Mus musculus

0 known processes

Adam21

a disintegrin and metallopeptidase domain 21

(Aliases: Adam31)

Adam21 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 20 0.205
regulation of protein kinase activity GO:0045859 232 0.179
Mouse
cellular amine metabolic process GO:0044106 44 0.121
positive regulation of protein phosphorylation GO:0001934 242 0.089
Mouse
regulation of transferase activity GO:0051338 263 0.085
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.083
regulation of lymphocyte activation GO:0051249 240 0.072
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.071
regulation of protein serine threonine kinase activity GO:0071900 157 0.071
Mouse
spermatogenesis GO:0007283 284 0.071
amine metabolic process GO:0009308 45 0.065
mapk cascade GO:0000165 281 0.064
Mouse
negative regulation of molecular function GO:0044092 258 0.064
nucleotide metabolic process GO:0009117 332 0.061
regulation of cellular amino acid metabolic process GO:0006521 5 0.060
small gtpase mediated signal transduction GO:0007264 97 0.054
positive regulation of protein modification process GO:0031401 299 0.052
Mouse
cellular ketone metabolic process GO:0042180 84 0.052
organic cyclic compound catabolic process GO:1901361 295 0.051
organophosphate catabolic process GO:0046434 232 0.050
protein maturation GO:0051604 176 0.050
sensory perception GO:0007600 245 0.047
male gamete generation GO:0048232 285 0.047
regulation of cytokine production GO:0001817 266 0.046
Mouse
ribonucleotide metabolic process GO:0009259 291 0.044
muscle tissue development GO:0060537 308 0.043
regulation of eosinophil migration GO:2000416 2 0.041
Mouse
regulation of protein localization GO:0032880 231 0.040
positive regulation of protein kinase activity GO:0045860 144 0.040
Mouse
regulation of defense response GO:0031347 233 0.040
Mouse
inflammatory response GO:0006954 244 0.039
Mouse
regulation of cell activation GO:0050865 289 0.039
Mouse
ribonucleotide catabolic process GO:0009261 208 0.039
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.038
regulation of angiogenesis GO:0045765 81 0.037
nucleobase containing small molecule metabolic process GO:0055086 352 0.037
purine containing compound catabolic process GO:0072523 213 0.037
regulation of neuron differentiation GO:0045664 281 0.037
regulation of establishment of protein localization GO:0070201 181 0.037
positive regulation of thymocyte migration GO:2000412 2 0.037
Mouse
regulation of cell projection organization GO:0031344 206 0.036
purine ribonucleotide metabolic process GO:0009150 290 0.036
regulation of cellular response to stress GO:0080135 159 0.036
immune effector process GO:0002252 321 0.036
cellular amino acid metabolic process GO:0006520 103 0.035
cytokine production GO:0001816 319 0.035
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.035
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.035
regulation of t cell activation GO:0050863 170 0.034
Mouse
positive regulation of eosinophil migration GO:2000418 2 0.034
Mouse
ribonucleoside metabolic process GO:0009119 245 0.034
peptidyl amino acid modification GO:0018193 336 0.034
nucleoside phosphate metabolic process GO:0006753 338 0.034
myotube differentiation GO:0014902 105 0.034
negative regulation of immune system process GO:0002683 209 0.033
regulation of membrane potential GO:0042391 192 0.033
Mouse
potassium ion transmembrane transport GO:0071805 43 0.032
cell adhesion GO:0007155 329 0.032
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.032
macromolecule catabolic process GO:0009057 281 0.032
Mouse
purine ribonucleoside metabolic process GO:0046128 241 0.031
regulation of protein transport GO:0051223 163 0.031
regulation of cell migration GO:0030334 219 0.031
Mouse
nucleoside triphosphate catabolic process GO:0009143 205 0.031
positive regulation of nervous system development GO:0051962 221 0.030
peptidyl tyrosine phosphorylation GO:0018108 143 0.030
cellular response to cytokine stimulus GO:0071345 189 0.030
cellular nitrogen compound catabolic process GO:0044270 280 0.030
negative regulation of intracellular signal transduction GO:1902532 167 0.030
ribose phosphate metabolic process GO:0019693 291 0.029
glycosyl compound metabolic process GO:1901657 246 0.029
purine containing compound metabolic process GO:0072521 311 0.029
negative regulation of protein metabolic process GO:0051248 282 0.029
regulation of ion transport GO:0043269 215 0.029
transmembrane transport GO:0055085 412 0.029
regulation of striated muscle cell differentiation GO:0051153 81 0.028
regulation of cell cycle GO:0051726 281 0.028
striated muscle tissue development GO:0014706 293 0.028
regulation of leukocyte differentiation GO:1902105 159 0.028
Mouse
negative regulation of phosphorylation GO:0042326 166 0.027
nucleoside metabolic process GO:0009116 246 0.027
nucleoside phosphate catabolic process GO:1901292 222 0.027
innate immune response GO:0045087 157 0.027
Mouse
ion transmembrane transport GO:0034220 361 0.027
b cell activation GO:0042113 161 0.027
