Mus musculus

35 known processes

Flg

filaggrin

(Aliases: AW107830,ft)

Flg biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of body fluid levels GO:0050878 162 0.186
wound healing GO:0042060 157 0.174
exocytosis GO:0006887 121 0.164
establishment of skin barrier GO:0061436 14 0.155
epidermis development GO:0008544 187 0.150
cellular amine metabolic process GO:0044106 44 0.148
cellular lipid metabolic process GO:0044255 323 0.141
developmental maturation GO:0021700 193 0.123
keratinocyte differentiation GO:0030216 48 0.109
multicellular organismal water homeostasis GO:0050891 23 0.106
response to inorganic substance GO:0010035 96 0.102
cellular amino acid metabolic process GO:0006520 103 0.091
molting cycle GO:0042303 90 0.086
epidermis morphogenesis GO:0048730 33 0.083
gland development GO:0048732 330 0.082
vitamin d biosynthetic process GO:0042368 3 0.078
skin development GO:0043588 220 0.077
monocarboxylic acid metabolic process GO:0032787 191 0.076
fatty acid metabolic process GO:0006631 121 0.072
response to acid chemical GO:0001101 111 0.071
transmission of nerve impulse GO:0019226 76 0.070
regulation of protein localization GO:0032880 231 0.066
positive regulation of cellular amine metabolic process GO:0033240 5 0.065
response to oxygen levels GO:0070482 62 0.065
cellular response to inorganic substance GO:0071241 37 0.063
hair follicle morphogenesis GO:0031069 29 0.061
multicellular organismal signaling GO:0035637 91 0.060
regulation of cellular ketone metabolic process GO:0010565 66 0.058
fat soluble vitamin biosynthetic process GO:0042362 4 0.053
defense response to bacterium GO:0042742 119 0.053
cellular response to acid chemical GO:0071229 68 0.053
regulation of membrane potential GO:0042391 192 0.051
glycerolipid metabolic process GO:0046486 122 0.051
action potential GO:0001508 78 0.050
camera type eye development GO:0043010 266 0.048
cellular response to organonitrogen compound GO:0071417 145 0.046
lipid modification GO:0030258 65 0.044
regulation of secretion GO:0051046 274 0.044
regulation of cellular amino acid metabolic process GO:0006521 5 0.043
placenta development GO:0001890 140 0.042
skin morphogenesis GO:0043589 38 0.042
small molecule biosynthetic process GO:0044283 132 0.041
neuron projection guidance GO:0097485 141 0.041
water homeostasis GO:0030104 27 0.041
oocyte axis specification GO:0007309 2 0.040
muscle tissue development GO:0060537 308 0.040
multi multicellular organism process GO:0044706 109 0.040
response to hypoxia GO:0001666 58 0.040
axon ensheathment GO:0008366 76 0.038
maintenance of location GO:0051235 89 0.038
protein secretion GO:0009306 111 0.037
calcium ion transport GO:0006816 159 0.037
lipid catabolic process GO:0016042 69 0.036
cellular ion homeostasis GO:0006873 165 0.035
cell maturation GO:0048469 127 0.035
hair follicle development GO:0001942 85 0.034
regulation of secretion by cell GO:1903530 249 0.033
neuronal action potential GO:0019228 54 0.033
cell adhesion GO:0007155 329 0.033
oxidation reduction process GO:0055114 342 0.031
response to organic cyclic compound GO:0014070 198 0.031
cellular response to hormone stimulus GO:0032870 150 0.031
peptide transport GO:0015833 133 0.030
hematopoietic progenitor cell differentiation GO:0002244 143 0.029
cellular ketone metabolic process GO:0042180 84 0.029
regulation of lymphocyte activation GO:0051249 240 0.029
regulation of t cell activation GO:0050863 170 0.029
cation transport GO:0006812 399 0.029
skeletal system development GO:0001501 356 0.028
cytokine production GO:0001816 319 0.027
response to metal ion GO:0010038 47 0.027
ensheathment of neurons GO:0007272 76 0.027
tolerance induction to self antigen GO:0002513 4 0.027
gonad development GO:0008406 141 0.026
macromolecule catabolic process GO:0009057 281 0.026
developmental growth involved in morphogenesis GO:0060560 138 0.026
fatty acid oxidation GO:0019395 28 0.026
regulation of protein transport GO:0051223 163 0.026
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.025
negative regulation of cell proliferation GO:0008285 296 0.025
regulation of transferase activity GO:0051338 263 0.025
regionalization GO:0003002 337 0.025
positive regulation of cell development GO:0010720 237 0.024
cellular response to lipid GO:0071396 145 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
regulation of establishment of protein localization GO:0070201 181 0.023
inflammatory response GO:0006954 244 0.023
response to decreased oxygen levels GO:0036293 59 0.023
regulation of leukocyte differentiation GO:1902105 159 0.022
phospholipid metabolic process GO:0006644 87 0.022
immune effector process GO:0002252 321 0.022
protein maturation GO:0051604 176 0.022
regulation of lymphocyte differentiation GO:0045619 107 0.022
cellular response to amino acid stimulus GO:0071230 29 0.022
