Mus musculus

266 known processes

Nrxn1

neurexin I

(Aliases: A230068P09Rik,1700062G21Rik,mKIAA0578,9330127H16Rik)

Nrxn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cerebellar granular layer development GO:0021681 13 1.000
negative regulation of filopodium assembly GO:0051490 2 1.000
regulation of synaptic vesicle recycling GO:1903421 2 1.000
Fly
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 1.000
cerebellar granular layer formation GO:0021684 9 0.998
regulation of glutamate receptor signaling pathway GO:1900449 16 0.998
cerebellar granule cell differentiation GO:0021707 9 0.998
cell cell adhesion GO:0098609 41 0.995
regulation of grooming behavior GO:2000821 4 0.995
regulation of synaptic vesicle endocytosis GO:1900242 2 0.995
Fly
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.993
postsynaptic membrane assembly GO:0097104 6 0.990
receptor localization to synapse GO:0097120 4 0.990
positive regulation of membrane potential GO:0045838 15 0.990
protein localization to synapse GO:0035418 11 0.989
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 20 0.988
positive regulation of synaptic vesicle endocytosis GO:1900244 1 0.983
Fly
cell differentiation in hindbrain GO:0021533 24 0.980
isoprenoid transport GO:0046864 3 0.980
Fly
cerebellum morphogenesis GO:0021587 42 0.975
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.970
postsynaptic density protein 95 clustering GO:0097119 6 0.968
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 10 0.961
cerebellar cortex formation GO:0021697 22 0.960
n methyl d aspartate receptor clustering GO:0097114 3 0.957
positive regulation of synaptic vesicle transport GO:1902805 1 0.955
Fly
hindbrain morphogenesis GO:0021575 46 0.946
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9 0.946
regulation of terminal button organization GO:2000331 1 0.934
Fly
neurotransmitter gated ion channel clustering GO:0072578 6 0.929
regulation of postsynaptic membrane potential GO:0060078 48 0.929
ion transmembrane transport GO:0034220 361 0.925
presynaptic membrane organization GO:0097090 8 0.924
positive regulation of synapse assembly GO:0051965 18 0.922
auditory behavior GO:0031223 3 0.918
Human
gephyrin clustering GO:0097116 3 0.918
social behavior GO:0035176 21 0.917
Human
membrane depolarization GO:0051899 64 0.912
vitamin transport GO:0051180 10 0.893
Fly
central nervous system neuron differentiation GO:0021953 162 0.893
positive regulation of excitatory postsynaptic membrane potential GO:2000463 14 0.881
neuromuscular process controlling balance GO:0050885 59 0.873
regulation of synaptic vesicle transport GO:1902803 13 0.869
Fly
terminal button organization GO:0072553 3 0.868
Fly
positive regulation of synaptic vesicle recycling GO:1903423 1 0.864
Fly
synaptic growth at neuromuscular junction GO:0051124 6 0.860
Fly
cerebellar cortex development GO:0021695 48 0.853
intraspecies interaction between organisms GO:0051703 21 0.835
Human
glutamate receptor signaling pathway GO:0007215 35 0.811
regulation of transmembrane transport GO:0034762 128 0.810
establishment of vesicle localization GO:0051650 81 0.807
Fly
synaptic vesicle transport GO:0048489 57 0.800
Fly
regulation of ion transmembrane transport GO:0034765 119 0.778
positive regulation of establishment of protein localization to plasma membrane GO:0090004 7 0.773
regulation of receptor activity GO:0010469 41 0.768
cellular response to carbohydrate stimulus GO:0071322 50 0.757
neuron cell cell adhesion GO:0007158 6 0.755
cerebellum development GO:0021549 77 0.750
membrane biogenesis GO:0044091 12 0.730
neuromuscular synaptic transmission GO:0007274 16 0.728
Fly
synapse maturation GO:0060074 14 0.727
cerebellar cortex morphogenesis GO:0021696 32 0.726
presynaptic membrane assembly GO:0097105 7 0.717
neuromuscular process GO:0050905 99 0.709
prepulse inhibition GO:0060134 10 0.688
glucose homeostasis GO:0042593 128 0.668
establishment of synaptic vesicle localization GO:0097480 57 0.668
Fly
regulation of ion transmembrane transporter activity GO:0032412 54 0.664
synaptic vesicle clustering GO:0097091 3 0.636
regulation of cell projection organization GO:0031344 206 0.636
cerebellar granular layer morphogenesis GO:0021683 10 0.634
associative learning GO:0008306 61 0.633
Fly
establishment of protein localization to membrane GO:0090150 54 0.627
lipid transport GO:0006869 98 0.622
