Mus musculus

150 known processes

Twist2

twist homolog 2 (Drosophila)

(Aliases: Dermo1,bHLHa39)

Twist2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
skeletal system development GO:0001501 356 0.998
trachea cartilage morphogenesis GO:0060535 4 0.997
mesenchyme development GO:0060485 152 0.996
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.996
epidermis development GO:0008544 187 0.994
Mouse
bronchiole development GO:0060435 3 0.994
skeletal system morphogenesis GO:0048705 203 0.992
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.991
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.987
embryonic organ morphogenesis GO:0048562 276 0.986
cell proliferation in hindbrain GO:0021534 10 0.986
limb morphogenesis GO:0035108 149 0.985
Mouse
embryonic appendage morphogenesis GO:0035113 126 0.981
Mouse
bmp signaling pathway GO:0030509 93 0.981
Mouse
stem cell differentiation GO:0048863 268 0.976
Mouse
embryonic skeletal system development GO:0048706 120 0.975
mesonephric duct morphogenesis GO:0072180 4 0.975
epithelial tube morphogenesis GO:0060562 303 0.974
Mouse Fly
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.972
blood vessel morphogenesis GO:0048514 285 0.968
Mouse
bone development GO:0060348 120 0.966
Mouse
appendage morphogenesis GO:0035107 149 0.965
Mouse
appendage development GO:0048736 166 0.964
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.962
regionalization GO:0003002 337 0.955
Mouse
chondrocyte differentiation GO:0002062 72 0.955
Mouse
lung development GO:0030324 164 0.954
urogenital system development GO:0001655 261 0.953
Fly
axonogenesis GO:0007409 274 0.950
Mouse
hypophysis morphogenesis GO:0048850 3 0.950
cartilage development GO:0051216 140 0.948
Mouse
regulation of cartilage development GO:0061035 44 0.947
Mouse
embryonic limb morphogenesis GO:0030326 126 0.944
Mouse
midbrain hindbrain boundary maturation GO:0021732 1 0.943
bone morphogenesis GO:0060349 78 0.939
Mouse
ossification GO:0001503 216 0.938
embryonic digit morphogenesis GO:0042733 56 0.936
Mouse
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.931
mesenchymal cell differentiation GO:0048762 107 0.931
Mouse
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.931
regulation of fat cell differentiation GO:0045598 81 0.926
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.926
regulation of chondrocyte differentiation GO:0032330 33 0.926
axis elongation involved in somitogenesis GO:0090245 4 0.922
angiogenesis GO:0001525 201 0.918
Mouse
limb development GO:0060173 166 0.917
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.913
Mouse
diencephalon development GO:0021536 63 0.912
Mouse
ear morphogenesis GO:0042471 118 0.902
Mouse
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.901
connective tissue development GO:0061448 179 0.900
Mouse
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.899
positive regulation of stem cell proliferation GO:2000648 59 0.898
palate development GO:0060021 76 0.892
Mouse
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.891
positive regulation of cardiac muscle tissue development GO:0055025 19 0.890
regulation of cardiac muscle tissue development GO:0055024 31 0.888
digestive tract morphogenesis GO:0048546 147 0.887
Mouse Worm Fly
regulation of canonical wnt signaling pathway GO:0060828 82 0.886
asymmetric neuroblast division GO:0055059 1 0.881
lung epithelium development GO:0060428 37 0.881
smoothened signaling pathway GO:0007224 105 0.880
stem cell development GO:0048864 219 0.880
Mouse
respiratory system development GO:0060541 190 0.878
establishment of neuroblast polarity GO:0045200 1 0.878
nephric duct formation GO:0072179 4 0.877
positive regulation of nervous system development GO:0051962 221 0.875
Mouse
definitive hemopoiesis GO:0060216 20 0.871
Mouse
mesenchymal cell development GO:0014031 93 0.870
Mouse
paraxial mesodermal cell fate commitment GO:0048343 2 0.855
lymphocyte differentiation GO:0030098 242 0.855
