Mus musculus

0 known processes

Tdp2

tyrosyl-DNA phosphodiesterase 2

(Aliases: Ttrap,D13Ertd656e)

Tdp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.422
Human
cellular response to dna damage stimulus GO:0006974 207 0.220
Human
cell cycle checkpoint GO:0000075 47 0.153
regulation of cell cycle process GO:0010564 160 0.152
dna repair GO:0006281 107 0.149
Human
organelle fission GO:0048285 170 0.140
cellular ketone metabolic process GO:0042180 84 0.124
cellular nitrogen compound catabolic process GO:0044270 280 0.112
mitotic nuclear division GO:0007067 48 0.097
heterocycle catabolic process GO:0046700 280 0.085
negative regulation of cell cycle GO:0045786 123 0.084
male gamete generation GO:0048232 285 0.075
regulation of mitotic cell cycle GO:0007346 126 0.075
mitotic cell cycle GO:0000278 195 0.074
apoptotic signaling pathway GO:0097190 306 0.072
mitotic chromosome condensation GO:0007076 1 0.068
macromolecule catabolic process GO:0009057 281 0.067
negative regulation of immune system process GO:0002683 209 0.064
regulation of organelle organization GO:0033043 289 0.063
dna replication GO:0006260 52 0.058
amp metabolic process GO:0046033 4 0.057
mitotic cell cycle process GO:1903047 159 0.057
homeostasis of number of cells GO:0048872 210 0.055
regulation of cell cycle GO:0051726 281 0.052
gonad development GO:0008406 141 0.052
spermatid development GO:0007286 108 0.052
chromosome segregation GO:0007059 48 0.049
nuclear division GO:0000280 158 0.048
nucleoside triphosphate metabolic process GO:0009141 230 0.047
compound eye development GO:0048749 1 0.047
rna catabolic process GO:0006401 29 0.047
negative regulation of phagocytosis GO:0050765 4 0.047
cytoplasmic transport GO:0016482 234 0.046
meiotic nuclear division GO:0007126 115 0.045
cellular amine metabolic process GO:0044106 44 0.045
regulation of cellular ketone metabolic process GO:0010565 66 0.045
negative regulation of cell cycle process GO:0010948 69 0.044
meiotic cell cycle process GO:1903046 77 0.044
ncrna 3 end processing GO:0043628 2 0.044
regulation of cellular amine metabolic process GO:0033238 20 0.043
lateral inhibition GO:0046331 1 0.042
cell division GO:0051301 120 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
nucleobase containing small molecule metabolic process GO:0055086 352 0.041
translation GO:0006412 93 0.040
spermatid differentiation GO:0048515 115 0.039
ras protein signal transduction GO:0007265 77 0.038
negative regulation of myeloid cell differentiation GO:0045638 38 0.035
organic cyclic compound catabolic process GO:1901361 295 0.035
nucleotide metabolic process GO:0009117 332 0.034
endocytosis GO:0006897 168 0.034
ribose phosphate metabolic process GO:0019693 291 0.034
ribonucleoside metabolic process GO:0009119 245 0.034
nucleoside metabolic process GO:0009116 246 0.034
glycosyl compound metabolic process GO:1901657 246 0.033
rna processing GO:0006396 105 0.033
cellular macromolecule catabolic process GO:0044265 206 0.032
mrna processing GO:0006397 63 0.032
negative regulation of cellular component organization GO:0051129 194 0.032
response to organic cyclic compound GO:0014070 198 0.032
amp biosynthetic process GO:0006167 2 0.032
protein localization to organelle GO:0033365 185 0.032
dna replication checkpoint GO:0000076 2 0.031
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.031
dna packaging GO:0006323 30 0.031
ribonucleoside monophosphate metabolic process GO:0009161 80 0.031
cellular homeostasis GO:0019725 240 0.031
leukocyte differentiation GO:0002521 342 0.031
regulation of cellular amino acid metabolic process GO:0006521 5 0.030
blastocyst development GO:0001824 80 0.030
ribonucleotide metabolic process GO:0009259 291 0.030
dna conformation change GO:0071103 37 0.029
microtubule cytoskeleton organization GO:0000226 157 0.029
cellular amino acid metabolic process GO:0006520 103 0.029
nucleoside phosphate metabolic process GO:0006753 338 0.029
