Mus musculus

68 known processes

Ern1

endoplasmic reticulum (ER) to nucleus signalling 1

(Aliases: Ire1a,Ire1alpha,AI225830,C85377,Ire1p,9030414B18Rik)

Ern1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
amine metabolic process GO:0009308 45 0.310
positive regulation of cellular amine metabolic process GO:0033240 5 0.303
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.238
regulation of cellular amine metabolic process GO:0033238 20 0.164
carbohydrate derivative catabolic process GO:1901136 231 0.128
regulation of cellular amino acid metabolic process GO:0006521 5 0.113
nucleotide metabolic process GO:0009117 332 0.108
nucleoside phosphate metabolic process GO:0006753 338 0.103
transmembrane transport GO:0055085 412 0.095
cellular amino acid metabolic process GO:0006520 103 0.091
positive regulation of protein oligomerization GO:0032461 4 0.088
regulation of cellular ketone metabolic process GO:0010565 66 0.083
response to endoplasmic reticulum stress GO:0034976 53 0.082
nucleobase containing small molecule metabolic process GO:0055086 352 0.081
purine nucleotide metabolic process GO:0006163 302 0.080
organic hydroxy compound metabolic process GO:1901615 203 0.077
Yeast
glycosyl compound metabolic process GO:1901657 246 0.075
cellular ketone metabolic process GO:0042180 84 0.074
cytoplasmic transport GO:0016482 234 0.073
anion transport GO:0006820 177 0.072
purine nucleoside triphosphate catabolic process GO:0009146 203 0.072
regulation of cell motility GO:2000145 236 0.071
ion transmembrane transport GO:0034220 361 0.070
purine containing compound metabolic process GO:0072521 311 0.070
membrane organization GO:0061024 245 0.068
reactive oxygen species metabolic process GO:0072593 84 0.067
muscle tissue development GO:0060537 308 0.066
aromatic compound catabolic process GO:0019439 286 0.065
neuron apoptotic process GO:0051402 142 0.064
response to organonitrogen compound GO:0010243 246 0.063
male gamete generation GO:0048232 285 0.063
peptidyl amino acid modification GO:0018193 336 0.062
purine ribonucleotide metabolic process GO:0009150 290 0.062
organonitrogen compound catabolic process GO:1901565 264 0.062
organic cyclic compound catabolic process GO:1901361 295 0.061
ribose phosphate metabolic process GO:0019693 291 0.058
negative regulation of cellular component organization GO:0051129 194 0.058
regulation of lymphocyte activation GO:0051249 240 0.058
protein modification by small protein conjugation or removal GO:0070647 207 0.058
purine ribonucleoside metabolic process GO:0046128 241 0.058
immune effector process GO:0002252 321 0.057
nucleoside phosphate catabolic process GO:1901292 222 0.057
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.056
cellular amine metabolic process GO:0044106 44 0.056
vesicle organization GO:0016050 60 0.055
response to acid chemical GO:0001101 111 0.054
gland development GO:0048732 330 0.052
activation induced cell death of t cells GO:0006924 10 0.052
cellular macromolecule catabolic process GO:0044265 206 0.051
modification by symbiont of host morphology or physiology GO:0044003 4 0.050
regulation of cellular response to stress GO:0080135 159 0.049
Human
angiogenesis GO:0001525 201 0.048
regulation of cellular component biogenesis GO:0044087 181 0.047
heterocycle catabolic process GO:0046700 280 0.047
apoptotic signaling pathway GO:0097190 306 0.046
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.046
muscle system process GO:0003012 141 0.045
extracellular matrix organization GO:0030198 147 0.043
negative regulation of cellular amine metabolic process GO:0033239 1 0.043
regulation of protein oligomerization GO:0032459 4 0.043
cellular response to hormone stimulus GO:0032870 150 0.043
purine ribonucleotide catabolic process GO:0009154 208 0.043
lymphocyte activation involved in immune response GO:0002285 93 0.043
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.042
nucleoside triphosphate metabolic process GO:0009141 230 0.042
organophosphate catabolic process GO:0046434 232 0.042
regulation of reactive oxygen species metabolic process GO:2000377 40 0.041
glial cell apoptotic process GO:0034349 3 0.041
covalent chromatin modification GO:0016569 163 0.041
circulatory system process GO:0003013 197 0.040
regulation of cell migration GO:0030334 219 0.040
extracellular structure organization GO:0043062 148 0.040
cellular lipid metabolic process GO:0044255 323 0.039