Mouse
pyramidal neuron migration GO:0021852 1 0.854
skin development GO:0043588 220 0.853
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.852
Mouse
hindbrain development GO:0030902 128 0.850
Mouse
regulation of cardiac muscle tissue growth GO:0055021 26 0.850
morphogenesis of a branching epithelium GO:0061138 193 0.846
forebrain development GO:0030900 302 0.844
Mouse
epithelial cell development GO:0002064 159 0.843
Mouse
regulation of bmp signaling pathway GO:0030510 60 0.838
somitogenesis GO:0001756 69 0.834
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.827
forelimb morphogenesis GO:0035136 40 0.823
Mouse
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.820
Mouse
mesenchymal cell proliferation GO:0010463 44 0.813
Mouse
cell differentiation in spinal cord GO:0021515 53 0.811
Mouse
central nervous system morphogenesis GO:0021551 2 0.811
prostate gland morphogenesis GO:0060512 32 0.808
muscle cell fate specification GO:0042694 1 0.806
cardiac muscle tissue development GO:0048738 130 0.805
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.805
Mouse
cardiac epithelial to mesenchymal transition GO:0060317 18 0.801
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.796
Mouse
cartilage condensation GO:0001502 18 0.794
nephron epithelium morphogenesis GO:0072088 68 0.793
renal vesicle induction GO:0072034 3 0.792
paraxial mesodermal cell differentiation GO:0048342 2 0.788
cardiac chamber morphogenesis GO:0003206 93 0.779
Mouse
cartilage morphogenesis GO:0060536 11 0.778
Mouse
head morphogenesis GO:0060323 34 0.774
neuroblast proliferation GO:0007405 49 0.771
Mouse
negative regulation of cell proliferation GO:0008285 296 0.771
regulation of mesenchymal cell proliferation GO:0010464 37 0.771
nephron tubule morphogenesis GO:0072078 68 0.765
negative regulation of bmp signaling pathway GO:0030514 35 0.764
cardiac chamber development GO:0003205 108 0.758
Mouse
establishment of organ orientation GO:0048561 1 0.758
regulation of angiogenesis GO:0045765 81 0.754
fat cell differentiation GO:0045444 160 0.753
mesonephric tubule development GO:0072164 94 0.751
ear development GO:0043583 200 0.749
Mouse
kidney development GO:0001822 213 0.744
pituitary gland development GO:0021983 38 0.743
semicircular canal fusion GO:0060879 1 0.740
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.739
lung cell differentiation GO:0060479 30 0.735
embryonic genitalia morphogenesis GO:0030538 4 0.731
regulation of cell motility GO:2000145 236 0.723
Mouse
response to growth factor GO:0070848 198 0.722
Mouse
lung induction GO:0060492 3 0.717
endocrine system development GO:0035270 98 0.716
Mouse
skin morphogenesis GO:0043589 38 0.706
forebrain generation of neurons GO:0021872 63 0.705
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.703
Mouse
bronchus development GO:0060433 10 0.701
olfactory bulb development GO:0021772 30 0.701
regulation of smoothened signaling pathway GO:0008589 58 0.698
cellular carbohydrate metabolic process GO:0044262 119 0.698
regulation of cellular response to growth factor stimulus GO:0090287 82 0.696
cell cell signaling involved in mammary gland development GO:0060764 2 0.695
asymmetric stem cell division GO:0098722 3 0.692
organ induction GO:0001759 21 0.690
regulation of stem cell proliferation GO:0072091 78 0.689
chemotaxis GO:0006935 247 0.688
Mouse
embryonic heart tube morphogenesis GO:0003143 51 0.688
Mouse
leukocyte differentiation GO:0002521 342 0.686
Mouse
mesonephric duct formation GO:0072181 2 0.686
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.686
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.679
forebrain morphogenesis GO:0048853 17 0.679
central nervous system vasculogenesis GO:0022009 3 0.679
stem cell proliferation GO:0072089 117 0.676
Mouse
hair cycle GO:0042633 90 0.672
striated muscle tissue development GO:0014706 293 0.666
Mouse Fly
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.659
