Mus musculus

216 known processes

Pink1

PTEN induced putative kinase 1

(Aliases: AU042772,1190006F07Rik,BRPK,AW557854,mFLJ00387)

Pink1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 342 0.099
cofactor metabolic process GO:0051186 80 0.069
cellular ketone metabolic process GO:0042180 84 0.057
camera type eye development GO:0043010 266 0.057
regulation of cellular ketone metabolic process GO:0010565 66 0.054
organic acid biosynthetic process GO:0016053 86 0.049
cellular amino acid metabolic process GO:0006520 103 0.047
protein catabolic process GO:0030163 221 0.045
Fly
lipid biosynthetic process GO:0008610 179 0.045
fat cell differentiation GO:0045444 160 0.044
regulation of fatty acid biosynthetic process GO:0042304 12 0.041
monocarboxylic acid biosynthetic process GO:0072330 61 0.041
transmembrane transport GO:0055085 412 0.040
regulation of cellular amine metabolic process GO:0033238 20 0.038
regulation of cell cycle process GO:0010564 160 0.038
dna metabolic process GO:0006259 303 0.037
fatty acid metabolic process GO:0006631 121 0.035
cellular response to dna damage stimulus GO:0006974 207 0.034
peptidyl amino acid modification GO:0018193 336 0.034
Human
response to radiation GO:0009314 165 0.032
muscle tissue development GO:0060537 308 0.032
nitrogen compound transport GO:0071705 271 0.031
macromolecule catabolic process GO:0009057 281 0.031
Fly
coenzyme metabolic process GO:0006732 52 0.031
response to light stimulus GO:0009416 135 0.031
cellular response to cytokine stimulus GO:0071345 189 0.030
amine metabolic process GO:0009308 45 0.030
negative regulation of cellular protein metabolic process GO:0032269 247 0.030
monosaccharide metabolic process GO:0005996 106 0.029
thioester biosynthetic process GO:0035384 7 0.028
generation of precursor metabolites and energy GO:0006091 103 0.028
hexose metabolic process GO:0019318 98 0.028
cellular carbohydrate metabolic process GO:0044262 119 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
striated muscle tissue development GO:0014706 293 0.027
anatomical structure homeostasis GO:0060249 145 0.027
regulation of lipid metabolic process GO:0019216 118 0.026
energy derivation by oxidation of organic compounds GO:0015980 77 0.026
regulation of cellular amino acid metabolic process GO:0006521 5 0.026
small molecule biosynthetic process GO:0044283 132 0.025
cellular response to hormone stimulus GO:0032870 150 0.025
response to peptide GO:1901652 136 0.025
chromatin organization GO:0006325 206 0.025
stem cell differentiation GO:0048863 268 0.025
carbohydrate metabolic process GO:0005975 230 0.025
regulation of homeostatic process GO:0032844 182 0.025
negative regulation of protein modification process GO:0031400 163 0.025
carboxylic acid biosynthetic process GO:0046394 86 0.024
cellular lipid metabolic process GO:0044255 323 0.024
protein localization to organelle GO:0033365 185 0.024
positive regulation of cellular amine metabolic process GO:0033240 5 0.024
regulation of fatty acid oxidation GO:0046320 10 0.023
response to organonitrogen compound GO:0010243 246 0.023
response to extracellular stimulus GO:0009991 127 0.023
cellular amine metabolic process GO:0044106 44 0.023
response to peptide hormone GO:0043434 127 0.023
mitotic cell cycle GO:0000278 195 0.023
fat soluble vitamin biosynthetic process GO:0042362 4 0.022
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.022
regulation of transferase activity GO:0051338 263 0.022
cation transmembrane transport GO:0098655 266 0.022
thioester metabolic process GO:0035383 19 0.022
sensory perception GO:0007600 245 0.022
positive regulation of cell death GO:0010942 224 0.021
Human
chemotaxis GO:0006935 247 0.021
Worm
acyl coa biosynthetic process GO:0071616 7 0.021
cation transport GO:0006812 399 0.021
regulation of neuron differentiation GO:0045664 281 0.020
fatty acid biosynthetic process GO:0006633 41 0.020
negative regulation of cell cycle GO:0045786 123 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
regulation of cell cycle GO:0051726 281 0.020
nucleobase containing small molecule metabolic process GO:0055086 352 0.020
maintenance of location GO:0051235 89 0.020
positive regulation of programmed cell death GO:0043068 218 0.020
Human
inorganic ion transmembrane transport GO:0098660 234 0.020
axonogenesis GO:0007409 274 0.019