Mouse
leukocyte mediated immunity GO:0002443 174 0.026
cell chemotaxis GO:0060326 81 0.026
Mouse
inorganic ion transmembrane transport GO:0098660 234 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.026
regulation of kinase activity GO:0043549 249 0.026
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.026
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
ribonucleoside catabolic process GO:0042454 206 0.025
regulation of mapk cascade GO:0043408 248 0.025
Mouse
cellularization GO:0007349 1 0.025
developmental maturation GO:0021700 193 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
regulation of cellular component biogenesis GO:0044087 181 0.025
skin development GO:0043588 220 0.025
purine nucleoside metabolic process GO:0042278 241 0.025
epidermis development GO:0008544 187 0.025
organic hydroxy compound metabolic process GO:1901615 203 0.025
adaptive immune response GO:0002250 155 0.025
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.024
lymphocyte differentiation GO:0030098 242 0.024
Mouse
ras protein signal transduction GO:0007265 77 0.024
neuronal action potential GO:0019228 54 0.024
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.024
Mouse
nucleotide catabolic process GO:0009166 217 0.024
purine ribonucleoside catabolic process GO:0046130 205 0.024
cellular response to oxidative stress GO:0034599 76 0.024
cellular response to biotic stimulus GO:0071216 92 0.024
positive regulation of programmed cell death GO:0043068 218 0.024
Mouse
synaptic transmission GO:0007268 329 0.024
multicellular organismal homeostasis GO:0048871 164 0.024
Mouse
response to lipopolysaccharide GO:0032496 128 0.024
heterocycle catabolic process GO:0046700 280 0.024
nucleoside triphosphate metabolic process GO:0009141 230 0.023
regulation of thymocyte migration GO:2000410 2 0.023
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.023
tissue homeostasis GO:0001894 115 0.023
Mouse
positive regulation of kinase activity GO:0033674 155 0.023
Mouse
angiogenesis GO:0001525 201 0.023
Mouse
regulation of hydrolase activity GO:0051336 246 0.022
organonitrogen compound catabolic process GO:1901565 264 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
cellular chemical homeostasis GO:0055082 215 0.022
peptidyl tyrosine modification GO:0018212 145 0.021
positive regulation of cytokine production GO:0001819 174 0.021
Mouse
cellular response to hormone stimulus GO:0032870 150 0.021
regulation of lymphocyte differentiation GO:0045619 107 0.021
Mouse
positive regulation of defense response GO:0031349 124 0.021
Mouse
spermatid differentiation GO:0048515 115 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
glycosyl compound catabolic process GO:1901658 206 0.021
dna metabolic process GO:0006259 303 0.021
membrane organization GO:0061024 245 0.021
regulation of organelle organization GO:0033043 289 0.021
positive regulation of transferase activity GO:0051347 167 0.021
Mouse
response to growth factor GO:0070848 198 0.021
Mouse
meiotic nuclear division GO:0007126 115 0.020
cellular homeostasis GO:0019725 240 0.020
muscle cell differentiation GO:0042692 261 0.020
purine ribonucleotide catabolic process GO:0009154 208 0.020
cation transmembrane transport GO:0098655 266 0.020
defense response to virus GO:0051607 68 0.020
aromatic compound catabolic process GO:0019439 286 0.020
regulation of microvillus assembly GO:0032534 3 0.020
purine nucleotide catabolic process GO:0006195 211 0.020
anatomical structure homeostasis GO:0060249 145 0.020
Mouse
neuron apoptotic process GO:0051402 142 0.020
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.019
i kappab kinase nf kappab signaling GO:0007249 85 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
Mouse
leukocyte proliferation GO:0070661 172 0.019
intracellular protein transport GO:0006886 204 0.019
lymphocyte proliferation GO:0046651 164 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
anion transport GO:0006820 177 0.019
protein processing GO:0016485 163 0.019
activation of mapk activity GO:0000187 59 0.018
Mouse
regulation of multi organism process GO:0043900 111 0.018
Mouse
cell type specific apoptotic process GO:0097285 268 0.018
Mouse
b cell proliferation GO:0042100 53 0.018
nuclear transport GO:0051169 139 0.018
rho protein signal transduction GO:0007266 32 0.018
positive regulation of protein transport GO:0051222 93 0.018
rna interference GO:0016246 2 0.018
regulation of defense response to bacterium GO:1900424 3 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
engulfment of apoptotic cell GO:0043652 3 0.018
regulation of lymphocyte mediated immunity GO:0002706 84 0.018
immune response regulating signaling pathway GO:0002764 125 0.018
Mouse
negative regulation of angiogenesis GO:0016525 25 0.018
lymphocyte mediated immunity GO:0002449 139 0.018
positive regulation of t cell activation GO:0050870 101 0.017
Mouse
regulation of t cell differentiation GO:0045580 83 0.017
Mouse
regulation of cell adhesion GO:0030155 154 0.017
Mouse