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.654
kidney rudiment formation GO:0072003 3 0.651
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.651
lung alveolus development GO:0048286 45 0.650
pancreas development GO:0031016 57 0.648
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.646
regulation of establishment of planar polarity involved in neural tube closure GO:0090178 15 0.646
molting cycle GO:0042303 90 0.646
regulation of cell migration GO:0030334 219 0.644
submandibular salivary gland formation GO:0060661 1 0.642
heart morphogenesis GO:0003007 178 0.640
Mouse
ventricular septum morphogenesis GO:0060412 27 0.637
odontogenesis of dentin containing tooth GO:0042475 66 0.636
Mouse
epidermis morphogenesis GO:0048730 33 0.636
kidney epithelium development GO:0072073 121 0.633
mesoderm development GO:0007498 100 0.631
Mouse Worm Fly
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.630
regulation of epithelial to mesenchymal transition GO:0010717 22 0.618
Mouse
positive regulation of smoothened signaling pathway GO:0045880 23 0.616
mammary gland epithelium development GO:0061180 65 0.614
hindbrain formation GO:0021576 1 0.613
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.610
Mouse
morphogenesis of embryonic epithelium GO:0016331 159 0.603
Mouse
muscle tissue morphogenesis GO:0060415 53 0.602
Mouse
regulation of muscle tissue development GO:1901861 97 0.595
Mouse Fly
regulation of transferase activity GO:0051338 263 0.593
stem cell maintenance GO:0019827 130 0.588
Mouse
endochondral bone growth GO:0003416 19 0.586
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.582
cell proliferation in external granule layer GO:0021924 10 0.581
cerebellar cortex development GO:0021695 48 0.579
Mouse
morphogenesis of a branching structure GO:0001763 203 0.574
alpha beta t cell differentiation GO:0046632 69 0.571
gland development GO:0048732 330 0.570
Mouse Fly
cerebellum formation GO:0021588 1 0.564
circadian rhythm GO:0007623 114 0.560
Mouse
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.560
spleen development GO:0048536 39 0.559
somatotropin secreting cell differentiation GO:0060126 4 0.559
deltoid tuberosity development GO:0035993 3 0.557
Mouse
cerebellar granule cell precursor proliferation GO:0021930 10 0.552
positive regulation of bmp signaling pathway GO:0030513 23 0.552
regulation of epidermis development GO:0045682 33 0.548
Mouse
lung morphogenesis GO:0060425 50 0.547
hair follicle development GO:0001942 85 0.546
sensory organ morphogenesis GO:0090596 242 0.544
Mouse
forebrain cell migration GO:0021885 58 0.544
lung secretory cell differentiation GO:0061140 13 0.544
lung proximal distal axis specification GO:0061115 1 0.544
regulation of embryonic development GO:0045995 71 0.542
Mouse
hippocampus development GO:0021766 52 0.541
Mouse
osteoblast development GO:0002076 17 0.541
pancreatic pp cell fate commitment GO:0003329 2 0.537
Mouse
segmentation GO:0035282 93 0.533
Mouse
white fat cell proliferation GO:0070343 2 0.533
embryonic placenta development GO:0001892 98 0.526
Mouse
respiratory tube development GO:0030323 167 0.523
endocardial cushion morphogenesis GO:0003203 18 0.523
Mouse
spinal cord development GO:0021510 81 0.520
Mouse
skeletal muscle organ development GO:0060538 163 0.520
Mouse
negative regulation of fat cell differentiation GO:0045599 36 0.517
epithelial to mesenchymal transition GO:0001837 47 0.512
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.512
compound eye development GO:0048749 1 0.512
t cell activation GO:0042110 289 0.512
uterus morphogenesis GO:0061038 2 0.512
determination of left right symmetry GO:0007368 80 0.509
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.509
chondrocyte development GO:0002063 24 0.509
neural precursor cell proliferation GO:0061351 121 0.507
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.503
Mouse
paramesonephric duct development GO:0061205 3 0.502
corticotropin hormone secreting cell differentiation GO:0060128 3 0.501