organic hydroxy compound biosynthetic process GO:1901617 77 0.022
cellular lipid catabolic process GO:0044242 52 0.022
positive regulation of transforming growth factor beta secretion GO:2001203 1 0.022
chemotaxis GO:0006935 247 0.021
epithelial cell proliferation GO:0050673 174 0.021
circulatory system process GO:0003013 197 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
small molecule catabolic process GO:0044282 71 0.021
response to amino acid GO:0043200 37 0.021
cytokine mediated signaling pathway GO:0019221 115 0.021
transforming growth factor beta secretion GO:0038044 1 0.021
lipid biosynthetic process GO:0008610 179 0.020
stem cell differentiation GO:0048863 268 0.020
regulation of hydrolase activity GO:0051336 246 0.020
sensory perception GO:0007600 245 0.020
cellular homeostasis GO:0019725 240 0.020
striated muscle tissue development GO:0014706 293 0.019
vitamin d3 metabolic process GO:0070640 3 0.019
sequestering of metal ion GO:0051238 19 0.019
intracellular receptor signaling pathway GO:0030522 74 0.019
cellular response to metal ion GO:0071248 31 0.019
regulation of interleukin 10 secretion GO:2001179 4 0.019
regulated secretory pathway GO:0045055 32 0.019
amide transport GO:0042886 138 0.019
cellular chemical homeostasis GO:0055082 215 0.019
regulation of defense response GO:0031347 233 0.019
divalent metal ion transport GO:0070838 172 0.019
lymphocyte mediated immunity GO:0002449 139 0.019
negative regulation of secretion GO:0051048 61 0.019
divalent inorganic cation transport GO:0072511 178 0.018
positive regulation of nervous system development GO:0051962 221 0.018
hair cycle GO:0042633 90 0.018
membrane organization GO:0061024 245 0.018
negative regulation of molecular function GO:0044092 258 0.018
lymphocyte differentiation GO:0030098 242 0.018
calcium mediated signaling using intracellular calcium source GO:0035584 3 0.018
carbohydrate catabolic process GO:0016052 32 0.018
compound eye development GO:0048749 1 0.018
lactation GO:0007595 25 0.018
positive regulation of fatty acid oxidation GO:0046321 4 0.018
regulation of cell projection organization GO:0031344 206 0.018
morphogenesis of a branching epithelium GO:0061138 193 0.018
cell type specific apoptotic process GO:0097285 268 0.018
axonogenesis GO:0007409 274 0.017
development of primary sexual characteristics GO:0045137 143 0.017
biomineral tissue development GO:0031214 64 0.017
chromatin modification GO:0016568 187 0.017
leukocyte apoptotic process GO:0071887 71 0.017
steroid metabolic process GO:0008202 119 0.017
response to retinoic acid GO:0032526 56 0.017
homeostasis of number of cells GO:0048872 210 0.017
embryonic placenta development GO:0001892 98 0.017
urogenital system development GO:0001655 261 0.017
wnt signaling pathway GO:0016055 188 0.016
keratinocyte migration GO:0051546 3 0.016
skeletal muscle organ development GO:0060538 163 0.016
neutral lipid metabolic process GO:0006638 57 0.016
alcohol biosynthetic process GO:0046165 43 0.016
nitrogen compound transport GO:0071705 271 0.016
lipid storage GO:0019915 36 0.016
response to lipopolysaccharide GO:0032496 128 0.016
segmentation GO:0035282 93 0.016
chromatin organization GO:0006325 206 0.016
regulation of cell cycle GO:0051726 281 0.015
glycerophospholipid metabolic process GO:0006650 71 0.015
regulation of kinase activity GO:0043549 249 0.015
vitamin metabolic process GO:0006766 23 0.015
peptide secretion GO:0002790 114 0.015
blood vessel morphogenesis GO:0048514 285 0.015
keratinization GO:0031424 9 0.015
positive regulation of cytokine production GO:0001819 174 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
insemination GO:0007320 6 0.014
nerve development GO:0021675 67 0.014
neuroblast fate commitment GO:0014017 1 0.014
endomembrane system organization GO:0010256 147 0.014
developmental cell growth GO:0048588 84 0.014
positive regulation of secretion GO:0051047 130 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
alcohol metabolic process GO:0006066 116 0.014
response to organonitrogen compound GO:0010243 246 0.014
immune response activating signal transduction GO:0002757 116 0.014
regulation of angiogenesis GO:0045765 81 0.014
positive regulation of angiogenesis GO:0045766 46 0.014
organic acid biosynthetic process GO:0016053 86 0.014
regulation of mapk cascade GO:0043408 248 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
cellular alcohol metabolic process GO:0044107 3 0.014
epithelial cell development GO:0002064 159 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
leukocyte differentiation GO:0002521 342 0.014
neuroblast fate determination GO:0007400 1 0.013
single organism reproductive behavior GO:0044704 3 0.013
protein catabolic process GO:0030163 221 0.013
membrane lipid metabolic process GO:0006643 53 0.013
cytoplasmic transport GO:0016482 234 0.013