cellular nitrogen compound catabolic process GO:0044270 280 0.039
steroid metabolic process GO:0008202 119 0.039
sphingolipid metabolic process GO:0006665 45 0.039
neuron death GO:0070997 154 0.039
alcohol metabolic process GO:0006066 116 0.038
Yeast
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.038
regulation of hormone levels GO:0010817 211 0.038
purine nucleotide catabolic process GO:0006195 211 0.037
purine containing compound catabolic process GO:0072523 213 0.037
engulfment of apoptotic cell GO:0043652 3 0.037
regulation of organelle organization GO:0033043 289 0.037
organonitrogen compound biosynthetic process GO:1901566 192 0.036
extrinsic apoptotic signaling pathway GO:0097191 126 0.036
response to extracellular stimulus GO:0009991 127 0.036
lymphocyte differentiation GO:0030098 242 0.036
multicellular organism growth GO:0035264 161 0.036
nucleotide catabolic process GO:0009166 217 0.036
regulation of interleukin 10 secretion GO:2001179 4 0.036
positive regulation of glial cell proliferation GO:0060252 4 0.036
macromolecule catabolic process GO:0009057 281 0.036
nucleoside metabolic process GO:0009116 246 0.036
positive regulation of cell activation GO:0050867 158 0.035
positive regulation of cellular catabolic process GO:0031331 148 0.035
purine nucleoside metabolic process GO:0042278 241 0.035
spermatogenesis GO:0007283 284 0.034
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.034
cellular response to molecule of bacterial origin GO:0071219 83 0.034
ribonucleotide metabolic process GO:0009259 291 0.034
ossification GO:0001503 216 0.034
response to amino acid GO:0043200 37 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
protein oligomerization GO:0051259 67 0.033
Yeast
compound eye development GO:0048749 1 0.033
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.033
Worm
glycosyl compound catabolic process GO:1901658 206 0.033
protein ubiquitination GO:0016567 171 0.033
purine ribonucleoside catabolic process GO:0046130 205 0.033
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.033
Worm
ribonucleoside triphosphate catabolic process GO:0009203 199 0.032
regulation of apoptotic signaling pathway GO:2001233 197 0.032
Worm
negative regulation of cellular protein metabolic process GO:0032269 247 0.032
positive regulation of cell development GO:0010720 237 0.032
posttranscriptional regulation of gene expression GO:0010608 155 0.032
nucleoside catabolic process GO:0009164 206 0.031
positive regulation of protein modification process GO:0031401 299 0.031
Human
positive regulation of protein homooligomerization GO:0032464 3 0.031
urogenital system development GO:0001655 261 0.031
blood circulation GO:0008015 195 0.031
regulation of neuron apoptotic process GO:0043523 122 0.031
ear development GO:0043583 200 0.030
response to inorganic substance GO:0010035 96 0.030
positive regulation of protein phosphorylation GO:0001934 242 0.030
Human
tissue homeostasis GO:0001894 115 0.030
regulation of cellular catabolic process GO:0031329 242 0.030
cellular protein catabolic process GO:0044257 155 0.029
purine nucleoside catabolic process GO:0006152 205 0.029
spermatid differentiation GO:0048515 115 0.029
ribonucleoside metabolic process GO:0009119 245 0.029
gliogenesis GO:0042063 141 0.029
protein modification by small protein conjugation GO:0032446 187 0.029
cellular response to peptidoglycan GO:0071224 4 0.029
fertilization GO:0009566 127 0.028
cation transmembrane transport GO:0098655 266 0.028
regulation of protein complex assembly GO:0043254 83 0.028
chromatin organization GO:0006325 206 0.028
response to radiation GO:0009314 165 0.028
protein homooligomerization GO:0051260 43 0.028
Yeast
cellular response to dna damage stimulus GO:0006974 207 0.028
regulation of membrane potential GO:0042391 192 0.028
interspecies interaction between organisms GO:0044419 83 0.028
cellular homeostasis GO:0019725 240 0.027
lipid transport GO:0006869 98 0.027
leukocyte activation involved in immune response GO:0002366 126 0.027
regulation of nucleotide metabolic process GO:0006140 169 0.027
regulation of multi organism process GO:0043900 111 0.027
placenta development GO:0001890 140 0.027
endocrine system development GO:0035270 98 0.027
lymphocyte mediated immunity GO:0002449 139 0.027
spleen development GO:0048536 39 0.027
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.027