peptidyl serine modification GO:0018209 83 0.017
positive regulation of ion transport GO:0043270 65 0.017
positive regulation of cellular catabolic process GO:0031331 148 0.017
Mouse
negative regulation of lymphocyte activation GO:0051250 91 0.017
oxidation reduction process GO:0055114 342 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
protein localization to organelle GO:0033365 185 0.017
axon ensheathment GO:0008366 76 0.017
Mouse
regulation of body fluid levels GO:0050878 162 0.017
protein secretion GO:0009306 111 0.017
regulation of vasculature development GO:1901342 88 0.016
germ cell development GO:0007281 185 0.016
leukocyte differentiation GO:0002521 342 0.016
Mouse
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.016
nitrogen compound transport GO:0071705 271 0.016
ribonucleoside triphosphate catabolic process GO:0009203 199 0.016
cellular amide metabolic process GO:0043603 58 0.016
negative regulation of leukocyte mediated immunity GO:0002704 29 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
protein catabolic process GO:0030163 221 0.016
Mouse
regulation of neuron projection development GO:0010975 169 0.016
regulation of t helper 2 cell cytokine production GO:2000551 3 0.016
skeletal muscle fiber development GO:0048741 58 0.016
regulation of inflammatory response GO:0050727 147 0.016
Mouse
regulation of skeletal muscle fiber development GO:0048742 36 0.015
regulation of lipid metabolic process GO:0019216 118 0.015
nucleoside catabolic process GO:0009164 206 0.015
b cell differentiation GO:0030183 78 0.015
Mouse
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
single fertilization GO:0007338 82 0.015
Mouse
stress activated protein kinase signaling cascade GO:0031098 81 0.015
positive regulation of innate immune response GO:0045089 80 0.015
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.015
single organism cell adhesion GO:0098602 156 0.015
Mouse
negative regulation of immune effector process GO:0002698 55 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
production of molecular mediator of immune response GO:0002440 103 0.015
cellular response to lipopolysaccharide GO:0071222 77 0.015
eosinophil migration GO:0072677 3 0.015
Mouse
response to molecule of bacterial origin GO:0002237 143 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
positive regulation of secretion GO:0051047 130 0.015
negative regulation of muscle cell differentiation GO:0051148 33 0.015
regulation of cellular component size GO:0032535 121 0.015
negative regulation of hydrolase activity GO:0051346 71 0.015
regulation of leukocyte proliferation GO:0070663 121 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.015
response to oxidative stress GO:0006979 123 0.015
regulation of intracellular protein transport GO:0033157 82 0.015
regulation of cellular catabolic process GO:0031329 242 0.014
Mouse
negative regulation of vasculature development GO:1901343 26 0.014
osteoclast differentiation GO:0030316 62 0.014
organic anion transport GO:0015711 137 0.014
sensory organ morphogenesis GO:0090596 242 0.014
regulation of map kinase activity GO:0043405 120 0.014
Mouse
endocytosis GO:0006897 168 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.014
t cell mediated immunity GO:0002456 50 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
Mouse
negative regulation of response to wounding GO:1903035 77 0.014
glycosylation GO:0070085 62 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
regulation of myotube differentiation GO:0010830 62 0.014
cation transport GO:0006812 399 0.014
negative regulation of cell development GO:0010721 169 0.014
multicellular organismal signaling GO:0035637 91 0.014
Mouse
regulation of action potential GO:0098900 4 0.014
peptide metabolic process GO:0006518 46 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
positive regulation of cell death GO:0010942 224 0.014
Mouse
glycoprotein metabolic process GO:0009100 116 0.014
microtubule based process GO:0007017 236 0.014
negative regulation of protein modification process GO:0031400 163 0.014
defense response to other organism GO:0098542 197 0.014
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.013
ribonucleoside monophosphate catabolic process GO:0009158 57 0.013
negative regulation of cell activation GO:0050866 111 0.013
homeostasis of number of cells GO:0048872 210 0.013
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.013
ensheathment of neurons GO:0007272 76 0.013
Mouse
antibacterial peptide production GO:0002778 2 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
neuron death GO:0070997 154 0.013
Mouse
regulation of antibacterial peptide production GO:0002786 1 0.013
erk1 and erk2 cascade GO:0070371 77 0.013
pigmentation GO:0043473 71 0.013
learning or memory GO:0007611 148 0.013
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
methylation GO:0032259 134 0.013
positive regulation of cell development GO:0010720 237 0.013
spermatid development GO:0007286 108 0.013
regulation of cytokine secretion GO:0050707 61 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