aromatic compound catabolic process GO:0019439 286 0.029
germ cell development GO:0007281 185 0.029
b cell activation GO:0042113 161 0.029
chemotaxis GO:0006935 247 0.028
cellular transition metal ion homeostasis GO:0046916 32 0.028
regulation of translation GO:0006417 71 0.027
myeloid cell differentiation GO:0030099 233 0.027
regulation of cell activation GO:0050865 289 0.026
regulation of cell cycle phase transition GO:1901987 77 0.026
respiratory tube development GO:0030323 167 0.026
nucleoside catabolic process GO:0009164 206 0.026
negative regulation of cell activation GO:0050866 111 0.026
ribonucleoside triphosphate metabolic process GO:0009199 220 0.026
posttranscriptional regulation of gene expression GO:0010608 155 0.025
carbohydrate derivative biosynthetic process GO:1901137 183 0.025
rna splicing GO:0008380 54 0.025
organonitrogen compound biosynthetic process GO:1901566 192 0.024
regulation of nuclear division GO:0051783 56 0.024
positive regulation of protein modification process GO:0031401 299 0.024
multicellular organism growth GO:0035264 161 0.023
monosaccharide metabolic process GO:0005996 106 0.023
meiosis i GO:0007127 60 0.023
respiratory system development GO:0060541 190 0.022
dna integrity checkpoint GO:0031570 28 0.022
protein modification by small protein conjugation or removal GO:0070647 207 0.021
negative regulation of cell cycle phase transition GO:1901988 48 0.021
sister chromatid segregation GO:0000819 20 0.021
stem cell development GO:0048864 219 0.021
positive regulation of glycogen catabolic process GO:0045819 2 0.021
mrna catabolic process GO:0006402 22 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
axonogenesis GO:0007409 274 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
negative regulation of lymphocyte activation GO:0051250 91 0.019
intra s dna damage checkpoint GO:0031573 4 0.019
negative regulation of dna replication GO:0008156 4 0.019
cellular ion homeostasis GO:0006873 165 0.019
negative regulation of apoptotic signaling pathway GO:2001234 104 0.018
adult behavior GO:0030534 135 0.018
regulation of cellular component biogenesis GO:0044087 181 0.018
organophosphate catabolic process GO:0046434 232 0.018
cellular metal ion homeostasis GO:0006875 151 0.018
stem cell maintenance GO:0019827 130 0.018
inflammatory response GO:0006954 244 0.018
rna 3 end processing GO:0031123 20 0.017
anatomical structure homeostasis GO:0060249 145 0.017
purine nucleoside metabolic process GO:0042278 241 0.017
regulation of mitotic cell cycle phase transition GO:1901990 73 0.017
nitrogen compound transport GO:0071705 271 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
snrna processing GO:0016180 1 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
peptidyl amino acid modification GO:0018193 336 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
lung development GO:0030324 164 0.016
cellular protein catabolic process GO:0044257 155 0.016
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.016
purine ribonucleoside metabolic process GO:0046128 241 0.016
regionalization GO:0003002 337 0.016
protein autophosphorylation GO:0046777 61 0.016
amine metabolic process GO:0009308 45 0.016
b cell differentiation GO:0030183 78 0.016
regulation of ras protein signal transduction GO:0046578 114 0.016
negative regulation of growth GO:0045926 99 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.015
determination of adult lifespan GO:0008340 11 0.015
development of primary sexual characteristics GO:0045137 143 0.015
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
stem cell differentiation GO:0048863 268 0.015
mrna splicing via spliceosome GO:0000398 43 0.015
regulation of response to dna damage stimulus GO:2001020 34 0.015
regulation of chromosome organization GO:0033044 83 0.014
regulation of cellular response to stress GO:0080135 159 0.014
lymphocyte differentiation GO:0030098 242 0.014
ion transmembrane transport GO:0034220 361 0.014