nucleoside triphosphate catabolic process GO:0009143 205 0.027
positive regulation of secretion by cell GO:1903532 114 0.026
cell type specific apoptotic process GO:0097285 268 0.026
regulation of cell activation GO:0050865 289 0.026
alpha beta t cell activation GO:0046631 91 0.026
metencephalon development GO:0022037 89 0.026
cellular response to organonitrogen compound GO:0071417 145 0.026
response to molecule of bacterial origin GO:0002237 143 0.026
carbohydrate derivative biosynthetic process GO:1901137 183 0.026
rhythmic process GO:0048511 174 0.026
cation transport GO:0006812 399 0.026
cellular ion homeostasis GO:0006873 165 0.026
tube formation GO:0035148 140 0.026
protein localization to organelle GO:0033365 185 0.026
dephosphorylation GO:0016311 129 0.025
cellular response to external stimulus GO:0071496 88 0.025
divalent inorganic cation transport GO:0072511 178 0.025
camera type eye development GO:0043010 266 0.025
positive regulation of apoptotic signaling pathway GO:2001235 95 0.025
Worm
mitochondrion organization GO:0007005 134 0.025
regulation of cell cycle GO:0051726 281 0.025
response to organic cyclic compound GO:0014070 198 0.025
histone modification GO:0016570 159 0.025
regulation of homeostatic process GO:0032844 182 0.025
positive regulation of homeostatic process GO:0032846 64 0.025
regulation of organ morphogenesis GO:2000027 144 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.025
regulation of cytokine production GO:0001817 266 0.025
renal system development GO:0072001 225 0.025
connective tissue development GO:0061448 179 0.024
hindbrain development GO:0030902 128 0.024
leukocyte mediated cytotoxicity GO:0001909 62 0.024
positive regulation of nervous system development GO:0051962 221 0.024
cell adhesion GO:0007155 329 0.024
anatomical structure homeostasis GO:0060249 145 0.024
multicellular organismal homeostasis GO:0048871 164 0.024
regulation of developmental pigmentation GO:0048070 14 0.024
peptidyl tyrosine modification GO:0018212 145 0.024
regulation of protein homooligomerization GO:0032462 3 0.024
protein processing GO:0016485 163 0.024
regulation of ion transport GO:0043269 215 0.024
mitochondrial membrane organization GO:0007006 26 0.024
striated muscle tissue development GO:0014706 293 0.024
regulation of anatomical structure size GO:0090066 178 0.023
peptidyl tyrosine phosphorylation GO:0018108 143 0.023
response to steroid hormone GO:0048545 56 0.023
appendage morphogenesis GO:0035107 149 0.023
myotube differentiation GO:0014902 105 0.023
b cell activation GO:0042113 161 0.023
gtp catabolic process GO:0006184 143 0.023
t cell activation involved in immune response GO:0002286 43 0.023
positive regulation of nucleotide metabolic process GO:0045981 114 0.023
cellular response to lipid GO:0071396 145 0.023
oxidation reduction process GO:0055114 342 0.023
regulation of neuron differentiation GO:0045664 281 0.023
glycoprotein metabolic process GO:0009100 116 0.023
mitochondrial transport GO:0006839 36 0.023
epithelial cell development GO:0002064 159 0.022
cerebral cortex development GO:0021987 86 0.022
regulation of lymphocyte mediated immunity GO:0002706 84 0.022
asymmetric stem cell division GO:0098722 3 0.022
muscle contraction GO:0006936 101 0.022
circadian rhythm GO:0007623 114 0.022
limb morphogenesis GO:0035108 149 0.022
sensory perception GO:0007600 245 0.022
g protein coupled receptor signaling pathway GO:0007186 243 0.022
kidney development GO:0001822 213 0.022
actin cytoskeleton organization GO:0030036 220 0.022
regulation of system process GO:0044057 200 0.022
blood vessel morphogenesis GO:0048514 285 0.022
positive regulation of cell death GO:0010942 224 0.022
Worm
reactive oxygen species biosynthetic process GO:1903409 8 0.022
multicellular organismal response to stress GO:0033555 62 0.022
cell activation involved in immune response GO:0002263 126 0.021
second messenger mediated signaling GO:0019932 73 0.021
small molecule biosynthetic process GO:0044283 132 0.021
regionalization GO:0003002 337 0.021
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.021
positive regulation of mitochondrion organization GO:0010822 17 0.021
action potential GO:0001508 78 0.021
regulation of transferase activity GO:0051338 263 0.021
Human
cellular response to cytokine stimulus GO:0071345 189 0.021
response to peptide GO:1901652 136 0.021
