Mus musculus

54 known processes

Pola2

polymerase (DNA directed), alpha 2

(Aliases: AI573378)

Pola2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.446
dna metabolic process GO:0006259 303 0.385
dna repair GO:0006281 107 0.366
double strand break repair via nonhomologous end joining GO:0006303 10 0.194
double strand break repair GO:0006302 48 0.178
meiotic cell cycle process GO:1903046 77 0.124
regulation of cell cycle GO:0051726 281 0.114
meiosis i GO:0007127 60 0.098
meiotic cell cycle GO:0051321 122 0.089
organic cyclic compound catabolic process GO:1901361 295 0.087
cellular nitrogen compound catabolic process GO:0044270 280 0.083
cellular amine metabolic process GO:0044106 44 0.081
single fertilization GO:0007338 82 0.078
rna dependent dna replication GO:0006278 3 0.072
purine nucleoside triphosphate metabolic process GO:0009144 226 0.071
apoptotic signaling pathway GO:0097190 306 0.071
dna dependent dna replication GO:0006261 24 0.071
Yeast
nucleus localization GO:0051647 20 0.068
dna biosynthetic process GO:0071897 22 0.059
Yeast Rat
purine nucleoside metabolic process GO:0042278 241 0.058
negative regulation of protein metabolic process GO:0051248 282 0.055
cellular amino acid metabolic process GO:0006520 103 0.054
ribonucleoside triphosphate metabolic process GO:0009199 220 0.052
regulation of cellular amino acid metabolic process GO:0006521 5 0.051
regulation of mitotic cell cycle phase transition GO:1901990 73 0.050
fertilization GO:0009566 127 0.050
nucleobase containing small molecule metabolic process GO:0055086 352 0.049
organonitrogen compound catabolic process GO:1901565 264 0.049
glycosyl compound metabolic process GO:1901657 246 0.047
nucleoside phosphate catabolic process GO:1901292 222 0.046
nucleoside phosphate metabolic process GO:0006753 338 0.045
regulation of cellular amine metabolic process GO:0033238 20 0.045
meiotic nuclear division GO:0007126 115 0.045
male gamete generation GO:0048232 285 0.043
cellular ketone metabolic process GO:0042180 84 0.043
organelle localization GO:0051640 179 0.042
glycosyl compound catabolic process GO:1901658 206 0.042
negative regulation of cell cycle GO:0045786 123 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.041
regulation of cellular ketone metabolic process GO:0010565 66 0.040
nucleoside metabolic process GO:0009116 246 0.039
recombinational repair GO:0000725 21 0.039
immune effector process GO:0002252 321 0.038
engulfment of apoptotic cell GO:0043652 3 0.038
peptidyl amino acid modification GO:0018193 336 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.037
ribonucleotide metabolic process GO:0009259 291 0.036
purine containing compound metabolic process GO:0072521 311 0.036
cytokine production GO:0001816 319 0.036
double strand break repair via homologous recombination GO:0000724 21 0.035
membrane organization GO:0061024 245 0.035
ribonucleoside metabolic process GO:0009119 245 0.034
purine ribonucleoside metabolic process GO:0046128 241 0.033
positive regulation of cellular amine metabolic process GO:0033240 5 0.033
ribonucleotide catabolic process GO:0009261 208 0.032
amine metabolic process GO:0009308 45 0.032
establishment of organelle localization GO:0051656 122 0.032
regulation of cytokine production GO:0001817 266 0.032
nucleotide metabolic process GO:0009117 332 0.032
spermatogenesis GO:0007283 284 0.032
heterocycle catabolic process GO:0046700 280 0.031
multicellular organism growth GO:0035264 161 0.031
negative regulation of cellular component organization GO:0051129 194 0.031
chromatin organization GO:0006325 206 0.031
macromolecule catabolic process GO:0009057 281 0.031
gonad development GO:0008406 141 0.031
development of primary sexual characteristics GO:0045137 143 0.029
chromatin modification GO:0016568 187 0.029
intracellular protein transport GO:0006886 204 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
nucleoside triphosphate metabolic process GO:0009141 230 0.028
nucleotide catabolic process GO:0009166 217 0.028
regulation of defense response GO:0031347 233 0.027
positive regulation of hydrolase activity GO:0051345 148 0.027
purine nucleotide catabolic process GO:0006195 211 0.027
small gtpase mediated signal transduction GO:0007264 97 0.027
dna replication GO:0006260 52 0.026
regulation of multi organism process GO:0043900 111 0.026
regulation of kinase activity GO:0043549 249 0.026
regulation of anatomical structure size GO:0090066 178 0.025
nucleoside triphosphate catabolic process GO:0009143 205 0.025
aromatic compound catabolic process GO:0019439 286 0.025
dna conformation change GO:0071103 37 0.025
ribonucleoside triphosphate catabolic process GO:0009203 199 0.025
cell division GO:0051301 120 0.025
cation transport GO:0006812 399 0.025
regulation of transferase activity GO:0051338 263 0.025
regulation of organelle organization GO:0033043 289 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
protein polymerization GO:0051258 57 0.024
regulation of cellular catabolic process GO:0031329 242 0.024
