Mus musculus

26 known processes

Plcz1

phospholipase C, zeta 1

(Aliases: PLCzeta,MGC123405,MGC123406,1700041H07Rik)

Plcz1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transmembrane transport GO:0034220 361 0.322
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.074
nucleobase containing small molecule metabolic process GO:0055086 352 0.072
transmembrane transport GO:0055085 412 0.071
Mouse
nitrogen compound transport GO:0071705 271 0.069
cellular ketone metabolic process GO:0042180 84 0.065
nucleoside phosphate metabolic process GO:0006753 338 0.064
positive regulation of cellular amine metabolic process GO:0033240 5 0.063
positive regulation of protein modification process GO:0031401 299 0.061
regulation of cellular amino acid metabolic process GO:0006521 5 0.060
ribose phosphate metabolic process GO:0019693 291 0.059
organic anion transport GO:0015711 137 0.058
purine ribonucleotide metabolic process GO:0009150 290 0.057
sensory perception GO:0007600 245 0.055
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.053
nucleotide metabolic process GO:0009117 332 0.053
metal ion homeostasis GO:0055065 189 0.051
Mouse
membrane organization GO:0061024 245 0.050
anion transport GO:0006820 177 0.049
male gamete generation GO:0048232 285 0.049
adult behavior GO:0030534 135 0.048
nucleoside triphosphate catabolic process GO:0009143 205 0.048
ribonucleotide catabolic process GO:0009261 208 0.045
purine ribonucleotide catabolic process GO:0009154 208 0.044
carbohydrate derivative catabolic process GO:1901136 231 0.044
purine nucleotide metabolic process GO:0006163 302 0.044
ribonucleoside metabolic process GO:0009119 245 0.043
positive regulation of mapk cascade GO:0043410 170 0.043
macromolecule catabolic process GO:0009057 281 0.043
protein catabolic process GO:0030163 221 0.043
purine containing compound metabolic process GO:0072521 311 0.042
purine nucleoside metabolic process GO:0042278 241 0.042
purine containing compound catabolic process GO:0072523 213 0.042
regulation of kinase activity GO:0043549 249 0.042
stem cell differentiation GO:0048863 268 0.042
regulation of hydrolase activity GO:0051336 246 0.042
cellular nitrogen compound catabolic process GO:0044270 280 0.041
positive regulation of protein phosphorylation GO:0001934 242 0.041
purine ribonucleoside metabolic process GO:0046128 241 0.040
carbohydrate metabolic process GO:0005975 230 0.040
cation transmembrane transport GO:0098655 266 0.039
Mouse
leukocyte differentiation GO:0002521 342 0.039
Mouse
nucleoside metabolic process GO:0009116 246 0.037
cellular amine metabolic process GO:0044106 44 0.037
cation transport GO:0006812 399 0.037
organophosphate catabolic process GO:0046434 232 0.037
response to light stimulus GO:0009416 135 0.036
ossification GO:0001503 216 0.036
regulation of transferase activity GO:0051338 263 0.036
aromatic compound catabolic process GO:0019439 286 0.036
glycosyl compound catabolic process GO:1901658 206 0.036
heterocycle catabolic process GO:0046700 280 0.035
inorganic ion transmembrane transport GO:0098660 234 0.035
Mouse
blood vessel morphogenesis GO:0048514 285 0.034
Mouse
cell adhesion GO:0007155 329 0.033
ribonucleoside triphosphate metabolic process GO:0009199 220 0.033
organic cyclic compound catabolic process GO:1901361 295 0.033
purine nucleoside triphosphate catabolic process GO:0009146 203 0.033
response to radiation GO:0009314 165 0.033
ribonucleotide metabolic process GO:0009259 291 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
organonitrogen compound catabolic process GO:1901565 264 0.032
cation homeostasis GO:0055080 212 0.031
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.031
cellular chemical homeostasis GO:0055082 215 0.031
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.031
regulation of purine nucleotide metabolic process GO:1900542 169 0.031
muscle contraction GO:0006936 101 0.030
nucleoside triphosphate metabolic process GO:0009141 230 0.030
cellular homeostasis GO:0019725 240 0.030
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.030
cytoplasmic transport GO:0016482 234 0.030
Mouse
nucleotide catabolic process GO:0009166 217 0.030
purine nucleoside triphosphate metabolic process GO:0009144 226 0.029
purine nucleotide catabolic process GO:0006195 211 0.028
nucleoside catabolic process GO:0009164 206 0.028