protein maturation GO:0051604 176 0.014
purine nucleotide metabolic process GO:0006163 302 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
myeloid leukocyte differentiation GO:0002573 119 0.014
negative regulation of molecular function GO:0044092 258 0.014
defense response to other organism GO:0098542 197 0.014
positive regulation of hydrolase activity GO:0051345 148 0.014
cellular chemical homeostasis GO:0055082 215 0.014
axon guidance GO:0007411 141 0.014
microtubule based process GO:0007017 236 0.014
transmembrane transport GO:0055085 412 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.013
atp metabolic process GO:0046034 75 0.013
cardiac muscle cell contraction GO:0086003 7 0.013
negative regulation of b cell differentiation GO:0045578 4 0.013
cellular protein complex assembly GO:0043623 116 0.013
dna dependent dna replication GO:0006261 24 0.013
regulation of chromatin silencing GO:0031935 2 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
purine ribonucleotide metabolic process GO:0009150 290 0.013
meiotic cell cycle GO:0051321 122 0.013
regulation of dna endoreduplication GO:0032875 3 0.013
regulation of cellular catabolic process GO:0031329 242 0.013
regulation of carbohydrate metabolic process GO:0006109 75 0.013
intracellular protein transport GO:0006886 204 0.013
purine ribonucleoside catabolic process GO:0046130 205 0.013
ribonucleoside catabolic process GO:0042454 206 0.013
positive regulation of cellular amine metabolic process GO:0033240 5 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
purine nucleoside triphosphate catabolic process GO:0009146 203 0.012
mrna metabolic process GO:0016071 84 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
adult locomotory behavior GO:0008344 91 0.012
skeletal system development GO:0001501 356 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
purine containing compound metabolic process GO:0072521 311 0.012
placenta development GO:0001890 140 0.012
protein targeting GO:0006605 143 0.012
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
muscle system process GO:0003012 141 0.011
positive regulation of innate immune response GO:0045089 80 0.011
rna interference GO:0016246 2 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
response to oxidative stress GO:0006979 123 0.011
negative regulation of cellular protein metabolic process GO:0032269 247 0.011
learning or memory GO:0007611 148 0.011
base excision repair GO:0006284 9 0.011
positive regulation of carbohydrate metabolic process GO:0045913 30 0.011
regulation of histone methylation GO:0031060 30 0.011
mitochondrion organization GO:0007005 134 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
meiotic chromosome segregation GO:0045132 19 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
dna damage checkpoint GO:0000077 26 0.011
negative regulation of leukocyte differentiation GO:1902106 51 0.011
g2 dna damage checkpoint GO:0031572 8 0.011
gland development GO:0048732 330 0.011
cognition GO:0050890 149 0.010
organelle assembly GO:0070925 177 0.010
positive regulation of protein phosphorylation GO:0001934 242 0.010
protein acylation GO:0043543 64 0.010
cell type specific apoptotic process GO:0097285 268 0.010
regulation of cell division GO:0051302 76 0.010
memory GO:0007613 58 0.010
maternal determination of anterior posterior axis embryo GO:0008358 2 0.010
regulation of b cell activation GO:0050864 81 0.010
developmental maturation GO:0021700 193 0.010
cellular carbohydrate metabolic process GO:0044262 119 0.010

Tdp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.066
disease of anatomical entity DOID:7 0 0.066
central nervous system disease DOID:331 0 0.043
neurodegenerative disease DOID:1289 0 0.032
musculoskeletal system disease DOID:17 0 0.016
muscle tissue disease DOID:66 0 0.013
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
motor neuron disease DOID:231 0 0.012
amyotrophic lateral sclerosis DOID:332 0 0.012