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.024
purine containing compound catabolic process GO:0072523 213 0.023
nuclear transport GO:0051169 139 0.023
microtubule cytoskeleton organization GO:0000226 157 0.023
regulation of proteolysis GO:0030162 164 0.023
purine nucleoside triphosphate catabolic process GO:0009146 203 0.023
purine nucleoside catabolic process GO:0006152 205 0.023
purine ribonucleoside catabolic process GO:0046130 205 0.023
positive regulation of protein modification process GO:0031401 299 0.022
regulation of cell cycle process GO:0010564 160 0.022
intrinsic apoptotic signaling pathway GO:0097193 132 0.022
purine nucleotide metabolic process GO:0006163 302 0.022
protein maturation GO:0051604 176 0.022
non recombinational repair GO:0000726 10 0.022
ras protein signal transduction GO:0007265 77 0.022
negative regulation of organelle organization GO:0010639 90 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.021
signal transduction by p53 class mediator GO:0072331 51 0.021
regulation of chromosome organization GO:0033044 83 0.021
lymphocyte proliferation GO:0046651 164 0.021
dna endoreduplication GO:0042023 4 0.020
cell adhesion GO:0007155 329 0.020
regulation of membrane potential GO:0042391 192 0.020
regulation of cellular component biogenesis GO:0044087 181 0.020
histone modification GO:0016570 159 0.020
negative regulation of cell proliferation GO:0008285 296 0.020
purine ribonucleotide catabolic process GO:0009154 208 0.020
microtubule based process GO:0007017 236 0.019
regulation of mitotic cell cycle GO:0007346 126 0.019
divalent inorganic cation transport GO:0072511 178 0.019
protein catabolic process GO:0030163 221 0.019
regulation of cell motility GO:2000145 236 0.019
muscle tissue development GO:0060537 308 0.019
blood vessel morphogenesis GO:0048514 285 0.019
cell cycle g1 s phase transition GO:0044843 57 0.019
rho protein signal transduction GO:0007266 32 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
cellular response to cytokine stimulus GO:0071345 189 0.019
leukocyte differentiation GO:0002521 342 0.019
receptor mediated endocytosis GO:0006898 51 0.019
single organism nuclear import GO:1902593 95 0.019
ion transmembrane transport GO:0034220 361 0.019
nuclear dna replication GO:0033260 3 0.019
regulation of apoptotic signaling pathway GO:2001233 197 0.018
cellular component assembly involved in morphogenesis GO:0010927 139 0.018
transmembrane transport GO:0055085 412 0.018
negative regulation of molecular function GO:0044092 258 0.018
negative regulation of immune system process GO:0002683 209 0.018
germ cell development GO:0007281 185 0.018
mitotic cell cycle process GO:1903047 159 0.018
positive regulation of cell death GO:0010942 224 0.018
regulation of ras gtpase activity GO:0032318 88 0.018
regulation of cellular component size GO:0032535 121 0.018
regulation of cell cycle phase transition GO:1901987 77 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
regulation of cell migration GO:0030334 219 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
cellular ion homeostasis GO:0006873 165 0.018
organelle fission GO:0048285 170 0.018
maintenance of location GO:0051235 89 0.018
regulation of protein kinase activity GO:0045859 232 0.018
regulation of cell activation GO:0050865 289 0.018
protein processing GO:0016485 163 0.018
regulation of reactive oxygen species metabolic process GO:2000377 40 0.018
leukocyte proliferation GO:0070661 172 0.017
mapk cascade GO:0000165 281 0.017
inorganic ion transmembrane transport GO:0098660 234 0.017
atp catabolic process GO:0006200 55 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.017
cellular protein catabolic process GO:0044257 155 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
negative regulation of cellular protein metabolic process GO:0032269 247 0.017
regulation of protein localization GO:0032880 231 0.017
ribonucleoside monophosphate metabolic process GO:0009161 80 0.017
regulation of secretion by cell GO:1903530 249 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
endomembrane system organization GO:0010256 147 0.017
response to organonitrogen compound GO:0010243 246 0.017
chromosome organization involved in meiosis GO:0070192 39 0.017
regulation of homeostatic process GO:0032844 182 0.016
carbohydrate derivative catabolic process GO:1901136 231 0.016
negative regulation of intracellular signal transduction GO:1902532 167 0.016
dna recombination GO:0006310 92 0.016
gland development GO:0048732 330 0.016
cell type specific apoptotic process GO:0097285 268 0.016
regulation of cellular response to stress GO:0080135 159 0.016
nucleoside catabolic process GO:0009164 206 0.016
translation GO:0006412 93 0.016
protein import into nucleus GO:0006606 95 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
male meiosis GO:0007140 37 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
organophosphate catabolic process GO:0046434 232 0.016
protein targeting GO:0006605 143 0.016
cellular protein complex assembly GO:0043623 116 0.016