telencephalon development GO:0021537 186 0.500
Mouse
mammary gland epithelial cell differentiation GO:0060644 13 0.499
regulation of neuron differentiation GO:0045664 281 0.499
Mouse
cardiac septum morphogenesis GO:0060411 46 0.497
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.495
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.494
central nervous system neuron differentiation GO:0021953 162 0.493
Mouse
ameboidal type cell migration GO:0001667 128 0.489
Mouse
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.487
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.486
morphogenesis of a polarized epithelium GO:0001738 37 0.486
Mouse
placenta development GO:0001890 140 0.484
Mouse
organ growth GO:0035265 117 0.481
lung vasculature development GO:0060426 7 0.479
positive regulation of ureteric bud formation GO:0072107 3 0.476
endochondral bone morphogenesis GO:0060350 50 0.474
Mouse
keratinocyte proliferation GO:0043616 21 0.472
branching involved in ureteric bud morphogenesis GO:0001658 56 0.464
mesonephric tubule formation GO:0072172 11 0.463
somite development GO:0061053 81 0.461
Mouse
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.459
metanephros morphogenesis GO:0003338 24 0.457
positive regulation of epithelial cell proliferation GO:0050679 68 0.456
otic placode formation GO:0043049 1 0.453
negative regulation of lymphocyte differentiation GO:0045620 32 0.450
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.449
Mouse
regulation of osteoblast differentiation GO:0045667 67 0.448
regulation of cell cycle GO:0051726 281 0.446
Mouse
digestive tract development GO:0048565 190 0.446
Mouse Worm Fly
gonad development GO:0008406 141 0.446
diencephalon morphogenesis GO:0048852 6 0.444
inner ear morphogenesis GO:0042472 101 0.442
Mouse
cd4 positive alpha beta t cell activation GO:0035710 45 0.442
renal vesicle development GO:0072087 17 0.441
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.440
regulation of establishment of planar polarity GO:0090175 28 0.437
male genitalia morphogenesis GO:0048808 4 0.434
hair follicle morphogenesis GO:0031069 29 0.434
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.432
Mouse
regulation of vasculature development GO:1901342 88 0.432
regulation of neural precursor cell proliferation GO:2000177 70 0.429
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.428
Mouse
renal outer medulla development GO:0072054 2 0.427
nephron morphogenesis GO:0072028 69 0.424
cochlea morphogenesis GO:0090103 22 0.422
positive regulation of cell growth GO:0030307 33 0.420
cardiac muscle tissue morphogenesis GO:0055008 44 0.417
Mouse
canonical wnt signaling pathway GO:0060070 130 0.417
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000081 1 0.415
embryonic viscerocranium morphogenesis GO:0048703 8 0.414
pancreatic a cell fate commitment GO:0003326 2 0.414
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.413
renal tubule development GO:0061326 87 0.413
Fly
regulation of organ morphogenesis GO:2000027 144 0.411
Mouse
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.411
embryonic forelimb morphogenesis GO:0035115 32 0.408
Mouse
craniofacial suture morphogenesis GO:0097094 10 0.408
Mouse
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.408
Mouse
neuroblast division GO:0055057 10 0.407
tube closure GO:0060606 91 0.403
Mouse
dendrite development GO:0016358 115 0.402
Mouse
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.401
mammary gland duct morphogenesis GO:0060603 38 0.400
neuron projection guidance GO:0097485 141 0.399
Mouse
metanephric nephron tubule formation GO:0072289 4 0.396
primary neural tube formation GO:0014020 95 0.395
Mouse
regulation of cell projection organization GO:0031344 206 0.392
Mouse
olfactory bulb interneuron differentiation GO:0021889 12 0.392
olfactory bulb interneuron development GO:0021891 7 0.391
covalent chromatin modification GO:0016569 163 0.391
Mouse
