Mus musculus

0 known processes

Klhdc2

kelch domain containing 2

(Aliases: 2310022K15Rik,D12Ertd522e,LCP,HCLP-1)

Klhdc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 155 0.169
protein modification by small protein conjugation or removal GO:0070647 207 0.167
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.137
proteasomal protein catabolic process GO:0010498 98 0.114
modification dependent protein catabolic process GO:0019941 133 0.114
ubiquitin dependent protein catabolic process GO:0006511 129 0.114
male gamete generation GO:0048232 285 0.110
protein modification by small protein conjugation GO:0032446 187 0.108
purine ribonucleotide metabolic process GO:0009150 290 0.088
purine nucleotide metabolic process GO:0006163 302 0.081
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.081
nucleotide metabolic process GO:0009117 332 0.079
spermatogenesis GO:0007283 284 0.073
protein ubiquitination GO:0016567 171 0.071
purine ribonucleoside metabolic process GO:0046128 241 0.065
ribonucleotide catabolic process GO:0009261 208 0.063
protein catabolic process GO:0030163 221 0.062
carbohydrate derivative catabolic process GO:1901136 231 0.060
negative regulation of cellular protein metabolic process GO:0032269 247 0.059
purine containing compound metabolic process GO:0072521 311 0.059
nucleobase containing small molecule metabolic process GO:0055086 352 0.058
nucleotide catabolic process GO:0009166 217 0.051
ribonucleoside metabolic process GO:0009119 245 0.050
ribonucleotide metabolic process GO:0009259 291 0.049
purine nucleoside catabolic process GO:0006152 205 0.049
ribonucleoside catabolic process GO:0042454 206 0.048
transmembrane transport GO:0055085 412 0.047
purine nucleoside metabolic process GO:0042278 241 0.046
regulation of apoptotic signaling pathway GO:2001233 197 0.046
nucleoside triphosphate metabolic process GO:0009141 230 0.045
regulation of cell cycle GO:0051726 281 0.045
nucleoside metabolic process GO:0009116 246 0.043
organelle assembly GO:0070925 177 0.043
ribose phosphate metabolic process GO:0019693 291 0.042
negative regulation of protein metabolic process GO:0051248 282 0.041
spermatid differentiation GO:0048515 115 0.041
purine nucleoside triphosphate metabolic process GO:0009144 226 0.041
multicellular organism growth GO:0035264 161 0.040
organelle fission GO:0048285 170 0.040
cellular macromolecule catabolic process GO:0044265 206 0.039
regulation of cellular protein catabolic process GO:1903362 61 0.039
apoptotic signaling pathway GO:0097190 306 0.039
glycosyl compound catabolic process GO:1901658 206 0.039
regulation of proteolysis GO:0030162 164 0.038
nucleoside phosphate metabolic process GO:0006753 338 0.038
regulation of cellular catabolic process GO:0031329 242 0.038
purine ribonucleotide catabolic process GO:0009154 208 0.038
action potential GO:0001508 78 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.035
cytoplasmic transport GO:0016482 234 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
peptidyl amino acid modification GO:0018193 336 0.035
nucleoside phosphate catabolic process GO:1901292 222 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.033
carbohydrate derivative biosynthetic process GO:1901137 183 0.032
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.032
regulation of mitotic cell cycle GO:0007346 126 0.032
purine containing compound catabolic process GO:0072523 213 0.032
glycosyl compound metabolic process GO:1901657 246 0.032
purine ribonucleoside catabolic process GO:0046130 205 0.031
organonitrogen compound biosynthetic process GO:1901566 192 0.031
cell division GO:0051301 120 0.031
dna metabolic process GO:0006259 303 0.031
cellular amino acid metabolic process GO:0006520 103 0.029
regulation of cellular amino acid metabolic process GO:0006521 5 0.029
mitotic cell cycle process GO:1903047 159 0.029
organophosphate catabolic process GO:0046434 232 0.028
germ cell development GO:0007281 185 0.028
regulation of protein maturation GO:1903317 96 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.027
dna recombination GO:0006310 92 0.026
muscle tissue development GO:0060537 308 0.026
cellular component assembly involved in morphogenesis GO:0010927 139 0.026
regulation of membrane potential GO:0042391 192 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
regulation of cell cycle process GO:0010564 160 0.026
regulation of protein catabolic process GO:0042176 108 0.026
cellular amine metabolic process GO:0044106 44 0.026
cellular response to dna damage stimulus GO:0006974 207 0.026
regulation of cell cycle phase transition GO:1901987 77 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
protein maturation GO:0051604 176 0.024
striated muscle tissue development GO:0014706 293 0.024
