Mus musculus

111 known processes

Insig1

insulin induced gene 1

(Aliases: 1810013C12Rik,Insig-1)

Insig1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lipid biosynthetic process GO:0008610 179 0.371
cellular alcohol biosynthetic process GO:0044108 3 0.316
small molecule biosynthetic process GO:0044283 132 0.165
alcohol metabolic process GO:0006066 116 0.142
cellular lipid metabolic process GO:0044255 323 0.141
oxidation reduction process GO:0055114 342 0.138
cellular amino acid metabolic process GO:0006520 103 0.126
sterol metabolic process GO:0016125 58 0.118
cellular alcohol metabolic process GO:0044107 3 0.097
organic hydroxy compound metabolic process GO:1901615 203 0.089
regulation of cellular amino acid metabolic process GO:0006521 5 0.074
cellular amine metabolic process GO:0044106 44 0.073
amine metabolic process GO:0009308 45 0.066
cholesterol biosynthetic process GO:0006695 15 0.065
alcohol biosynthetic process GO:0046165 43 0.064
fat cell differentiation GO:0045444 160 0.059
steroid metabolic process GO:0008202 119 0.058
regulation of cellular ketone metabolic process GO:0010565 66 0.055
cholesterol metabolic process GO:0008203 56 0.055
organonitrogen compound biosynthetic process GO:1901566 192 0.048
negative regulation of molecular function GO:0044092 258 0.042
response to organonitrogen compound GO:0010243 246 0.040
regulation of cellular amine metabolic process GO:0033238 20 0.039
sulfur compound metabolic process GO:0006790 100 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
transmembrane transport GO:0055085 412 0.034
organic acid biosynthetic process GO:0016053 86 0.033
glycerolipid metabolic process GO:0046486 122 0.032
inflammatory response GO:0006954 244 0.032
response to radiation GO:0009314 165 0.032
response to organic cyclic compound GO:0014070 198 0.032
regulation of membrane potential GO:0042391 192 0.031
negative regulation of protein metabolic process GO:0051248 282 0.031
nitrogen compound transport GO:0071705 271 0.030
negative regulation of cellular protein metabolic process GO:0032269 247 0.030
leukocyte differentiation GO:0002521 342 0.029
cellular ketone metabolic process GO:0042180 84 0.029
monocarboxylic acid metabolic process GO:0032787 191 0.029
regulation of secretion GO:0051046 274 0.028
positive regulation of cellular amine metabolic process GO:0033240 5 0.028
spermatogenesis GO:0007283 284 0.028
purine ribonucleotide metabolic process GO:0009150 290 0.028
cellular homeostasis GO:0019725 240 0.028
cation transport GO:0006812 399 0.027
protein maturation GO:0051604 176 0.027
male gamete generation GO:0048232 285 0.026
striated muscle tissue development GO:0014706 293 0.026
peptidyl amino acid modification GO:0018193 336 0.026
positive regulation of protein modification process GO:0031401 299 0.026
purine nucleotide metabolic process GO:0006163 302 0.026
organic anion transport GO:0015711 137 0.026
sterol biosynthetic process GO:0016126 17 0.026
ion transmembrane transport GO:0034220 361 0.026
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
camera type eye development GO:0043010 266 0.025
microtubule based process GO:0007017 236 0.025
aromatic compound catabolic process GO:0019439 286 0.024
organic hydroxy compound biosynthetic process GO:1901617 77 0.024
regulation of organelle organization GO:0033043 289 0.024
Human
forebrain development GO:0030900 302 0.024
organic cyclic compound catabolic process GO:1901361 295 0.023
response to extracellular stimulus GO:0009991 127 0.023
regulation of hormone levels GO:0010817 211 0.023
regulation of hydrolase activity GO:0051336 246 0.023
cofactor metabolic process GO:0051186 80 0.022
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
gland development GO:0048732 330 0.022
protein processing GO:0016485 163 0.022
immune effector process GO:0002252 321 0.022
sensory perception GO:0007600 245 0.022
multicellular organismal signaling GO:0035637 91 0.022
response to light stimulus GO:0009416 135 0.022
multicellular organism growth GO:0035264 161 0.022