gastrulation GO:0007369 116 0.390
Mouse Worm Fly
positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 0.390
metanephric renal vesicle morphogenesis GO:0072283 12 0.390
positive regulation of muscle tissue development GO:1901863 32 0.389
mitotic cell cycle process GO:1903047 159 0.388
Mouse
cell aggregation GO:0098743 18 0.386
axon guidance GO:0007411 141 0.385
Mouse
cranial suture morphogenesis GO:0060363 8 0.385
Mouse
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.384
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.383
negative regulation of neuron projection development GO:0010977 50 0.379
artery development GO:0060840 53 0.375
Mouse
nephron epithelium development GO:0072009 92 0.373
regulation of heart growth GO:0060420 31 0.372
nuclear transport GO:0051169 139 0.372
intestinal epithelial cell maturation GO:0060574 2 0.372
central nervous system neuron development GO:0021954 67 0.371
Mouse
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.370
regulation of extent of cell growth GO:0061387 52 0.370
neural tube patterning GO:0021532 43 0.368
regulation of epidermal cell differentiation GO:0045604 21 0.368
Mouse
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.367
apoptotic signaling pathway GO:0097190 306 0.367
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.365
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.364
regulation of neuron projection development GO:0010975 169 0.361
Mouse
lung epithelial cell differentiation GO:0060487 29 0.359
nephron tubule development GO:0072080 84 0.358
positive regulation of anagen GO:0051885 1 0.358
negative regulation of t cell differentiation GO:0045581 23 0.355
positive regulation of neural precursor cell proliferation GO:2000179 42 0.354
type b pancreatic cell proliferation GO:0044342 10 0.351
nephron development GO:0072006 109 0.351
positive regulation of immature t cell proliferation GO:0033091 4 0.351
heart formation GO:0060914 16 0.349
Mouse
pallium development GO:0021543 120 0.349
Mouse
regulation of ossification GO:0030278 112 0.347
bronchiole morphogenesis GO:0060436 1 0.346
retina development in camera type eye GO:0060041 119 0.345
Mouse
cardiocyte differentiation GO:0035051 87 0.343
Mouse
negative regulation of cartilage development GO:0061037 17 0.340
regulation of cellular catabolic process GO:0031329 242 0.339
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.337
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9 0.335
regulation of wnt signaling pathway GO:0030111 123 0.334
renal tubule morphogenesis GO:0061333 72 0.334
Fly
lobar bronchus development GO:0060482 6 0.333
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 4 0.332
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.330
forebrain neuron differentiation GO:0021879 52 0.329
glandular epithelial cell differentiation GO:0002067 38 0.328
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.328
Mouse
olfactory lobe development GO:0021988 32 0.326
embryonic camera type eye development GO:0031076 36 0.326
regulation of organ growth GO:0046620 61 0.325
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.324
spinal cord patterning GO:0021511 25 0.324
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.322
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.322
Mouse
positive regulation of lymphocyte proliferation GO:0050671 70 0.322
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.321
negative regulation of leukocyte differentiation GO:1902106 51 0.319
dorsal ventral axon guidance GO:0033563 3 0.319
regulation of protein kinase activity GO:0045859 232 0.318
wound healing spreading of cells GO:0044319 8 0.318
regulation of system process GO:0044057 200 0.315
Mouse
immature t cell proliferation GO:0033079 8 0.315
negative regulation of neuron differentiation GO:0045665 101 0.314
tongue development GO:0043586 18 0.313
Mouse
lung pattern specification process GO:0060432 1 0.313
positive regulation of epidermis development GO:0045684 13 0.311