Fly
synaptic transmission GO:0007268 329 0.616
regulation of secretion by cell GO:1903530 249 0.615
hindbrain development GO:0030902 128 0.613
regulation of synapse maturation GO:0090128 9 0.595
postsynaptic membrane organization GO:0001941 18 0.577
synaptic vesicle localization GO:0097479 59 0.570
peptide transport GO:0015833 133 0.566
regulation of neurotransmitter levels GO:0001505 87 0.560
grooming behavior GO:0007625 16 0.555
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.555
transmembrane transport GO:0055085 412 0.551
regulation of synapse assembly GO:0051963 29 0.550
positive regulation of synaptic transmission glutamatergic GO:0051968 8 0.546
regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178 31 0.542
organelle localization GO:0051640 179 0.537
membrane organization GO:0061024 245 0.529
synaptic vesicle recycling GO:0036465 19 0.524
Fly
membrane assembly GO:0071709 12 0.515
regulation of peptide transport GO:0090087 91 0.511
vesicle localization GO:0051648 86 0.508
cell adhesion GO:0007155 329 0.508
amide transport GO:0042886 138 0.501
cellular response to monosaccharide stimulus GO:0071326 47 0.497
synaptic transmission glutamatergic GO:0035249 36 0.497
regulation of cell projection assembly GO:0060491 38 0.487
insulin secretion GO:0030073 89 0.484
regulation of peptide secretion GO:0002791 77 0.482
metencephalon development GO:0022037 89 0.478
lipid localization GO:0010876 126 0.478
Fly
regulation of homeostatic process GO:0032844 182 0.460
positive regulation of protein localization to plasma membrane GO:1903078 7 0.459
carbohydrate homeostasis GO:0033500 128 0.459
neuron maturation GO:0042551 29 0.458
regulation of establishment of protein localization to plasma membrane GO:0090003 12 0.456
cellular response to glucose stimulus GO:0071333 45 0.451
negative regulation of cellular component organization GO:0051129 194 0.450
regulation of endocytosis GO:0030100 69 0.436
Fly
response to monosaccharide GO:0034284 67 0.425
protein localization to membrane GO:0072657 108 0.425
regulation of cellular component biogenesis GO:0044087 181 0.418
regulation of hormone secretion GO:0046883 88 0.416
establishment of organelle localization GO:0051656 122 0.412
Fly
positive regulation of nervous system development GO:0051962 221 0.408
regulation of protein localization to plasma membrane GO:1903076 13 0.392
neurotransmitter transport GO:0006836 76 0.392
plasma membrane organization GO:0007009 90 0.392
positive regulation of cellular component biogenesis GO:0044089 94 0.385
learning GO:0007612 98 0.371
regulation of membrane potential GO:0042391 192 0.368
synapse organization GO:0050808 125 0.360
regulation of ion transport GO:0043269 215 0.359
endomembrane system organization GO:0010256 147 0.358
regulation of peptide hormone secretion GO:0090276 75 0.340
neuron neuron synaptic transmission GO:0007270 69 0.338
single organism cell adhesion GO:0098602 156 0.330
positive regulation of synapse maturation GO:0090129 7 0.300
peptide hormone secretion GO:0030072 109 0.298
synaptic vesicle endocytosis GO:0048488 19 0.295
Fly
cellular glucose homeostasis GO:0001678 52 0.284
positive regulation of endocytosis GO:0045807 42 0.283
Fly
single organismal cell cell adhesion GO:0016337 131 0.263
cellular response to hexose stimulus GO:0071331 47 0.262
negative regulation of cell projection organization GO:0031345 56 0.260
neurotransmitter secretion GO:0007269 62 0.257
synapse assembly GO:0007416 56 0.257
establishment of protein localization to plasma membrane GO:0090002 34 0.248
adult behavior GO:0030534 135 0.217
guanylate kinase associated protein clustering GO:0097117 2 0.209
regulation of hormone levels GO:0010817 211 0.187
axonogenesis GO:0007409 274 0.186
regulation of synaptic transmission glutamatergic GO:0051966 19 0.183
regulation of filopodium assembly GO:0051489 13 0.181
regulation of cellular ketone metabolic process GO:0010565 66 0.175
regulation of secretion GO:0051046 274 0.174
cellular homeostasis GO:0019725 240 0.168
cognition GO:0050890 149 0.167
regulation of protein localization GO:0032880 231 0.163
neuron projection guidance GO:0097485 141 0.162
learned vocalization behavior or vocal learning GO:0098598 1 0.162
Human
regulation of platelet derived growth factor receptor signaling pathway GO:0010640 9 0.159
protein localization to plasma membrane GO:0072659 57 0.151