macromolecule catabolic process GO:0009057 281 0.022
cellular response to lipid GO:0071396 145 0.022
sensory organ morphogenesis GO:0090596 242 0.022
regulation of system process GO:0044057 200 0.022
mitochondrion organization GO:0007005 134 0.022
cation transmembrane transport GO:0098655 266 0.021
alpha amino acid metabolic process GO:1901605 59 0.021
innate immune response GO:0045087 157 0.021
cation homeostasis GO:0055080 212 0.021
germ cell development GO:0007281 185 0.021
blood circulation GO:0008015 195 0.020
inorganic cation transmembrane transport GO:0098662 207 0.020
dna metabolic process GO:0006259 303 0.020
positive regulation of cell development GO:0010720 237 0.020
cell type specific apoptotic process GO:0097285 268 0.020
neutral lipid metabolic process GO:0006638 57 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.019
muscle tissue development GO:0060537 308 0.019
ossification GO:0001503 216 0.019
cellular chemical homeostasis GO:0055082 215 0.019
cytokine production GO:0001816 319 0.019
chromatin organization GO:0006325 206 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.019
cytoplasmic transport GO:0016482 234 0.019
Human
positive regulation of programmed cell death GO:0043068 218 0.019
t cell activation GO:0042110 289 0.019
divalent metal ion transport GO:0070838 172 0.019
metal ion homeostasis GO:0055065 189 0.019
circulatory system process GO:0003013 197 0.019
monocarboxylic acid biosynthetic process GO:0072330 61 0.019
action potential GO:0001508 78 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
ribonucleotide metabolic process GO:0009259 291 0.018
anion transport GO:0006820 177 0.018
monosaccharide metabolic process GO:0005996 106 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
regulation of secretion by cell GO:1903530 249 0.018
cellular ion homeostasis GO:0006873 165 0.018
purine containing compound biosynthetic process GO:0072522 70 0.018
membrane lipid metabolic process GO:0006643 53 0.018
apoptotic signaling pathway GO:0097190 306 0.018
embryonic organ morphogenesis GO:0048562 276 0.017
cellular nitrogen compound catabolic process GO:0044270 280 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
dephosphorylation GO:0016311 129 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
coenzyme biosynthetic process GO:0009108 23 0.017
regulation of ion transport GO:0043269 215 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
Human
locomotory behavior GO:0007626 195 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.017
muscle system process GO:0003012 141 0.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.017
steroid biosynthetic process GO:0006694 47 0.017
cellular metal ion homeostasis GO:0006875 151 0.017
response to acid chemical GO:0001101 111 0.017
response to oxidative stress GO:0006979 123 0.017
regulation of transferase activity GO:0051338 263 0.017
endomembrane system organization GO:0010256 147 0.017
respiratory system development GO:0060541 190 0.017
transmission of nerve impulse GO:0019226 76 0.017
homeostasis of number of cells GO:0048872 210 0.016
regulation of cytokine production GO:0001817 266 0.016
heterocycle catabolic process GO:0046700 280 0.016
protein catabolic process GO:0030163 221 0.016
ear development GO:0043583 200 0.016
activation of immune response GO:0002253 138 0.016
cellular modified amino acid metabolic process GO:0006575 63 0.016
regulation of cell cycle GO:0051726 281 0.016
fatty acid metabolic process GO:0006631 121 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
neuronal action potential GO:0019228 54 0.016
synaptic transmission GO:0007268 329 0.016
carboxylic acid transport GO:0046942 100 0.016
nuclear division GO:0000280 158 0.016
nucleotide metabolic process GO:0009117 332 0.016
lipid catabolic process GO:0016042 69 0.016
carboxylic acid catabolic process GO:0046395 51 0.016
response to nutrient levels GO:0031667 109 0.016
organelle fission GO:0048285 170 0.016
response to molecule of bacterial origin GO:0002237 143 0.016
carboxylic acid biosynthetic process GO:0046394 86 0.016