regulation of cell killing GO:0031341 40 0.020
metal ion homeostasis GO:0055065 189 0.020
endomembrane system organization GO:0010256 147 0.020
calcium ion transport GO:0006816 159 0.020
sensory organ morphogenesis GO:0090596 242 0.020
regulation of feeding behavior GO:0060259 3 0.020
peptidyl lysine modification GO:0018205 77 0.020
guanosine containing compound catabolic process GO:1901069 144 0.020
protein localization to nucleus GO:0034504 121 0.020
respiratory system development GO:0060541 190 0.020
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.020
cytokine production GO:0001816 319 0.020
smooth muscle tissue development GO:0048745 22 0.020
positive regulation of gtp catabolic process GO:0033126 85 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
reactive nitrogen species metabolic process GO:2001057 0 0.019
purine nucleoside triphosphate metabolic process GO:0009144 226 0.019
ribonucleotide catabolic process GO:0009261 208 0.019
apoptotic process involved in mammary gland involution GO:0060057 4 0.019
neural tube development GO:0021915 160 0.019
t cell homeostasis GO:0043029 35 0.019
pallium development GO:0021543 120 0.019
negative regulation of interleukin 10 secretion GO:2001180 2 0.019
respiratory tube development GO:0030323 167 0.019
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.019
membrane lipid metabolic process GO:0006643 53 0.019
cellular response to growth factor stimulus GO:0071363 197 0.019
negative regulation of lymphocyte activation GO:0051250 91 0.019
dna metabolic process GO:0006259 303 0.019
carboxylic acid transport GO:0046942 100 0.019
negative regulation of protein metabolic process GO:0051248 282 0.019
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.019
leukocyte differentiation GO:0002521 342 0.018
signal transduction in absence of ligand GO:0038034 55 0.018
cytokine mediated signaling pathway GO:0019221 115 0.018
homeostasis of number of cells GO:0048872 210 0.018
intestinal epithelial structure maintenance GO:0060729 4 0.018
t cell activation GO:0042110 289 0.018
mitotic cell cycle GO:0000278 195 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
viral process GO:0016032 41 0.018
intracellular receptor signaling pathway GO:0030522 74 0.018
peptide secretion GO:0002790 114 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.018
divalent metal ion transport GO:0070838 172 0.018
muscle cell differentiation GO:0042692 261 0.018
glucose homeostasis GO:0042593 128 0.018
inflammatory response GO:0006954 244 0.018
skeletal system development GO:0001501 356 0.018
small gtpase mediated signal transduction GO:0007264 97 0.018
intrinsic apoptotic signaling pathway GO:0097193 132 0.018
negative regulation of immune system process GO:0002683 209 0.018
modulation by virus of host morphology or physiology GO:0019048 3 0.018
negative regulation of response to wounding GO:1903035 77 0.018
b cell apoptotic process GO:0001783 19 0.018
stem cell differentiation GO:0048863 268 0.018
viral life cycle GO:0019058 36 0.018
detection of chemical stimulus involved in sensory perception of smell GO:0050911 4 0.018
cell killing GO:0001906 67 0.018
divalent inorganic cation homeostasis GO:0072507 138 0.018
t cell apoptotic process GO:0070231 39 0.017
antigen receptor mediated signaling pathway GO:0050851 64 0.017
regulation of body fluid levels GO:0050878 162 0.017
myeloid cell differentiation GO:0030099 233 0.017
cardiac muscle tissue development GO:0048738 130 0.017
learning or memory GO:0007611 148 0.017
ribonucleoside catabolic process GO:0042454 206 0.017
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.017
lymphocyte proliferation GO:0046651 164 0.017
cellular response to lipopolysaccharide GO:0071222 77 0.017
regulation of engulfment of apoptotic cell GO:1901074 2 0.017
cellular response to organic cyclic compound GO:0071407 87 0.017
organelle localization GO:0051640 179 0.017
pigmentation GO:0043473 71 0.017
negative regulation of inflammatory response GO:0050728 61 0.017
organic anion transport GO:0015711 137 0.017
regulation of cytoplasmic transport GO:1903649 112 0.017
positive regulation of leukocyte proliferation GO:0070665 73 0.017
cell substrate adhesion GO:0031589 130 0.017
activation of cysteine type endopeptidase activity GO:0097202 27 0.017
renal system process GO:0003014 48 0.017
cellular response to biotic stimulus GO:0071216 92 0.017
