605 143 0.016
adaptive immune response GO:0002250 155 0.016
sulfur compound metabolic process GO:0006790 100 0.016
regulation of ion transport GO:0043269 215 0.016
single organism cell adhesion GO:0098602 156 0.016
cell fate commitment GO:0045165 210 0.016
inorganic cation transmembrane transport GO:0098662 207 0.016
production of molecular mediator of immune response GO:0002440 103 0.016
regulation of nucleoside metabolic process GO:0009118 130 0.016
transmission of nerve impulse GO:0019226 76 0.016
regulation of mitochondrion organization GO:0010821 27 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
mitochondrial transport GO:0006839 36 0.016
intracellular protein transport GO:0006886 204 0.016
cellular chemical homeostasis GO:0055082 215 0.016
organelle assembly GO:0070925 177 0.016
cation transmembrane transport GO:0098655 266 0.016
cellular protein complex assembly GO:0043623 116 0.016
negative regulation of immune system process GO:0002683 209 0.015
negative regulation of phosphorylation GO:0042326 166 0.015
ras protein signal transduction GO:0007265 77 0.015
purine nucleoside monophosphate metabolic process GO:0009126 81 0.015
t cell activation GO:0042110 289 0.015
metal ion homeostasis GO:0055065 189 0.015
response to organic cyclic compound GO:0014070 198 0.015
divalent metal ion transport GO:0070838 172 0.015
cation homeostasis GO:0055080 212 0.015
protein tetramerization GO:0051262 23 0.015
Human
regulation of cellular component size GO:0032535 121 0.015
purine containing compound biosynthetic process GO:0072522 70 0.015
Human
regulation of hydrolase activity GO:0051336 246 0.015
protein localization to membrane GO:0072657 108 0.015
positive regulation of lymphocyte activation GO:0051251 140 0.015
inflammatory response GO:0006954 244 0.015
regulation of translation GO:0006417 71 0.015
meiotic nuclear division GO:0007126 115 0.015
stem cell differentiation GO:0048863 268 0.015
homeostasis of number of cells GO:0048872 210 0.015
response to radiation GO:0009314 165 0.015
negative regulation of protein modification process GO:0031400 163 0.015
heart contraction GO:0060047 93 0.015
carboxylic acid transport GO:0046942 100 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
multicellular organism growth GO:0035264 161 0.015
divalent inorganic cation transport GO:0072511 178 0.015
negative regulation of organelle organization GO:0010639 90 0.015
establishment of organelle localization GO:0051656 122 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
vitamin transmembrane transport GO:0035461 4 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
dna dependent dna replication GO:0006261 24 0.014
regulation of transferase activity GO:0051338 263 0.014
regulation of transmembrane transport GO:0034762 128 0.014
monosaccharide metabolic process GO:0005996 106 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
regulation of actin filament based process GO:0032970 99 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
mrna metabolic process GO:0016071 84 0.014
establishment or maintenance of cell polarity GO:0007163 86 0.014
regulation of cell cycle GO:0051726 281 0.014
glucose metabolic process GO:0006006 92 0.014
organelle fission GO:0048285 170 0.014
digestive system development GO:0055123 200 0.014
calcium ion transport GO:0006816 159 0.014
serine family amino acid biosynthetic process GO:0009070 4 0.014
regulation of cell migration GO:0030334 219 0.014
translation GO:0006412 93 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
purine ribonucleoside biosynthetic process GO:0046129 19 0.014
atp metabolic process GO:0046034 75 0.014
negative regulation of cell cycle GO:0045786 123 0.014
cellular response to hormone stimulus GO:0032870 150 0.013
intracellular mrna localization GO:0008298 4 0.013
cellular response to molecule of bacterial origin GO:0071219 83 0.013
positive regulation of cytokine production GO:0001819 174 0.013
molting cycle GO:0042303 90 0.013
fatty acid metabolic process GO:0006631 121 0.013
gtp metabolic process GO:0046039 144 0.013
cofactor transport GO:0051181 4 0.013
placenta development GO:0001890 140 0.013
positive regulation of defense response GO:0031349 124 0.013
positive regulation of t cell activation GO:0050870 101 0.013
dna recombination GO:0006310 92 0.013
dna endoreduplication GO:0042023 4 0.013
chromatin modification GO:0016568 187 0.013
multi multicellular organism process GO:0044706 109 0.013
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.013
positive regulation of cell development GO:0010720 237 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
regulation of mrna metabolic process GO:1903311 43 0.013
leukocyte proliferation GO:0070661 172 0.013
b cell activation GO:0042113 161 0.013
organelle localization GO:0051640 179 0.013
actin filament based movement GO:0030048 23 0.013
regulation of proteolysis GO:0030162 164 0.013