regulation of proteolysis GO:0030162 164 0.015
membrane organization GO:0061024 245 0.015
Human
regulation of homeostatic process GO:0032844 182 0.015
regulation of body fluid levels GO:0050878 162 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.015
meiotic cell cycle GO:0051321 122 0.015
cellular response to external stimulus GO:0071496 88 0.015
cellular response to acid chemical GO:0071229 68 0.015
cofactor transport GO:0051181 4 0.015
mapk cascade GO:0000165 281 0.015
coenzyme metabolic process GO:0006732 52 0.015
myeloid cell differentiation GO:0030099 233 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
regulation of cell activation GO:0050865 289 0.015
cellular carbohydrate metabolic process GO:0044262 119 0.015
organic acid catabolic process GO:0016054 51 0.015
calcium ion transport GO:0006816 159 0.015
amide transport GO:0042886 138 0.015
sequestering of calcium ion GO:0051208 18 0.015
long chain fatty acid import GO:0044539 2 0.015
maintenance of location GO:0051235 89 0.015
purine nucleoside metabolic process GO:0042278 241 0.014
skeletal system development GO:0001501 356 0.014
regulation of defense response GO:0031347 233 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
regulation of mapk cascade GO:0043408 248 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
regulation of kinase activity GO:0043549 249 0.014
ribonucleoside metabolic process GO:0009119 245 0.014
response to inorganic substance GO:0010035 96 0.014
actin cytoskeleton organization GO:0030036 220 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
divalent inorganic cation transport GO:0072511 178 0.014
regulation of lipid metabolic process GO:0019216 118 0.014
spermatid differentiation GO:0048515 115 0.014
blood vessel morphogenesis GO:0048514 285 0.014
response to lipopolysaccharide GO:0032496 128 0.014
cellular response to extracellular stimulus GO:0031668 81 0.014
positive regulation of nervous system development GO:0051962 221 0.014
small molecule catabolic process GO:0044282 71 0.014
chromatin modification GO:0016568 187 0.014
compound eye development GO:0048749 1 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
intracellular protein transport GO:0006886 204 0.014
myotube differentiation GO:0014902 105 0.014
kidney development GO:0001822 213 0.014
circadian rhythm GO:0007623 114 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
negative regulation of protein modification process GO:0031400 163 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.013
rhythmic process GO:0048511 174 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
adult behavior GO:0030534 135 0.013
glutamate metabolic process GO:0006536 9 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
regulation of neuron differentiation GO:0045664 281 0.013
glucose homeostasis GO:0042593 128 0.013
liver development GO:0001889 66 0.013
regulation of lymphocyte activation GO:0051249 240 0.013
skeletal muscle organ development GO:0060538 163 0.013
heart contraction GO:0060047 93 0.013
response to peptide GO:1901652 136 0.013
retrograde transport endosome to golgi GO:0042147 2 0.013
cellular amino acid biosynthetic process GO:0008652 22 0.013
fat soluble vitamin biosynthetic process GO:0042362 4 0.013
positive regulation of secretion GO:0051047 130 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
lymphocyte differentiation GO:0030098 242 0.013
negative regulation of lipid metabolic process GO:0045833 30 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
negative regulation of hydrolase activity GO:0051346 71 0.013
cellular response to organonitrogen compound GO:0071417 145 0.013
carbohydrate metabolic process GO:0005975 230 0.013
ribonucleotide biosynthetic process GO:0009260 59 0.013
organelle localization GO:0051640 179 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.013
regulation of protein maturation GO:1903317 96 0.013
organophosphate catabolic process GO:0046434 232 0.013
cellular divalent inorganic cation homeostasis GO:0072503 127 0.013