regulation of cytoskeleton organization GO:0051493 122 0.016
regulation of protein localization GO:0032880 231 0.016
positive regulation of defense response GO:0031349 124 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
response to oxygen levels GO:0070482 62 0.016
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.016
forebrain development GO:0030900 302 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.016
mesenchymal cell development GO:0014031 93 0.016
nitrogen compound transport GO:0071705 271 0.016
embryonic limb morphogenesis GO:0030326 126 0.016
cell junction organization GO:0034330 77 0.016
rho protein signal transduction GO:0007266 32 0.016
response to starvation GO:0042594 65 0.016
regulation of ph GO:0006885 26 0.016
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.016
axonogenesis GO:0007409 274 0.016
interleukin 6 production GO:0032635 58 0.016
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.016
organophosphate biosynthetic process GO:0090407 122 0.016
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.016
defense response to other organism GO:0098542 197 0.016
monocarboxylic acid metabolic process GO:0032787 191 0.016
cartilage development GO:0051216 140 0.016
regulation of muscle system process GO:0090257 80 0.016
heart contraction GO:0060047 93 0.016
regulation of purine nucleotide catabolic process GO:0033121 122 0.016
regulation of cytokine secretion involved in immune response GO:0002739 4 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
negative regulation of cell activation GO:0050866 111 0.015
gtp metabolic process GO:0046039 144 0.015
cellular chemical homeostasis GO:0055082 215 0.015
cellular response to nutrient levels GO:0031669 64 0.015
positive regulation of nucleoside metabolic process GO:0045979 91 0.015
ribonucleoside monophosphate metabolic process GO:0009161 80 0.015
response to nutrient levels GO:0031667 109 0.015
muscle cell development GO:0055001 133 0.015
limb development GO:0060173 166 0.015
positive regulation of hydrolase activity GO:0051345 148 0.015
Human
immune response regulating signaling pathway GO:0002764 125 0.015
positive regulation of apoptotic process GO:0043065 217 0.015
Worm
t cell mediated immunity GO:0002456 50 0.015
regulation of leukocyte mediated immunity GO:0002703 104 0.015
appendage development GO:0048736 166 0.015
immune response activating signal transduction GO:0002757 116 0.015
notch signaling pathway GO:0007219 71 0.015
positive regulation of apoptotic cell clearance GO:2000427 3 0.015
protein catabolic process GO:0030163 221 0.015
nephron development GO:0072006 109 0.015
chemotaxis GO:0006935 247 0.015
ras protein signal transduction GO:0007265 77 0.015
regulation of kinase activity GO:0043549 249 0.015
Human
negative regulation of phosphorylation GO:0042326 166 0.015
cognition GO:0050890 149 0.015
hormone metabolic process GO:0042445 86 0.014
establishment of organelle localization GO:0051656 122 0.014
positive regulation of mammary gland involution GO:1903521 4 0.014
interaction with host GO:0051701 22 0.014
innate immune response GO:0045087 157 0.014
negative regulation of protein transport GO:0051224 46 0.014
guanosine containing compound metabolic process GO:1901068 144 0.014
negative regulation of interleukin 5 secretion GO:2000663 1 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
neurotransmitter transport GO:0006836 76 0.014
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.014
positive regulation of interferon alpha production GO:0032727 4 0.014
alpha beta t cell activation involved in immune response GO:0002287 31 0.014
actin filament organization GO:0007015 113 0.014
circadian regulation of gene expression GO:0032922 48 0.014
cell growth GO:0016049 130 0.014
organelle fission GO:0048285 170 0.014
b cell differentiation GO:0030183 78 0.014
embryonic placenta development GO:0001892 98 0.014
neuronal action potential GO:0019228 54 0.014
nucleotide sugar metabolic process GO:0009225 4 0.014
cell cell junction organization GO:0045216 72 0.014
epithelial tube formation GO:0072175 130 0.014
atp metabolic process GO:0046034 75 0.014
odontogenesis GO:0042476 78 0.014
intracellular protein transport GO:0006886 204 0.014
positive regulation of cell motility GO:2000147 116 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
asymmetric neuroblast division GO:0055059 1 0.014
regulation of leukocyte differentiation GO:1902105 159 0.013
