|
|
phototransduction
|
GO:0007602 |
17 |
0.980
|
|
|
|
protein desumoylation
|
GO:0016926 |
2 |
0.967
|
Fly |
|
|
g protein coupled receptor internalization
|
GO:0002031 |
3 |
0.928
|
Human |
|
|
negative regulation of toll signaling pathway
|
GO:0045751 |
1 |
0.874
|
Fly |
|
|
negative regulation of protein tyrosine kinase activity
|
GO:0061099 |
3 |
0.849
|
Fly |
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.844
|
Mouse |
|
|
protein modification by small protein removal
|
GO:0070646 |
21 |
0.823
|
Fly |
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
20 |
0.791
|
Mouse |
|
|
desensitization of g protein coupled receptor protein signaling pathway
|
GO:0002029 |
5 |
0.776
|
Human |
|
|
regulation of protein binding
|
GO:0043393 |
60 |
0.769
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.760
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.757
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.753
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.752
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
40 |
0.747
|
Human |
|
|
positive regulation of synaptic transmission dopaminergic
|
GO:0032226 |
5 |
0.729
|
Mouse |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.721
|
|
|
|
regulation of toll signaling pathway
|
GO:0008592 |
1 |
0.712
|
Fly |
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
17 |
0.707
|
Fly |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.694
|
Human |
|
|
negative regulation of interleukin 1 beta production
|
GO:0032691 |
5 |
0.692
|
Mouse |
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.689
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.681
|
Human |
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
17 |
0.659
|
Fly |
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.653
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.652
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.639
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.623
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.598
|
Fly |
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.594
|
Human |
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.591
|
Human Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.590
|
Human |
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.583
|
Mouse |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.581
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.576
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.576
|
Human Mouse |
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.574
|
Fly |
|
|
regulation of receptor binding
|
GO:1900120 |
4 |
0.560
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.554
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.553
|
Mouse |
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.551
|
Human |
|
|
positive regulation of peptide secretion
|
GO:0002793 |
33 |
0.550
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.540
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.531
|
|
|
|
positive regulation of receptor internalization
|
GO:0002092 |
4 |
0.529
|
Human |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.528
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.528
|
Mouse |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.522
|
Human |
|
|
negative regulation of g protein coupled receptor protein signaling pathway
|
GO:0045744 |
12 |
0.518
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.515
|
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.506
|
|
|
|
receptor recycling
|
GO:0001881 |
11 |
0.504
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.501
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.494
|
Human Mouse |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.491
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.489
|
Human |
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
32 |
0.488
|
Mouse |
|
|
positive regulation of binding
|
GO:0051099 |
49 |
0.487
|
|
|
|
cellular response to carbohydrate stimulus
|
GO:0071322 |
50 |
0.482
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.476
|
Human |
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.474
|
Mouse |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.463
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.457
|
|
|
|
regulation of leukocyte mediated cytotoxicity
|
GO:0001910 |
38 |
0.456
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.455
|
Human |
|
|
cellular response to glucose stimulus
|
GO:0071333 |
45 |
0.448
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
30 |
0.447
|
Fly |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.446
|
Mouse |
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.445
|
Human |
|
|
positive regulation of peptide hormone secretion
|
GO:0090277 |
31 |
0.444
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
75 |
0.443
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.434
|
Fly |
|
|
activation of immune response
|
GO:0002253 |
138 |
0.429
|
Mouse |
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.427
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.426
|
Human |
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.424
|
Human |
|
|
hormone secretion
|
GO:0046879 |
128 |
0.419
|
|
|
|
regulation of protein processing
|
GO:0070613 |
96 |
0.419
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
71 |
0.418
|
|
|
|
detection of stimulus
|
GO:0051606 |
84 |
0.414
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.412
|
Human |
|
|
regulation of peptide transport
|
GO:0090087 |
91 |
0.406
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
17 |
0.403
|
Human Mouse |
|
|
negative adaptation of signaling pathway
|
GO:0022401 |
5 |
0.403
|
Human |
|
|
regulation of hormone secretion
|
GO:0046883 |
88 |
0.402
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.402
|
Mouse |
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.401
|
Human |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.397
|
|
|
|
amide transport
|
GO:0042886 |
138 |
0.397
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.395
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.389
|
Human |
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.388
|
Mouse Fly |
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.385
|
Human |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.384
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.381
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.378
|
Human |
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.376
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.376
|
Human |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.374
|
|
|
|
negative regulation of innate immune response
|
GO:0045824 |
17 |
0.373
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.369
|
Human |
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.365
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.358
|
Human |
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.356
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
39 |
0.350
|
|
|
|
leukocyte mediated cytotoxicity
|
GO:0001909 |
62 |
0.348
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
46 |
0.348
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
84 |
0.346
|
Human Mouse |
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.337
|
Mouse |
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.330
|
Human |
|
|
positive regulation of hormone secretion
|
GO:0046887 |
38 |
0.328
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.323
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.321
|
Fly |
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
56 |
0.319
|
Mouse |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.316
|
Human |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.315
|
Human |
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.310
|
Human |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.308