regulation of transporter activity GO:0032409 57 0.143
regulation of establishment of protein localization GO:0070201 181 0.143
regulation of platelet derived growth factor receptor alpha signaling pathway GO:2000583 2 0.138
chemotaxis GO:0006935 247 0.123
endocytosis GO:0006897 168 0.109
Fly
filopodium assembly GO:0046847 19 0.105
vocalization behavior GO:0071625 7 0.103
Human
peptide secretion GO:0002790 114 0.098
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.092
lymphocyte mediated immunity GO:0002449 139 0.090
immune effector process GO:0002252 321 0.081
ear development GO:0043583 200 0.076
negative regulation of cellular protein metabolic process GO:0032269 247 0.074
inorganic cation transmembrane transport GO:0098662 207 0.071
cell maturation GO:0048469 127 0.071
axon guidance GO:0007411 141 0.070
regulation of protein serine threonine kinase activity GO:0071900 157 0.070
regulation of neuron projection development GO:0010975 169 0.068
fatty acid metabolic process GO:0006631 121 0.068
negative regulation of intracellular signal transduction GO:1902532 167 0.065
negative regulation of protein metabolic process GO:0051248 282 0.064
leukocyte mediated immunity GO:0002443 174 0.063
cation transport GO:0006812 399 0.063
positive regulation of kinase activity GO:0033674 155 0.061
dendrite development GO:0016358 115 0.058
regulation of glucose metabolic process GO:0010906 60 0.057
cellular lipid metabolic process GO:0044255 323 0.056
negative regulation of platelet derived growth factor receptor alpha signaling pathway GO:2000584 2 0.056
positive regulation of protein modification process GO:0031401 299 0.055
regulation of transferase activity GO:0051338 263 0.054
gluconeogenesis GO:0006094 39 0.054
carbohydrate metabolic process GO:0005975 230 0.053
metanephric glomerular visceral epithelial cell development GO:0072249 2 0.051
adaptive immune response GO:0002250 155 0.051
multi organism behavior GO:0051705 62 0.051
Human
negative regulation of protein phosphorylation GO:0001933 126 0.050
lipid oxidation GO:0034440 29 0.050
motor neuron axon guidance GO:0008045 26 0.050
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.050
negative regulation of platelet derived growth factor receptor signaling pathway GO:0010642 7 0.048
negative regulation of carbohydrate metabolic process GO:0045912 19 0.047
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.046
regulation of cellular amino acid metabolic process GO:0006521 5 0.046
positive regulation of protein phosphorylation GO:0001934 242 0.045
protein heterooligomerization GO:0051291 14 0.045
positive regulation of glucose transport GO:0010828 16 0.045
cellular chemical homeostasis GO:0055082 215 0.043
hexose biosynthetic process GO:0019319 39 0.043
regulation of mapk cascade GO:0043408 248 0.042
negative regulation of phosphorylation GO:0042326 166 0.041
negative regulation of gluconeogenesis GO:0045721 9 0.041
regulation of gluconeogenesis GO:0006111 30 0.041
hexose metabolic process GO:0019318 98 0.041
regulation of lipid metabolic process GO:0019216 118 0.040
monosaccharide biosynthetic process GO:0046364 44 0.040
activation of immune response GO:0002253 138 0.039
regulation of feeding behavior GO:0060259 3 0.039
regulation of fatty acid metabolic process GO:0019217 28 0.039
regulation of cell migration GO:0030334 219 0.038
regulation of neuron differentiation GO:0045664 281 0.038
hormone secretion GO:0046879 128 0.035
carbohydrate biosynthetic process GO:0016051 74 0.035
neuroblast division in subventricular zone GO:0021849 2 0.034
regulation of protein kinase activity GO:0045859 232 0.034
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 3 0.033
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.033
nitrogen compound transport GO:0071705 271 0.032
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.031
cellular ketone metabolic process GO:0042180 84 0.031
monocarboxylic acid catabolic process GO:0072329 27 0.031
sensory perception GO:0007600 245 0.030
epithelial cell differentiation involved in kidney development GO:0035850 23 0.029
regulation of response to wounding GO:1903034 189 0.029
cation transmembrane transport GO:0098655 266 0.029
cellular carbohydrate metabolic process GO:0044262 119 0.029
regulation of neuron death GO:1901214 134 0.028
negative regulation of phosphorus metabolic process GO:0010563 184 0.028
