Mus musculus

0 known processes

Slfn8

schlafen 8

(Aliases: MGC30719)

Slfn8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 197 0.373
Human
defense response to virus GO:0051607 68 0.364
Human
immune effector process GO:0002252 321 0.352
Human
activation of innate immune response GO:0002218 56 0.349
regulation of innate immune response GO:0045088 91 0.252
regulation of defense response GO:0031347 233 0.180
cellular response to interferon beta GO:0035458 21 0.144
interspecies interaction between organisms GO:0044419 83 0.138
negative regulation of multi organism process GO:0043901 68 0.134
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.130
negative regulation of immune system process GO:0002683 209 0.128
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.122
viral process GO:0016032 41 0.122
cytokine production GO:0001816 319 0.111
cellular response to interferon alpha GO:0035457 4 0.098
cellular nitrogen compound catabolic process GO:0044270 280 0.092
cellular amino acid metabolic process GO:0006520 103 0.090
positive regulation of innate immune response GO:0045089 80 0.089
innate immune response GO:0045087 157 0.087
defense response to bacterium GO:0042742 119 0.083
regulation of multi organism process GO:0043900 111 0.082
purine containing compound metabolic process GO:0072521 311 0.081
positive regulation of defense response GO:0031349 124 0.076
regulation of cellular ketone metabolic process GO:0010565 66 0.076
regulation of defense response to virus GO:0050688 18 0.075
positive regulation of cytokine production GO:0001819 174 0.074
rho protein signal transduction GO:0007266 32 0.073
regulation of response to biotic stimulus GO:0002831 38 0.068
aromatic compound catabolic process GO:0019439 286 0.067
cellular amine metabolic process GO:0044106 44 0.067
negative regulation of viral genome replication GO:0045071 10 0.064
protein ubiquitination GO:0016567 171 0.064
regulation of hydrolase activity GO:0051336 246 0.063
response to interferon beta GO:0035456 22 0.062
cellular response to cytokine stimulus GO:0071345 189 0.061
regulation of cytokine production GO:0001817 266 0.061
nucleobase containing small molecule metabolic process GO:0055086 352 0.061
regulation of nlrp3 inflammasome complex assembly GO:1900225 4 0.061
positive regulation of viral genome replication GO:0045070 2 0.060
organic cyclic compound catabolic process GO:1901361 295 0.059
entry into cell of other organism involved in symbiotic interaction GO:0051806 15 0.057
nucleoside phosphate metabolic process GO:0006753 338 0.056
negative regulation of molecular function GO:0044092 258 0.052
mapk cascade GO:0000165 281 0.052
positive regulation of secretion by cell GO:1903532 114 0.050
negative regulation of protein metabolic process GO:0051248 282 0.048
heterocycle catabolic process GO:0046700 280 0.046
cellular response to biotic stimulus GO:0071216 92 0.045
negative regulation of hydrolase activity GO:0051346 71 0.044
negative regulation of viral process GO:0048525 23 0.044
amine metabolic process GO:0009308 45 0.043
cellular ketone metabolic process GO:0042180 84 0.043
cellular response to lipopolysaccharide GO:0071222 77 0.042
nucleotide metabolic process GO:0009117 332 0.042
carbohydrate derivative catabolic process GO:1901136 231 0.041
regulation of cellular amino acid metabolic process GO:0006521 5 0.041
negative regulation of defense response GO:0031348 77 0.041
regulation of interferon beta production GO:0032648 13 0.040
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.039
regulation of cellular component biogenesis GO:0044087 181 0.039
t cell activation GO:0042110 289 0.038
purine nucleotide metabolic process GO:0006163 302 0.038
protein modification by small protein conjugation GO:0032446 187 0.038
ribonucleoside catabolic process GO:0042454 206 0.038
ossification GO:0001503 216 0.037
organonitrogen compound catabolic process GO:1901565 264 0.037
macromolecule catabolic process GO:0009057 281 0.036
organophosphate catabolic process GO:0046434 232 0.036
regulation of secretion GO:0051046 274 0.035
positive regulation of cellular amine metabolic process GO:0033240 5 0.035
positive regulation of protein phosphorylation GO:0001934 242 0.034
negative regulation of protein processing GO:0010955 79 0.034
regulation of protein localization GO:0032880 231 0.034
protein processing GO:0016485 163 0.034
protein modification by small protein conjugation or removal GO:0070647 207 0.034
negative regulation of proteolysis GO:0045861 74 0.034
negative regulation of cellular protein metabolic process GO:0032269 247 0.033
viral transcription GO:0019083 3 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
purine ribonucleotide metabolic process GO:0009150 290 0.032
glycosyl compound metabolic process GO:1901657 246 0.032
ear development GO:0043583 200 0.032
positive regulation of interferon alpha production GO:0032727 4 0.032
nucleoside triphosphate metabolic process GO:0009141 230 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.032