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.307
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.305
|
Fly |
|
|
regulation of androgen receptor signaling pathway
|
GO:0060765 |
3 |
0.303
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.299
|
Mouse |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.299
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
30 |
0.299
|
Mouse |
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.294
|
Fly |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.294
|
Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.290
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.289
|
|
|
|
adult walking behavior
|
GO:0007628 |
41 |
0.286
|
Mouse |
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.284
|
Mouse |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.284
|
|
|
|
protein processing
|
GO:0016485 |
163 |
0.281
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
74 |
0.280
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
44 |
0.280
|
|
|
|
cellular response to monosaccharide stimulus
|
GO:0071326 |
47 |
0.277
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.277
|
Human |
|
|
regulation of cell killing
|
GO:0031341 |
40 |
0.276
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.274
|
Fly |
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.273
|
Human |
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.272
|
Human |
|
|
interleukin 12 production
|
GO:0032615 |
32 |
0.272
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.272
|
Human Mouse |
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.270
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
29 |
0.268
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
22 |
0.267
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.266
|
Fly |
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.259
|
Human Mouse |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.259
|
Human |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.259
|
Human |
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.258
|
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.256
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
211 |
0.253
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
55 |
0.252
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
79 |
0.252
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.251
|
Human |
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.251
|
Fly |
|
|
negative regulation of natural killer cell mediated immunity
|
GO:0002716 |
5 |
0.249
|
|
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.248
|
Human |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.248
|
Human |
|
|
cellular response to hexose stimulus
|
GO:0071331 |
47 |
0.248
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.246
|
Human |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.242
|
Human |
|
|
neuron neuron synaptic transmission
|
GO:0007270 |
69 |
0.240
|
Mouse |
|
|
innate immune response
|
GO:0045087 |
157 |
0.239
|
|
|
|
regulation of natural killer cell mediated immunity
|
GO:0002715 |
19 |
0.239
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.236
|
Fly |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.235
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.234
|
Fly |
|
|
smoothened signaling pathway
|
GO:0007224 |
105 |
0.233
|
|
|
|
regulation of interleukin 1 production
|
GO:0032652 |
26 |
0.233
|
Mouse |
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.231
|
Human |
|
|
regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061178 |
31 |
0.229
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.225
|
Human |
|
|
regulation of synaptic transmission dopaminergic
|
GO:0032225 |
8 |
0.225
|
Mouse |
|
|
maintenance of location
|
GO:0051235 |
89 |
0.222
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.219
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
91 |
0.219
|
Mouse |
|
|
negative regulation of leukocyte mediated immunity
|
GO:0002704 |
29 |
0.219
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.217
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.216
|
Human |
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.215
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.214
|
Fly |
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.213
|
|
|
|
detection of abiotic stimulus
|
GO:0009582 |
60 |
0.213
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.207
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.207
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.201
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.198
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.195
|
Human |
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.192
|
Human |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.192
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.189
|
Human |
|
|
regulation of receptor recycling
|
GO:0001919 |
8 |
0.187
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.186
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.185
|
Human Mouse |
|
|
positive regulation of growth
|
GO:0045927 |
104 |
0.185
|
Worm |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.183
|
Human |
|
|
adult behavior
|
GO:0030534 |
135 |
0.178
|
Mouse |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.177
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.176
|
Human Fly |
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
74 |
0.176
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.173
|
Human |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.173
|
Human |
|
|
cell killing
|
GO:0001906 |
67 |
0.170
|
|
|
|
notch signaling pathway
|
GO:0007219 |
71 |
0.164
|
Fly |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.163
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.162
|
Human |
|
|
detection of external stimulus
|
GO:0009581 |
61 |
0.162
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.160
|
|
|
|
regulation of chemotaxis
|
GO:0050920 |
53 |
0.160
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.157
|
Human Fly |
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.157
|
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.156
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
20 |
0.155
|
Human |
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.154
|
Human |
|
|
positive regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0035774 |
13 |
0.152
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.149
|
Mouse |
|
|
response to growth factor
|
GO:0070848 |
198 |
0.145
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.145
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.144
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.143
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.142
|
Human |
|
|
membrane organization
|
GO:0061024 |
245 |
0.140
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
27 |
0.139
|
|
|
|
regulation of interleukin 1 beta production
|
GO:0032651 |
25 |
0.136
|
Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.133
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.132
|
Human |
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.131
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
49 |
0.131
|
Mouse |
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.129
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.128
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
127 |
0.127
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.126
|
Human |
|
|
regulation of intracellular steroid hormone receptor signaling pathway
|
GO:0033143 |
18 |
0.125
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.125
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.124
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.123
|
Human |
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.123
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.122
|
|
|
|
natural killer cell mediated immunity
|
GO:0002228 |
29 |