cellular divalent inorganic cation homeostasis GO:0072503 127 0.028
Mouse
cellular amino acid metabolic process GO:0006520 103 0.028
microtubule based process GO:0007017 236 0.028
regulation of membrane potential GO:0042391 192 0.028
action potential GO:0001508 78 0.027
glycosyl compound metabolic process GO:1901657 246 0.027
cellular metal ion homeostasis GO:0006875 151 0.027
Mouse
regulation of cell projection organization GO:0031344 206 0.027
purine nucleoside catabolic process GO:0006152 205 0.027
regulation of ion transport GO:0043269 215 0.026
Mouse
response to growth factor GO:0070848 198 0.026
positive regulation of kinase activity GO:0033674 155 0.026
cellular ion homeostasis GO:0006873 165 0.026
Mouse
actin cytoskeleton organization GO:0030036 220 0.026
muscle system process GO:0003012 141 0.026
regulation of actin filament based process GO:0032970 99 0.025
positive regulation of transferase activity GO:0051347 167 0.025
regulation of homeostatic process GO:0032844 182 0.025
Mouse
regulation of transmembrane transport GO:0034762 128 0.025
Mouse
divalent inorganic cation transport GO:0072511 178 0.025
purine ribonucleoside catabolic process GO:0046130 205 0.025
ear development GO:0043583 200 0.025
peptide transport GO:0015833 133 0.025
amide transport GO:0042886 138 0.025
regulation of cell migration GO:0030334 219 0.024
circulatory system process GO:0003013 197 0.024
regulation of mapk cascade GO:0043408 248 0.024
positive regulation of cellular catabolic process GO:0031331 148 0.024
peptidyl amino acid modification GO:0018193 336 0.024
Mouse
regulation of muscle system process GO:0090257 80 0.023
cellular response to organonitrogen compound GO:0071417 145 0.023
inorganic cation transmembrane transport GO:0098662 207 0.023
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.023
regulation of organelle organization GO:0033043 289 0.023
carboxylic acid transport GO:0046942 100 0.023
amine metabolic process GO:0009308 45 0.023
regulation of ion transmembrane transport GO:0034765 119 0.023
Mouse
regionalization GO:0003002 337 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
cytokine production GO:0001816 319 0.022
regulation of hormone levels GO:0010817 211 0.022
response to transforming growth factor beta GO:0071559 88 0.022
regulation of metal ion transport GO:0010959 106 0.022
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
regulation of blood circulation GO:1903522 93 0.022
learning or memory GO:0007611 148 0.022
cognition GO:0050890 149 0.022
positive regulation of hydrolase activity GO:0051345 148 0.022
multicellular organismal signaling GO:0035637 91 0.021
regulation of cellular component biogenesis GO:0044087 181 0.021
leukocyte proliferation GO:0070661 172 0.021
Mouse
regulation of secretion GO:0051046 274 0.021
regulation of cell adhesion GO:0030155 154 0.021
homeostasis of number of cells GO:0048872 210 0.021
response to organic cyclic compound GO:0014070 198 0.020
single fertilization GO:0007338 82 0.020
regulation of defense response GO:0031347 233 0.020
negative regulation of growth GO:0045926 99 0.020
locomotory behavior GO:0007626 195 0.020
skeletal system development GO:0001501 356 0.020
positive regulation of cell development GO:0010720 237 0.020
skin development GO:0043588 220 0.020
carbohydrate derivative biosynthetic process GO:1901137 183 0.020
negative regulation of immune system process GO:0002683 209 0.020
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
mapk cascade GO:0000165 281 0.020
regulation of protein kinase activity GO:0045859 232 0.020
g protein coupled receptor signaling pathway GO:0007186 243 0.020
Mouse
positive regulation of cell migration GO:0030335 109 0.020
extracellular matrix organization GO:0030198 147 0.020
regulation of secretion by cell GO:1903530 249 0.019
cytosolic calcium ion homeostasis GO:0051480 70 0.019
Mouse
regulation of cellular catabolic process GO:0031329 242 0.019
ras protein signal transduction GO:0007265 77 0.019
transmission of nerve impulse GO:0019226 76 0.019
embryonic organ morphogenesis GO:0048562 276 0.019
multicellular organism growth GO:0035264 161 0.019
monocarboxylic acid metabolic process GO:0032787 191 0.019
axonogenesis GO:0007409 274 0.019
developmental maturation GO:0021700 193 0.019
regulation of purine nucleotide catabolic process GO:0033121 122 0.019