carbohydrate metabolic process GO:0005975 230 0.032
nucleoside phosphate catabolic process GO:1901292 222 0.032
regulation of protein processing GO:0070613 96 0.031
regulation of cytoskeleton organization GO:0051493 122 0.031
inflammatory response GO:0006954 244 0.030
myeloid cell differentiation GO:0030099 233 0.030
regulation of establishment of protein localization GO:0070201 181 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.030
regulation of peptidase activity GO:0052547 96 0.029
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.029
purine nucleoside metabolic process GO:0042278 241 0.029
purine containing compound catabolic process GO:0072523 213 0.029
ras protein signal transduction GO:0007265 77 0.029
homeostasis of number of cells GO:0048872 210 0.029
positive regulation of secretion GO:0051047 130 0.028
positive regulation of immune effector process GO:0002699 107 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
negative regulation of protein maturation GO:1903318 79 0.027
positive regulation of cellular component biogenesis GO:0044089 94 0.027
cellular response to lipid GO:0071396 145 0.027
activation of immune response GO:0002253 138 0.027
muscle cell development GO:0055001 133 0.027
viral life cycle GO:0019058 36 0.027
negative regulation of endopeptidase activity GO:0010951 44 0.027
purine ribonucleotide catabolic process GO:0009154 208 0.027
regulation of organelle organization GO:0033043 289 0.026
purine ribonucleoside catabolic process GO:0046130 205 0.026
guanosine containing compound metabolic process GO:1901068 144 0.026
myeloid leukocyte differentiation GO:0002573 119 0.026
regulation of cellular catabolic process GO:0031329 242 0.026
regulation of protein maturation GO:1903317 96 0.026
regulation of mapk cascade GO:0043408 248 0.026
small gtpase mediated signal transduction GO:0007264 97 0.026
viral gene expression GO:0019080 3 0.026
response to lipopolysaccharide GO:0032496 128 0.025
guanosine containing compound catabolic process GO:1901069 144 0.025
purine nucleoside triphosphate metabolic process GO:0009144 226 0.025
negative regulation of cellular amine metabolic process GO:0033239 1 0.025
regulation of cysteine type endopeptidase activity GO:2000116 65 0.024
nucleocytoplasmic transport GO:0006913 139 0.024
cellular chemical homeostasis GO:0055082 215 0.024
purine nucleotide catabolic process GO:0006195 211 0.024
immune response regulating signaling pathway GO:0002764 125 0.024
muscle tissue development GO:0060537 308 0.024
regulation of protein transport GO:0051223 163 0.024
positive regulation of ossification GO:0045778 47 0.024
positive regulation of osteoblast differentiation GO:0045669 34 0.024
regulation of ossification GO:0030278 112 0.024
cytoplasmic transport GO:0016482 234 0.023
response to organic cyclic compound GO:0014070 198 0.023
response to molecule of bacterial origin GO:0002237 143 0.023
modification dependent protein catabolic process GO:0019941 133 0.022
cellular macromolecule catabolic process GO:0044265 206 0.022
negative regulation of viral transcription GO:0032897 3 0.022
modification dependent macromolecule catabolic process GO:0043632 133 0.022
toll like receptor 7 signaling pathway GO:0034154 4 0.022
purine nucleoside catabolic process GO:0006152 205 0.022
skeletal muscle organ development GO:0060538 163 0.022
ubiquitin dependent protein catabolic process GO:0006511 129 0.022
nucleotide catabolic process GO:0009166 217 0.022
glycosyl compound catabolic process GO:1901658 206 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.022
regulation of secretion by cell GO:1903530 249 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.021
negative regulation of cytokine production GO:0001818 84 0.021
peptidyl amino acid modification GO:0018193 336 0.021
positive regulation of cell death GO:0010942 224 0.021
regulation of cytoplasmic transport GO:1903649 112 0.021
regulation of osteoblast differentiation GO:0045667 67 0.021
dna metabolic process GO:0006259 303 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
protein maturation GO:0051604 176 0.020
viral genome replication GO:0019079 17 0.020
muscle cell differentiation GO:0042692 261 0.020
ribose phosphate metabolic process GO:0019693 291 0.020
regulation of actin cytoskeleton organization GO:0032956 84 0.020
purine ribonucleoside metabolic process GO:0046128 241 0.019
regulation of cell cycle GO:0051726 281 0.019
Human
negative regulation of cellular component organization GO:0051129 194 0.019
glycoprotein metabolic process GO:0009100 116 0.019
organonitrogen compound biosynthetic process GO:1901566 192 0.019
negative regulation of phosphorus metabolic process GO:0010563 184 0.019
striated muscle tissue development GO:0014706 293 0.019
regulation of protein secretion GO:0050708 82 0.019
myotube differentiation GO:0014902 105 0.019
sequestering of metal ion GO:0051238 19 0.019