activation of immune response GO:0002253 138 0.012
regulation of hormone levels GO:0010817 211 0.012
purine nucleotide biosynthetic process GO:0006164 65 0.012
regulation of system process GO:0044057 200 0.012
circulatory system process GO:0003013 197 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
response to oxidative stress GO:0006979 123 0.012
inorganic ion transmembrane transport GO:0098660 234 0.012
protein localization to organelle GO:0033365 185 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
response to lipopolysaccharide GO:0032496 128 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
dephosphorylation GO:0016311 129 0.012
dna catabolic process endonucleolytic GO:0000737 15 0.012
alcohol metabolic process GO:0006066 116 0.012
striated muscle tissue development GO:0014706 293 0.012
protein import GO:0017038 101 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
response to peptide GO:1901652 136 0.012
synaptic transmission GO:0007268 329 0.012
anatomical structure homeostasis GO:0060249 145 0.012
response to peptide hormone GO:0043434 127 0.012
liver development GO:0001889 66 0.012
regulation of cell motility GO:2000145 236 0.012
muscle tissue development GO:0060537 308 0.012
defecation GO:0030421 1 0.012
skin development GO:0043588 220 0.012
ribonucleoside monophosphate catabolic process GO:0009158 57 0.012
ribonucleoside biosynthetic process GO:0042455 21 0.012
rna processing GO:0006396 105 0.012
positive regulation of apoptotic signaling pathway GO:2001235 95 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
actin filament polymerization GO:0030041 44 0.012
spermatid development GO:0007286 108 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
adult locomotory behavior GO:0008344 91 0.012
cellular response to arsenic containing substance GO:0071243 4 0.011
neuronal action potential GO:0019228 54 0.011
response to nutrient levels GO:0031667 109 0.011
organic acid transport GO:0015849 101 0.011
response to extracellular stimulus GO:0009991 127 0.011
glucose homeostasis GO:0042593 128 0.011
developmental maturation GO:0021700 193 0.011
regulation of cell adhesion GO:0030155 154 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
regulation of inflammatory response GO:0050727 147 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.011
immunoglobulin production GO:0002377 73 0.011
gonad development GO:0008406 141 0.011
regulation of protein kinase activity GO:0045859 232 0.011
fertilization GO:0009566 127 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
regulation of protein localization GO:0032880 231 0.011
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.011
t cell differentiation GO:0030217 174 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
rho protein signal transduction GO:0007266 32 0.011
glycosyl compound biosynthetic process GO:1901659 21 0.011
organ growth GO:0035265 117 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
regulation of t cell activation GO:0050863 170 0.011
covalent chromatin modification GO:0016569 163 0.011
hepaticobiliary system development GO:0061008 67 0.011
hexose metabolic process GO:0019318 98 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
morphogenesis of a branching epithelium GO:0061138 193 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
digestive tract development GO:0048565 190 0.011
apoptotic mitochondrial changes GO:0008637 48 0.011
cellular modified amino acid metabolic process GO:0006575 63 0.011
Human
regulation of homeostatic process GO:0032844 182 0.011
nucleoside biosynthetic process GO:0009163 21 0.011
carbohydrate homeostasis GO:0033500 128 0.010
respiratory tube development GO:0030323 167 0.010
mitotic cell cycle GO:0000278 195 0.010
cell type specific apoptotic process GO:0097285 268 0.010
guanosine containing compound metabolic process GO:1901068 144 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
myosin filament assembly GO:0031034 2 0.010
blood circulation GO:0008015 195 0.010
adult behavior GO:0030534 135 0.010
respiratory system development GO:0060541 190 0.010
regulation of neuron differentiation GO:0045664 281 0.010
response to light stimulus GO:0009416 135 0.010
dna biosynthetic process GO:0071897 22 0.010
defense response to other organism GO:0098542 197 0.010
response to acid chemical GO:0001101 111 0.010
metaphase plate congression GO:0051310 2 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
muscle system process GO:0003012 141 0.010

Shmt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.034
amino acid metabolic disorder DOID:9252 0 0.034
inherited metabolic disorder DOID:655 0 0.034
immune system disease DOID:2914 0 0.016
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.014
central nervous system disease DOID:331 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
musculoskeletal system disease DOID:17 0 0.010