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.019
regulation of anatomical structure size GO:0090066 178 0.019
positive regulation of cell motility GO:2000147 116 0.019
dephosphorylation GO:0016311 129 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
regulation of cytoskeleton organization GO:0051493 122 0.018
t cell activation GO:0042110 289 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
organic acid transport GO:0015849 101 0.018
sequestering of calcium ion GO:0051208 18 0.018
Mouse
adaptive immune response GO:0002250 155 0.018
nuclear transport GO:0051169 139 0.018
regulation of protein catabolic process GO:0042176 108 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
adult locomotory behavior GO:0008344 91 0.018
intracellular protein transport GO:0006886 204 0.018
cellular calcium ion homeostasis GO:0006874 119 0.018
Mouse
cell type specific apoptotic process GO:0097285 268 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
regulation of cell activation GO:0050865 289 0.018
calcium ion transport GO:0006816 159 0.018
muscle tissue development GO:0060537 308 0.017
regulation of muscle contraction GO:0006937 49 0.017
spermatogenesis GO:0007283 284 0.017
digestive tract development GO:0048565 190 0.017
negative regulation of protein metabolic process GO:0051248 282 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.017
regulation of system process GO:0044057 200 0.017
endocytosis GO:0006897 168 0.017
sequestering of metal ion GO:0051238 19 0.017
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.017
t cell differentiation GO:0030217 174 0.017
positive regulation of nervous system development GO:0051962 221 0.017
respiratory system development GO:0060541 190 0.017
regulation of protein transport GO:0051223 163 0.017
response to organonitrogen compound GO:0010243 246 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.017
heart morphogenesis GO:0003007 178 0.017
peptide hormone secretion GO:0030072 109 0.017
peptide secretion GO:0002790 114 0.017
anion transmembrane transport GO:0098656 71 0.016
myeloid cell differentiation GO:0030099 233 0.016
regulation of cellular component size GO:0032535 121 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
Mouse
glycerolipid metabolic process GO:0046486 122 0.016
Mouse
synaptic transmission GO:0007268 329 0.016
Mouse
cellular response to lipid GO:0071396 145 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
neural precursor cell proliferation GO:0061351 121 0.016
positive regulation of nucleotide metabolic process GO:0045981 114 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
cellular protein complex assembly GO:0043623 116 0.016
exocytosis GO:0006887 121 0.016
Mouse
forebrain development GO:0030900 302 0.016
regulation of cell motility GO:2000145 236 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
carbohydrate transport GO:0008643 62 0.016
response to peptide hormone GO:0043434 127 0.016
rhodopsin mediated signaling pathway GO:0016056 4 0.016
positive regulation of neuron differentiation GO:0045666 141 0.016
calcium ion homeostasis GO:0055074 127 0.015
Mouse
microtubule based movement GO:0007018 84 0.015
regulation of protein complex assembly GO:0043254 83 0.015
sensory perception of light stimulus GO:0050953 54 0.015
regulation of leukocyte differentiation GO:1902105 159 0.015
glycoprotein metabolic process GO:0009100 116 0.015
regulation of lymphocyte activation GO:0051249 240 0.015
regulation of proteolysis GO:0030162 164 0.015
stem cell development GO:0048864 219 0.015
regulation of ossification GO:0030278 112 0.015
leukocyte homeostasis GO:0001776 79 0.015
protein processing GO:0016485 163 0.015
regulation of cell cycle GO:0051726 281 0.015
organic hydroxy compound metabolic process GO:1901615 203 0.015
Mouse
sterol homeostasis GO:0055092 45 0.015
epithelial cell development GO:0002064 159 0.015
myotube differentiation GO:0014902 105 0.015
kidney development GO:0001822 213 0.015
protein localization to organelle GO:0033365 185 0.015
protein maturation GO:0051604 176 0.015
tissue remodeling GO:0048771 102 0.015
renal system development GO:0072001 225 0.015
protein ubiquitination GO:0016567 171 0.015
gtp metabolic process GO:0046039 144 0.015
lymphocyte proliferation GO:0046651 164 0.015
Mouse