production of molecular mediator of immune response GO:0002440 103 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
regulation of viral transcription GO:0046782 3 0.019
sequestering of calcium ion GO:0051208 18 0.019
cellular response to hormone stimulus GO:0032870 150 0.019
regulation of ras protein signal transduction GO:0046578 114 0.019
regulation of purine nucleotide catabolic process GO:0033121 122 0.019
nucleotide biosynthetic process GO:0009165 78 0.019
cell type specific apoptotic process GO:0097285 268 0.018
nucleoside metabolic process GO:0009116 246 0.018
regulation of defense response to fungus GO:1900150 1 0.018
cellular homeostasis GO:0019725 240 0.018
regulation of leukocyte mediated immunity GO:0002703 104 0.018
i kappab kinase nf kappab signaling GO:0007249 85 0.018
mitotic cytokinesis GO:0000281 4 0.018
actin polymerization or depolymerization GO:0008154 54 0.018
mitotic cell cycle process GO:1903047 159 0.018
Human
macromolecule glycosylation GO:0043413 55 0.018
organelle assembly GO:0070925 177 0.018
protein catabolic process GO:0030163 221 0.018
ribonucleoside triphosphate catabolic process GO:0009203 199 0.018
negative regulation of peptidase activity GO:0010466 46 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
chemokine production GO:0032602 34 0.017
regulation of proteolysis GO:0030162 164 0.017
cation transport GO:0006812 399 0.017
regulation of protein complex assembly GO:0043254 83 0.017
lymphocyte mediated immunity GO:0002449 139 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
regulation of intracellular protein transport GO:0033157 82 0.017
antimicrobial peptide production GO:0002775 2 0.017
glycosylation GO:0070085 62 0.017
proteasomal protein catabolic process GO:0010498 98 0.017
protein secretion GO:0009306 111 0.017
negative regulation of cell proliferation GO:0008285 296 0.016
regulation of actin filament based process GO:0032970 99 0.016
regulation of endopeptidase activity GO:0052548 89 0.016
positive regulation of protein transport GO:0051222 93 0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.016
response to growth factor GO:0070848 198 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.016
spermatogenesis GO:0007283 284 0.016
ribonucleotide metabolic process GO:0009259 291 0.016
ribonucleotide catabolic process GO:0009261 208 0.016
anatomical structure homeostasis GO:0060249 145 0.016
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.016
cellular response to molecule of bacterial origin GO:0071219 83 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
gtp catabolic process GO:0006184 143 0.016
regulation of intracellular transport GO:0032386 159 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
innate immune response activating signal transduction GO:0002758 50 0.015
regulation of defense response to bacterium GO:1900424 3 0.015
positive regulation of protein secretion GO:0050714 52 0.015
regulation of type i interferon production GO:0032479 22 0.015
regulation of cell motility GO:2000145 236 0.015
regulation of protein catabolic process GO:0042176 108 0.015
positive regulation of programmed cell death GO:0043068 218 0.015
positive regulation of actin nucleation GO:0051127 3 0.015
cellular component assembly involved in morphogenesis GO:0010927 139 0.015
rna catabolic process GO:0006401 29 0.015
leukocyte proliferation GO:0070661 172 0.015
cellular protein complex assembly GO:0043623 116 0.015
ribonucleoside triphosphate metabolic process GO:0009199 220 0.015
regulation of anatomical structure size GO:0090066 178 0.015
microtubule based process GO:0007017 236 0.015
metal ion homeostasis GO:0055065 189 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.015
immune response activating signal transduction GO:0002757 116 0.015
regulation of cell activation GO:0050865 289 0.015
striated muscle cell development GO:0055002 125 0.014
gtp metabolic process GO:0046039 144 0.014
angiogenesis GO:0001525 201 0.014
positive regulation of apoptotic process GO:0043065 217 0.014
interferon beta production GO:0032608 16 0.014
positive regulation of mapk cascade GO:0043410 170 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
glycoprotein biosynthetic process GO:0009101 89 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
regulation of cell migration GO:0030334 219 0.014
regulation of nucleotide metabolic process GO:0006140 169 0.014
protein glycosylation GO:0006486 55 0.014
positive regulation of viral entry into host cell GO:0046598 3 0.014
glucose homeostasis GO:0042593 128 0.014
purine nucleotide biosynthetic process GO:0006164 65 0.014
telencephalon development GO:0021537 186 0.014
response to organonitrogen compound GO:0010243 246 0.014
nucleoside catabolic process GO:0009164 206 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.013
negative regulation of cell development GO:0010721 169 0.013
mitotic cell cycle GO:0000278 195 0.013
Human
cellular ion homeostasis GO:0006873 165 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