gland development GO:0048732 330 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
t helper 2 cell cytokine production GO:0035745 4 0.012
atp catabolic process GO:0006200 55 0.012
myeloid cell differentiation GO:0030099 233 0.012
stem cell differentiation GO:0048863 268 0.012
Mouse
regulation of response to wounding GO:1903034 189 0.012
Mouse
ear morphogenesis GO:0042471 118 0.012
regulation of innate immune response GO:0045088 91 0.012
Mouse
protein import into nucleus GO:0006606 95 0.012
positive regulation of cell activation GO:0050867 158 0.012
Mouse
regulation of cell motility GO:2000145 236 0.012
Mouse
negative regulation of blood vessel morphogenesis GO:2000181 25 0.012
positive regulation of defense response to bacterium GO:1900426 1 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
dendrite development GO:0016358 115 0.012
thymocyte migration GO:0072679 2 0.012
Mouse
atp metabolic process GO:0046034 75 0.012
myotube cell development GO:0014904 60 0.012
hepaticobiliary system development GO:0061008 67 0.012
forebrain development GO:0030900 302 0.012
photoreceptor cell differentiation GO:0046530 52 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
Mouse
antibacterial peptide biosynthetic process GO:0002780 2 0.012
regulation of interleukin 6 production GO:0032675 55 0.012
positive regulation of intracellular transport GO:0032388 70 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
cell cell recognition GO:0009988 44 0.011
Mouse
nucleoside monophosphate catabolic process GO:0009125 59 0.011
transmission of nerve impulse GO:0019226 76 0.011
Mouse
negative regulation of nervous system development GO:0051961 156 0.011
regulation of protein maturation GO:1903317 96 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.011
Mouse
positive regulation of apoptotic process GO:0043065 217 0.011
Mouse
sensory perception of chemical stimulus GO:0007606 51 0.011
lateral inhibition GO:0046331 1 0.011
dna methylation involved in gamete generation GO:0043046 15 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
response to radiation GO:0009314 165 0.011
Mouse
regulation of response to biotic stimulus GO:0002831 38 0.011
muscle fiber development GO:0048747 76 0.011
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.011
regulation of anatomical structure size GO:0090066 178 0.011
regulation of metal ion transport GO:0010959 106 0.011
asymmetric stem cell division GO:0098722 3 0.011
regulation of peptidase activity GO:0052547 96 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
sperm motility GO:0030317 47 0.011
positive regulation of interleukin 18 production GO:0032741 2 0.011
muscle cell development GO:0055001 133 0.011
negative regulation of cytokine production GO:0001818 84 0.011
carbohydrate metabolic process GO:0005975 230 0.011
leukocyte migration GO:0050900 124 0.011
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
regulation of muscle tissue development GO:1901861 97 0.011
regulation of circadian sleep wake cycle GO:0042749 3 0.011
regulation of secretion by cell GO:1903530 249 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
regionalization GO:0003002 337 0.011
positive regulation of growth GO:0045927 104 0.011
negative regulation of interleukin 13 production GO:0032696 2 0.011
respiratory gaseous exchange GO:0007585 43 0.010
dephosphorylation GO:0016311 129 0.010
positive regulation of cell migration GO:0030335 109 0.010
Mouse
gtp metabolic process GO:0046039 144 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
myeloid leukocyte migration GO:0097529 57 0.010
Mouse
anion transmembrane transport GO:0098656 71 0.010
cytokine production involved in immune response GO:0002367 34 0.010
ribonucleoside monophosphate metabolic process GO:0009161 80 0.010
regulation of neuron apoptotic process GO:0043523 122 0.010
Mouse
activation of immune response GO:0002253 138 0.010
Mouse
multicellular organism growth GO:0035264 161 0.010
rna processing GO:0006396 105 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.010
negative regulation of t cell activation GO:0050868 65 0.010
sensory perception of light stimulus GO:0050953 54 0.010
defense response to bacterium GO:0042742 119 0.010
multi multicellular organism process GO:0044706 109 0.010
sperm individualization GO:0007291 1 0.010
renal system development GO:0072001 225 0.010
organelle localization GO:0051640 179 0.010
cellular lipid metabolic process GO:0044255 323 0.010
jnk cascade GO:0007254 72 0.010
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.010
pirna metabolic process GO:0034587 12 0.010
cellular response to molecule of bacterial origin GO:0071219 83 0.010
negative regulation of myoblast differentiation GO:0045662 18 0.010

Adam21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.027
cancer DOID:162 0 0.024
organ system cancer DOID:0050686 0 0.024
disease of metabolism DOID:0014667 0 0.012
immune system disease DOID:2914 0 0.010
disease of anatomical entity DOID:7 0 0.010