regulation of intracellular transport GO:0032386 159 0.013
Human
mitotic cell cycle GO:0000278 195 0.013
nucleoside phosphate biosynthetic process GO:1901293 79 0.013
energy derivation by oxidation of organic compounds GO:0015980 77 0.013
plasma membrane organization GO:0007009 90 0.013
muscle cell differentiation GO:0042692 261 0.013
nucleotide catabolic process GO:0009166 217 0.013
negative regulation of phosphorus metabolic process GO:0010563 184 0.013
morphogenesis of a branching structure GO:0001763 203 0.013
cellular biogenic amine metabolic process GO:0006576 28 0.013
positive regulation of protein phosphorylation GO:0001934 242 0.013
spermatid development GO:0007286 108 0.013
purine containing compound metabolic process GO:0072521 311 0.013
telencephalon development GO:0021537 186 0.013
nucleoside phosphate catabolic process GO:1901292 222 0.012
regulation of peptidase activity GO:0052547 96 0.012
regulation of t cell activation GO:0050863 170 0.012
epithelial cell proliferation GO:0050673 174 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
hormone secretion GO:0046879 128 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
peptide transport GO:0015833 133 0.012
regulation of lipid catabolic process GO:0050994 15 0.012
acylglycerol metabolic process GO:0006639 55 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
regulation of leukocyte differentiation GO:1902105 159 0.012
neuron death GO:0070997 154 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
regulation of protein localization GO:0032880 231 0.012
cell activation involved in immune response GO:0002263 126 0.012
connective tissue development GO:0061448 179 0.012
leukocyte activation involved in immune response GO:0002366 126 0.012
regulation of protein serine threonine kinase activity GO:0071900 157 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
regulation of neuron death GO:1901214 134 0.012
peptide metabolic process GO:0006518 46 0.012
ribose phosphate biosynthetic process GO:0046390 59 0.012
glycerophospholipid metabolic process GO:0006650 71 0.012
detection of stimulus GO:0051606 84 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
regulation of anatomical structure size GO:0090066 178 0.012
response to insulin GO:0032868 100 0.012
divalent inorganic cation homeostasis GO:0072507 138 0.012
cellular amide metabolic process GO:0043603 58 0.012
anatomical structure homeostasis GO:0060249 145 0.012
leukocyte proliferation GO:0070661 172 0.012
ribonucleoside triphosphate metabolic process GO:0009199 220 0.012
organic acid transport GO:0015849 101 0.012
glutathione metabolic process GO:0006749 16 0.012
regulation of ion transmembrane transport GO:0034765 119 0.012
ras protein signal transduction GO:0007265 77 0.012
meiotic nuclear division GO:0007126 115 0.012
positive regulation of cell death GO:0010942 224 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
negative regulation of lipid catabolic process GO:0050995 6 0.012
regulation of cell migration GO:0030334 219 0.012
regulation of neuron projection development GO:0010975 169 0.012
placenta development GO:0001890 140 0.012
regulation of response to wounding GO:1903034 189 0.012
b cell activation GO:0042113 161 0.012
calcium ion homeostasis GO:0055074 127 0.012
peptide secretion GO:0002790 114 0.012
interleukin 8 production GO:0032637 4 0.012
intrinsic apoptotic signaling pathway GO:0097193 132 0.012
wnt signaling pathway GO:0016055 188 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
cellular response to abiotic stimulus GO:0071214 56 0.012
nucleoside metabolic process GO:0009116 246 0.012
myeloid leukocyte differentiation GO:0002573 119 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
carbohydrate homeostasis GO:0033500 128 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
ear morphogenesis GO:0042471 118 0.011
cell adhesion GO:0007155 329 0.011
defense response to other organism GO:0098542 197 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
coenzyme a biosynthetic process GO:0015937 5 0.011