regulation of antimicrobial humoral response GO:0002759 3 0.013
sensory perception GO:0007600 245 0.013
nucleoside phosphate biosynthetic process GO:1901293 79 0.013
response to radiation GO:0009314 165 0.013
regulation of homeostatic process GO:0032844 182 0.013
b cell activation GO:0042113 161 0.013
regulation of system process GO:0044057 200 0.013
regulation of nucleoside metabolic process GO:0009118 130 0.013
lymphocyte proliferation GO:0046651 164 0.013
calcium ion homeostasis GO:0055074 127 0.013
intracellular protein transport GO:0006886 204 0.013
actin cytoskeleton organization GO:0030036 220 0.013
positive regulation of interleukin 18 production GO:0032741 2 0.013
protein localization to nucleus GO:0034504 121 0.013
regulation of binding GO:0051098 111 0.013
toll like receptor signaling pathway GO:0002224 38 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
methylation GO:0032259 134 0.013
maintenance of location GO:0051235 89 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
regulation of inflammatory response GO:0050727 147 0.013
antimicrobial peptide biosynthetic process GO:0002777 2 0.013
calcium ion transport GO:0006816 159 0.013
stem cell development GO:0048864 219 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
interleukin 8 production GO:0032637 4 0.012
cellular lipid metabolic process GO:0044255 323 0.012
forebrain development GO:0030900 302 0.012
rna interference GO:0016246 2 0.012
cytokine secretion GO:0050663 72 0.012
regulation of renin secretion into blood stream GO:1900133 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 183 0.012
regulation of antimicrobial peptide production GO:0002784 1 0.012
regulation of viral genome replication GO:0045069 13 0.012
movement in environment of other organism involved in symbiotic interaction GO:0052192 15 0.012
cation transmembrane transport GO:0098655 266 0.012
cellular protein catabolic process GO:0044257 155 0.012
negative regulation of viral entry into host cell GO:0046597 10 0.012
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.012
negative regulation of nervous system development GO:0051961 156 0.012
limb morphogenesis GO:0035108 149 0.012
intestinal epithelial structure maintenance GO:0060729 4 0.012
regulation of leukocyte proliferation GO:0070663 121 0.012
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
chromatin organization GO:0006325 206 0.011
cell adhesion GO:0007155 329 0.011
regulation of kinase activity GO:0043549 249 0.011
developmental maturation GO:0021700 193 0.011
regulation of membrane potential GO:0042391 192 0.011
response to type i interferon GO:0034340 12 0.011
response to interferon gamma GO:0034341 34 0.011
dna modification GO:0006304 50 0.011
leukocyte differentiation GO:0002521 342 0.011
regulation of striated muscle cell differentiation GO:0051153 81 0.011
response to acid chemical GO:0001101 111 0.011
purine containing compound biosynthetic process GO:0072522 70 0.011
circulatory system process GO:0003013 197 0.011
regulation of hormone levels GO:0010817 211 0.011
t cell proliferation GO:0042098 120 0.011
positive regulation of cell motility GO:2000147 116 0.011
regulation of neuron differentiation GO:0045664 281 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
transmembrane transport GO:0055085 412 0.011
regulation of b cell activation GO:0050864 81 0.011
negative regulation of interleukin 6 production GO:0032715 17 0.011
stem cell differentiation GO:0048863 268 0.011
carbohydrate homeostasis GO:0033500 128 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
multicellular organismal signaling GO:0035637 91 0.011
leukocyte mediated immunity GO:0002443 174 0.011
positive regulation of multi organism process GO:0043902 26 0.011
erythrocyte differentiation GO:0030218 88 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
regulation of chemokine production GO:0032642 30 0.010
nuclear transport GO:0051169 139 0.010
positive regulation of response to biotic stimulus GO:0002833 15 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
skin development GO:0043588 220 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.010
interferon beta biosynthetic process GO:0045350 4 0.010
rig i signaling pathway GO:0039529 4 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
chromatin modification GO:0016568 187 0.010
regulation of cell adhesion GO:0030155 154 0.010
action potential GO:0001508 78 0.010
regulation of mitotic cell cycle phase transition GO:1901990 73 0.010
Human
transmission of nerve impulse GO:0019226 76 0.010
adaptive immune response GO:0002250 155 0.010
defense response to gram negative bacterium GO:0050829 28 0.010
myeloid cell homeostasis GO:0002262 114 0.010
compound eye development GO:0048749 1 0.010
extracellular structure organization GO:0043062 148 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010

Slfn8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.016
musculoskeletal system disease DOID:17 0 0.011
disease of anatomical entity DOID:7 0 0.011