0.122
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.121
|
Fly |
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.121
|
|
|
|
locomotory exploration behavior
|
GO:0035641 |
10 |
0.120
|
Fly |
|
|
axonogenesis
|
GO:0007409 |
274 |
0.120
|
|
|
|
receptor internalization
|
GO:0031623 |
16 |
0.119
|
Human |
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.118
|
Fly |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
155 |
0.117
|
Fly |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.117
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.116
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.116
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.116
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.116
|
Fly |
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.115
|
Fly |
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.115
|
|
|
|
natural killer cell mediated cytotoxicity
|
GO:0042267 |
29 |
0.114
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
29 |
0.113
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
165 |
0.111
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
50 |
0.110
|
Mouse |
|
|
negative regulation of lymphocyte mediated immunity
|
GO:0002707 |
21 |
0.110
|
|
|
|
negative regulation of notch signaling pathway
|
GO:0045746 |
14 |
0.109
|
Fly |
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.106
|
|
|
|
negative regulation of binding
|
GO:0051100 |
39 |
0.106
|
|
|
|
glucose transport
|
GO:0015758 |
56 |
0.104
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.104
|
|
|
|
positive regulation of receptor mediated endocytosis
|
GO:0048260 |
9 |
0.103
|
Human |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.103
|
Human |
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.102
|
Human |
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.102
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
51 |
0.100
|
Mouse |
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.100
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.099
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.099
|
|
|
|
carbohydrate homeostasis
|
GO:0033500 |
128 |
0.099
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.095
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.094
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.091
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.091
|
Mouse Fly |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.090
|
Human |
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.089
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.089
|
Human |
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.088
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.087
|
|
|
|
negative regulation of interleukin 12 production
|
GO:0032695 |
10 |
0.087
|
Mouse |
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.085
|
|
|
|
regulation of smoothened signaling pathway
|
GO:0008589 |
58 |
0.085
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
51 |
0.085
|
Human |
|
|
regulation of receptor internalization
|
GO:0002090 |
7 |
0.085
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.085
|
|
|
|
retina development in camera type eye
|
GO:0060041 |
119 |
0.085
|
|
|
|
regulation of natural killer cell mediated cytotoxicity
|
GO:0042269 |
19 |
0.084
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.084
|
Fly |
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
16 |
0.083
|
Human |
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.083
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.083
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
19 |
0.080
|
Human |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.079
|
Human |
|
|
negative regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903556 |
17 |
0.079
|
Mouse |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.079
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.078
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
8 |
0.077
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.077
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.076
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.074
|
Human |
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.074
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.073
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.073
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.072
|
|
|
|
protein localization to membrane
|
GO:0072657 |
108 |
0.071
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.071
|
Human |
|
|
cell adhesion
|
GO:0007155 |
329 |
0.070
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.069
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.069
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.068
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.068
|
|
|
|
leukocyte migration
|
GO:0050900 |
124 |
0.066
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.066
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.065
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.065
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
234 |
0.064
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.064
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.064
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.063
|
Fly |
|
|
plasma membrane organization
|
GO:0007009 |
90 |
0.063
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.063
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
207 |
0.063
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.063
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.061
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.061
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.059
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.058
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.058
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.058
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.057
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.057
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.056
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.056
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.056
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.056
|
Fly |
|
|
action potential
|
GO:0001508 |
78 |
0.056
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.056
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.055
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.055
|
|
|
|
negative regulation of synapse assembly
|
GO:0051964 |
3 |
0.054
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
56 |
0.054
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.053
|
Fly |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.053
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.053
|
|
|
|
placenta development
|
GO:0001890 |
140 |
0.053
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.053
|
Human |
|
|
male gamete generation
|
GO:0048232 |
285 |
0.053
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.052
|
|
|
|
skin development
|
GO:0043588 |
220 |
0.052
|
|
|
|
heart process
|
GO:0003015 |
94 |
0.052
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.052
|
Human |
|
|
camera type eye development
|
GO:0043010 |
266 |
0.051
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.051
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.051
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
119 |
0.050
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.050
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.049
|
|
|
|
retrograde transport endosome to golgi
|
GO:0042147 |
2 |
0.049
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.049
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.049
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.049
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.048
|
|
|
|
neural tube formation
|
GO:0001841 |
108 |
0.048
|
|
|
|
neuronal action potential
|
GO:0019228 |