Mouse
negative regulation of immature t cell proliferation GO:0033087 3 0.311
synaptic transmission GO:0007268 329 0.309
Mouse
histone modification GO:0016570 159 0.308
Mouse
cellular ketone metabolic process GO:0042180 84 0.308
eye photoreceptor cell development GO:0042462 31 0.308
carbohydrate metabolic process GO:0005975 230 0.307
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.307
embryonic hindlimb morphogenesis GO:0035116 32 0.305
Mouse
activation of mapkk activity GO:0000186 15 0.304
regulation of mapk cascade GO:0043408 248 0.302
cardiac right atrium morphogenesis GO:0003213 3 0.302
cell proliferation in forebrain GO:0021846 30 0.300
metanephric nephron morphogenesis GO:0072273 19 0.300
regulation of white fat cell proliferation GO:0070350 2 0.300
positive regulation of mitotic cell cycle GO:0045931 41 0.299
Mouse
mammary gland specification GO:0060594 4 0.298
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.297
middle ear morphogenesis GO:0042474 23 0.295
frontal suture morphogenesis GO:0060364 2 0.295
establishment of planar polarity GO:0001736 28 0.294
muscle cell proliferation GO:0033002 52 0.292
regulation of chromosome organization GO:0033044 83 0.291
Mouse
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.291
regulation of high voltage gated calcium channel activity GO:1901841 2 0.290
cytokine mediated signaling pathway GO:0019221 115 0.290
positive regulation of protein phosphorylation GO:0001934 242 0.288
anterior commissure morphogenesis GO:0021960 6 0.288
muscle tissue development GO:0060537 308 0.288
Mouse Fly
metanephric loop of henle development GO:0072236 4 0.288
cellular response to growth factor stimulus GO:0071363 197 0.288
Mouse
cell division GO:0051301 120 0.287
Mouse
establishment or maintenance of cell polarity GO:0007163 86 0.287
Mouse
positive regulation of striated muscle tissue development GO:0045844 31 0.287
neural tube closure GO:0001843 90 0.286
Mouse
mesonephros development GO:0001823 97 0.284
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 14 0.283
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.283
growth plate cartilage development GO:0003417 14 0.280
positive regulation of leukocyte proliferation GO:0070665 73 0.280
gliogenesis GO:0042063 141 0.277
Mouse
spinal cord motor neuron cell fate specification GO:0021520 13 0.277
negative regulation of immune system process GO:0002683 209 0.276
regulation of t cell differentiation GO:0045580 83 0.276
bone marrow development GO:0048539 3 0.276
cerebral cortex development GO:0021987 86 0.275
Mouse
regulation of anagen GO:0051884 1 0.275
rhythmic process GO:0048511 174 0.274
Mouse
trachea cartilage development GO:0060534 8 0.274
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.273
response to transforming growth factor beta GO:0071559 88 0.272
Mouse
inner medullary collecting duct development GO:0072061 2 0.271
neuroendocrine cell differentiation GO:0061101 7 0.271
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.270
dorsal ventral neural tube patterning GO:0021904 28 0.270
locomotory behavior GO:0007626 195 0.269
Mouse
female sex differentiation GO:0046660 84 0.269
morphogenesis of an epithelial fold GO:0060571 28 0.268
digestive system development GO:0055123 200 0.267
Mouse Worm Fly
outflow tract morphogenesis GO:0003151 53 0.266
Mouse
primitive streak formation GO:0090009 10 0.266
mesenchymal epithelial cell signaling GO:0060638 9 0.266
positive regulation of cell cell adhesion mediated by cadherin GO:2000049 2 0.264
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.263
establishment or maintenance of neuroblast polarity GO:0045196 1 0.263
hindlimb morphogenesis GO:0035137 42 0.262
Mouse
response to fibroblast growth factor GO:0071774 47 0.260
positive regulation of white fat cell proliferation GO:0070352 1 0.260
regulation of ras protein signal transduction GO:0046578 114 0.259
somatic stem cell maintenance GO:0035019 47 0.259