microtubule based process GO:0007017 236 0.013
regulation of response to wounding GO:1903034 189 0.013
regulation of neuron differentiation GO:0045664 281 0.013
positive regulation of defense response GO:0031349 124 0.013
sensory perception of sound GO:0007605 97 0.013
myelination GO:0042552 74 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
fatty acid biosynthetic process GO:0006633 41 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
calcium ion dependent exocytosis GO:0017156 35 0.012
myeloid cell homeostasis GO:0002262 114 0.012
regulation of system process GO:0044057 200 0.012
cellular alcohol biosynthetic process GO:0044108 3 0.012
adult behavior GO:0030534 135 0.012
axon guidance GO:0007411 141 0.012
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.012
adaptive immune response GO:0002250 155 0.012
brown fat cell differentiation GO:0050873 36 0.012
kidney development GO:0001822 213 0.012
dicarboxylic acid metabolic process GO:0043648 18 0.012
covalent chromatin modification GO:0016569 163 0.012
alpha amino acid metabolic process GO:1901605 59 0.012
regulation of protein secretion GO:0050708 82 0.012
regulation of nucleotide catabolic process GO:0030811 122 0.012
negative regulation of protein processing GO:0010955 79 0.012
muscle cell differentiation GO:0042692 261 0.012
cell growth GO:0016049 130 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
amine metabolic process GO:0009308 45 0.012
lens development in camera type eye GO:0002088 62 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
regulation of transforming growth factor beta secretion GO:2001201 1 0.012
response to insulin GO:0032868 100 0.012
glycerolipid biosynthetic process GO:0045017 50 0.012
epithelial cell maturation GO:0002070 15 0.012
sensory organ morphogenesis GO:0090596 242 0.012
sterol homeostasis GO:0055092 45 0.012
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.012
negative regulation of protein modification process GO:0031400 163 0.012
regulation of cell activation GO:0050865 289 0.012
negative regulation of lymphocyte activation GO:0051250 91 0.012
fat cell differentiation GO:0045444 160 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
leukocyte mediated immunity GO:0002443 174 0.012
defense response to other organism GO:0098542 197 0.012
t cell activation GO:0042110 289 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
renal system development GO:0072001 225 0.012
regulation of cytokine production GO:0001817 266 0.012
regulation of binding GO:0051098 111 0.012
response to lithium ion GO:0010226 10 0.011
regulation of hormone levels GO:0010817 211 0.011
positive regulation of protein transport GO:0051222 93 0.011
post mating behavior GO:0045297 3 0.011
glutamine family amino acid metabolic process GO:0009064 15 0.011
cellular response to peptide GO:1901653 92 0.011
cellular response to organic cyclic compound GO:0071407 87 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
blood circulation GO:0008015 195 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
regulation of skeletal muscle fiber development GO:0048742 36 0.011
ceramide metabolic process GO:0006672 31 0.011
regulation of organelle organization GO:0033043 289 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
regulation of peptidase activity GO:0052547 96 0.011
inositol lipid mediated signaling GO:0048017 41 0.011
cell differentiation involved in embryonic placenta development GO:0060706 26 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
membrane lipid biosynthetic process GO:0046467 32 0.011
posttranscriptional regulation of gene expression GO:0010608 155 0.010
negative regulation of epithelial cell proliferation GO:0050680 64 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010
negative regulation of response to wounding GO:1903035 77 0.010
cellular response to steroid hormone stimulus GO:0071383 33 0.010
heart process GO:0003015 94 0.010
ventral spinal cord development GO:0021517 48 0.010
regulation of response to drug GO:2001023 2 0.010
steroid biosynthetic process GO:0006694 47 0.010
regulation of cellular component biogenesis GO:0044087 181 0.010
acylglycerol metabolic process GO:0006639 55 0.010
negative regulation of immune system process GO:0002683 209 0.010
leukocyte mediated cytotoxicity GO:0001909 62 0.010
calcium ion homeostasis GO:0055074 127 0.010
negative regulation of protein maturation GO:1903318 79 0.010
negative regulation of cell activation GO:0050866 111 0.010
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.010
germ cell development GO:0007281 185 0.010
rna processing GO:0006396 105 0.010
cell junction organization GO:0034330 77 0.010
single fertilization GO:0007338 82 0.010
regulation of tissue remodeling GO:0034103 38 0.010

Flg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org