Mus musculus

69 known processes

Sarm1

sterile alpha and HEAT/Armadillo motif containing 1

(Aliases: C78606,MyD885,A830091I15Rik,Sarm)

Sarm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of membrane potential GO:0042391 192 0.125
cilium morphogenesis GO:0060271 102 0.071
acetylcholine secretion neurotransmission GO:0014055 2 0.062
synapse organization GO:0050808 125 0.059
cilium assembly GO:0042384 81 0.058
protein modification by small protein conjugation GO:0032446 187 0.057
regulation of cellular amine metabolic process GO:0033238 20 0.056
synaptic vesicle localization GO:0097479 59 0.056
regulation of neuron differentiation GO:0045664 281 0.056
vesicle localization GO:0051648 86 0.055
camera type eye development GO:0043010 266 0.054
inorganic cation transmembrane transport GO:0098662 207 0.054
regulation of cellular amino acid metabolic process GO:0006521 5 0.054
fertilization GO:0009566 127 0.050
ion transmembrane transport GO:0034220 361 0.050
central nervous system maturation GO:0021626 6 0.050
transmembrane transport GO:0055085 412 0.049
neurotransmitter secretion GO:0007269 62 0.048
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.048
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.047
neurotransmitter transport GO:0006836 76 0.047
organelle localization GO:0051640 179 0.047
axonogenesis GO:0007409 274 0.046
protein modification by small protein conjugation or removal GO:0070647 207 0.045
acetylcholine transport GO:0015870 2 0.045
microtubule based process GO:0007017 236 0.044
germ cell development GO:0007281 185 0.044
sperm motility GO:0030317 47 0.043
sensory perception GO:0007600 245 0.043
cellular component assembly involved in morphogenesis GO:0010927 139 0.043
cognition GO:0050890 149 0.042
amine metabolic process GO:0009308 45 0.039
cellular amine metabolic process GO:0044106 44 0.039
developmental growth involved in morphogenesis GO:0060560 138 0.039
regulation of cellular component biogenesis GO:0044087 181 0.038
divalent inorganic cation transport GO:0072511 178 0.037
nucleoside phosphate metabolic process GO:0006753 338 0.037
establishment of organelle localization GO:0051656 122 0.037
regulation of neurotransmitter transport GO:0051588 35 0.036
cation transmembrane transport GO:0098655 266 0.036
gland development GO:0048732 330 0.036
locomotory behavior GO:0007626 195 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
ubiquitin dependent protein catabolic process GO:0006511 129 0.034
retina development in camera type eye GO:0060041 119 0.034
dna metabolic process GO:0006259 303 0.034
membrane organization GO:0061024 245 0.033
negative regulation of molecular function GO:0044092 258 0.033
skeletal system development GO:0001501 356 0.033
cellular amino acid metabolic process GO:0006520 103 0.033
regulation of cellular catabolic process GO:0031329 242 0.033
ribonucleotide metabolic process GO:0009259 291 0.033
cell adhesion GO:0007155 329 0.032
protein ubiquitination GO:0016567 171 0.032
regulation of neurotransmitter levels GO:0001505 87 0.031
compound eye development GO:0048749 1 0.031
epithelial tube morphogenesis GO:0060562 303 0.031
regulation of cell projection organization GO:0031344 206 0.029
positive regulation of protein modification process GO:0031401 299 0.028
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
regulation of neuron projection development GO:0010975 169 0.028
actin cytoskeleton organization GO:0030036 220 0.028
regulation of vesicle mediated transport GO:0060627 139 0.028
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
negative regulation of cellular component organization GO:0051129 194 0.027
regulation of proteolysis GO:0030162 164 0.027
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.027
aromatic compound catabolic process GO:0019439 286 0.027
myeloid cell differentiation GO:0030099 233 0.027
cellular macromolecule catabolic process GO:0044265 206 0.026
embryonic organ morphogenesis GO:0048562 276 0.026
mesodermal cell migration GO:0008078 4 0.026
circadian sleep wake cycle rem sleep GO:0042747 1 0.026
synaptic transmission GO:0007268 329 0.026
peptidyl amino acid modification GO:0018193 336 0.026
nitrogen compound transport GO:0071705 271 0.025
chemotaxis GO:0006935 247 0.025
hormone secretion GO:0046879 128 0.025
response to radiation GO:0009314 165 0.025
synaptic vesicle transport GO:0048489 57 0.024
posttranscriptional regulation of gene expression GO:0010608 155 0.024
regulation of organelle organization GO:0033043 289 0.024
peptide secretion GO:0002790 114 0.024
positive regulation of cell death GO:0010942 224 0.024
cell growth GO:0016049 130 0.024
chromatin organization GO:0006325 206 0.024
immune effector process GO:0002252 321 0.023
cellular lipid metabolic process GO:0044255 323 0.023
macromolecule catabolic process GO:0009057 281 0.023