fatty acid catabolic process GO:0009062 25 0.027
regulation of cell activation GO:0050865 289 0.027
monocarboxylic acid metabolic process GO:0032787 191 0.026
regulation of synaptic plasticity GO:0048167 87 0.026
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.026
regulation of anatomical structure size GO:0090066 178 0.026
regulation of vesicle mediated transport GO:0060627 139 0.026
Fly
lipid modification GO:0030258 65 0.026
positive regulation of fatty acid metabolic process GO:0045923 8 0.025
sensory organ morphogenesis GO:0090596 242 0.025
glucose metabolic process GO:0006006 92 0.025
organic anion transport GO:0015711 137 0.025
response to radiation GO:0009314 165 0.025
b cell mediated immunity GO:0019724 71 0.024
negative regulation of protein modification process GO:0031400 163 0.024
calcium ion transport GO:0006816 159 0.024
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.023
exocytosis GO:0006887 121 0.023
regulation of neurotransmitter secretion GO:0046928 29 0.023
response to pain GO:0048265 26 0.023
regulation of cell motility GO:2000145 236 0.023
positive regulation of transferase activity GO:0051347 167 0.023
positive regulation of glucose import GO:0046326 14 0.023
regulation of carbohydrate metabolic process GO:0006109 75 0.023
regulation of glucose import GO:0046324 26 0.022
divalent inorganic cation transport GO:0072511 178 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
inflammatory response GO:0006954 244 0.022
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.022
protein catabolic process GO:0030163 221 0.022
amine metabolic process GO:0009308 45 0.021
inner ear morphogenesis GO:0042472 101 0.021
regulation of glucose transport GO:0010827 32 0.021
cellular response to peptide hormone stimulus GO:0071375 92 0.021
locomotory behavior GO:0007626 195 0.020
regulation of defense response GO:0031347 233 0.020
fatty acid beta oxidation GO:0006635 16 0.020
cellular potassium ion transport GO:0071804 43 0.020
protein oligomerization GO:0051259 67 0.020
cell differentiation involved in metanephros development GO:0072202 12 0.020
regulation of kinase activity GO:0043549 249 0.019
camera type eye development GO:0043010 266 0.019
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.019
cell activation involved in immune response GO:0002263 126 0.019
ribonucleotide metabolic process GO:0009259 291 0.018
positive regulation of cell development GO:0010720 237 0.018
multicellular organismal signaling GO:0035637 91 0.018
response to endoplasmic reticulum stress GO:0034976 53 0.018
cellular response to insulin stimulus GO:0032869 78 0.018
small molecule catabolic process GO:0044282 71 0.018
nucleobase containing small molecule metabolic process GO:0055086 352 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
cellular lipid catabolic process GO:0044242 52 0.017
response to peptide GO:1901652 136 0.017
organic acid catabolic process GO:0016054 51 0.017
negative regulation of fat cell differentiation GO:0045599 36 0.017
cellular response to peptide GO:1901653 92 0.017
rhythmic process GO:0048511 174 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
inter male aggressive behavior GO:0002121 3 0.017
positive regulation of rac gtpase activity GO:0032855 14 0.017
response to organonitrogen compound GO:0010243 246 0.017
positive regulation of jnk cascade GO:0046330 46 0.017
cation homeostasis GO:0055080 212 0.017
activation of meiosis involved in egg activation GO:0060466 2 0.017
glucose transport GO:0015758 56 0.016
male courtship behavior GO:0008049 2 0.016
renal system development GO:0072001 225 0.016
lipid catabolic process GO:0016042 69 0.016
cellular amine metabolic process GO:0044106 44 0.016
regulation of neuron apoptotic process GO:0043523 122 0.015
regulation of organelle organization GO:0033043 289 0.015
peptidyl amino acid modification GO:0018193 336 0.015
negative regulation of cell motility GO:2000146 61 0.015
spinal cord development GO:0021510 81 0.015
oocyte anterior posterior axis specification GO:0007314 2 0.015
respiratory system development GO:0060541 190 0.015
response to auditory stimulus GO:0010996 5 0.015
Human
maternal determination of anterior posterior axis embryo GO:0008358 2 0.015
response to peptide hormone GO:0043434 127 0.015
ribonucleoside catabolic process GO:0042454 206 0.015