Worm
regulation of fatty acid metabolic process GO:0019217 28 0.019
regulation of organelle organization GO:0033043 289 0.019
Human Fly
sensory organ morphogenesis GO:0090596 242 0.019
aromatic compound catabolic process GO:0019439 286 0.019
connective tissue development GO:0061448 179 0.019
cellular macromolecule catabolic process GO:0044265 206 0.019
Fly
skeletal muscle organ development GO:0060538 163 0.018
heart morphogenesis GO:0003007 178 0.018
negative regulation of cellular component organization GO:0051129 194 0.018
Fly
chromatin modification GO:0016568 187 0.018
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.018
developmental growth involved in morphogenesis GO:0060560 138 0.018
Worm
action potential GO:0001508 78 0.018
reactive oxygen species metabolic process GO:0072593 84 0.018
transmission of nerve impulse GO:0019226 76 0.018
cellular response to organonitrogen compound GO:0071417 145 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
coenzyme biosynthetic process GO:0009108 23 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
substantia nigra development GO:0021762 2 0.017
circulatory system process GO:0003013 197 0.017
pyrimidine containing compound catabolic process GO:0072529 3 0.017
regulation of ion transport GO:0043269 215 0.017
negative regulation of organelle organization GO:0010639 90 0.017
Fly
organelle fission GO:0048285 170 0.017
Fly
negative regulation of cell proliferation GO:0008285 296 0.017
regulation of circadian sleep wake cycle GO:0042749 3 0.017
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.017
stem cell maintenance GO:0019827 130 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
ras protein signal transduction GO:0007265 77 0.016
polysaccharide metabolic process GO:0005976 39 0.016
histone modification GO:0016570 159 0.016
rhythmic process GO:0048511 174 0.016
nucleocytoplasmic transport GO:0006913 139 0.016
negative regulation of protein metabolic process GO:0051248 282 0.016
glucose metabolic process GO:0006006 92 0.016
mitotic cell cycle process GO:1903047 159 0.016
male gamete generation GO:0048232 285 0.015
cation homeostasis GO:0055080 212 0.015
translation GO:0006412 93 0.015
fertilization GO:0009566 127 0.015
digestive system development GO:0055123 200 0.015
t cell activation GO:0042110 289 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
Human
microtubule based process GO:0007017 236 0.015
carbohydrate biosynthetic process GO:0016051 74 0.015
blood circulation GO:0008015 195 0.015
methylation GO:0032259 134 0.015
apoptotic signaling pathway GO:0097190 306 0.015
hexose biosynthetic process GO:0019319 39 0.014
covalent chromatin modification GO:0016569 163 0.014
regulation of membrane potential GO:0042391 192 0.014
Human
defense response to other organism GO:0098542 197 0.014
cartilage development GO:0051216 140 0.014
dephosphorylation GO:0016311 129 0.014
cellular nitrogen compound catabolic process GO:0044270 280 0.014
homeostasis of number of cells GO:0048872 210 0.014
Zebrafish
regulation of transmembrane transport GO:0034762 128 0.014
nucleotide metabolic process GO:0009117 332 0.014
heart contraction GO:0060047 93 0.014
cellular response to nutrient levels GO:0031669 64 0.014
cellular response to growth factor stimulus GO:0071363 197 0.013
Zebrafish
stem cell development GO:0048864 219 0.013
cellular homeostasis GO:0019725 240 0.013
positive regulation of protein modification process GO:0031401 299 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
respiratory system development GO:0060541 190 0.013
cytokine production GO:0001816 319 0.013
acetyl coa biosynthetic process GO:0006085 5 0.013
meiotic nuclear division GO:0007126 115 0.013
blood vessel morphogenesis GO:0048514 285 0.013
adiponectin activated signaling pathway GO:0033211 4 0.013
cardiac muscle contraction GO:0060048 32 0.013
regulation of kinase activity GO:0043549 249 0.013
cell type specific apoptotic process GO:0097285 268 0.013
organic acid catabolic process GO:0016054 51 0.013
response to insulin GO:0032868 100 0.013
autophagy GO:0006914 45 0.013
Human Fly
response to growth factor GO:0070848 198 0.013
Zebrafish
mitochondrion organization GO:0007005 134 0.013
Human Zebrafish Worm Fly
nuclear division GO:0000280 158 0.013
regulation of chromosome organization GO:0033044 83 0.013