positive regulation of apoptotic process GO:0043065 217 0.014
positive regulation of nucleoside metabolic process GO:0045979 91 0.014
maintenance of location GO:0051235 89 0.014
Mouse
organophosphate biosynthetic process GO:0090407 122 0.014
Mouse
response to lipopolysaccharide GO:0032496 128 0.014
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
lymphocyte differentiation GO:0030098 242 0.014
Mouse
response to amino acid GO:0043200 37 0.014
negative regulation of protein modification process GO:0031400 163 0.014
neuromuscular process GO:0050905 99 0.014
neuron apoptotic process GO:0051402 142 0.014
regulation of neuron differentiation GO:0045664 281 0.014
neuron death GO:0070997 154 0.014
monosaccharide metabolic process GO:0005996 106 0.014
dna metabolic process GO:0006259 303 0.014
cell substrate adhesion GO:0031589 130 0.014
lipid transport GO:0006869 98 0.014
immune effector process GO:0002252 321 0.014
Mouse
regulation of postsynaptic membrane potential GO:0060078 48 0.014
cellular protein catabolic process GO:0044257 155 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
hormone secretion GO:0046879 128 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
positive regulation of nucleotide catabolic process GO:0030813 88 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
regulation of nucleotide catabolic process GO:0030811 122 0.014
spleen development GO:0048536 39 0.014
regulation of leukocyte proliferation GO:0070663 121 0.013
protein localization to membrane GO:0072657 108 0.013
response to extracellular stimulus GO:0009991 127 0.013
heart process GO:0003015 94 0.013
neuronal action potential GO:0019228 54 0.013
sensory perception of sound GO:0007605 97 0.013
t cell proliferation GO:0042098 120 0.013
biomineral tissue development GO:0031214 64 0.013
regulation of protein localization GO:0032880 231 0.013
camera type eye development GO:0043010 266 0.013
cell growth GO:0016049 130 0.013
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.013
regulation of lymphocyte proliferation GO:0050670 117 0.013
positive regulation of cell adhesion GO:0045785 80 0.013
sulfur compound metabolic process GO:0006790 100 0.013
neuron neuron synaptic transmission GO:0007270 69 0.013
Mouse
respiratory tube development GO:0030323 167 0.013
sterol metabolic process GO:0016125 58 0.013
engulfment of apoptotic cell GO:0043652 3 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
regulation of inflammatory response GO:0050727 147 0.013
photoreceptor cell morphogenesis GO:0008594 3 0.013
gtp catabolic process GO:0006184 143 0.013
regulation of t cell activation GO:0050863 170 0.013
response to temperature stimulus GO:0009266 55 0.012
organelle localization GO:0051640 179 0.012
glycosylation GO:0070085 62 0.012
negative regulation of molecular function GO:0044092 258 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
mesenchymal cell differentiation GO:0048762 107 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
detection of stimulus GO:0051606 84 0.012
eosinophil migration GO:0072677 3 0.012
regulation of stem cell proliferation GO:0072091 78 0.012
regulation of nucleoside metabolic process GO:0009118 130 0.012
gland development GO:0048732 330 0.012
extracellular structure organization GO:0043062 148 0.012
skeletal muscle organ development GO:0060538 163 0.012
epidermis development GO:0008544 187 0.012
detection of external stimulus GO:0009581 61 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
sensory organ morphogenesis GO:0090596 242 0.012
mitochondrion organization GO:0007005 134 0.012
protein localization to nucleus GO:0034504 121 0.012
endomembrane system organization GO:0010256 147 0.012
positive regulation of protein catabolic process GO:0045732 60 0.012
cellular response to hormone stimulus GO:0032870 150 0.012
regulation of eosinophil migration GO:2000416 2 0.012
positive regulation of defense response GO:0031349 124 0.012
chemotaxis GO:0006935 247 0.012
response to peptide GO:1901652 136 0.012
protein glycosylation GO:0006486 55 0.012
detection of abiotic stimulus GO:0009582 60 0.012
midgut development GO:0007494 4 0.012
protein import GO:0017038 101 0.012
striated muscle tissue development GO:0014706 293 0.012
regulation of heart contraction GO:0008016 77 0.012
skeletal system morphogenesis GO:0048705 203 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