nuclear division GO:0000280 158 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
acetate ester transport GO:1901374 2 0.023
neuron projection extension GO:1990138 64 0.023
regulation of secretion by cell GO:1903530 249 0.023
establishment of synaptic vesicle localization GO:0097480 57 0.023
morphogenesis of embryonic epithelium GO:0016331 159 0.022
positive regulation of nervous system development GO:0051962 221 0.022
synaptic transmission involved in micturition GO:0060084 3 0.022
carboxylic acid transport GO:0046942 100 0.022
sensory organ morphogenesis GO:0090596 242 0.022
ear development GO:0043583 200 0.022
organic anion transport GO:0015711 137 0.022
endomembrane system organization GO:0010256 147 0.022
single organismal cell cell adhesion GO:0016337 131 0.022
glycosyl compound metabolic process GO:1901657 246 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.021
regulation of feeding behavior GO:0060259 3 0.021
stem cell development GO:0048864 219 0.021
wnt signaling pathway GO:0016055 188 0.021
microtubule cytoskeleton organization GO:0000226 157 0.021
forebrain development GO:0030900 302 0.021
regulation of hormone levels GO:0010817 211 0.021
respiratory system development GO:0060541 190 0.021
organelle fission GO:0048285 170 0.021
purine ribonucleotide metabolic process GO:0009150 290 0.021
mrna processing GO:0006397 63 0.021
protein targeting GO:0006605 143 0.021
oxidation reduction process GO:0055114 342 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
cytoplasmic transport GO:0016482 234 0.020
neural tube development GO:0021915 160 0.020
regulation of peptide transport GO:0090087 91 0.020
spinal cord development GO:0021510 81 0.020
cation transport GO:0006812 399 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.020
negative regulation of cellular amine metabolic process GO:0033239 1 0.020
intrinsic apoptotic signaling pathway GO:0097193 132 0.020
establishment of vesicle localization GO:0051650 81 0.020
axoneme assembly GO:0035082 15 0.020
response to growth factor GO:0070848 198 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
Worm
endocytosis GO:0006897 168 0.019
Worm
cellular response to growth factor stimulus GO:0071363 197 0.019
regulation of ion transport GO:0043269 215 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.019
purine nucleoside metabolic process GO:0042278 241 0.019
apoptotic signaling pathway GO:0097190 306 0.019
heterocycle catabolic process GO:0046700 280 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
rhythmic process GO:0048511 174 0.019
stem cell maintenance GO:0019827 130 0.019
dendrite development GO:0016358 115 0.019
nucleoside catabolic process GO:0009164 206 0.019
positive regulation of cellular component biogenesis GO:0044089 94 0.019
regulation of neuron death GO:1901214 134 0.019
peptide hormone secretion GO:0030072 109 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
purine nucleotide metabolic process GO:0006163 302 0.018
detection of abiotic stimulus GO:0009582 60 0.018
stem cell differentiation GO:0048863 268 0.018
purine containing compound metabolic process GO:0072521 311 0.018
nucleoside metabolic process GO:0009116 246 0.018
macromolecule methylation GO:0043414 120 0.018
regulation of cell adhesion GO:0030155 154 0.018
cellular protein complex assembly GO:0043623 116 0.018
sulfur compound metabolic process GO:0006790 100 0.018
cellular nitrogen compound catabolic process GO:0044270 280 0.018
organelle assembly GO:0070925 177 0.018
central nervous system neuron differentiation GO:0021953 162 0.017
cellular ketone metabolic process GO:0042180 84 0.017
methylation GO:0032259 134 0.017
protein catabolic process GO:0030163 221 0.017
calcium ion homeostasis GO:0055074 127 0.017
intracellular protein transport GO:0006886 204 0.017
spermatid development GO:0007286 108 0.017
regulation of anatomical structure size GO:0090066 178 0.017
synapse assembly GO:0007416 56 0.017
photoreceptor cell maintenance GO:0045494 19 0.017
nucleotide catabolic process GO:0009166 217 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
covalent chromatin modification GO:0016569 163 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
mitochondrion distribution GO:0048311 4 0.017
sensory perception of mechanical stimulus GO:0050954 107 0.017
cell type specific apoptotic process GO:0097285 268 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.017
positive regulation of organelle organization GO:0010638 128 0.017
epithelial tube formation GO:0072175 130 0.017
regulation of transmembrane transport GO:0034762 128 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
lateral inhibition GO:0046331 1 0.016
cellular protein catabolic process GO:0044257 155 0.016
regulation of protein kinase activity GO:0045859 232 0.016
Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.016
photoreceptor cell differentiation GO:0046530 52 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
nucleoside triphosphate catabolic process GO:0009143 205 0.016
response to light stimulus GO:0009416 135 0.016
regulation of secretion GO:0051046 274 0.016
cellular calcium ion homeostasis GO:0006874 119 0.016
regulation of voltage gated calcium channel activity GO:1901385 4 0.016
ribonucleoside triphosphate metabolic process GO:0009199 220 0.016
negative regulation of protein metabolic process GO:0051248 282 0.016
central nervous system neuron development GO:0021954 67 0.016
carbohydrate derivative biosynthetic process GO:1901137 183 0.016
mitotic cell cycle GO:0000278 195 0.016
regulation of cell cycle GO:0051726 281 0.016
positive regulation of growth GO:0045927 104 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.015
cellular response to abiotic stimulus GO:0071214 56 0.015
chromatin modification GO:0016568 187 0.015
monocarboxylic acid metabolic process GO:0032787 191 0.015
retina morphogenesis in camera type eye GO:0060042 45 0.015
histone modification GO:0016570 159 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
regulation of purine nucleotide metabolic process GO:1900542 169 0.015
positive regulation of secretion by cell GO:1903532 114 0.015
regulation of exocytosis GO:0017157 61 0.015
single organism cell adhesion GO:0098602 156 0.015
striated muscle tissue development GO:0014706 293 0.015
multicellular organism growth GO:0035264 161 0.015
learning GO:0007612 98 0.015
spermatid differentiation GO:0048515 115 0.015
carbohydrate homeostasis GO:0033500 128 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
regulation of protein catabolic process GO:0042176 108 0.015
sensory system development GO:0048880 3 0.015
neural retina development GO:0003407 41 0.015
glucose homeostasis GO:0042593 128 0.015
inorganic ion transmembrane transport GO:0098660 234 0.014
developmental cell growth GO:0048588 84 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
anion transport GO:0006820 177 0.014
divalent metal ion transport GO:0070838 172 0.014
detection of external stimulus GO:0009581 61 0.014
ribonucleoside triphosphate catabolic process GO:0009203 199 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
muscle cell differentiation GO:0042692 261 0.014
dephosphorylation GO:0016311 129 0.014
lateral line system development GO:0048925 1 0.014
regulation of protein processing GO:0070613 96 0.014
detection of stimulus GO:0051606 84 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
oocyte construction GO:0007308 2 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
purine nucleotide catabolic process GO:0006195 211 0.014
calcium ion transmembrane transport GO:0070588 85 0.014
regulation of multi organism process GO:0043900 111 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.014
regulation of norepinephrine secretion GO:0014061 2 0.014
mesoderm development GO:0007498 100 0.013
calcium ion transport GO:0006816 159 0.013
cellular chemical homeostasis GO:0055082 215 0.013
spermatogenesis GO:0007283 284 0.013
regulation of chromatin modification GO:1903308 57 0.013
leukocyte mediated immunity GO:0002443 174 0.013
anatomical structure homeostasis GO:0060249 145 0.013
sensory perception of sound GO:0007605 97 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
inner ear morphogenesis GO:0042472 101 0.013
ovulation cycle GO:0042698 59 0.013
glycerolipid metabolic process GO:0046486 122 0.013
retina homeostasis GO:0001895 23 0.013
ras protein signal transduction GO:0007265 77 0.013
defecation GO:0030421 1 0.013
somatotropin secreting cell differentiation GO:0060126 4 0.013
digestive tract morphogenesis GO:0048546 147 0.013
regulation of synapse assembly GO:0051963 29 0.013
rna processing GO:0006396 105 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
positive regulation of cell development GO:0010720 237 0.013
regulation of transferase activity GO:0051338 263 0.013
Worm
female gamete generation GO:0007292 74 0.013
protein localization to organelle GO:0033365 185 0.013
mrna splicing via spliceosome GO:0000398 43 0.013
purine ribonucleoside catabolic process GO:0046130 205 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
potassium ion transport GO:0006813 52 0.013
regulation of hormone secretion GO:0046883 88 0.013
regulation of protein transport GO:0051223 163 0.013
organophosphate catabolic process GO:0046434 232 0.013
tube formation GO:0035148 140 0.013
insulin secretion GO:0030073 89 0.013
regulation of nucleotide metabolic process GO:0006140 169 0.013
negative regulation of wnt signaling pathway GO:0030178 73 0.012
embryonic skeletal system development GO:0048706 120 0.012
negative regulation of cell development GO:0010721 169 0.012
terminal button organization GO:0072553 3 0.012