positive regulation of cell development GO:0010720 237 0.013
digestive tract development GO:0048565 190 0.013
regulation of voltage gated calcium channel activity GO:1901385 4 0.013
cellular response to lipid GO:0071396 145 0.013
alpha amino acid metabolic process GO:1901605 59 0.012
steroid metabolic process GO:0008202 119 0.012
response to acid chemical GO:0001101 111 0.012
anion transport GO:0006820 177 0.012
neuron apoptotic process GO:0051402 142 0.012
protein ubiquitination GO:0016567 171 0.012
Human Fly
cellular response to external stimulus GO:0071496 88 0.012
muscle cell differentiation GO:0042692 261 0.012
negative regulation of nervous system development GO:0051961 156 0.012
carboxylic acid transport GO:0046942 100 0.012
chromosome segregation GO:0007059 48 0.012
gland development GO:0048732 330 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
glucose homeostasis GO:0042593 128 0.012
protein methylation GO:0006479 81 0.012
small gtpase mediated signal transduction GO:0007264 97 0.012
cellular response to acid chemical GO:0071229 68 0.012
monosaccharide biosynthetic process GO:0046364 44 0.012
negative regulation of molecular function GO:0044092 258 0.012
limb development GO:0060173 166 0.012
nucleoside phosphate catabolic process GO:1901292 222 0.012
forebrain development GO:0030900 302 0.011
multicellular organismal signaling GO:0035637 91 0.011
gene silencing GO:0016458 38 0.011
epithelial tube formation GO:0072175 130 0.011
detection of external stimulus GO:0009581 61 0.011
positive regulation of organelle organization GO:0010638 128 0.011
Human Fly
retina development in camera type eye GO:0060041 119 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.011
myeloid cell homeostasis GO:0002262 114 0.011
Zebrafish
germ cell development GO:0007281 185 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.011
muscle contraction GO:0006936 101 0.011
ion transmembrane transport GO:0034220 361 0.011
endomembrane system organization GO:0010256 147 0.011
organic anion transport GO:0015711 137 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
regulation of defense response to bacterium GO:1900424 3 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
ribonucleotide biosynthetic process GO:0009260 59 0.011
spermatogenesis GO:0007283 284 0.011
organic cyclic compound catabolic process GO:1901361 295 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
regulation of carbohydrate metabolic process GO:0006109 75 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
meiosis i GO:0007127 60 0.011
l glutamate import into cell GO:1990123 3 0.011
protein localization to nucleus GO:0034504 121 0.011
carbohydrate transport GO:0008643 62 0.011
meiotic cell cycle GO:0051321 122 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.010
regulation of hormone levels GO:0010817 211 0.010
macromolecule methylation GO:0043414 120 0.010
regulation of chromatin modification GO:1903308 57 0.010
regulation of fat cell differentiation GO:0045598 81 0.010
male meiosis i GO:0007141 16 0.010
nuclear transport GO:0051169 139 0.010
sodium ion transport GO:0006814 73 0.010
acyl coa metabolic process GO:0006637 19 0.010
negative regulation of phosphate metabolic process GO:0045936 184 0.010
lateral inhibition GO:0046331 1 0.010
coenzyme catabolic process GO:0009109 5 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010
regulation of system process GO:0044057 200 0.010
multi multicellular organism process GO:0044706 109 0.010
positive regulation of fatty acid oxidation GO:0046321 4 0.010
macromolecular complex disassembly GO:0032984 43 0.010
regulation of cellular catabolic process GO:0031329 242 0.010
response to inorganic substance GO:0010035 96 0.010
Human
appendage development GO:0048736 166 0.010
tube formation GO:0035148 140 0.010
locomotory behavior GO:0007626 195 0.010
regulation of acyl coa biosynthetic process GO:0050812 4 0.010
mapk cascade GO:0000165 281 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010

Pink1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
Human
nervous system disease DOID:863 0 0.028
Human
eye and adnexa disease DOID:1492 0 0.027
sensory system disease DOID:0050155 0 0.027
eye disease DOID:5614 0 0.027
disease of metabolism DOID:0014667 0 0.019
inherited metabolic disorder DOID:655 0 0.015
retinal disease DOID:5679 0 0.014