negative regulation of growth GO:0045926 99 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.014
protein modification by small protein conjugation or removal GO:0070647 207 0.014
carboxylic acid catabolic process GO:0046395 51 0.014
retina development in camera type eye GO:0060041 119 0.014
regulation of cellular catabolic process GO:0031329 242 0.014
negative regulation of response to wounding GO:1903035 77 0.014
regulation of system process GO:0044057 200 0.014
negative regulation of kinase activity GO:0033673 81 0.013
sensory system development GO:0048880 3 0.013
negative regulation of cell development GO:0010721 169 0.013
inner ear receptor cell development GO:0060119 39 0.013
metanephric mesenchymal cell migration GO:0035789 2 0.013
detection of stimulus involved in sensory perception GO:0050906 44 0.013
lymphocyte activation involved in immune response GO:0002285 93 0.013
cellular amino acid metabolic process GO:0006520 103 0.013
renal filtration cell differentiation GO:0061318 10 0.013
glycosyl compound catabolic process GO:1901658 206 0.013
potassium ion transmembrane transport GO:0071805 43 0.013
sodium ion transmembrane transport GO:0035725 49 0.013
glycosyl compound metabolic process GO:1901657 246 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.012
complement activation GO:0006956 16 0.012
sensory perception of pain GO:0019233 47 0.012
immunoglobulin mediated immune response GO:0016064 69 0.012
protein polymerization GO:0051258 57 0.012
epithelial cell development GO:0002064 159 0.012
calcium ion transmembrane transport GO:0070588 85 0.012
cell migration involved in metanephros development GO:0035788 2 0.012
regulation of cellular component size GO:0032535 121 0.012
regulation of voltage gated calcium channel activity GO:1901385 4 0.012
renal system process GO:0003014 48 0.012
directional locomotion GO:0033058 3 0.012
engulfment of apoptotic cell GO:0043652 3 0.012
methylation GO:0032259 134 0.012
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
detection of abiotic stimulus GO:0009582 60 0.012
cytokine production GO:0001816 319 0.012
response to insulin GO:0032868 100 0.012
glomerular visceral epithelial cell differentiation GO:0072112 10 0.012
glomerular epithelium development GO:0072010 11 0.012
monosaccharide transport GO:0015749 58 0.011
aromatic compound catabolic process GO:0019439 286 0.011
negative regulation of nervous system development GO:0051961 156 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
sensory perception of mechanical stimulus GO:0050954 107 0.011
purine ribonucleoside metabolic process GO:0046128 241 0.011
cellular response to lipid GO:0071396 145 0.011
macromolecule catabolic process GO:0009057 281 0.011
regulation of metal ion transport GO:0010959 106 0.011
response to oxidative stress GO:0006979 123 0.011
divalent metal ion transport GO:0070838 172 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
t cell activation GO:0042110 289 0.011
cell migration involved in kidney development GO:0035787 3 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
facioacoustic ganglion development GO:1903375 3 0.011
glomerular epithelial cell development GO:0072310 6 0.011
regulation of body fluid levels GO:0050878 162 0.011
detection of external stimulus GO:0009581 61 0.011
response to acid chemical GO:0001101 111 0.011
purine containing compound metabolic process GO:0072521 311 0.011
covalent chromatin modification GO:0016569 163 0.011
neuron apoptotic process GO:0051402 142 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
nucleoside metabolic process GO:0009116 246 0.011
actin filament organization GO:0007015 113 0.011
negative regulation of defense response GO:0031348 77 0.010
lateral inhibition GO:0046331 1 0.010
negative regulation of mapk cascade GO:0043409 65 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
metanephric glomerular epithelium development GO:0072244 3 0.010
regulation of fat cell differentiation GO:0045598 81 0.010
cellular nitrogen compound catabolic process GO:0044270 280 0.010

Nrxn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.030
brain disease DOID:936 0 0.030
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.022
epilepsy syndrome DOID:1826 0 0.017
electroclinical syndrome DOID:0050701 0 0.017
neurodegenerative disease DOID:1289 0 0.012
gastrointestinal system cancer DOID:3119 0 0.011