regulation of neuron death GO:1901214 134 0.012
multi multicellular organism process GO:0044706 109 0.012
regulation of peptide transport GO:0090087 91 0.012
insulin secretion GO:0030073 89 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
bone mineralization GO:0030282 54 0.011
tissue homeostasis GO:0001894 115 0.011
sodium ion transport GO:0006814 73 0.011
response to acid chemical GO:0001101 111 0.011
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.011
sensory perception of chemical stimulus GO:0007606 51 0.011
Mouse
actin filament polymerization GO:0030041 44 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
positive regulation of cell activation GO:0050867 158 0.011
stem cell proliferation GO:0072089 117 0.011
cellular response to external stimulus GO:0071496 88 0.011
rho protein signal transduction GO:0007266 32 0.011
negative regulation of neuron differentiation GO:0045665 101 0.011
appendage development GO:0048736 166 0.011
spermatid development GO:0007286 108 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
telencephalon development GO:0021537 186 0.011
olfactory learning GO:0008355 2 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
negative regulation of neuron death GO:1901215 98 0.011
apoptotic signaling pathway GO:0097190 306 0.011
nucleoside monophosphate metabolic process GO:0009123 85 0.011
steroid metabolic process GO:0008202 119 0.011
protein polymerization GO:0051258 57 0.011
negative regulation of muscle contraction GO:0045932 12 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
bone development GO:0060348 120 0.011
neuron migration GO:0001764 122 0.011
anatomical structure homeostasis GO:0060249 145 0.011
digestive system development GO:0055123 200 0.011
positive regulation of thymocyte migration GO:2000412 2 0.011
regulation of actin cytoskeleton organization GO:0032956 84 0.011
cell division GO:0051301 120 0.011
synapse organization GO:0050808 125 0.011
ribonucleoside monophosphate catabolic process GO:0009158 57 0.011
developmental cell growth GO:0048588 84 0.011
angiogenesis GO:0001525 201 0.011
Mouse
smooth muscle contraction GO:0006939 44 0.011
carbohydrate homeostasis GO:0033500 128 0.011
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.010
muscle cell differentiation GO:0042692 261 0.010
divalent metal ion transport GO:0070838 172 0.010
connective tissue development GO:0061448 179 0.010
posttranscriptional regulation of gene expression GO:0010608 155 0.010
nuclear import GO:0051170 95 0.010
multicellular organismal homeostasis GO:0048871 164 0.010
regulation of organ morphogenesis GO:2000027 144 0.010
spermatid differentiation GO:0048515 115 0.010
immune response regulating signaling pathway GO:0002764 125 0.010
Mouse
cellular response to extracellular stimulus GO:0031668 81 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
positive regulation of inflammatory response GO:0050729 47 0.010
positive regulation of leukocyte differentiation GO:1902107 86 0.010
regulation of leukocyte apoptotic process GO:2000106 56 0.010
lung development GO:0030324 164 0.010
positive regulation of eosinophil migration GO:2000418 2 0.010
atp catabolic process GO:0006200 55 0.010
positive regulation of proteolysis GO:0045862 85 0.010
cellular response to peptide GO:1901653 92 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010
negative regulation of neuron apoptotic process GO:0043524 92 0.010
protein import into nucleus GO:0006606 95 0.010
single organism cell adhesion GO:0098602 156 0.010
visual learning GO:0008542 44 0.010
organonitrogen compound biosynthetic process GO:1901566 192 0.010
cardiac muscle contraction GO:0060048 32 0.010
mesenchyme development GO:0060485 152 0.010
glucose metabolic process GO:0006006 92 0.010
response to steroid hormone GO:0048545 56 0.010
digestion GO:0007586 40 0.010
neuron projection guidance GO:0097485 141 0.010
ribonucleoside monophosphate metabolic process GO:0009161 80 0.010
gliogenesis GO:0042063 141 0.010
glial cell development GO:0021782 54 0.010

Plcz1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
nervous system disease DOID:863 0 0.046
sensory system disease DOID:0050155 0 0.026
eye and adnexa disease DOID:1492 0 0.020
eye disease DOID:5614 0 0.016
retinal disease DOID:5679 0 0.011
retinal degeneration DOID:8466 0 0.010