regulation of transmembrane transport GO:0034762 128 0.024
negative regulation of cellular component organization GO:0051129 194 0.023
dna repair GO:0006281 107 0.023
microtubule cytoskeleton organization GO:0000226 157 0.023
endomembrane system organization GO:0010256 147 0.023
amine metabolic process GO:0009308 45 0.023
transmission of nerve impulse GO:0019226 76 0.023
exocytosis GO:0006887 121 0.023
nucleoside catabolic process GO:0009164 206 0.022
positive regulation of cell death GO:0010942 224 0.022
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.022
protein processing GO:0016485 163 0.022
synaptic transmission GO:0007268 329 0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.022
adult behavior GO:0030534 135 0.022
nucleoside monophosphate metabolic process GO:0009123 85 0.022
cognition GO:0050890 149 0.021
male meiosis GO:0007140 37 0.021
cellularization GO:0007349 1 0.021
cellular response to growth factor stimulus GO:0071363 197 0.021
regulation of protein processing GO:0070613 96 0.021
negative regulation of proteolysis GO:0045861 74 0.021
nucleoside triphosphate catabolic process GO:0009143 205 0.021
atp metabolic process GO:0046034 75 0.020
actin cytoskeleton organization GO:0030036 220 0.020
cell cycle g1 s phase transition GO:0044843 57 0.020
ribonucleoside triphosphate catabolic process GO:0009203 199 0.020
positive regulation of protein modification process GO:0031401 299 0.020
membrane organization GO:0061024 245 0.020
regulation of cellular ketone metabolic process GO:0010565 66 0.019
purine nucleoside triphosphate catabolic process GO:0009146 203 0.019
negative regulation of cell proliferation GO:0008285 296 0.019
sperm individualization GO:0007291 1 0.019
neuronal action potential GO:0019228 54 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
negative regulation of mitotic cell cycle GO:0045930 58 0.019
negative regulation of protein modification process GO:0031400 163 0.019
anatomical structure homeostasis GO:0060249 145 0.018
ion transmembrane transport GO:0034220 361 0.018
negative regulation of protein maturation GO:1903318 79 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
regulation of mapk cascade GO:0043408 248 0.018
muscle cell development GO:0055001 133 0.018
g1 s transition of mitotic cell cycle GO:0000082 57 0.018
negative regulation of molecular function GO:0044092 258 0.018
negative regulation of cell development GO:0010721 169 0.017
negative regulation of protein processing GO:0010955 79 0.017
regulation of cellular response to stress GO:0080135 159 0.017
gtp metabolic process GO:0046039 144 0.017
wnt signaling pathway GO:0016055 188 0.017
multicellular organismal response to stress GO:0033555 62 0.017
cation transport GO:0006812 399 0.017
cell maturation GO:0048469 127 0.017
nitrogen compound transport GO:0071705 271 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.016
double strand break repair GO:0006302 48 0.016
microtubule based process GO:0007017 236 0.016
response to extracellular stimulus GO:0009991 127 0.016
learning or memory GO:0007611 148 0.016
meiosis i GO:0007127 60 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
aromatic compound catabolic process GO:0019439 286 0.016
regulation of organelle organization GO:0033043 289 0.016
mapk cascade GO:0000165 281 0.016
spermatid development GO:0007286 108 0.016
carbohydrate metabolic process GO:0005975 230 0.016
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.016
cellular ketone metabolic process GO:0042180 84 0.016
positive regulation of organelle organization GO:0010638 128 0.016
regulation of cell division GO:0051302 76 0.016
regionalization GO:0003002 337 0.015
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.015
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
regulation of secretion GO:0051046 274 0.015
maintenance of location GO:0051235 89 0.015
fertilization GO:0009566 127 0.014
protein polyubiquitination GO:0000209 33 0.014
regulation of ion transmembrane transport GO:0034765 119 0.014
regulation of mitotic cell cycle phase transition GO:1901990 73 0.014
synapse organization GO:0050808 125 0.014
ras protein signal transduction GO:0007265 77 0.014
muscle cell differentiation GO:0042692 261 0.014
mitotic cell cycle GO:0000278 195 0.014
regulation of protein transport GO:0051223 163 0.014
protein import GO:0017038 101 0.014
compound eye development GO:0048749 1 0.014
developmental maturation GO:0021700 193 0.014
homeostasis of number of cells GO:0048872 210 0.014
response to growth factor GO:0070848 198 0.014
regulation of cellular component biogenesis GO:0044087 181 0.014
atp catabolic process GO:0006200 55 0.013
male meiosis i GO:0007141 16 0.013
organic cyclic compound catabolic process GO:1901361 295 0.013