nucleoside monophosphate metabolic process GO:0009123 85 0.016
endocytosis GO:0006897 168 0.016
lymphocyte mediated immunity GO:0002449 139 0.016
regulation of chromatin silencing GO:0031935 2 0.016
negative regulation of phosphorylation GO:0042326 166 0.015
lymphocyte differentiation GO:0030098 242 0.015
cellular homeostasis GO:0019725 240 0.015
phagocytosis GO:0006909 66 0.015
striated muscle tissue development GO:0014706 293 0.015
interspecies interaction between organisms GO:0044419 83 0.015
t cell activation GO:0042110 289 0.015
reciprocal dna recombination GO:0035825 16 0.015
atp metabolic process GO:0046034 75 0.015
divalent metal ion transport GO:0070838 172 0.015
spermatid development GO:0007286 108 0.015
innate immune response GO:0045087 157 0.015
regulation of translation GO:0006417 71 0.015
negative regulation of dna replication GO:0008156 4 0.015
leukocyte mediated immunity GO:0002443 174 0.015
response to oxidative stress GO:0006979 123 0.015
somatic diversification of immune receptors GO:0002200 53 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
striated muscle myosin thick filament assembly GO:0071688 1 0.015
regulation of ras protein signal transduction GO:0046578 114 0.015
regulation of cell cycle g1 s phase transition GO:1902806 35 0.015
mitotic cell cycle GO:0000278 195 0.015
cation homeostasis GO:0055080 212 0.014
regulation of leukocyte proliferation GO:0070663 121 0.014
actin cytoskeleton organization GO:0030036 220 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.014
modification dependent protein catabolic process GO:0019941 133 0.014
positive regulation of apoptotic signaling pathway GO:2001235 95 0.014
digestive system development GO:0055123 200 0.014
activation of immune response GO:0002253 138 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
cell growth GO:0016049 130 0.014
negative regulation of protein modification process GO:0031400 163 0.014
synapsis GO:0007129 34 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
action potential GO:0001508 78 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
negative regulation of cell cycle phase transition GO:1901988 48 0.014
regulation of purine nucleotide metabolic process GO:1900542 169 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.014
ubiquitin dependent protein catabolic process GO:0006511 129 0.014
regulation of t cell proliferation GO:0042129 92 0.014
regulation of binding GO:0051098 111 0.014
regulation of lymphocyte proliferation GO:0050670 117 0.014
stem cell differentiation GO:0048863 268 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
regulation of secretion GO:0051046 274 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
regulation of mapk cascade GO:0043408 248 0.013
female meiosis chromosome segregation GO:0016321 1 0.013
sequestering of metal ion GO:0051238 19 0.013
t cell proliferation GO:0042098 120 0.013
oxidation reduction process GO:0055114 342 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
negative regulation of protein processing GO:0010955 79 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
ribonucleoside monophosphate catabolic process GO:0009158 57 0.013
myosin filament assembly GO:0031034 2 0.013
cellular chemical homeostasis GO:0055082 215 0.013
cell activation involved in immune response GO:0002263 126 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
cell fate commitment GO:0045165 210 0.013
wnt signaling pathway GO:0016055 188 0.013
intra s dna damage checkpoint GO:0031573 4 0.013
positive regulation of cell cycle GO:0045787 92 0.013
response to acid chemical GO:0001101 111 0.013
skeletal system development GO:0001501 356 0.013
carbohydrate metabolic process GO:0005975 230 0.013
metal ion homeostasis GO:0055065 189 0.013
sister chromatid segregation GO:0000819 20 0.012
extracellular structure organization GO:0043062 148 0.012
response to inorganic substance GO:0010035 96 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
regulation of neuron differentiation GO:0045664 281 0.012
blastocyst development GO:0001824 80 0.012
regulation of nucleoside metabolic process GO:0009118 130 0.012
genitalia development GO:0048806 37 0.012
sequestering of calcium ion GO:0051208 18 0.012
negative regulation of cell development GO:0010721 169 0.012
transmission of nerve impulse GO:0019226 76 0.012
negative regulation of nervous system development GO:0051961 156 0.012
negative regulation of chromatin silencing GO:0031936 1 0.012
regulation of protein maturation GO:1903317 96 0.012
camera type eye development GO:0043010 266 0.012
angiogenesis GO:0001525 201 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
actin filament polymerization GO:0030041 44 0.012
regulation of hydrolase activity GO:0051336 246 0.012
locomotory behavior GO:0007626 195 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
lateral inhibition GO:0046331 1 0.012
localization within membrane GO:0051668 4 0.012
regulation of protein complex assembly GO:0043254 83 0.012
calcium ion transport GO:0006816 159 0.012