nuclear transport GO:0051169 139 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
Human
male sex differentiation GO:0046661 109 0.011
skin development GO:0043588 220 0.011
cellular response to gamma radiation GO:0071480 4 0.011
positive regulation of cytokine production GO:0001819 174 0.011
positive regulation of secretion by cell GO:1903532 114 0.011
regulation of vesicle mediated transport GO:0060627 139 0.011
Human
protein localization to organelle GO:0033365 185 0.011
triglyceride biosynthetic process GO:0019432 17 0.011
muscle contraction GO:0006936 101 0.011
response to oxygen levels GO:0070482 62 0.011
nucleoside catabolic process GO:0009164 206 0.011
rna interference GO:0016246 2 0.011
glycerolipid biosynthetic process GO:0045017 50 0.011
methylation GO:0032259 134 0.011
protein oligomerization GO:0051259 67 0.011
meiosis i GO:0007127 60 0.011
sphingolipid metabolic process GO:0006665 45 0.011
purine nucleotide biosynthetic process GO:0006164 65 0.011
lateral inhibition GO:0046331 1 0.011
aspartate family amino acid metabolic process GO:0009066 10 0.011
oocyte construction GO:0007308 2 0.011
purine nucleoside triphosphate catabolic process GO:0009146 203 0.011
negative regulation of proteolysis GO:0045861 74 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
cellular response to insulin stimulus GO:0032869 78 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
cellular response to peptide GO:1901653 92 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
defense response to bacterium GO:0042742 119 0.011
immune response regulating signaling pathway GO:0002764 125 0.011
positive regulation of cell activation GO:0050867 158 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
asymmetric stem cell division GO:0098722 3 0.011
glucose metabolic process GO:0006006 92 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
sequestering of metal ion GO:0051238 19 0.011
tissue homeostasis GO:0001894 115 0.011
fatty acid elongation GO:0030497 3 0.011
positive regulation of mapk cascade GO:0043410 170 0.010
urogenital system development GO:0001655 261 0.010
cellular protein catabolic process GO:0044257 155 0.010
alpha amino acid biosynthetic process GO:1901607 15 0.010
response to starvation GO:0042594 65 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
regulation of cellular catabolic process GO:0031329 242 0.010
positive regulation of t cell activation GO:0050870 101 0.010
negative regulation of neuron apoptotic process GO:0043524 92 0.010
cellularization GO:0007349 1 0.010
regulation of endopeptidase activity GO:0052548 89 0.010
rhodopsin mediated signaling pathway GO:0016056 4 0.010
negative regulation of peptidase activity GO:0010466 46 0.010
negative regulation of endopeptidase activity GO:0010951 44 0.010
cognition GO:0050890 149 0.010
regulation of peptide transport GO:0090087 91 0.010
cellular response to nutrient levels GO:0031669 64 0.010
regulation of protein processing GO:0070613 96 0.010
triglyceride metabolic process GO:0006641 51 0.010
cellular response to lipopolysaccharide GO:0071222 77 0.010
developmental maturation GO:0021700 193 0.010
positive regulation of lymphocyte activation GO:0051251 140 0.010
heart process GO:0003015 94 0.010
fertilization GO:0009566 127 0.010
renal system development GO:0072001 225 0.010
detection of external stimulus GO:0009581 61 0.010
regulation of protein kinase activity GO:0045859 232 0.010
nucleoside triphosphate metabolic process GO:0009141 230 0.010
histone modification GO:0016570 159 0.010
angiogenesis GO:0001525 201 0.010
negative regulation of protein maturation GO:1903318 79 0.010

Insig1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.046
inherited metabolic disorder DOID:655 0 0.036
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
disease of cellular proliferation DOID:14566 0 0.015
connective tissue disease DOID:65 0 0.014
musculoskeletal system disease DOID:17 0 0.014
cancer DOID:162 0 0.012
immune system disease DOID:2914 0 0.011
cardiovascular system disease DOID:1287 0 0.011
bone disease DOID:0080001 0 0.010