regulation of intracellular protein transport GO:0033157 82 0.013
negative regulation of immune system process GO:0002683 209 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
dephosphorylation GO:0016311 129 0.013
regulation of protein kinase activity GO:0045859 232 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
cellular nitrogen compound catabolic process GO:0044270 280 0.013
lipid localization GO:0010876 126 0.013
positive regulation of proteolysis GO:0045862 85 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.013
regulation of proteasomal protein catabolic process GO:0061136 46 0.013
cellular homeostasis GO:0019725 240 0.013
energy derivation by oxidation of organic compounds GO:0015980 77 0.013
response to organic cyclic compound GO:0014070 198 0.013
regulation of protein localization GO:0032880 231 0.013
regulation of transferase activity GO:0051338 263 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.012
negative regulation of cellular protein catabolic process GO:1903363 22 0.012
cation transmembrane transport GO:0098655 266 0.012
regulation of intracellular transport GO:0032386 159 0.012
positive regulation of apoptotic signaling pathway GO:2001235 95 0.012
regulation of secretion by cell GO:1903530 249 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
camera type eye development GO:0043010 266 0.012
positive regulation of protein catabolic process GO:0045732 60 0.012
response to fibroblast growth factor GO:0071774 47 0.012
multicellular organismal signaling GO:0035637 91 0.012
morphogenesis of embryonic epithelium GO:0016331 159 0.012
negative regulation of cell cycle process GO:0010948 69 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
olfactory learning GO:0008355 2 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
adult locomotory behavior GO:0008344 91 0.012
regulation of anatomical structure size GO:0090066 178 0.012
regulation of kinase activity GO:0043549 249 0.012
cilium morphogenesis GO:0060271 102 0.012
protein targeting GO:0006605 143 0.012
locomotory behavior GO:0007626 195 0.012
sensory perception GO:0007600 245 0.012
translation GO:0006412 93 0.011
cell cycle checkpoint GO:0000075 47 0.011
regulation of hydrolase activity GO:0051336 246 0.011
epithelial cell proliferation GO:0050673 174 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
response to organonitrogen compound GO:0010243 246 0.011
regulation of sarcomere organization GO:0060297 4 0.011
neural tube closure GO:0001843 90 0.011
cofactor metabolic process GO:0051186 80 0.011
lymphocyte mediated immunity GO:0002449 139 0.011
cellular protein complex assembly GO:0043623 116 0.011
skeletal muscle cell differentiation GO:0035914 66 0.011
lymphocyte differentiation GO:0030098 242 0.011
macromolecule methylation GO:0043414 120 0.011
negative regulation of cell cycle GO:0045786 123 0.011
negative regulation of cell motility GO:2000146 61 0.011
gtp catabolic process GO:0006184 143 0.011
regulation of cell motility GO:2000145 236 0.011
regulation of cell migration GO:0030334 219 0.011
macromolecule catabolic process GO:0009057 281 0.011
response to light stimulus GO:0009416 135 0.011
positive regulation of immature t cell proliferation in thymus GO:0033092 3 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
meiotic nuclear division GO:0007126 115 0.011
protein localization to organelle GO:0033365 185 0.011
urogenital system development GO:0001655 261 0.010
negative regulation of cellular catabolic process GO:0031330 47 0.010
forebrain development GO:0030900 302 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
establishment of organelle localization GO:0051656 122 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
negative regulation of phosphate metabolic process GO:0045936 184 0.010
protein alkylation GO:0008213 81 0.010
t cell activation GO:0042110 289 0.010
erk1 and erk2 cascade GO:0070371 77 0.010
nuclear transport GO:0051169 139 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
carboxylic acid biosynthetic process GO:0046394 86 0.010
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.010
positive regulation of cellular catabolic process GO:0031331 148 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.010

Klhdc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.068
nervous system disease DOID:863 0 0.068
sensory system disease DOID:0050155 0 0.033
eye and adnexa disease DOID:1492 0 0.030
musculoskeletal system disease DOID:17 0 0.023
eye disease DOID:5614 0 0.022
retinal disease DOID:5679 0 0.018
retinal degeneration DOID:8466 0 0.018
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
central nervous system disease DOID:331 0 0.013
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011