positive regulation of protein kinase activity GO:0045860 144 0.258
type ii pneumocyte differentiation GO:0060510 7 0.258
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.257
establishment of anatomical structure orientation GO:0048560 1 0.256
positive regulation of osteoblast differentiation GO:0045669 34 0.256
renal system development GO:0072001 225 0.255
Fly
ventral spinal cord development GO:0021517 48 0.253
male anatomical structure morphogenesis GO:0090598 4 0.251
spinal cord ventral commissure morphogenesis GO:0021965 2 0.250
cell migration involved in gastrulation GO:0042074 13 0.250
placenta blood vessel development GO:0060674 31 0.249
endocardial cushion to mesenchymal transition GO:0090500 5 0.248
Mouse
tube formation GO:0035148 140 0.248
Mouse
regulation of cell adhesion GO:0030155 154 0.247
intracellular protein transport GO:0006886 204 0.247
specification of organ identity GO:0010092 30 0.247
renal vesicle morphogenesis GO:0072077 15 0.246
regulation of epithelial cell proliferation GO:0050678 141 0.246
nephron tubule formation GO:0072079 20 0.246
regulation of mitotic cell cycle GO:0007346 126 0.245
Mouse
cell differentiation involved in embryonic placenta development GO:0060706 26 0.245
Mouse
otic vesicle development GO:0071599 14 0.245
lung associated mesenchyme development GO:0060484 10 0.242
mammary placode formation GO:0060596 4 0.242
embryonic digestive tract morphogenesis GO:0048557 17 0.241
negative regulation of growth GO:0045926 99 0.241
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.240
Mouse
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.240
exocrine system development GO:0035272 45 0.239
Fly
mammary gland bud formation GO:0060615 2 0.239
cell type specific apoptotic process GO:0097285 268 0.238
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.237
positive regulation of fat cell proliferation GO:0070346 1 0.237
lung field specification GO:0060424 3 0.237
positive regulation of high voltage gated calcium channel activity GO:1901843 1 0.237
positive regulation of cardioblast differentiation GO:0051891 3 0.237
planar cell polarity pathway involved in neural tube closure GO:0090179 14 0.236
oviduct development GO:0060066 3 0.236
trachea gland development GO:0061153 3 0.235
bone trabecula formation GO:0060346 9 0.234
t cell differentiation GO:0030217 174 0.234
ureteric bud morphogenesis GO:0060675 62 0.233
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.233
cell proliferation involved in heart valve development GO:2000793 2 0.232
Mouse
telencephalon cell migration GO:0022029 55 0.232
wnt signaling pathway GO:0016055 188 0.231
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.231
Mouse
metanephric mesenchymal cell differentiation GO:0072162 3 0.230
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.230
heart valve development GO:0003170 23 0.230
Mouse
otic vesicle formation GO:0030916 8 0.228
mapk cascade GO:0000165 281 0.227
regulation of kinase activity GO:0043549 249 0.227
mesenchymal epithelial cell signaling involved in lung development GO:0060496 1 0.226
convergent extension GO:0060026 14 0.225
spemann organizer formation GO:0060061 2 0.225
muscle cell differentiation GO:0042692 261 0.224
Fly
positive regulation of leukocyte differentiation GO:1902107 86 0.223
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.223
Mouse
metanephric capsule specification GO:0072267 1 0.221
cellular amine metabolic process GO:0044106 44 0.221
female gonad development GO:0008585 71 0.220
neural tube formation GO:0001841 108 0.220
Mouse
positive regulation of cell adhesion GO:0045785 80 0.219
ureteric bud development GO:0001657 94 0.218
mammary gland morphogenesis GO:0060443 54 0.218
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.217
epithelial cell proliferation GO:0050673 174 0.217

Twist2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.613
musculoskeletal system disease DOID:17 0 0.613
connective tissue disease DOID:65 0 0.613