skin development GO:0043588 220 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
amide transport GO:0042886 138 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
pancreatic a cell fate commitment GO:0003326 2 0.012
regulation of chromosome organization GO:0033044 83 0.012
regulation of intracellular transport GO:0032386 159 0.012
meiotic nuclear division GO:0007126 115 0.012
muscle tissue development GO:0060537 308 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
protein localization to membrane GO:0072657 108 0.012
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure GO:0001988 1 0.012
regulation of synaptic plasticity GO:0048167 87 0.012
regulation of hydrolase activity GO:0051336 246 0.012
mapk cascade GO:0000165 281 0.012
Worm
calcium ion dependent exocytosis GO:0017156 35 0.012
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.012
modification dependent macromolecule catabolic process GO:0043632 133 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
baroreceptor response to decreased systemic arterial blood pressure GO:0001982 2 0.012
mitotic cell cycle process GO:1903047 159 0.012
regulation of postsynaptic membrane potential GO:0060078 48 0.012
rna splicing GO:0008380 54 0.012
eye photoreceptor cell differentiation GO:0001754 41 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.012
Worm
modification dependent protein catabolic process GO:0019941 133 0.012
regulation of neural retina development GO:0061074 3 0.012
establishment or maintenance of cell polarity GO:0007163 86 0.012
regulation of embryonic development GO:0045995 71 0.012
leukocyte differentiation GO:0002521 342 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
proteasomal protein catabolic process GO:0010498 98 0.011
rap protein signal transduction GO:0032486 3 0.011
circulatory system process GO:0003013 197 0.011
adult walking behavior GO:0007628 41 0.011
lipid localization GO:0010876 126 0.011
oogenesis GO:0048477 56 0.011
epithelial cell development GO:0002064 159 0.011
lipid transport GO:0006869 98 0.011
cell recognition GO:0008037 83 0.011
skeletal muscle organ development GO:0060538 163 0.011
positive regulation of neuron differentiation GO:0045666 141 0.011
regulation of retina development in camera type eye GO:1902866 3 0.011
meiotic cell cycle GO:0051321 122 0.011
neuroblast differentiation GO:0014016 2 0.011
regulation of translation GO:0006417 71 0.011
b cell activation GO:0042113 161 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
mrna metabolic process GO:0016071 84 0.011
extracellular matrix organization GO:0030198 147 0.011
peptidyl lysine modification GO:0018205 77 0.011
neural tube closure GO:0001843 90 0.011
regulation of lymphocyte mediated immunity GO:0002706 84 0.011
neuron death GO:0070997 154 0.011
adult locomotory behavior GO:0008344 91 0.011
regulation of lymphocyte activation GO:0051249 240 0.011
cellular homeostasis GO:0019725 240 0.011
protein maturation GO:0051604 176 0.011
nuclear transport GO:0051169 139 0.011
regulation of cell activation GO:0050865 289 0.011
gastrulation GO:0007369 116 0.011
membrane depolarization GO:0051899 64 0.011
synaptic transmission cholinergic GO:0007271 7 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.010
protein import GO:0017038 101 0.010
cartilage development GO:0051216 140 0.010
regulation of cell motility GO:2000145 236 0.010
maternal determination of anterior posterior axis embryo GO:0008358 2 0.010
epidermis development GO:0008544 187 0.010
hindbrain development GO:0030902 128 0.010
multi multicellular organism process GO:0044706 109 0.010
peptide transport GO:0015833 133 0.010
intracellular distribution of mitochondria GO:0048312 1 0.010
deltoid tuberosity development GO:0035993 3 0.010
exocytosis GO:0006887 121 0.010
multi organism behavior GO:0051705 62 0.010
regulation of cell growth GO:0001558 91 0.010
protein homotrimerization GO:0070207 4 0.010
axon cargo transport GO:0008088 33 0.010
regulation of cytokine production GO:0001817 266 0.010
regulation of extent of cell growth GO:0061387 52 0.010
regulation of stem cell differentiation GO:2000736 50 0.010
regulation of apoptotic signaling pathway GO:2001233 197 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
t cell activation GO:0042110 289 0.010
engulfment of apoptotic cell GO:0043652 3 0.010
mitochondrion organization GO:0007005 134 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
somite development GO:0061053 81 0.010

Sarm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.024
disease of anatomical entity DOID:7 0 0.024
eye and adnexa disease DOID:1492 0 0.024
nervous system disease DOID:863 0 0.024
eye disease DOID:5614 0 0.024
retinal disease DOID:5679 0 0.019
retinal degeneration DOID:8466 0 0.015
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.011