microtubule cytoskeleton organization GO:0000226 157 0.013
response to peptide hormone GO:0043434 127 0.013
skin development GO:0043588 220 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
striated muscle contraction GO:0006941 45 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.013
regulation of cell adhesion GO:0030155 154 0.013
lipid biosynthetic process GO:0008610 179 0.013
skeletal muscle organ development GO:0060538 163 0.013
regulation of ossification GO:0030278 112 0.013
liposaccharide metabolic process GO:1903509 27 0.013
cellular response to amino acid stimulus GO:0071230 29 0.013
purine nucleotide biosynthetic process GO:0006164 65 0.013
regulation of interleukin 13 secretion GO:2000665 2 0.013
regulation of mitotic cell cycle GO:0007346 126 0.013
embryonic epithelial tube formation GO:0001838 130 0.013
calcium ion homeostasis GO:0055074 127 0.013
regulation of mitochondrion organization GO:0010821 27 0.013
vascular process in circulatory system GO:0003018 62 0.013
retrograde transport endosome to golgi GO:0042147 2 0.013
release of cytochrome c from mitochondria GO:0001836 23 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
rna interference GO:0016246 2 0.013
mapk cascade GO:0000165 281 0.013
immunoglobulin production GO:0002377 73 0.013
defecation GO:0030421 1 0.013
kidney epithelium development GO:0072073 121 0.013
leukocyte apoptotic process GO:0071887 71 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
neuron migration GO:0001764 122 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.013
monovalent inorganic cation homeostasis GO:0055067 33 0.013
transmission of nerve impulse GO:0019226 76 0.013
negative regulation of interleukin 5 production GO:0032714 4 0.013
regulation of hydrolase activity GO:0051336 246 0.013
Human
regulation of gtp catabolic process GO:0033124 113 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
positive regulation of cell cycle GO:0045787 92 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
mesonephros development GO:0001823 97 0.013
adaptive immune response GO:0002250 155 0.013
lymphocyte apoptotic process GO:0070227 54 0.013
protein maturation GO:0051604 176 0.012
oxidative demethylation GO:0070989 1 0.012
carboxylic acid catabolic process GO:0046395 51 0.012
membrane fusion GO:0061025 38 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.012
positive regulation of organelle organization GO:0010638 128 0.012
leukocyte mediated immunity GO:0002443 174 0.012
nucleotide biosynthetic process GO:0009165 78 0.012
positive regulation of smooth muscle cell migration GO:0014911 4 0.012
cellular response to steroid hormone stimulus GO:0071383 33 0.012
defense response to bacterium GO:0042742 119 0.012
apoptotic mitochondrial changes GO:0008637 48 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.012
ribonucleoside monophosphate catabolic process GO:0009158 57 0.012
regulation of defense response GO:0031347 233 0.012
regulation of secretion by cell GO:1903530 249 0.012
protein alkylation GO:0008213 81 0.012
transepithelial chloride transport GO:0030321 4 0.012
calcium mediated signaling GO:0019722 46 0.012
somatic diversification of immunoglobulins GO:0016445 43 0.012
necroptotic signaling pathway GO:0097527 3 0.012
regulation of blood pressure GO:0008217 93 0.012
regulation of myotube differentiation GO:0010830 62 0.012
positive regulation of lymphocyte proliferation GO:0050671 70 0.012
atp catabolic process GO:0006200 55 0.012
erk1 and erk2 cascade GO:0070371 77 0.012

Ern1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.050
nervous system disease DOID:863 0 0.050
immune system disease DOID:2914 0 0.045
central nervous system disease DOID:331 0 0.041
disease of metabolism DOID:0014667 0 0.039
musculoskeletal system disease DOID:17 0 0.028
disease of cellular proliferation DOID:14566 0 0.025
retinal disease DOID:5679 0 0.021
sensory system disease DOID:0050155 0 0.021
eye and adnexa disease DOID:1492 0 0.021
eye disease DOID:5614 0 0.021
connective tissue disease DOID:65 0 0.020
neurodegenerative disease DOID:1289 0 0.020
bone disease DOID:0080001 0 0.018
hematopoietic system disease DOID:74 0 0.017
inherited metabolic disorder DOID:655 0 0.016
immune system cancer DOID:0060083 0 0.015
hematologic cancer DOID:2531 0 0.015
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
lysosomal storage disease DOID:3211 0 0.014