54 |
0.048
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.048
|
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.047
|
|
|
|
epidermis development
|
GO:0008544 |
187 |
0.047
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
93 |
0.046
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.046
|
|
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.046
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
93 |
0.046
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.046
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
203 |
0.045
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
128 |
0.045
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
91 |
0.044
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.044
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.044
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.043
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.043
|
|
|
|
negative regulation of neuron differentiation
|
GO:0045665 |
101 |
0.043
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.043
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.043
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.042
|
|
|
|
circulatory system process
|
GO:0003013 |
197 |
0.042
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.042
|
|
|
|
endomembrane system organization
|
GO:0010256 |
147 |
0.041
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.041
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.040
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.040
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.040
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.040
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.039
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.039
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.039
|
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.039
|
|
|
|
response to monosaccharide
|
GO:0034284 |
67 |
0.039
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.038
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.038
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.038
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.038
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.038
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.038
|
|
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.037
|
Mouse |
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.037
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.037
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
70 |
0.037
|
|
|
|
neural tube development
|
GO:0021915 |
160 |
0.037
|
|
|
|
positive regulation of protein export from nucleus
|
GO:0046827 |
4 |
0.037
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
191 |
0.037
|
|
|
|
monosaccharide transport
|
GO:0015749 |
58 |
0.036
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
69 |
0.036
|
|
|
|
heart contraction
|
GO:0060047 |
93 |
0.036
|
|
|
|
negative regulation of neuron projection development
|
GO:0010977 |
50 |
0.036
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
38 |
0.036
|
|
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.035
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.035
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.035
|
Human |
|
|
cognition
|
GO:0050890 |
149 |
0.035
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.035
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.035
|
Human |
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.034
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.034
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
54 |
0.034
|
|
|
|
neural tube closure
|
GO:0001843 |
90 |
0.034
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.034
|
|
|
|
retina morphogenesis in camera type eye
|
GO:0060042 |
45 |
0.034
|
|
|
|
response to inorganic substance
|
GO:0010035 |
96 |
0.034
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.034
|
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.034
|
|
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.034
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.034
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.033
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.033
|
|
|
|
tube closure
|
GO:0060606 |
91 |
0.033
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
73 |
0.033
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.033
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.032
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
59 |
0.032
|
|
|
|
tissue homeostasis
|
GO:0001894 |
115 |
0.032
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
42 |
0.032
|
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.032
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.032
|
|
|
|
primary neural tube formation
|
GO:0014020 |
95 |
0.032
|
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.032
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.031
|
|
|
|
lipid transport
|
GO:0006869 |
98 |
0.031
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.031
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.031
|
|
|
|
glucose homeostasis
|
GO:0042593 |
128 |
0.031
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
116 |
0.031
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.031
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.031
|
|
|
|
regulation of cell growth
|
GO:0001558 |
91 |
0.030
|
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.030
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.030
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
81 |
0.030
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.030
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.030
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.030
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.029
|
|
|
|
epithelial tube formation
|
GO:0072175 |
130 |
0.029
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.029
|
|
|
|
negative regulation of cell projection organization
|
GO:0031345 |
56 |
0.029
|
|
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.029
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.029
|
|
|
|
neuron projection extension
|
GO:1990138 |
64 |
0.029
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
57 |
0.029
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.029
|
|
|
|
cellular component assembly involved in morphogenesis
|
GO:0010927 |
139 |
0.028
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
57 |
0.028
|
|
|
|
embryonic limb morphogenesis
|
GO:0030326 |
126 |
0.028
|
|
|
|
hexose metabolic process
|
GO:0019318 |
98 |
0.028
|
|
|
|
calcium ion transmembrane transport
|
GO:0070588 |
85 |
0.028
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.028
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
130 |
0.028
|
|
|
|
negative regulation of t cell activation
|
GO:0050868 |
65 |
0.028
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.028
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.028
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.027
|
|
|
|
membrane fusion
|
GO:0061025 |
38 |
0.027
|
|
|
|
muscle cell development
|
GO:0055001 |
133 |
0.027
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
138 |
0.027
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.027
|
|
|
|
regulation of response to drug
|
GO:2001023 |
2 |
0.027
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.027
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.027
|
|
|
|
cellularization
|
GO:0007349 |
1 |
0.027
|
|
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
49 |
0.027
|
|
|
|
cardiac chamber development
|
GO:0003205 |
108 |
0.026
|
|
|
|
photoreceptor cell morphogenesis
|
GO:0008594 |
3 |
0.026
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
109 |
0.026
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.026
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.026
|
|
|
|
liver development
|
GO:0001889 |
66 |
0.026
|
|