sensory perception GO:0007600 245 0.012
regionalization GO:0003002 337 0.012
negative regulation of proteolysis GO:0045861 74 0.012
anion transport GO:0006820 177 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
telencephalon development GO:0021537 186 0.012
nucleus organization GO:0006997 45 0.012
regulation of protein catabolic process GO:0042176 108 0.012
regulation of actin filament based process GO:0032970 99 0.012
signal transduction involved in dna damage checkpoint GO:0072422 3 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.012
nitrogen compound transport GO:0071705 271 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
negative regulation of mitotic cell cycle GO:0045930 58 0.011
dna damage response signal transduction resulting in transcription GO:0042772 2 0.011
bone development GO:0060348 120 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.011
methylation GO:0032259 134 0.011
negative regulation of protein maturation GO:1903318 79 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
b cell activation GO:0042113 161 0.011
forebrain development GO:0030900 302 0.011
signal transduction in absence of ligand GO:0038034 55 0.011
cellular lipid metabolic process GO:0044255 323 0.011
multicellular organismal signaling GO:0035637 91 0.011
circulatory system process GO:0003013 197 0.011
regulation of ion transport GO:0043269 215 0.011
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.011
actin polymerization or depolymerization GO:0008154 54 0.011
regulation of actin filament length GO:0030832 45 0.011
modification dependent macromolecule catabolic process GO:0043632 133 0.011
morphogenesis of a branching epithelium GO:0061138 193 0.011
actin filament organization GO:0007015 113 0.011
intestinal epithelial structure maintenance GO:0060729 4 0.011
regulation of lymphocyte mediated immunity GO:0002706 84 0.011
myosin filament organization GO:0031033 3 0.011
mitotic cytokinesis GO:0000281 4 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
stem cell maintenance GO:0019827 130 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
immunoglobulin production GO:0002377 73 0.011
compound eye development GO:0048749 1 0.011
regulation of innate immune response GO:0045088 91 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
gene silencing GO:0016458 38 0.011
glycoprotein metabolic process GO:0009100 116 0.011
inflammatory response GO:0006954 244 0.011
regulation of protein transport GO:0051223 163 0.011
divalent inorganic cation homeostasis GO:0072507 138 0.011
protein methylation GO:0006479 81 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
cell aging GO:0007569 35 0.011
positive regulation of secretion GO:0051047 130 0.011
histone methylation GO:0016571 71 0.011
negative regulation of cytokine production GO:0001818 84 0.011
synaptic transmission GO:0007268 329 0.011
covalent chromatin modification GO:0016569 163 0.011
regulation of dna replication GO:0006275 17 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
negative regulation of growth GO:0045926 99 0.011
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.011
gtp catabolic process GO:0006184 143 0.011
regulation of cysteine type endopeptidase activity GO:2000116 65 0.011
leukocyte migration GO:0050900 124 0.010
regulation of cytoskeleton organization GO:0051493 122 0.010
regulation of actin polymerization or depolymerization GO:0008064 45 0.010
axonogenesis GO:0007409 274 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
protein alkylation GO:0008213 81 0.010
digestive tract development GO:0048565 190 0.010
regulation of cell projection organization GO:0031344 206 0.010
regulation of rho protein signal transduction GO:0035023 71 0.010
regulation of transcription by chromatin organization GO:0034401 0 0.010
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.010
stem cell development GO:0048864 219 0.010
response to lipopolysaccharide GO:0032496 128 0.010
cilium morphogenesis GO:0060271 102 0.010
adaptive immune response GO:0002250 155 0.010
neuron migration GO:0001764 122 0.010
wound healing GO:0042060 157 0.010
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.010
blood circulation GO:0008015 195 0.010
membrane invagination GO:0010324 17 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
negative regulation of protein phosphorylation GO:0001933 126 0.010
regulation of inflammatory response GO:0050727 147 0.010
cellular response to abiotic stimulus GO:0071214 56 0.010

Pola2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.043
disease of cellular proliferation DOID:14566 0 0.043
immune system disease DOID:2914 0 0.042
disease of anatomical entity DOID:7 0 0.042
congenital hypoplastic anemia DOID:1342 0 0.041
aplastic anemia DOID:12449 0 0.041
bone marrow disease DOID:4961 0 0.041
anemia DOID:2355 0 0.041
hematopoietic system disease DOID:74 0 0.041
organ system cancer DOID:0050686 0 0.021
nervous system disease DOID:863 0 0.015
central nervous system disease DOID:331 0 0.011
disease of metabolism DOID:0014667 0 0.011